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Archive, 2022-08

5 Treatment history shapes the evolution of complex carbapenem-resistant phenotypes in Klebsiella spp.
Lithgow, T.; Zhou, T.; MCDONALD, M.; Rosas, N.; Wilksch, J.; Barber, J.; Li, J.; Wang, Y.; Sun, Z.; Rocker, A.; Webb, C.; Perlaza-Jimenez, L.; Stubenrauch, C.; Vijaykrishn, D.; Song, J.; Taiaroa, G.; Davies, M. R.; Strugnell, R.; Bao, Q.
10.1101/2022.08.30.505938 — microbiology — Posted on 2022-08-30
9 Rejection of inappropriate synaptic partners mediated by transcellular FLRT2-UNC5 signaling
Prigge, C. L.; Sharma, A.; Dembla, M.; El-Quessny, M.; Kozlowski, C.; Paisley, C. E.; Johnson, T.; Della Santina, L.; Feller, M.; Kay, J. N.
10.1101/2022.08.29.505771 — neuroscience — Posted on 2022-08-30
11 Structural and mechanistic insights into inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4
Gao, Z.; Zhang, L.; Ge, Z.; Wang, H.; Yue, Y.; Jiang, Z.; Wang, X.; Xu, C.; Zhang, Y.; Yang, M.; Feng, Y.
10.1101/2022.08.30.504949 — molecular biology — Posted on 2022-08-30
14 Early Signaling Events in Renal Compensatory Hypertrophy Revealed by Multi-Omics
Kikuchi, H.; Chou, C.-L.; Yang, C.-R.; Chen, L.; Jung, H. J.; Limbutara, K.; Carter, B.; Knepper, M. A.
10.1101/2022.08.29.505304 — systems biology — Posted on 2022-08-30
16 A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae
Smidler, A. L.; Pai, J. J.; Apte, R. A.; Sanchez C., H. M.; Corder, R. M.; Gutierrez, E. J.; Thakre, N.; Antoshechkin, I.; Marshall, J. M.; Akbari, O.
10.1101/2022.08.30.505861 — bioengineering — Posted on 2022-08-30
19 benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes
Murthy, S.; Nizi, M. G.; Maksimainen, M. M.; Massari, S.; Alaviuhkola, J.; Lippok, B. E.; Vagaggini, C.; Sowa, S. T.; Galera-Prat, A.; Ashok, Y.; Venkannagari, H.; Prunskaite-Hyyryläinen, R.; Dreassi, E.; Lüscher, B.; Korn, P.; Tabarrini, O.; Lehtiö, L.
10.1101/2022.08.29.505683 — biochemistry — Posted on 2022-08-30
23 Embryonic cortical layer 5 pyramidal neurons form an active, transient circuit motif perturbed by autism-associated mutations
Munz, M.; Bharioke, A.; Kosche, G.; Moreno-Juan, V.; Brignall, A.; Graff-Meyer, A.; Ulmer, T.; Rodrigues, T.; Haeuselmann, S.; Pavlinic, D.; Ledergerber, N.; Gross-Scherf, B.; Rozsa, B.; Krol, J.; Picelli, S.; Cowan, C. S.; Roska, B.
10.1101/2022.08.31.506080 — neuroscience — Posted on 2022-08-31
24 Experience, not time, determines representational drift in the hippocampus
Khatib, D.; Ratzon, A.; Sellevoll, M.; Barak, O.; Morris, G.; Derdikman, D.
10.1101/2022.08.31.506041 — neuroscience — Posted on 2022-08-31
25 Lack of the glycine alpha 2 receptor impairs reward-motivated behavior and striatal signal integration.
Devoght, J.; Comhair, J.; Morelli, G.; Rigo, J.-M.; D'Hooge, R.; Touma, C.; Palme, R.; Dewachter, I.; vandeVen, M.; Harvey, R. J.; Schiffmann, S.; Piccart, E.; Brone, B.
10.1101/2022.08.31.506020 — neuroscience — Posted on 2022-08-31
26 A slow 5-HT1AR-mediated recurrent inhibitory network in raphe computes contextual value through synaptic facilitation
Lynn, M. B.; Geddes, S.; Chahrour, M.; Maille, S.; Harkin, E.; Harvey-Girard, E.; Haj-Dahmane, S.; Naud, R. B.; Beique, J.-C.
10.1101/2022.08.31.506056 — neuroscience — Posted on 2022-08-31
33 Primate Social Organization Evolved from a Flexible Pair-Living Ancestor
Olivier, C.-A.; Martin, J. S.; Pilisi, C.; Agnani, P.; Kaufmann, C.; Hayes, L. D.; Jaeggi, A.; Schradin, C.
10.1101/2022.08.29.505776 — evolutionary biology — Posted on 2022-08-30
34 Epigenetic variations are landmarks of freshwater adaptation in threespine sticklebacks
Golden, A.; Starshin, A.; Mazur, A.; Mugue, N.; Kaplun, D.; Artemov, A.; Khrameeva, E.; Prokhortchouk, E.
10.1101/2022.08.22.504457 — evolutionary biology — Posted on 2022-08-31
38 Mechanotransduction coordinates extracellular matrix protein homeostasis promoting longevity in C. elegans
Teuscher, A.; Statzer, C.; Goyala, A.; Domenig, S.; Schoen, I.; Hess, M.; Hofer, A.; Fossati, A.; Vogel, V.; Goksel, O.; Aebersold, R.; Ewald, C. Y.
10.1101/2022.08.30.505802 — molecular biology — Posted on 2022-08-30
39 The cancer-associated RBM39 bridges the pre-mRNA, U1 and U2 snRNPs to regulate alternative splicing
Campagne, S.; Jutzi, D.; Malard, F.; Matoga, M.; Romane, K.; Feldmuller, M.; Colombo, M.; Ruepp, M.-D.; Allain, F. H.- T.
10.1101/2022.08.30.505862 — molecular biology — Posted on 2022-08-30
40 Dorsal striatum coding for the timely execution of action sequences
Martinez, M. C.; Zold, C. L.; Coletti, M. A.; Murer, M. G.; Belluscio, M. A.
10.1101/2021.11.01.466347 — neuroscience — Posted on 2022-08-31
41 Contrast and luminance gain control in the macaque's lateral geniculate nucleus
Raghavan, R. T.; Kelly, J. G.; Hasse, J. M.; Levy, P. G.; Hawken, M. J.; Movshon, J. A.
10.1101/2022.08.29.505733 — neuroscience — Posted on 2022-08-31
42 Disentangling five dimensions of animacy in human brain and behaviour
Jozwik, K. M.; Najarro, E.; van den Bosch, J. J.; Charest, I.; Cichy, R. M.; Kriegeskorte, N.
10.1101/2021.09.12.459854 — neuroscience — Posted on 2022-08-31
44 TMEM100, a Lung-Specific Endothelium Gene
Liu, B.; Yi, D.; Yu, Z.; Pan, J.; Ramirez, K.; Li, S.; Wang, T.; Glembotski, C.; Fallon, M.; Oh, P.; Gu, M.; Kalucka, J.; Dai, Z.
10.1101/2022.08.26.504609 — physiology — Posted on 2022-08-31
45 PGC-1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2
Frodyma, D. E.; Troia, T. C.; Berg, J. A.; Rao, C.; Svoboda, R. A.; Shinde, D. D.; Thomas, V. C.; Lewis, R. E.; Fisher, K. W.
10.1101/2022.05.20.492006 — cancer biology — Posted on 2022-08-31
47 Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy
Ehrmann, J. F.; Grabarczyk, D. B.; Heinke, M.; Deszcz, L.; Kurzbauer, R.; Hudecz, O.; Shulkina, A.; Gogova, R.; Meinhart, A.; Versteeg, G. A.; Clausen, T.
10.1101/2022.08.30.505823 — biochemistry — Posted on 2022-08-30
48 GRaNIE and GRaNPA: Inference and evaluation of enhancer-mediated gene regulatory networks applied to study macrophages
Kamal, A.; Arnold, C.; Claringbould, A.; Moussa, R.; Servaas, N.; Kholmatov, M.; Daga, N.; Nogina, D.; Mueller-Dott, S.; Reyes-Palomares, A.; Palla, G.; Sigalova, O.; Bunina, D.; Pabst, C.; Zaugg, J. B.
10.1101/2021.12.18.473290 — genomics — Posted on 2022-08-31
52 Non-target effects of ten essential oils on the egg parasitoid Trichogramma evanescens
van Oudenhove, L.; Cazier, A.; Fillaud, M.; Lavoir, A.-V.; Fatnassi, H.; Perez, G.; Calcagno, V.
10.1101/2022.01.14.476310 — ecology — Posted on 2022-08-31
55 Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-beta Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis
Dong, Y.; Wang, B.; Du, M.; Zhu, B.; Cui, K.; Chan, K.; Cowan, D. B.; Bhattacharjee, S.; Wong, S.; Bischoff, J.; Linton, M. F.; Chen, H.
10.1101/2022.08.09.503324 — cell biology — Posted on 2022-08-31
56 Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression
Cui, K.; Gao, X.; Wang, B.; Wu, H.; Dong, Y.; Xiao, Y.; Jiang, X.; Malovichko, M. V.; Li, K.; Peng, Q.; Lu, Y. W.; Zhu, B.; Zheng, R.; Wong, S.; Cowan, D. B.; Linton, M. F.; Srivastava, S.; Shi, J.; Chen, K. F.; Chen, H.
10.1101/2022.08.09.503334 — cell biology — Posted on 2022-08-31
65 Targeting of the human nasal microbiota by secretory IgA antibodies
van Dalen, R.; Elsherbini, A. M. A.; Harms, M.; Alber, S.; Stemmler, R.; Peschel, A.
10.1101/2022.08.31.505993 — microbiology — Posted on 2022-08-31
67 BNIP3L-mediated mitophagy triggered by Brucella in host cells is required for bacterial egress
Verbeke, J.; Fayt, Y.; Martin, L.; Yilmaz, O.; Sedzicki, J.; Reboul, A.; Jadot, M.; Renard, P.; Dehio, C.; Renard, H.-F.; Letesson, J.-J.; De Bolle, X.; Arnould, T.
10.1101/2022.08.31.505824 — microbiology — Posted on 2022-08-31
68 A Metabolic Sum Rule Dictates Bacterial Response to Short-Chain Fatty Acid Stress
Taylor, B. R.; Patsalo, V.; Okano, H.; Shen, Y.; Zhange, Z.; Williamson, J. R.; Rabinowitz, J. D.; Hwa, T.
10.1101/2022.08.31.506075 — microbiology — Posted on 2022-08-31
70 Chitosan diet alters the microbiome of adult house flies
Schaal, H.; Choudoir, M.; Diwanji, V.; Stoffolano, J.; DeAngelis, K. M.
10.1101/2022.08.31.502951 — microbiology — Posted on 2022-08-31
72 Methanotrophs are vigorous H2S oxidizers using a sulfide:quinone oxidoreductase and a ba3-type terminal oxidase
Schmitz, R. A.; Peeters, S. H.; Mohammadi, S. S.; Berben, T.; van Erven, T.; Iosif, C. A.; van Alen, T.; Versantvoort, W.; Jetten, M. S. M.; Op den Camp, H. J. M.; Pol, A.
10.1101/2022.08.31.505896 — microbiology — Posted on 2022-08-31
80 Global and tissue-specific aging effects on murine proteomes
Keele, G. R.; Zhang, J.-G.; Szpyt, J.; Korstanje, R.; Gygi, S.; Churchill, G. A.; Schweppe, D. K.
10.1101/2022.05.17.492125 — systems biology — Posted on 2022-08-31
83 Multiplexed and millimeter-scale superresolution imaging of cells and tissue sections via prism-illumination and microfluidics-enhanced DNA-PAINT
Rames, M. J.; Kenison, J.; Heineck, D.; Civitci, F.; Szczepaniak, M.; Tao, K.; Zheng, T.; Shangguan, J.; Esener, S.; Nan, X.
10.1101/2022.08.07.503091 — biophysics — Posted on 2022-08-31
86 Interaction with C21ORF2 controls the cellular functions of the NEK1 kinase
Rouse, J.; Gregorczyk, M.; Pastore, G.; Lis, P.; Lange, S.; Lamoliatte, F.; Macartney, T.; Toth, R.; Brown, F.; Hastie, J.; Durocher, D.
10.1101/2022.08.31.505651 — biochemistry — Posted on 2022-08-31
87 Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells
Gerdes, P.; Lim, S. M.; Ewing, A. D.; Larcombe, M. R.; Chan, D.; Sanchez-Luque, F. J.; Walkner, L.; Carleton, A. L.; James, C.; Knaupp, A. S.; Carreira, P. E.; Nefzger, C. M.; Lister, R.; Richardson, S. R.; Polo, J. M.; Faulkner, G. J.
10.1101/2022.02.16.480772 — genomics — Posted on 2022-08-31
88 Ratio-based sensing of two transcription factors regulates the transit to differentiation
Bernasek, S. M.; Hur, S. S.; Pelaez, N.; Boisclair Lachance, J.-F.; Bakker, R.; Navarro, H. T.; Sanchez-Luege, N.; Amaral, L. A. N.; Bagheri, N.; Rebay, I.; Carthew, R. W.
10.1101/430744 — developmental biology — Posted on 2022-08-31
89 NRF2 activation induces NADH-reductive stress providing a metabolic vulnerability in lung cancer
Weiss-Sadan, T.; Ge, M.; de Groot, A.; Carlin, A.; Gohar, M.; Fischer, H.; Shi, L.; Wei, T.-Y.; Adelmann, C. H.; Vornbaumen, T.; Durr, B. R.; Takahashi, M.; Richter, M.; Zhang, J.; Yang, T.-Y.; Vijay, V.; Hayashi, M.; Fischer, D. E.; Hata, A. N.; Papaginanakopoulos, T.; Mostoslavsky, R.; Bardeesy, N.; bar-peled, l.
10.1101/2022.08.31.506025 — molecular biology — Posted on 2022-08-31
90 Taxonomic and metagenomic analyses define the development of the microbiota in the chick
Bogomolnaya, L. M.; Talamantes, M.; Rocha, J.; Nagarajan, A.; Zhu, W.; Spiga, L.; Winter, M. G.; Konganti, K.; Adams, L. G.; Winter, S.; Andrews-Polymenis, H. L.
10.1101/2022.08.30.505967 — microbiology — Posted on 2022-08-31
91 Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.
Ng, K. M.; Pannu, S.; Liu, S.; Burckhardt, J. C.; Hughes, T.; Van Treuren, W.; Nguyen, J.; Naqvi, K.; Nguyen, B.; Clayton, C. A.; Pepin, D. M.; Collins, S. R.; Tropini, C.
10.1101/2022.08.31.505752 — microbiology — Posted on 2022-08-31
94 Functional succession of actively growing soil microorganisms during rewetting is shaped by precipitation history
Sieradzki, E. T.; Greenlon, A.; Nicolas, A. M.; Firestone, M. K.; Pett-Ridge, J.; Blazewicz, S. J.; Banfield, J.
10.1101/2022.06.28.498032 — microbiology — Posted on 2022-08-31
96 Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome
Mykins, M.; Layo-Carris, D. E.; Dunn, L.; Skinner, D. W.; McBryar, A.; Perez, S.; Shultz, T. R.; Willems, A.; Lau, B. Y. B.; Hong, T.; Krishnan, K.
10.1101/2022.04.25.482695 — neuroscience — Posted on 2022-08-31
97 Stac1 Regulates Sensory Stimulus Induced Escape Locomotion
Linsley, J. W.; Perez, N.; Hsu, I.-U.; Yu, Y.; Jasti, N.; Waalkes, M.; Horstick, E. J.; Kuwada, J. Y.
10.1101/2022.08.24.505176 — neuroscience — Posted on 2022-08-31
99 Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters
Shiwa-Sudo, N.; Sakai, Y.; Iwata-Yoshikawa, N.; Watanabe, S.; Yamada, S.; Kuroda, Y.; Yamamoto, T.; Shirakura, M.; Fujisaki, S.; Miyazaki, K.; Miura, H.; Nagata, S.; Fukushi, S.; Maeda, K.; Hasegawa, H.; Suzuki, T.; Nagata, N.
10.1101/2022.08.30.505966 — microbiology — Posted on 2022-08-31
100 Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants
de Melo, G. D.; Perraud, V.; Alvarez, F.; Vieites-Prado, A.; Kim, S.; Kergoat, L.; Trueb, B. S.; Tichit, M.; Piazza, A.; Thierry, A.; Hardy, D.; Wolff, N.; Munier, S.; Koszul, R.; Simon-Loriere, E.; Thiel, V.; Lecuit, M.; Lledo, P.-M.; Renier, N.; Larrous, F.; Bourhy, H.
10.1101/2022.08.31.505985 — neuroscience — Posted on 2022-08-31
105 Uracil-DNA glycosylase efficiency is modulated by substrate rigidity
Orndorff, P. B.; Poddar, S.; Owens, A. M.; Ugaz, B. T.; Kumari, N.; Amin, S.; Van Horn, W. D.; van der Vaart, A.; Levitus, M.
10.1101/2022.08.30.505906 — biophysics — Posted on 2022-08-31
108 Negative allosteric modulation of the glucagon receptor by RAMP2
Krishna Kumar, K.; O'Brien, E.; Habrian, C.; Latorraca, N. R.; Wang, H.; Tuneew, I.; Montabana, E.; Marqusee, S.; Hilger, D.; Isacoff, E. Y.; Mathiesen, J. M.; Kobilka, B. K.
10.1101/2022.08.30.505955 — biochemistry — Posted on 2022-08-31
109 Regional and LTP-Dependent Variation of Synaptic Information Storage Capacity in Rat Hippocampus
Samavat, M.; Bartol, T. M.; Bromer, C.; Bowden, J. B.; Hubbard, D. D.; Hanka, D. C.; Kuwajima, M.; Mendenhall, J. M.; Parker, P. H.; Abraham, W. C.; Harris, K. M.; Sejnowski, T. J.
10.1101/2022.08.29.505464 — neuroscience — Posted on 2022-08-31
112 Contrast and luminance gain control in the macaque'slateral geniculate nucleus
Raghavan, R. T.; Kelly, J. G.; Hasse, J. M.; Levy, P.; Hawken, M.; Movshon, J. A.
10.1101/2022.08.29.505733 — neuroscience — Posted on 2022-08-31
113 Special Nuclear Layer Contacts Among Starburst Amacrine Cells in the Mouse Retina
Mu, S.; Turner, N. L.; Silversmith, W. M.; Jordan, C. S.; Kemnitz, N.; Sorek, M.; David, C.; Jones, D. L.; Bland, D.; Moore, M.; Sterling, A. R.; Seung, H. S.; the Eyewirers,
10.1101/2022.08.28.504668 — neuroscience — Posted on 2022-08-31
115 Tracking subject's strategies in behavioural choice experiments at trial resolution
Maggi, S.; Hock, R. M.; O'Neill, M.; Buckley, M. J.; Moran, P. M.; Bast, T.; Sami, M.; Humphries, M. D.
10.1101/2022.08.30.505807 — neuroscience — Posted on 2022-08-31
116 Chrna5 and lynx prototoxins identify acetylcholine super-responder subplate neurons
Venkatesan, S.; Chen, T.; Liu, Y.; Turner, E. E.; Tripathy, S.; Lambe, E. K.
10.1101/2022.06.20.496737 — neuroscience — Posted on 2022-08-31
117 Trans-collicular pathways for sensory-motor integration in the whisker system
Martin-Cortecero, J.; Isaias-Camacho, E. U.; Boztepe, B.; Ziegler, K.; Mease, R. A.; Groh, A.
10.1101/2022.08.30.505868 — neuroscience — Posted on 2022-08-31
121 Hormone-sleep interactions predict cerebellar connectivity and behavior in aging females
Ballard, H. K.; Jackson, T. B.; Hicks, T. H.; Cox, S. J.; Miller, A. C.; Maldonado, T.; Bernard, J. A.
10.1101/2022.08.30.505858 — neuroscience — Posted on 2022-08-31
124 Alveolar epithelial progenitor cells drive lung regeneration via dynamic changes in chromatin topology modulated by lineage-specific Nkx2-1 activity
Toth, A.; Kannan, P. S.; Snowball, J.; Kofron, J. M.; Wayman, J. A.; Bridges, J. P.; Miraldi, E. R.; Swarr, D.; Zacharias, W. J.
10.1101/2022.08.30.505919 — developmental biology — Posted on 2022-08-31
125 Positional cues underlie cell fate specification during branching morphogenesis of the embryonic mammary epithelium
Carabana, C.; Sun, W.; Perkins, M.; Kapoor, V.; Journot, R.; Hartani, F.; Faraldo, M. M.; Lloyd-Lewis, B.; Fre, S.
10.1101/2022.08.30.505826 — developmental biology — Posted on 2022-08-31
126 Lipotype acquisition during neural development in vivo is not recapitulated in stem cell-derived neurons
Gopalan, A. B.; van Uden, L.; Sprenger, R. R.; Fernandez-Novel Marx, N.; Bogetofte, H.; Neveu, P.; Meyer, M.; Noh, K.-M.; Diz-Munoz, A.; Ejsing, C. S.
10.1101/2022.08.31.505694 — developmental biology — Posted on 2022-08-31
136 Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan
Schoenfeldt, L.; Paine, P. T.; Kamaludeen M., N. H.; Phelps, G. B.; Mrabti, C.; Perez, K.; Ocampo, A.
10.1101/2022.08.29.505222 — cell biology — Posted on 2022-08-31
137 Myo1f has an essential role in γδT intraepithelial lymphocyte adhesion and migration
Martinez-Vargas, I. U.; Sanchez-Bello, M. E.; Miguel-Rodriguez, C. E.; Hernandez-Cazares, F.; Santos-Argumedo, L.; Talamas-Rohana, P.
10.1101/2022.08.30.505932 — cell biology — Posted on 2022-08-31
138 Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors
Pedraza, N.; Monserrat, M. V.; Ferrezuelo, F.; Torres-Rosell, J.; Colomina, N.; Soto, D.; Esteban, J. A.; Miguez, F.; Egea, J.; Gari, E.
10.1101/2022.06.30.498219 — molecular biology — Posted on 2022-08-31
139 Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains
Hay, I. M.; Shamin, M.; Caroe, E. R.; Mohammed, A. S. A.; Svergun, D. I.; Jeffries, C. M.; Graham, S. C.; Sharpe, H. J.; Deane, J. E.
10.1101/2022.06.23.497309 — biochemistry — Posted on 2022-08-31
141 Frameshift Mutations in the Microevolution and Macroevolution of Viruses
Yufei, J.; Jianwei, S.; Minghui, S.; Guohui, L.; Huanyu, G.; Ruixu, C.; Chen, J.-M.
10.1101/2022.07.20.500745 — evolutionary biology — Posted on 2022-08-31
142 The human small intestine contains two subsets of regulatory Foxp3+ CD4+ T cells with very different life span and functional properties.
Chauhan, S. K.; Casado, R. B.; Landsverk, O. J. B.; Johannessen, H.; Phung, D.; Saetre, F.; Jahnsen, J.; Horneland, R.; Yaqub, S.; Aandahl, E. M.; Lundin, K. E. A.; Baekkevold, E. S.; Jahnsen, F. L.
10.1101/2020.02.12.941369 — immunology — Posted on 2022-08-31
144 Red blood cell lingering modulates hematocrit distribution in the microcirculation
Rashidi, Y.; Simionato, G.; Zhou, Q.; John, T.; Kihm, A.; Bendaoud, M.; Krueger, T.; Bernabeu, M. O.; Kaestner, L.; Laschke, M. W.; Menger, M. D.; Wagner, C.; Darras, A.
10.1101/2022.08.16.504126 — biophysics — Posted on 2022-08-31
145 Dear-DIAXMBD: deep autoencoder for data-independent acquisition proteomics
He, Q.; Zhong, C.; Li, X.; Guo, H.; Li, Y.; Gao, M.; Yu, R.; Liu, X.; Zhang, F.; Guo, T.; Guo, D.; Ye, F.; Shuai, J.; Han, J.
10.1101/2022.08.27.505516 — bioinformatics — Posted on 2022-08-31
150 GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Cordova, R.; Misra, J.; Amin, P. H.; Klunk, A. J.; Damayanti, N. P.; Carlson, K. R.; Elmendorf, A. J.; Hyeong-Geug, K.; Mirek, E. T.; Elzey, B. D.; Miller, M. J.; Dong, X. C.; Cheng, L.; Anthony, T. G.; Pili, R.; Wek, R. C.; Staschke, K. A.
10.1101/2022.06.17.496598 — cancer biology — Posted on 2022-08-30
152 MC profiling: a novel approach to analyze DNA methylation heterogeneity from bulk bisulfite sequencing data
De Riso, G.; Sarnataro, A.; Scala, G.; Cuomo, M.; Della Monica, R.; Amente, S.; Chiariotti, L.; Miele, G.; Cocozza, S.
10.1101/2022.07.06.498979 — bioinformatics — Posted on 2022-08-30
154 Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression
Cui, K.; Gao, X.; Wang, B.; Wu, H.; Dong, Y.; Xiao, Y.; Jiang, X.; Malovichko, M. V.; Li, K.; Shan, D.; Peng, Q.; Lu, Y. W.; Zhu, B.; Zheng, R.; Wong, S.; Cowan, D. B.; Linton, M. F.; Srivastava, S.; Shi, J.; Chen, K. F.; Chen, H.
10.1101/2022.08.09.503334 — cell biology — Posted on 2022-08-30
155 Mechanosensory Systems and Sensory Integration Mediate C. elegans Negative Gravitaxis
Ackley, C. R.; Ziaei Kajbaf, N.; Washiashi, L.; Krishnamurthy, R.; Joshi, P.; Rothman, J. H.
10.1101/2022.03.03.482913 — neuroscience — Posted on 2022-08-30
159 snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling
Vallejo, A. F.; Harvey, K.; Wang, T.; Wise, K.; Butler, L. M.; Polo, J.; Plummer, J. T.; Swarbrick, A.; Martelotto, L. G.
10.1101/2022.08.23.505054 — cancer biology — Posted on 2022-08-30
160 Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis
Shimpi, A. A.; Tan, M. L.; Vilkhovoy, M.; Dai, D.; Roberts, L. M.; Kuo, J. C.-H.; Huang, L.; Varner, J.; Paszek, M. J.; Fischbach, C.
10.1101/2022.06.08.495338 — cancer biology — Posted on 2022-08-30
164 wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome
Watson, C. J.; Tang, W. J.; Rojas, M. F.; Fiedler, I. A. K.; Morfin Montes de Oca, E.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Ahmed, A. R.; Sethuraman, V.; Addish, S.; Farr, G. H.; Gomez, A. E.; Rai, J.; Monstad-Rios, A. T.; Gardiner, E. M.; Karasik, D.; Maves, L.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2022-08-30
165 Precision Discovery of Novel Inhibitors of Human Cancer Target HsMetAP1 from Vast Unexplored Metagenomic Diversity
Liu, O. W.; Akers, S.; Alvarez, G.; Brown, S.; Cai, W.; Charlop-Powers, Z.; Crispell, K.; Goh, E.-B.; Hwang, W. W.; Eyles, T. H.; Ganesh, S.; Haverty, P.; Kulp, J. L.; Kulp, J. L.; Kurtz, Z.; Lubbe, A.; Jamison, M.; Milshteyn, A.; Mokthari, P.; Naylor, S. G.; Oteng-Pabi, S.; Overacker, R.; Robertson, A. W.; van Aggelen, H.; Viswanathan, U.; Yang, X.; Yoder, S.; Colletti, S. L.; Scannell, D. R.
10.1101/2022.06.11.495772 — microbiology — Posted on 2022-08-30
166 Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
Meyers, A. K.; Wang, Z.; Han, W.; Zhao, Q.; Zabalawi, M.; Zhang, Q.; Liu, J.; Manne, R. K.; Lorenzo, F.; Quinn, M. A.; Song, Q.; Fan, D.; Lin, H.-K.; Furdui, C. M.; Locasale, J. W.; McCall, C. M.; Zhu, X.
10.1101/2021.10.02.462869 — immunology — Posted on 2022-08-30
167 Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity
Rushdi, M. N.; Pan, V.; Li, K.; Choi, H.-K.; Choi, S.; Hong, J.; Griffitts, F.; Agnihotri, P.; Mariuzza, R. A.; Ke, Y.; Zhu, C.
10.1101/2021.11.22.469547 — immunology — Posted on 2022-08-30
168 Decoding natural astrocyte rhythms: dynamic actin waves result from environmental sensing by primary rodent astrocytes
O'Neill, K. M.; Saracino, E.; Barile, B.; Mennona, N. J.; Mola, M. G.; Pathak, S.; Posati, T.; Zamboni, R.; Nicchia, G. P.; Benfenati, V.; Losert, W.
10.1101/2021.09.13.460152 — neuroscience — Posted on 2022-08-30
170 Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice
Deol, S. P.; Ruegger, P.; Logan, G.; Shawki, A.; Li, J.; Mitchell, J.; Yu, J.; Piamthai, V.; Radi, S. H.; Newman, J.; Fiehn, O.; McCole, D.; Nair, M. G.; Hsiao, A.; Borneman, J.; Sladek, F. M.
10.1101/2021.02.08.430328 — physiology — Posted on 2022-08-30
171 BindingSiteAugmentedDTA: Enabling A Next-Generation Pipeline for Interpretable Prediction Models in Drug-Repurposing
Yousefi, N.; Yazdani-Jahromi, M.; Tayebi, A.; Kolanthai, E.; J. Neal, C.; Banerjee, T.; Gosai, A.; Balasubramanian, G.; Seal, S.; Ozmen Garibay, O.
10.1101/2022.08.30.505897 — bioinformatics — Posted on 2022-08-30
172 Genomically mined acoustic reporter genes enable real-time in vivo monitoring of tumors and tumor-homing probiotics
Hurt, R. C.; Buss, M. T.; Duan, M.; Wong, K.; You, M. Y.; Sawyer, D. P.; Swift, M. B.; Dutka, P.; Barturen-Larrea, P.; Mittelstein, D. R.; Jin, Z.; Abedi, M. H.; Farhadi, A.; Deshpande, R.; Shapiro, M. G.
10.1101/2021.04.26.441537 — bioengineering — Posted on 2022-08-30
173 A paralog of Pcc1 is the fifth core subunit of KEOPS complex in Archaea
Daugeron, M.-C.; Missoury, S.; Da Cunha, V.; Lazar, N.; Collinet, B.; van Tilbeurgh, H.; Basta, T.
10.1101/2022.08.30.505904 — biochemistry — Posted on 2022-08-30
174 Structural basis for intrinsic transcription termination
You, L.; Omollo, E.; Yu, C.; Mooney, R. A.; Shi, J.; Shen, L.; Wu, X.; Wen, A.; He, D.; Zeng, Y.; Feng, Y.; Landick, R.; Zhang, Y.
10.1101/2022.08.30.505822 — molecular biology — Posted on 2022-08-30
178 Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2
Farrell, A. G.; Dadonaite, B.; Greaney, A. J.; Eguia, R.; Loes, A. N.; Francko, N. M.; Logue, J.; Carreno, J. M.; Abbad, A.; Chu, H. Y.; Matreyek, K. A.; Bloom, J. D.
10.1101/2022.08.29.505713 — immunology — Posted on 2022-08-30
179 Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar ataxia type 1 mice
Rosa, J.-G.; Hamel, K.; Sheeler, C.; Borgenheimer, E.; Gilliat, S.; Soles, A.; Ghannoum, F.; Sbrocco, K.; Rainwater, O.; Orr, H.; Cvetanovic, M.
10.1101/2021.09.13.460129 — neuroscience — Posted on 2022-08-30
181 Uni-Fold Symmetry: Harnessing Symmetry in Folding Large Protein Complexes
Li, Z.; Yang, S.; Liu, X.; Chen, W.; Wen, H.; Shen, F.; Ke, G.; Zhang, L.
10.1101/2022.08.30.505833 — bioinformatics — Posted on 2022-08-30
182 The translating bacterial ribosome at 1.55 A resolution by open access cryo-EM
Fromm, S. A.; O'Connor, K. M.; Purdy, M.; Bhatt, P. R.; Loughran, G.; Atkins, J. F.; Jomaa, A.; Mattei, S.
10.1101/2022.08.30.505838 — molecular biology — Posted on 2022-08-30
183 Host network-based discovery of critical regulators of innate immunity, virus growth, and pathogenesis in influenza virus infection
Eisfeld, A. J.; Fan, S.; Rao, H.; Venkatachalam, B. A.; Smith, D. W.; Halfmann, P. J.; Walters, K. B.; Nair, S.; Thackray, L. B.; Kocher, J. F.; Sims, A. C.; Mitchell, H. D.; Neumann, G.; Blank, V.; Waters, K. M.; Baric, R. S.; Diamond, M. S.; Kawaoka, Y.
10.1101/2022.08.29.505723 — microbiology — Posted on 2022-08-30
184 Influenza virus transcription and progeny production are poorly correlated in single cells
Bacsik, D. J.; Dadonaite, B.; Butler, A.; Greaney, A. J.; Heaton, N. S.; Bloom, J. D.
10.1101/2022.08.30.505828 — microbiology — Posted on 2022-08-30
189 Honeybees vary collective decision making across landscapes
Palmer, J.; Samuelson, A. E.; Gill, R. J.; Leadbeater, E.; Jansen, V. A.
10.1101/2022.08.30.505816 — animal behavior and cognition — Posted on 2022-08-30
191 Can SARS-CoV-2 transmit from a dead body?
Iwatsuki-Horimoto, K.; Ueki, H.; Ito, M.; Nagasawa, S.; Hirata, Y.; Hashizume, K.; Ushiwata, K.; Iwase, H.; Makino, Y.; Ushiku, T.; Akitomi, S.; Imai, M.; Saitoh, H.; Kawaoka, Y.
10.1101/2022.08.29.505777 — microbiology — Posted on 2022-08-30
193 Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization
Schiepers, A.; van 't Wout, M. F.; Greaney, A. J.; Zang, T.; Muramatsu, H.; Lin, P. J.; Tam, Y. K.; Mesin, L.; Starr, T. N.; Bieniasz, P. D.; Pardi, N.; Bloom, J. D.; Victora, G. D.
10.1101/2022.08.29.505743 — immunology — Posted on 2022-08-30
194 Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemic
Geckin, B.; Zoodsma, M.; Kilic, G.; Debisarun, P. A.; Rakshit, S.; Adiga, V.; Ahmed, A.; Parthiban, C.; Kumar, N. C.; DSouza, G.; Baltissen, M. P.; Martens, J. H. A.; Andres, J. D.; Li, Y.; Vyakarnam, A.; Netea, M. G.
10.1101/2022.08.30.505791 — immunology — Posted on 2022-08-30
195 CHRNA5 links chandelier cells to protection against amyloid pathology in human aging and Alzheimer's Disease
Rybnicek, J.; Chen, Y.; Milic, M.; McLaurin, J.; De Jager, P.; Schneider, J. A.; Wang, Y.; Bennett, D. A.; Tripathy, S.; Felsky, D.; Lambe, E. K.
10.1101/2022.05.03.490491 — neuroscience — Posted on 2022-08-30
196 Myeloid mechano-metabolic programming restricts anti-tumor immunity
Tharp, K.; Kersten, K.; Maller, O.; Timblin, G.; Stashko, C.; Canale, F.; Hayward, M.-K.; Berestjuk, I.; ten Hoeve-Scott, J.; Samad, B.; Geiger, R.; Combes, A.; Weaver, V.
10.1101/2022.07.14.499764 — cancer biology — Posted on 2022-08-30
197 Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets
Philippi, M.; Richter, C. P.; Kappen, M.; Watrinet, I.; Miao, Y.; Runge, M.; Jorde, L.; Korneev, S.; Holtmannspoetter, M.; Kurre, R.; Holthuis, J.; Garcia, K. C.; Plueckthun, A.; Steinhart, M.; Piehler, J.; You, C.
10.1101/2022.06.11.495600 — biophysics — Posted on 2022-08-30
198 TM-Vec: template modeling vectors for fast homology detection and alignment
Hamamsy, T.; Morton, J.; Berenberg, D.; Carriero, N.; Gligorijevic, V.; Blackwell, R.; Strauss, C.; Leman, J. K.; Cho, K.; Bonneau, R.
10.1101/2022.07.25.501437 — bioinformatics — Posted on 2022-08-30
199 Inherent evolutionary unpredictability in cancer model system
Chattopadhyay, S.; Karlsson, J.; Manas, A.; Kanzaki, R.; Fredlund, E.; Murphy, A. J.; Morton, C. L.; Woolard, M. A.; Andersson, N.; Hansson, K.; Radke, K.; Davidoff, A. M.; Mohlin, S.; Pietras, K.; Bexell, D.; Gisselsson, D.
10.1101/2022.06.01.494285 — evolutionary biology — Posted on 2022-08-30
203 SARS-CoV-2 Omicron BA.2.75 variant may be much more infective than preexisting variants
Sugano, A.; Takaoka, Y.; Kataguchi, H.; Kumaoka, M.; Ohta, M.; Kimura, S.; Araki, M.; Morinaga, Y.; Yamamoto, Y.
10.1101/2022.08.25.505217 — bioinformatics — Posted on 2022-08-30
205 Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
Shi, G.; Chiramel, A. I.; Lai, K. K.; Kenney, A.; Li, T.; Dempsey, T.; Zani, A.; Zhang, L.; Majdoul, S.; Das, S.; Beare, P. A.; Kar, S.; Andresson, T.; Best, S. M.; Yount, J. S.; Compton, A. A.
10.1101/2021.04.15.440067 — microbiology — Posted on 2022-08-30
207 Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27
Jensen, M.; Garcia-Bonete, M.-J.; Anindya, A. L.; Andersson, K.; Erlandsson, M. C.; Oparina, N.; Brath, U.; Chandrasekaran, V.; Bokarewa, M.; Katona, G.
10.1101/2022.04.27.489567 — molecular biology — Posted on 2022-08-30
208 Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity
van den Bosch, R.; Hezemans, F. H.; Määttä, J. I.; Hofmans, L.; Papadopetraki, D.; Verkes, R.-J.; Marquand, A. F.; Booij, J.; Cools, R.
10.1101/2022.07.11.499570 — neuroscience — Posted on 2022-08-30
211 Klarigi: Characteristic Explanations for Semantic Data
Slater, L. T.; Williams, J. A.; Schofield, P. N.; Russell, S.; Pendleton, S. C.; Karwath, A.; Fanning, H.; Ball, S.; Hoehndorf, R. T.; Gkoutos, G. V.
10.1101/2021.06.14.448423 — bioinformatics — Posted on 2022-08-30
213 Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC
Dietz, L.; Ellison, C. J.; Riechmann, C.; Cassidy, C. K.; Felfoldi, F. D.; Pinto-Fernandez, A.; Kessler, B. M.; Elliott, P. R.
10.1101/2022.08.30.505748 — biochemistry — Posted on 2022-08-30
214 Asymmetric horseshoe-like assembly of peroxisomal Yeast Oxalyl-CoA synthetase
Bürgi, J.; Lill, P.; Giannopoulou, E.-A.; Jeffries, C. M.; Chojnowski, G.; Raunser, S.; Gatsogiannis, C.; Wilmanns, M.
10.1101/2022.08.30.505785 — molecular biology — Posted on 2022-08-30
215 Cloud-native distributed genomic pileup operations
Wiewiorka, M.; Szmurlo, A.; Stankiewicz, P.; Gambin, T. L.
10.1101/2022.08.27.475646 — bioinformatics — Posted on 2022-08-30
216 Redox signaling regulates breast cancer metastasis via HIF1alpha-stimulated EMT dynamics and metabolic reprogramming
Ren, Z.; Dharmaratne, M.; Liang, H.; Benard, O.; Morales-Gallego, M.; Suyama, K.; Fard, A. T.; Mar, J. C.; Prystowsky, M.; Norton, L.; Hazan, R. B.
10.1101/2022.08.29.503508 — cancer biology — Posted on 2022-08-30
219 Tissue recoil in the early Drosophila embryo is a passive not active process
Goldner, A. N.; Fessehaye, S. M.; Mapes, K. A.; Osterfield, M.; Doubrovinski, K.
10.1101/2022.08.29.505741 — cell biology — Posted on 2022-08-30
222 Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character
Powell, G. T.; Faro, A.; Zhao, Y.; Stickney, H. L.; Novellasdemunt, L.; Henriques, P.; Gestri, G.; Redhouse White, E.; Ren, J.; Lu, W.; Young, R. M.; Hawkins, T. A.; Cavodeassi, F.; Schwarz, Q.; Dreosti, E.; Raible, D. W.; Li, V. S. W.; Wright, G. J.; Jones, E. Y.; Wilson, S. W.
10.1101/2022.05.16.492129 — developmental biology — Posted on 2022-08-30
224 An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer
Noguchi, Y.; Suzuki, T.; Matsutani, K.; Sakakibara, R.; Nakahigashi, R.; Adachi, M.; Nishikawa, T.; Abe, H.
10.1101/2021.09.12.459881 — zoology — Posted on 2022-08-30
225 Spontaneously blinking fluorophores for accelerated MINFLUX nanoscopy
Remmel, M.; Scheiderer, L.; Butkevich, A. N.; Bossi, M. L.; Hell, S. W.
10.1101/2022.08.29.505670 — biophysics — Posted on 2022-08-30
227 Tissue recoil in the early Drosophila embryo is a passive not active process
Goldner, A. N.; Fessehaye, S. M.; Mapes, K. A.; Osterfield, M.; Doubrovinski, K.
10.1101/2022.08.29.505741 — cell biology — Posted on 2022-08-30
228 HP1 deficiency results in De-Repression of Endogenous Retroviruses and Induction of Neurodegeneration via Complement
Newman, A. G.; Sharif, J.; Bessa, P.; Zaqout, S.; Brown, J.; Nakayama, M.; Mueller, S.; Böhm-Sturm, P.; Ohara, O.; Koseki, H.; Singh, P. B.; Tarabykin, V.
10.1101/2022.08.29.505641 — neuroscience — Posted on 2022-08-30
229 Ankrd26 is critical for cell differentiation and cancer-linked mutations affect its key properties
Hofbrucker-MacKenzie, S. A.; Englisch, A. S.; Izadi, M.; Metzner, K.; Kessels, M. M.; Qualmann, B.
10.1101/2021.05.19.444897 — cancer biology — Posted on 2022-08-30
232 Differential Expression Enrichment Tool (DEET): an interactive atlas of human differential gene expression
Sokolowski, D. J.; Ahn, J.; Erdman, L.; Hou, H.; Ellis, K.; Wang, L.; Goldenberg, A.; Wilson, M. D.
10.1101/2022.08.29.505468 — bioinformatics — Posted on 2022-08-29
233 Metrics of High Cofluctuation and Entropy to Describe Control of Cardiac Function in the Stellate Ganglion
Gurel, N. Z.; Sudarshan, K. B.; Hadaya, J.; Karavos, A.; Temma, T.; Hori, Y.; Armour, A. J.; Kember, G.; Ajijola, O. A.
10.1101/2021.09.28.462183 — bioengineering — Posted on 2022-08-29
240 Locus Coeruleus firing patterns selectively modulate brain activity and dynamics
Grimm, C.; Duss, S. N.; Privitera, M.; Munn, B. N.; Frassle, S.; Chernysheva, M.; Patriarchi, T.; Razansky, D.; Wenderoth, N.; Shine, J.; Bohacek, J.; Zerbi, V.
10.1101/2022.08.29.505672 — neuroscience — Posted on 2022-08-29
242 ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells
Parejo-Alonso, B.; Royo-Garcia, A.; Espiau-Romera, P.; Courtois, S.; Curiel-Garcia, A.; Zagorac, S.; Villaoslada, I.; Olive, K. P.; Heeschen, C.; Sancho, P.
10.1101/2022.08.29.505637 — cancer biology — Posted on 2022-08-29
243 Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma
Orozco Morales, M. L.; Rinaldi, C. A.; de Jong, E.; Lansley, S. M.; Lee, Y. C. G.; Zemek, R. M.; Bosco, A.; Lake, R. A.; Lesterhuis, W. J.
10.1101/2022.08.29.505655 — cancer biology — Posted on 2022-08-29
244 The Botrytis cinerea Gene Expression Browser.
Perez-Lara, G.; Moyano, T. C.; Vega, A.; Larrondo, L.; Polanco, R.; Alvarez, J. M.; Aguayo, D.; Canessa, P.
10.1101/2022.08.29.504976 — bioinformatics — Posted on 2022-08-29
245 Stable isotopomers of myo-inositol to uncover the complex MINPP1-dependent inositol phosphate network
Nguyen Trung, M.; Kieninger, S.; Fandi, Z.; Qiu, D.; Liu, G.; Saiardi, A.; Jessen, H.; Keller, B.; Fiedler, D.
10.1101/2022.08.29.505671 — biochemistry — Posted on 2022-08-29
248 Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance
Dou, X.; Long, Q.; Liu, S.; Zou, Y.; Fu, D.; Chen, X.; Xu, Q.; Wang, C.; Ren, X.; Zhang, G.; Fu, Q.; Campisi, J.; Zhao, Y.; Sun, Y.
10.1101/2022.08.29.505761 — cell biology — Posted on 2022-08-29
249 Revisiting the impact of synthetic ORF sequences on engineered LINE-1 retrotransposition
Richardson, S. R.; Chan, D.; Gerdes, P.; Han, J. S.; Boeke, J. D.; Faulkner, G. J.
10.1101/2022.08.29.505632 — molecular biology — Posted on 2022-08-29
251 The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites
Loubens, M.; Marinach, C.; Paquereau, C.-E.; Hamada, S.; Hoareau-Coudert, B.; Akbar, D.; Franetich, J.-F.; Silvie, O.
10.1101/2022.08.29.505663 — microbiology — Posted on 2022-08-29
252 Application of RT-LAMP-CRISPR-Cas13a technology to the detection of OXA-48 producing Klebsiella pneumoniae
Ortiz-Cartagena, C.; Blasco, L.; Fernandez-Garcia, L.; Pacios, O.; Bleriot, I.; Lopez Diaz, M.; Fernandez-Cuenca, F.; Canton, R.; Tomas, M.
10.1101/2022.08.29.505698 — microbiology — Posted on 2022-08-29
254 Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor
Munoz, A.; Urak, R.; Taus, E.; Hsieh, H.-J.; Jin, K.; Lin, S.-H.; Awuah, D.; Vyas, V.; Priceman, S. J.; Clark, M.; Forman, S.; Wang, X.
10.1101/2022.08.29.505735 — immunology — Posted on 2022-08-29
264 A second unveiling: haplotig masking of the eastern oyster genome improves population-level inference
Puritz, J. B.; Guo, X.; Hare, M. P.; He, Y.; Hillier, L.; Liu, M.; Lotterhos, K. E.; Minx, P.; Modak, T.; Proestou, D.; Rice, E. S.; Tomlison, C.; Warren, W. C.; Witkop, E.; Zhao, H.; Gomez-Chiarri, M.
10.1101/2022.08.29.505626 — genomics — Posted on 2022-08-29
265 Enhancer-promoter interactions form independently of genomic distance and are functional across TAD boundaries
Pinto, P. B.; Grasso, A.; Balasubramanian, D.; Vincent, S.; Tarayre, H.; Lajoignie, D.; Ghavi-Helm, Y.
10.1101/2022.08.29.505755 — genomics — Posted on 2022-08-29
266 A Small Subset of Cytosolic dsRNAs Must Be Edited by ADAR1 to Evade MDA5-Mediated Autoimmunity
Sun, T.; Li, Q.; Geisinger, J. M.; Hu, S.-B.; Fan, B.; Su, S.; Tsui, W.; Guo, H.; Ma, J.; Li, J. B.
10.1101/2022.08.29.505707 — genetics — Posted on 2022-08-29
270 HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation
Scinicariello, S.; Soederholm, A.; Schaefer, M.; Shulkina, A.; Schwartz, I.; Hacker, K.; Gogova, R.; Kalis, R.; Froussios, K.; Budroni, V.; Bestehorn, A.; Clausen, T.; Kovarik, P.; Zuber, J.; Versteeg, G. A.
10.1101/2022.08.29.505645 — cell biology — Posted on 2022-08-29
272 Structural basis of Rho-dependent transcription termination
Molodtsov, V.; Wang, C.; Firlar, E.; Kaelber, J. T.; Ebright, R. H.
10.1101/2022.08.29.505764 — molecular biology — Posted on 2022-08-29
274 Synaptic Expression of TAR-DNA-Binding Protein 43 in the Mouse Spinal Cord Determined Using Super-Resolution Microscopy
Broadhead, M. J.; Doucet, K.; Kantelberg, O. G.; Zhu, F.; Grant, S. G. N.; Horrocks, M. H.; Miles, G. B.
10.1101/2022.08.29.505610 — neuroscience — Posted on 2022-08-29
275 HP1 deficiency results in De-Repression of Endogenous Retroviruses and Induction of Neurodegeneration via Complement
Newman, A. G.; Sharif, J.; Bessa, P.; Zaqout, S.; Brown, J.; Nakayama, M.; Mueller, S.; Böhm-Sturm, P.; Ohara, O.; Koseki, H.; Singh, P.; Tarabykin, V.
10.1101/2022.08.29.505641 — neuroscience — Posted on 2022-08-29
276 Circadian distribution of epileptiform discharges in epilepsy: candidate mechanisms of variability
Marinelli, I.; Walker, J. J.; Seneviratne, U.; DSouza, W.; Cook, M. J.; Anderson, C.; Bagshaw, A. P.; Lightman, S. L.; Woldman, W.; Terry, J. R.
10.1101/2022.08.24.505077 — neuroscience — Posted on 2022-08-29
280 A pharmacoproteomic landscape of organotypic intervention responses in gram-negative sepsis
Mohanty, T.; Karlsson, C. A. Q.; Chao, Y.; Malmstrom, E.; Bratanis, E.; Grentzmann, A.; Morch, M.; Nizet, V.; Malmstrom, L.; Linder, A.; Shannon, O.; Malmstrom, J.
10.1101/2022.08.29.503941 — systems biology — Posted on 2022-08-29
284 Cardiomyocyte alpha-1A adrenergic receptors mitigate post-infarct remodeling and mortality by constraining necroptosis
Zhang, J.; Sandroni, P. B.; Huang, W.; Oswalt, L.; Smith, A. J.; Ash, T.; Lee, S.-H.; Shih, Y.-Y. I.; Huang, H.-Y. S.; Myagmar, B.-E.; Schisler, J. C.; Jensen, B. C.
10.1101/2022.08.29.505687 — pathology — Posted on 2022-08-29
291 Alignment, Segmentation and Neighborhood Analysis in Cyclic Immunohistochemistry Data Using CASSATT
Brockman, A.; Khurana, R.; Bartkowiak, T.; Thomas, P. L.; Sivagnanam, S.; Betts, C. B.; Coussens, L. M.; Lovly, C.; Irish, J. M.; Ihrie, R. A.
10.1101/2022.08.29.504975 — bioinformatics — Posted on 2022-08-29
293 Deep Neural Networks Predict MHC-I Epitope Presentation and Transfer Learn Neoepitope Immunogenicity
Albert, B. A.; Yang, Y.; Shao, X. M.; Singh, D.; Smith, K. N.; Anagnostou, V.; Karchin, R.
10.1101/2022.08.29.505690 — bioinformatics — Posted on 2022-08-29
296 Dear-DIAXMBD: deep autoencoder for data-independent acquisition proteomics
He, Q.; Zhong, C.; Li, X.; Guo, H.; Li, Y.; Gao, M.; Yu, R.; Liu, X.; Zhang, F.; Guo, T.; Guo, D.; Ye, F.; Shuai, J.; Han, J.
10.1101/2022.08.27.505516 — bioinformatics — Posted on 2022-08-29
297 Utah Array Characterization and Histological Analysis of a Multi-Year Implant in Non-Human Primate Motor and Sensory Cortices
Patel, P. R.; Welle, E. J.; Letner, J. G.; Shen, H.; Bullard, A. J.; Caldwell, C. M.; Richie, J. M.; Thayer, H. E.; Patil, P. G.; Cai, D.; Chestek, C. A.
10.1101/2022.08.27.505114 — bioengineering — Posted on 2022-08-29
298 Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA
Heyden, K. E.; Fiddler, J. L.; Xiu, Y.; Malysheva, O. V.; Handzlik, M. K.; Phinney, W. N.; Stiles, L.; Stabler, S. S.; Metallo, C.; Caudill, M. A.; Field, M. S.
10.1101/2022.08.29.505750 — biochemistry — Posted on 2022-08-29
300 Structures of ferroportin in complex with its specific inhibitor vamifeport
Lehmann, E. F.; Liziczai, M.; Drozdzyk, K.; Altermatt, P.; Manolova, V.; Sundstrom, H.; Duerrenberger, F.; Dutzler, R.; Manatschal, C.
10.1101/2022.08.29.505642 — biochemistry — Posted on 2022-08-29
301 Cryptic functional diversity in ant tandem runs
Mizumoto, N.; Tanaka, Y.; Valentini, G.; Richardson, T. O.; Annagiri, S.; Pratt, S. C.; Shimoji, H.
10.1101/2022.08.28.505613 — animal behavior and cognition — Posted on 2022-08-29
302 Increased ozone levels disrupt insect sexual communication
Jiang, N.; Chang, H.; Weisflog, J.; Eberl, F.; Veit, D.; Weniger, K.; Hansson, B. S.; Knaden, M.
10.1101/2022.08.27.505511 — animal behavior and cognition — Posted on 2022-08-29
303 Structural diversity of silk heavy-chain fibroins across major caddisfly (Trichoptera) clades
Heckenhauer, J.; Stewart, R. J.; Rios-Touma, B.; Powell, A.; Frandsen, P. B.; Pauls, S. U.
10.1101/2022.08.29.505681 — genomics — Posted on 2022-08-29
305 Two sides to every coin: complementary introgression line populations in Caenorhabditis elegans
Sterken, M. G.; van Sluijs, L. v.; van Creij, J. W.; Cook, D. E.; Riksen, J. A. G.; Jovic, K.; Schouten, J.; Steeghs, M.; Wang, Y. A.; Stastna, J. J.; Snoek, L. B.; Harvey, S. C.; Kammenga, J. E.
10.1101/2022.08.29.505240 — genetics — Posted on 2022-08-29
307 FAVOR: Functional Annotation of Variants Online Resource and Annotator for Variation across the Human Genome
Zhou, H.; Arapoglou, T.; Li, X.; Li, Z.; Zheng, X.; Moore, J. E.; Asok, A.; Kumar, S.; Blue, E. E.; Buyske, S.; Cox, N.; Felsenfeld, A.; Gerstein, M.; Kenny, E.; Li, B.; Matise, T.; Philippakis, A.; Rehm, H.; Sofia, H. J.; Neale, B.; Snyder, G.; Weng, Z.; Sunyaev, S.; Lin, X.
10.1101/2022.08.28.505582 — genetics — Posted on 2022-08-29
314 Prioritizing landscapes to reconcile biodiversity conservation, ecosystem services, and human well-being in India
Srivathsa, A.; Vasudev, D.; Nair, T.; Chakrabarti, S.; Chanchani, P.; DeFries, R.; Deomurari, A.; Dutta, S.; Ghose, D.; Goswami, V.; Nayak, R.; Neelakantan, A.; Thatte, P.; Vaidyanathan, S.; Verma, M.; Krishnaswamy, J.; Sankaran, M.; Ramakrishnan, U.
10.1101/2022.08.27.505513 — ecology — Posted on 2022-08-29
316 A Spatiotemporal History of Key San Francisco Estuary Pelagic Fish Species
Stompe, D. K.; Moyle, P. B.; Oken, K. L.; Hobbs, J. A.; Durand, J. R.
10.1101/2022.08.26.505491 — ecology — Posted on 2022-08-29
319 Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium
Shirazyan, A.; Park, H.; Joiner, A. M.; Ra, J.; Kim, M. S.; Kumari, A.; Franks, N. E.; PENG, T.; Bradley, R. M.; Mistretta, C. M.; Dlugosz, A. A.; Allen, B. L.
10.1101/2022.08.29.504820 — cell biology — Posted on 2022-08-29
326 Bacterial Microbiome of Foreskin Tissue: Impact of Short-course PrEP and Host Inflammation
Maust, B. S.; Petkov, S.; Herrera, C.; Feng, C.; Brown, B. P.; Lebina, L.; Opoka, D.; Ssemata, A.; Pillay, N.; Serwanga, J.; Seatlholo, P.; Namubiru, P.; Odoch, G.; Mugaba, S.; Seiphetlo, T.; Gray, C. M.; Kaleebu, P.; Webb, E. L.; Martinson, N.; Chiodi, F.; Fox, J.; Jaspan, H. B.; the CHAPS team,
10.1101/2022.08.29.505718 — microbiology — Posted on 2022-08-29
327 GPR183 targets lung-resident CD301b+ conventional dendritic cells type 2 to a subtissular TSLP-TSLP receptor-mediated survival niche within the adventitial cuff
Zhang, L.; Yu, J.; Spath, S.; Sheoran, S.; Bejarano, D.; Vandestienne, M.; Weier, A.-K.; Quast, T.; Ibrahim, M.; Reimer, S.; Uderhardt, S.; Mass, E.; Hasenauer, J.; Pfeifer, A.; Kiermaier, E.; Kolanus, W.; Ziegler, S.; Schlitzer, A.
10.1101/2022.08.28.505379 — immunology — Posted on 2022-08-29
328 Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS
Agrafiotis, A.; Dizerens, R.; Vincenti, I.; Wagner, I.; Kuhn, R.; Shlesinger, D.; Manero-Carranza, M.; Cotet, T.-S.; Hong, K.-L.; Page, N.; Fonta, N.; Shammas, G.; Mariotte, A.; Piccinno, M.; Kreutzfeldt, M.; Gruntz, B.; Ehling, R.; Genovese, A.; Pedrioli, A.; Dounas, A.; Franzenburg, S.; Kavaka, V.; Gerdes, L. A.; Dornmair, K.; Beltran, E.; Oxenius, A.; Reddy, S. T.; Merkler, D.; Yermanos, A.
10.1101/2022.08.29.505678 — immunology — Posted on 2022-08-29
329 Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen-specificity
Agrafiotis, A.; Neumeier, D.; Hong, K.-L.; Chowdhury, T.; Ehling, R. A.; Kuhn, R.; Sandu, I.; Kreiner, V.; Cotet, T.-S.; Laslo, D.; Anzböck, S.; Starkie, D.; Lightwood, D. J.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2021.11.09.467876 — immunology — Posted on 2022-08-29
330 The Immunological Proteome Resource
Brenes, A. J.; Hukelmann, J. L.; Spinelli, L.; Howden, A. J. M.; Marchingo, J. M.; Sinclair, L. V.; Rollings, C.; James, O. J.; Phair, I. R.; Matthews, S. P.; Ross, S. H.; Arthur, S. C.; Swamy, M.; Finlay, D. K.; Lamond, A. I. I.; Cantrell, D. A.
10.1101/2022.08.29.505666 — immunology — Posted on 2022-08-29
331 Auditory accessory stimulus boosts pupil-linked arousal and reduces choice bias
Bruel, B. M.; Katopodis, V. G.; de Vries, R.; Donner, T. H.; McGinley, M. J.; de Gee, J. W.
10.1101/2022.08.28.505585 — neuroscience — Posted on 2022-08-29
332 LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics
Ruffini, G.; Damiani, G.; Lozano-Soldevilla, D.; Deco, N.; Rosas, F.; Kiani, N.; Ponce-Alvarez, A.; Kringelbach, M. L.; Carhart-Harris, R.; Deco, G. L.
10.1101/2022.08.27.505518 — neuroscience — Posted on 2022-08-29
335 Minimal exposures reveal visual processing priorities
Lanfranco, R. C.; Canales-Johnson, A.; Rabagliati, H.; Cleeremans, A.; Carmel, D.
10.1101/2021.10.06.462913 — neuroscience — Posted on 2022-08-29
337 A Large-Scale ENIGMA Multisite Replication Study of Brain Age in Depression
Han, L. K.; Dinga, R.; Leenings, R.; Hahn, T.; Cole, J.; Aftanas, L.; Amod, A.; Besteher, B.; Colle, R.; Corruble, E.; Couvy-Duchesne, B.; Danilenko, K.; Fuentes-Claramonte, P.; Saffet Gonul, A.; Gotlib, I.; Goya-Maldonado, R.; Groenewold, N.; Hamilton, P.; Ichikawa, N.; Ipser, J.; Itai, E.; Koopowitz, S.-M.; Li, M.; Okada, G.; Okamoto, Y.; Olga, C.; Osipov, E.; Penninx, B.; Pomarol-Clotet, E.; Rogriguez-Cano, E.; Sacchet, M.; Shinzato, H.; Sim, K.; Stein, D.; Uyar-Demir, A.; Veltman, D.; Schmaal, L.
10.1101/2022.08.29.505635 — neuroscience — Posted on 2022-08-29
338 A low dimensional cognitive-network space in Alzheimer's disease and frontotemporal dementia
Pini, L.; de Lange, S.; Pizzini, F. B.; Boscolo Galazzo, I.; Manenti, R.; Cotelli, M.; Galluzzi, S.; Cotelli, M. S.; Corbetta, M.; Van den Heuvel, M.; Pievani, M.
10.1101/2022.08.29.504748 — neuroscience — Posted on 2022-08-29
342 Reconstitution of ribosome self-replication outside a living cell
Kosaka, Y.; Miyawaki, Y.; Mori, M.; Aburaya, S.; Fukuyama, M.; Ueda, M.; Aoki, W.
10.1101/2022.08.29.505692 — synthetic biology — Posted on 2022-08-29
343 OHP2 is not required for psbA translation in Chlamydomonas
Wang, F.; Dischinger, K.; Westrich, L. D.; Meindl, I.; Egidi, F.; Troesch, R.; Sommer, F.; Johnson, X.; Schroda, M.; Nickelsen, J.; Willmund, F.; Vallon, O.; Bohne, A.-V.
10.1101/2022.08.29.505686 — plant biology — Posted on 2022-08-29
344 The western redcedar genome reveals low genetic diversity in a self-compatible conifer
Shalev, T. J.; Gamal El-Dien, O.; Yuen, M. M. S.; Shengqiang, S.; Jackman, S. D.; Warren, R. L.; Coombe, L.; van der Merwe, L.; Stewart, A.; Boston, L. B.; Plott, C.; Jenkins, J.; He, G.; Yan, J.; Yan, M.; Guo, J.; Breinholt, J. W.; Neves, L. G.; Grimwood, J.; Rieseberg, L. H.; Schmutz, J.; Birol, I.; Kirst, M.; Yanchuk, A. D.; Ritland, C.; Russell, J. H.; Bohlmann, J.
10.1101/2022.08.26.505492 — plant biology — Posted on 2022-08-29
345 Wild grass isolates of Magnaporthe (Syn. Pyricularia) spp. from Germany can cause blast disease on cereal crops
Barragan, A. C.; Latorre, S. M.; Mock, P. G.; Harant, A.; Win, J.; Malmgren, A.; Burbano, H. A.; Kamoun, S.; Langner, T.
10.1101/2022.08.29.505667 — plant biology — Posted on 2022-08-29
346 Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice
Deol, S. P.; Ruegger, P.; Logan, G.; Shawki, A.; Li, J.; Mitchell, J.; Yu, J.; Piamthai, V.; Radi, S. H.; Newman, J.; Fiehn, O.; McCole, D.; Nair, M. G.; Hsiao, A.; Borneman, J.; Sladek, F. M.
10.1101/2021.02.08.430328 — physiology — Posted on 2022-08-29
347 Automatic grading of cervical biopsies by combining full and self-supervision
Lubrano, M.; Lazard, T.; Balezo, G.; Bellahsen-Harrar, Y.; Badoual, C.; Berlemont, S.; Walter, T.
10.1101/2022.01.14.476330 — cancer biology — Posted on 2022-08-29
348 Spatial transcriptomics reveals ovarian cancer subclones with distinct tumour microenvironments
Denisenko, E.; de Kock, L.; Tan, A.; Beasley, A.; Beilin, M.; Jones, M. E.; Hou, R.; O Muiri, D.; Bilic, S.; Mohan, G. R. K. A.; Salfinger, S.; Fox, S.; Hmon, K.; Yeow, Y.; Gray, E.; Cohen, P. A.; Yu, Y.; Forrest, A. R. R.
10.1101/2022.08.29.505206 — cancer biology — Posted on 2022-08-29
350 Spontaneously blinking fluorophores for accelerated MINFLUX nanoscopy
Remmel, M.; Scheiderer, L.; Butkevich, A. N.; Bossi, M. L.; Hell, S. W.
10.1101/2022.08.29.505670 — biophysics — Posted on 2022-08-29
354 Super-resolution vibrational imaging based on photoswitchable Raman probe
Shou, J.; Komazawa, A.; Wachi, Y.; Kawatani, M.; Fujioka, H.; Spratt, S. J.; Mizuguchi, T.; Oguchi, K.; Obata, F.; Tachibana, R.; Misawa, Y.; Kojima, R.; Urano, Y.; Kamiya, M.; Ozeki, Y.
10.1101/2022.08.28.505494 — bioengineering — Posted on 2022-08-29
357 Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import.
Nashed, S.; El Barbry, H.; Benchouaia, M.; Dijoux-Marechal, A.; Ruiz Gutierrez, N.; Gaulier, L.; Chevreux, G.; Le Crom, S.; Palancade, B.; Devaux, F.; Laine, E.; Garcia, M.
10.1101/2022.08.19.504527 — genomics — Posted on 2022-08-29
358 Evaluation of Association between CSN2 Genetic Marker 7:32016718C>A with A1/A2 Milk in Pakistani Buffaloes
Mushtaq, M.; Saif, R.; Raza, M. H.; Zafar, M. O.; Ahmed, Z.; Ullah, S.; Ahmad, M.; Karim, A.
10.1101/2022.08.28.505567 — genetics — Posted on 2022-08-29
360 The zebrafish dmrt family genes have cooperative and antagonistic roles in sex determination and oogenesis
Steinfeld, J. S.; Ameyaw, K. K.; Wood, C. G.; Johnston, R. M.; Johnson Escauriza, A. J.; Torija, E. G.; Quiles, K.; Venkataramani, K.; MacNeil, J. N.; Siegfried, K. R.
10.1101/2022.08.28.505603 — developmental biology — Posted on 2022-08-29
362 Cohort-mean measured macromolecules lead to more robust linear-combination modeling than subject-specific or parameterized ones
Zöllner, H. J.; Davies-Jenkins, C. W.; Murali-Manohar, S.; Gong, T.; Song, Y.; Hui, S. C. N.; Chen, W.; Wang, G.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2022.07.07.499181 — neuroscience — Posted on 2022-08-29
367 Validation of saline, PBS and a locally produced VTM at varying storage conditions to detect the SARS-CoV-2 virus by qRT-PCR
Ngetsa, C.; Osoti, V.; Okanda, D.; Marura, F.; Shah, K.; Karanja, H.; Mugo, D.; Gitonga, J.; Mutunga, M.; Lewa, C.; Orindi, B.; Bejon, P.; Ochola-Oyier, L. I.
10.1101/2022.08.29.505649 — molecular biology — Posted on 2022-08-29
368 T cell responses induced by SARS-CoV-2 mRNA vaccination are associated with clonal replacement
Aoki, H.; Kitabatake, M.; Abe, H.; Shichino, S.; Hara, A.; Ouji-Sageshima, N.; Ito, T.; Matsushima, K.; Ueha, S.
10.1101/2022.08.27.504955 — immunology — Posted on 2022-08-29
370 Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain
Willemen, H.; Ribeiro, P.; Broeks, M.; Meijer, N.; Versteeg, S.; Malecki, J.; Falnes, P.; Jans, J.; Eijkelkamp, N.
10.1101/2022.08.29.505682 — neuroscience — Posted on 2022-08-29
371 Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
Beneyto-Calabuig, S.; Ludwig, A. K.; Kniffka, J.-A.; Szu-Tu, C.; Rohde, C.; Antes, M.; Waclawiczek, A.; Pervan, P.; Janssen, M.; Landry, J. J. M.; Benes, V.; Jauch, A.; Brough, M.; Bauer, M.; Besenbeck, B.; Felden, J.; Baeumer, S.; Hundemer, M.; Sauer, T.; Pabst, C.; Wickenhauser, C.; Angenendt, L.; Schliemann, C.; Trumpp, A.; Haas, S.; Scherer, M.; Raffel, S.; Mueller-Tidow, C.; Velten, L.
10.1101/2022.08.29.505648 — cancer biology — Posted on 2022-08-29
373 Pharmacogenetic allele variant frequencies: An analysis of the VAs Million Veteran Program (MVP) as a representation of the diversity in US population.
Markianos, K.; Dong, F.; Gorman, B.; Shi, Y.; Dochtermann, D.; Saxena, U.; Devineni, P.; Moser, J.; Muralidhar, S.; Ramoni, R.; Tsao, P.; Pyarajan, S.; Przygodzki, R.; Million Veteran Program,
10.1101/2022.08.26.505483 — genomics — Posted on 2022-08-29
374 Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption
Bhatt, T.; Khedkar, S. U.; Dam, B.; Lall, S.; Pandey, S.; Kataria, S.; Dias, P. M.; Waskar, M.; Raut, J.; Sundaramurthy, V.; Vemula, P. K.; Ghatlia, N.; Majumdar, A.; Jamora, C.
10.1101/2022.08.26.505399 — pathology — Posted on 2022-08-29
375 Alcohol dependence modifies brain networks activated during abstinence and reaccess: a c-fos-based analysis in mice
Roland, A.; Coelho, C.; Haun, H.; Gianessi, C.; Lopez, M.; D'Ambrosio, S.; Machinski, S.; Kroenke, C.; Frankland, P.; Becker, H.; Kash, T.
10.1101/2022.08.26.505400 — neuroscience — Posted on 2022-08-29
376 Automatic grading of cervical biopsies by combining full and self-supervision
Lubrano, M.; Lazard, T.; Balezo, G.; Bellahsen-Harrar, Y.; Badoual, C.; Berlemont, S.; Walter, T.
10.1101/2022.01.14.476330 — cancer biology — Posted on 2022-08-29
378 Graph neural networks ameliorate potential impacts of imprecise large-scale autonomous immunofluorescence labeling of immune cells on whole slide images
Reddy, R.; Reddy, R.; Sharma, C.; Jackson, C.; Palisoul, S.; Barney, R.; Kolling, F.; Salas, L.; Christensen, B.; Tsongalis, G.; Vaickus, L.; Levy, J.
10.1101/2022.08.28.505606 — pathology — Posted on 2022-08-29
381 Singlet oxygen-induced signalling depends on the metabolic status of the Chlamydomonas cell
Al Youssef, W.; Feil, R.; Saint-Sorny, M.; Johnson, X.; Lunn, J. E.; Grimm, B.; Brzezowski, P.
10.1101/2021.11.03.467076 — cell biology — Posted on 2022-08-29
382 eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
Duan, H.; Zhang, S.; Zarai, Y.; Oellinger, R.; Wu, Y.; Sun, L.; Hu, C.; Tian, G.; Rad, R.; Cheng, Y.; Tuller, T.; Wolf, D. A.
10.1101/2022.08.28.505560 — cell biology — Posted on 2022-08-29
384 Calibration of crop phenology models: Going beyond recommendations
Wallach, D.; Palosuo, T.; Thorburn, P.; Mielenz, H.; Buis, S.; Hochman, Z.; Gourdain, E.; Garcia, C.; Andrianasolo, F.; Dumont, B.; Ferrise, R.; Gaiser, T.; Gayler, S.; Hiremath, S.; Horan, H.; Hoogenboom, G.; Jansson, P.-E.; Jing, Q.; Qian, B.; Justes, E.; Kersebaum, K.-C.; Launay, M.; Lewan, E.; Mequanint, F.; Moriondo, M.; Nendel, C.; Padovan, G.; Schuetze, N.; Seserman, D.-M.; Souissi, A.; Shelia, V.; Specka, X.; Srivastava, A. K.; Trombi, G.; Weber, T.; Weihermueller, L.; Woehling, T.; Seidel, S.
10.1101/2022.06.08.495355 — plant biology — Posted on 2022-08-29
386 On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes
van der Gulik, P. T. S.; Egas, M.; Kraaijeveld, K.; Dombrowski, N.; Groot, A. T.; Spang, A.; Hoff, W. D.; Gallie, J.
10.1101/2022.07.05.498093 — genomics — Posted on 2022-08-29
391 Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
Berquez, M.; Chen, Z.; Festa, B. P.; Krohn, P.; Keller, S. A.; Parolo, S.; Laczko, E.; Domenici, E.; Devuyst, O.; Luciani, A.
10.1101/2022.08.28.505580 — cell biology — Posted on 2022-08-28
392 Linking neuronal and hemodynamic network signatures in the resting human brain
Elshahabi, A.; Ethofer, s.; Lerche, H.; Wehrl, H.; la Fougere, C.; Braun, C.; Focke, N. K.
10.1101/2022.08.28.505586 — neuroscience — Posted on 2022-08-28
394 Developing and optimizing a personalized probiotic treatment regime for nasal endogenous Staphylococcus aureus decolonization
Tepekule, B.; Bergada-Pijuan, J.; Scheier, T.; Günthard, H. F.; Hilty, M.; Kouyos, R. D.; Brugger, S. D.
10.1101/2022.08.28.505587 — microbiology — Posted on 2022-08-28
396 naRNA is a canonical neutrophil extracellular trap (NET) component and novel inflammation-amplifying composite DAMP
Bork, F.; Greve, C. L.; Youn, C.; Chen, S.; Wang, Y.; Nasri, M.; Focken, J.; Scheurer, J.; Engels, P.; Dubbelaar, M.; Hipp, K.; Schittek, B.; Bugl, S.; Loeffler, M. W.; Skokowa, J.; Archer, N. K.; Weber, A. N.
10.1101/2022.07.26.499571 — immunology — Posted on 2022-08-28
397 Graph neural networks ameliorate potential impacts of imprecise large-scale autonomous immunofluorescence labeling of immune cells on whole slide images
Reddy, R.; Reddy, R.; Sharma, C.; Jackson, C.; Palisoul, S.; Barney, R.; Kolling, F.; Salas, L.; Christensen, B.; Brooks, G.; Tsongalis, G.; Vaickus, L.; Levy, J.
10.1101/2022.08.28.505606 — pathology — Posted on 2022-08-28
399 Quantitative clonal analysis reveals vast heterogeneity among fallopian tube cells for ovarian cancer-initiation and progression
Zeng, J.; Yela, A. A.; Casarez, E.; Jiang, Y.; Wang, L.; Kelly, B. E.; Ke, E.; Jenkins, T. M.; Atkins, K. A.; Janes, K. A.; Slack-Davis, J. K.; Zong, H.
10.1101/2022.01.23.477434 — cancer biology — Posted on 2022-08-28
400 Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor
Brown, A. D.; Vergunst, K. L.; Branch, M.; Blair, C. M.; Dupre, D. J.; Baillie, G. S.; Langelaan, D. N.
10.1101/2022.08.28.505448 — biochemistry — Posted on 2022-08-28
401 Five decades of data yield no support for adaptive biasing of offspring sex ratio in wild baboons (Papio cynocephalus)
Zipple, M. N.; Archie, E. A.; Tung, J.; Warutere, J. K.; Mututua, R. S.; Siodi, I. L.; Altmann, J.; Alberts, S. C.
10.1101/2022.08.28.505562 — evolutionary biology — Posted on 2022-08-28
402 Dynamic coastal pelagic habitat drives rapid changes in growth and condition of juvenile sockeye salmon (Oncorhynchus nerka) during early marine migration
Garzke, J.; Forster, I.; Godwin, S.; Johnson, B. T.; Krkosek, M.; Mahara, N.; Pakhomov, E. A.; Rogers, L. A.; Hunt, B. P.
10.1101/2022.03.21.484660 — ecology — Posted on 2022-08-28
405 Bacterial communities associated with the surfaces of the fresh fruits sold around Dhaka Medical College and Hospital and their anti-microbial profiles
Kabir, R. B.; Zaman, R.; Tania, N.-E.-J.; Asaduzzaman, M.; Haque, A.; Habib, F. B.; Tanni, N. N.; Nesa, M.; Chowdhury, A.; Rahman, M. F.; Sarker, A.; Halder, K.; Sharmin, N.; Chowdhury, M.; Nahar, S. S.; Rahman, M. M.; Shahid, S. B.; Shamsuzzaman, S. M.
10.1101/2022.08.26.505509 — microbiology — Posted on 2022-08-28
406 Mechanical morphotype switching as an adaptive response in mycobacteria
Eskandarian, H. A.; Chen, Y.-X.; Toniolo, C.; Belardinelli, J. M.; Palcekova, Z.; Ashby, P. D.; Fantner, G. E.; Jackson, M.; McKinney, J. D.; Javid, B.
10.1101/2022.04.06.487411 — microbiology — Posted on 2022-08-28
407 Distance estimation from monocular cues in an ethological visuomotor task
Parker, P. R. L.; Abe, E. T. T.; Beatie, N. T.; Leonard, E. S. P.; Martins, D. M.; Sharp, S. L.; Wyrick, D. G.; Mazzucato, L.; Niell, C. M.
10.1101/2021.09.29.462468 — neuroscience — Posted on 2022-08-28
412 Glisson's capsule structure and function is altered in cirrhotic patients irrespective of etiology
Llewellyn, J.; Fede, C.; Loneker, A. E.; Friday, C. S.; Hast, M. W.; Theise, N. D.; Furth, E. E.; Guido, M.; Stecco, C.; Wells, R. G.
10.1101/2022.08.28.505570 — physiology — Posted on 2022-08-28
414 Cell Atlas at Single-Nuclei Resolution of the Adult Human Adrenal Gland and Adrenocortical Adenomas
Altieri, B.; Secener, K.; Sai, S.; Fischer, C.; Sbiera, S.; Arampatzi, P.; Herterich, S.; Landwehr, L.-S.; Vitcetz, S.; Braeuning, C.; Fassnacht, M.; Ronchi, C.; Sauer, S.
10.1101/2022.08.27.505530 — physiology — Posted on 2022-08-28
415 In vivo quantitative high-throughput screening for drug discovery and comparative toxicology
Inglese, J.; Dranchak, P.; Oliphant, E.; Queme, B.; Lamy, L.; Wang, Y.; Huang, R.; Xia, M.; Tao, D.
10.1101/2022.08.26.505462 — pharmacology and toxicology — Posted on 2022-08-28
416 PML controls angiogenesis and EMT to limit metastasis in MDAMB231 cells
Vogiatzoglou, A. P.; Spanou, S.; Sachini, N.; Drakos, E.; Nikolaou, C.; Makatounakis, T.; Kretsovali, A.; Papamatheakis, J.
10.1101/2022.08.28.505601 — cancer biology — Posted on 2022-08-28
417 Disassembly of embryonic keratin filaments promotes pancreatic cancer
Kawalerski, R. R.; Torrente Goncalves, M.; Pan, C.-H.; Tseng, R.; Roa-Pena, L.; Leiton, C. V.; Torre-Healy, L. A.; Boyle, T.; Chowdhury, S.; Snider, N. T.; Shroyer, K. R.; Escobar-Hoyos, L. F.
10.1101/2022.08.27.504988 — cancer biology — Posted on 2022-08-28
421 eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
Wolf, D. A.; Duan, H.; Zhang, S.; Zarai, Y.; Oellinger, R.; Wu, Y.; Sun, L.; Hu, C.; Tian, G.; Tuller, T.; Rad, R.; Cheng, Y.
10.1101/2022.08.28.505560 — cell biology — Posted on 2022-08-28
422 Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation
Roberts, M. A.; Deol, K. K.; Lange, M.; Leto, D. E.; Mathiowetz, A. J.; Stevenson, J.; Hashemi, S. H.; Morgens, D. W.; Easter, E.; Heydari, K.; Nalls, M. A.; Bassik, M. C.; Kampmann, M.; Kopito, R. R.; Faghri, F.; Olzmann, J. A.
10.1101/2022.08.27.505556 — cell biology — Posted on 2022-08-28
423 Wounding promotes root regeneration through a cell wall integrity sensor, the receptor kinase FERONIA
Xie, Q.; Chen, W.; Xu, F.; Ouyang, S.; Chen, J.; Wang, X.; Wang, Y.; Mao, L.; Zhou, W.; Yu, F.
10.1101/2022.08.27.505519 — cell biology — Posted on 2022-08-28
425 Genomic and phenotypic evolution of nematode-infecting microsporidia
Wadi, L.; El Jarkass, H. T.; Tran, T. D.; Islah, N.; Luallen, R. J.; Reinke, A. W.
10.1101/2022.08.28.505597 — microbiology — Posted on 2022-08-28
426 Discovery of phage determinants that confer sensitivity to bacterial immune systems
Stokar-Avihail, A.; Fedorenko, T.; Garb, J.; Leavitt, A.; Millman, A.; Shulman, G.; Wojtania, N.; Melamed, S.; Amitai, G.; Sorek, R.
10.1101/2022.08.27.505566 — microbiology — Posted on 2022-08-28
427 Human XIRP1 is a macrophage podosome protein utilized by Listeria for actin-based motility
Urbano, R.; Park, E.-S.; Tretina, K.; Tunaru, A.; Gaudet, R. G.; Hu, X.; Wang, D.-Z.; MacMicking, J. D.
10.1101/2022.08.28.505595 — immunology — Posted on 2022-08-28
429 Simultaneous identification of m6A and m5C reveals coordinated RNA modification at single-molecule resolution
Acera Mateos, P.; Sethi, A. J.; Ravindran, A.; Guarnacci, M.; Srivastava, A.; Xu, J.; Woodward, K.; Yuen, Z. W.-S.; Hamilton, W.; Gao, J.; Starrs, L. M.; Hayashi, R.; Wickramasinghe, V. O.; Preiss, T.; Burgio, G.; Dehorter, N.; Shirokikh, N. E.; Eyras, E.
10.1101/2022.03.14.484124 — bioinformatics — Posted on 2022-08-28
430 Glucagon-like peptide-1 receptors in the gustatory cortex influence food intake
Dossat, A.; Kokoska, M. M.; Whitaker-Fornek, J.; Kulkarni, A. S.; Levitt, E. S.; Wesson, D. W.
10.1101/2022.08.26.505475 — neuroscience — Posted on 2022-08-28
435 Three-dimensional imaging of vascular development in the mouse epididymis: a prerequisite to better understand the post-testicular immune context of spermatozoa
Damon-Soubeyrand, C.; Bongiovanni, A.; Chorfa, A.; Goubely, C.; Pirot, N.; Pardanaud, L.; Piboin-Fragner, L.; Vachias, C.; Bravard, S.; Guiton, R.; Thomas, J.-L.; Saez, F.; Kocer, A.; Tardivel, M.; Drevet, J. R.; Henry-Berger, J.
10.1101/2022.08.26.505406 — developmental biology — Posted on 2022-08-28
436 Development and application of an uncapped mRNA platform
Liu, B.; Ni, P.; Cai, L.; Shi, X.; Ji, S.; Ke, Z.; Zhang, S.; Hu, B.; Yang, B.; Xu, Y.; Long, W.; Fang, Z.; Hu, H.; Wang, Y.; Zhang, W.; Geng, H.; Xu, Y.; Zheng, X.; Wang, Z.; Zhang, B.; Pan, K.; Zhou, K.; Cui, Y.; Wang, H.; Liu, B.
10.1101/2022.06.05.494796 — bioengineering — Posted on 2022-08-28
439 An Open Microfluidic Coculture Model of Fibroblasts and Eosinophils to Investigate Mechanisms of Airway Inflammation
Zeng, Y.; Su, X.; Takezawa, M. G.; Fichtinger, P. S.; Lee, U. N.; Pippin, J. W.; Shankland, S. J.; Lim, F. Y.; Denlinger, L. C.; Jarjour, N. N.; Mathur, S. K.; Sandbo, N.; Berthier, E.; Esnault, S.; Bernau, K.; Theberge, A. B.
10.1101/2022.07.11.499658 — cell biology — Posted on 2022-08-27
442 Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastoma
Ruiz Moreno, C.; Stunnenberg, H. G.; Nilsson, M.; Brandner, S.; Kranendonk, M. E.; Samuelsson, E.; Marco Salas, S.
10.1101/2022.08.27.505439 — cancer biology — Posted on 2022-08-27
444 A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation
Ghanbarpour, A.; Cohen, S. E.; Fei, X.; Bell, T. A.; Baker, T. A.; Davis, J. H.; Sauer, R. T.
10.1101/2022.08.27.505532 — biochemistry — Posted on 2022-08-27
445 High sensitivity single cell RNA sequencing with split pool barcoding
Tran, V.; Papalexi, E.; Schroeder, S.; Kim, G.; Sapre, A.; Pangallo, J.; Sova, A.; Matulich, P.; Kenyon, L.; Sayar, Z.; Koehler, R.; Diaz, D.; Gadkari, A.; Howitz, K.; Nigos, M.; Roco, C. M.; Rosenberg, A. B.
10.1101/2022.08.27.505512 — genomics — Posted on 2022-08-27
446 Genome sequencing and de novo and reference-based genome assemblies of Bos indicus breeds
Chakraborty, A.; Bisht, M. S.; Saxena, R.; Mahajan, S.; Pulikkan, J.; Sharma, V. K.
10.1101/2022.08.27.505546 — genomics — Posted on 2022-08-27
447 Genome assembly of the acoel flatworm Symsagittifera roscoffensis, a model for research on photosymbiosis
Martinez, P.; Ustyantsev, K.; Biryukov, M.; Mouton, S.; Glazenburg, L.; Sprecher, S.; Bailly, X.; Berezikov, E.
10.1101/2022.08.27.505549 — genomics — Posted on 2022-08-27
448 Environmental DNA reveals invasive crayfish microbial associates and ecosystem-wide biodiversity before and after eradication
Ballare, K. M.; Worth, A.; Goodearly, T.; Ruiz-Ramos, D. V.; Beraut, E.; Nava, H.; Fairbairn, C.; Wayne, R. K.; Shapiro, B.; Short, G.; Meyer, R. S.
10.1101/2022.05.20.492886 — ecology — Posted on 2022-08-27
449 Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension
Ali, M. K.; Liu, Y.; Wu, J. C.; Perez, V. d. J.; Rhodes, C. J.; Cao, A.; Wilkins, M. R.; Nicolls, M. R.; Spiekerkoetter, E. F.
10.1101/2022.08.27.505495 — cell biology — Posted on 2022-08-27
450 Lipid droplets are intracellular mechanical stressors in fatty hepatocytes
Loneker, A. E.; Alisafaei, F.; Kant, A.; Janmey, P. A.; Shenoy, V. B.; Wells, R. G.
10.1101/2022.08.27.505524 — cell biology — Posted on 2022-08-27
451 Predicting proprioceptive cortical anatomy and neural coding with topographic autoencoders
Blum, K. P.; Grogan, M. D.; Wu, Y.; Harston, A. J.; Miller, L. E.; Faisal, A. A.
10.1101/2021.12.10.472161 — neuroscience — Posted on 2022-08-27
452 Role of mPFC DUSP1 in regulating the sensitivity to cocaine in adolescent cocaine-exposed mice of adulthood
Wei, X.; Cheng, Z.; Chen, W.; Guo, H.; Liu, Z.; Hu, T.; Zhang, Y.; Cai, Q.; Ge, F.; Fan, Y.; Chang, J.; Guan, X.
10.1101/2022.08.26.505502 — neuroscience — Posted on 2022-08-27
454 Optimizing CpG spatial distribution with DNA origami for Th1-polarized therapeutic vaccination
Zeng, Y. C.; Young, O. J.; Wintersinger, C. M.; Anastassacos, F. M.; MacDonald, J. I.; Isinelli, G.; Dellacherie, M. O.; Sobral, M.; Bai, H.; Graveline, A.; Vernet, A.; Sanchez-Ventura, M.; Mulligan, K.; Choi, Y.-J.; Ferrante, T. C.; Keskin, D.; Fell, G.; Neuberg, D.; Wu, C.; Mooney, D.; Kwon, I.-C.; Ryu, J.-H.; Shih, W.
10.1101/2022.06.08.495340 — synthetic biology — Posted on 2022-08-27
461 Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated Viruses
Yin, V. C.; Devine, P.; Saunders, J.; Hines, A.; Shepherd, S.; Dembek, M.; Dobson, C.; Snijder, J.; Bond, N.; Heck, A. J. R.
10.1101/2022.08.27.505551 — biochemistry — Posted on 2022-08-27
462 A thousand-genome panel retraces the global spread and climatic adaptation of a major crop pathogen
Feurtey, A.; Lorrain, C.; McDonald, M. C.; Milgate, A.; Solomon, P.; Warren, R.; Puccetti, G.; Scalliet, G.; Torriani, S.; Gout, L.; Marcel, T.; Suffert, F.; Alassimone, J.; Lipzen, A.; Yoshinaga, Y.; Daum, C.; Barry, K.; Grigoriev, I. V.; Goodwin, S. B.; Genissel, A.; Lebrun, M.-H.; Kema, G. H. J.; McDonald, B. A.; Croll, D.
10.1101/2022.08.26.505378 — genomics — Posted on 2022-08-27
464 Highly precise genome editing using enhanced CRISPR-Cas12a nickase module
Lee, S. H.; Kim, C. H.; Kim, H.; Lee, Y.; Lee, H.; Lim, K.-S.; Park, S. J.; Huh, J.-W.; Kim, Y.-H.; Lee, D.-S.; Kim, K. M.; Hur, J. K.
10.1101/2022.08.27.505535 — molecular biology — Posted on 2022-08-27
467 Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.
Morrone Parfitt, G.; Coccia, E.; Goldman, C.; Whitney, K.; Reyes, R.; Sarrafha, L.; Nam, K. H.; Jones, D.; crary, J. F.; Ordureau, A.; Blanchard, J.; Ahfeldt, T. D.
10.1101/2022.08.26.505472 — neuroscience — Posted on 2022-08-27
468 Cell-type-specific whole-genome landscape of ΔFOSB binding in nucleus accumbens after chronic cocaine exposure
Yeh, S.-Y.; Estill, M.; Lardner, C. K.; Browne, C. J.; Minier-Toribio, A.; Futamura, R.; Beach, K.; McManus, C. A.; Xu, S.-j.; Zhang, S.; Heller, E. A.; Shen, L.; Nestler, E. J.
10.1101/2022.08.27.505547 — neuroscience — Posted on 2022-08-27
469 CRISPR/Cas-based precision gene replacement in plants via homologous recombination-independent approaches
Vu, T. V.; Lim, G.-H.; Choi, S. H.; Moon, J. Y.; Nguyen, N. T.; Das, S.; Tran, M. T.; Sung, Y. W.; Kim, J.; Song, Y. J.; Kim, S. W.; Jeong, J. C.; Kim, J.-Y.
10.1101/2022.08.27.505510 — synthetic biology — Posted on 2022-08-27
470 Evolutionary barriers to horizontal gene transfer in macrophage associated Salmonella.
Bhatia, R. P.; Kirit, H. A.; Lewis, C. M.; Sankaranarayanan, K.; Bollback, J. P.
10.1101/2022.04.01.486712 — microbiology — Posted on 2022-08-27
473 Degenerate oligonucleotide primer MIG-seq: an effective PCR-based method for high-throughput genotyping
Nishimura, K.; Kokaji, H.; Motoki, K.; Yamazaki, A.; Nagasaka, K.; Takisawa, R.; Yasui, Y.; Kawai, T.; Ushijima, K.; Yamasaki, M.; Saito, H.; Nakano, R.; Nakazaki, T.
10.1101/2022.08.25.504752 — genetics — Posted on 2022-08-27
474 A single-cell transcriptome atlas of human early embryogenesis
Xu, Y.; Zhang, T.; Zhou, Q.; Hu, M.; Qi, Y.; Xue, Y.; Wang, L.; Nie, Y.; Bao, Z.; Shi, W.
10.1101/2021.11.30.470583 — developmental biology — Posted on 2022-08-27
477 Antimicrobial copper as an effective and practical deterrent to surface transmission of SARS-CoV-2
Vera-Otarola, J.; Mendez, N.; Martinez-Valdebenito, C.; Mannheim, R.; Lu, K.; Rhodes, S.
10.1101/2022.08.25.505365 — microbiology — Posted on 2022-08-27
478 Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study
Millar, P. R.; the Dominantly Inherited Alzheimer Network, ; Gordon, B. A.; Luckett, P. H.; Benzinger, T.; Cruchaga, C.; Fagan, A. M.; Hassenstab, J.; Perrin, R. J.; Schindler, S. E.; Allegri, R. F.; Day, G. S.; Farlow, M. R.; Mori, H.; Nübling, G.; Bateman, R.; Morris, J.; Ances, B.
10.1101/2022.08.25.505251 — neuroscience — Posted on 2022-08-27
481 Orchestration of Proteins in cyanobacterial Circadian Clock System 1
Sugiyama, M.; Morishima, K.; Yunoki, Y.; Inoue, R.; Sato, N.; Yagi, H.; Kato, K.
10.1101/2022.08.26.505376 — biophysics — Posted on 2022-08-27
484 Cooperative host-microbe metabolism of a plant toxin in bees
Motta, E.; Gage, A.; Smith, T. E.; Blake, K. J.; Kwong, W. K.; Riddington, I. M.; Moran, N.
10.1101/2022.08.25.505265 — ecology — Posted on 2022-08-27
485 A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings
Sanchez-Todo, R.; Bastos, A.; Lopez-Sola, E.; Mercadal, B.; Santarnecchi, E.; Miller, E. K.; Deco, G.; Ruffini, G.
10.1101/2022.07.19.500618 — neuroscience — Posted on 2022-08-27
486 Global loss of fine-scale chromatin architecture and rebalancing of gene expression during early colorectal cancer development
Zhu, Y.; Lee, H.; Weimer, A. K.; Horning, A.; Nevins, S. A.; Esplin, E. D.; Paul, K.; Krieger, G.; Shipony, Z.; Mills, M.; Laquindanum, R.; Ladabaum, U.; Chiu, R.; Longacre, T.; Shen, J.; Jaimovich, A.; Lipson, D.; Kundaje, A.; Greenleaf, W. J.; Curtis, C.; Ford, J. M.; Snyder, M. P.
10.1101/2022.08.26.505505 — genomics — Posted on 2022-08-27
488 Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition
Gerrick, E. R.; Zlitni, S.; West, P. T.; Mechler, C. M.; Li, J. A.; Higginbottom, S. K.; Severyn, C. J.; Kracke, F.; Spormann, A. M.; Sonnenburg, J. L.; Bhatt, A. S.; Howitt, M. R.
10.1101/2022.08.26.505490 — microbiology — Posted on 2022-08-27
490 Data Fusion by Matrix Completion for Exposome Target Interaction Prediction
Wang, K.; Kim, N.; Bagherian, M.; Li, K.; Chou, E.; Colacino, J. A.; Dolinoy, D. C.; Sartor, M. A.
10.1101/2022.08.24.505125 — pharmacology and toxicology — Posted on 2022-08-27
494 Orchestration of Proteins in cyanobacterial Circadian Clock System 1
Sugiyama, M.; Morishima, K.; Yunoki, Y.; Inoue, R.; Sato, N.; Yagi, H.; Kato, K.
10.1101/2022.08.26.505376 — biophysics — Posted on 2022-08-27
495 Identification and characterization of repressive domains in Drosophila transcription factors
Klaus, L.; de Almeida, B. P.; Vlasova, A.; Nemcko, F.; Schleiffer, A.; Bergauer, K.; Rath, M.; Stark, A.
10.1101/2022.08.26.505062 — molecular biology — Posted on 2022-08-27
496 An evolutionally conserved archaeal KEOPS complex functions in DNA repair
Wu, P.; Gan, Q.; Zhang, X.; Yang, Y.; Xiao, Y.; She, Q.; Ni, J.; Huang, Q.; Shen, Y.
10.1101/2022.08.26.505501 — microbiology — Posted on 2022-08-27
497 Productive and latent HIV infections originate in resting CD4+ T cells
Wietgrefe, S.; Anderson, J.; Duan, L.; Southern, P. J.; Zuck, P.; Wu, G.; Howell, B.; Reilly, C.; Kroon, E.; Chottanapund, S.; Buranapraditkun, S.; Sacdalan, C.; Tulmethakaan, N.; Colby, D. J.; Chomchey, N.; Prueksakaew, P.; Pinyakorn, S.; Trichavaroj, R.; Hsu, D.; Vasan, S.; Manasnayakorn, S.; de Souza, M.; Tovanabutra, S.; Schuetz, A.; Robb, M. L.; Phanuphak, N.; Ananworanich, J.; Schacker, T.; Haase, A. T.
10.1101/2022.08.26.505461 — immunology — Posted on 2022-08-27
501 TMEM100, a Lung-Specific Endothelium Gene
Liu, B.; Yi, D.; Yu, Z.; Pan, J.; Ramirez, K.; Li, S.; Wang, T.; Glembotski, C.; Fallon, M.; Oh, P.; Gu, M.; Kalucka, J.; Dai, Z.
10.1101/2022.08.26.504609 — physiology — Posted on 2022-08-27
504 CNTNAP4 signaling regulates osteosarcoma disease progression
James, A.; Qin, Q.; Ramesh, S.; Gomez-Salazar, M.; Zhong, L.; Cherief, M.; Pratapneni, A.; Morris, C. D.; McCarthy, E. F.; Zhang, X.
10.1101/2022.08.26.505419 — cancer biology — Posted on 2022-08-27
507 Engineered nickel bioaccumulation in Escherichia coli by NikABCDE transporter and metallothionein overexpression
Diep, P.; Shen, L.; Wiesner, J. A.; Mykytczuk, N.; Papangelakis, V.; Yakunin, A. F.; Mahadevan, R.
10.1101/2022.08.26.505507 — bioengineering — Posted on 2022-08-27
514 Population coding of strategic variables during foraging in freely-moving macaques
Shahidi, N.; Parajuli, A.; Franch, M.; Schrater, P.; Wright, A.; Pitkow, X.; Dragoi, V.
10.1101/811992 — neuroscience — Posted on 2022-08-26
515 Large-scale mapping and systematic mutagenesis of human transcriptional effector domains
DelRosso, N.; Tycko, J.; Suzuki, P.; Andrews, C.; Aradhana, F.; Mukund, A.; Liongson, I.; Ludwig, C.; Spees, K.; Fordyce, P.; Bassik, M. C.; Bintu, L.
10.1101/2022.08.26.505496 — systems biology — Posted on 2022-08-26
518 Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis
Johnson, J. M.; Peterlin, A. D.; Balderas, E.; Sustarsic, E. G.; Maschek, J. A.; Lang, M. J.; Jara-Ramos, A.; Panic, V.; Morgan, J. T.; Villanueva, C. J.; Sanchez, A.; Rutter, J.; Lodhi, I. J.; Cox, J. E.; Fisher-Wellman, K. H.; Chaudhuri, D.; Gerhart-Hines, Z.; Funai, K.
10.1101/2022.08.26.505474 — biochemistry — Posted on 2022-08-26
520 wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome
Watson, C. J.; Tang, W. J.; Rojas, M. F.; Fiedler, I. A. K.; Morfin Montes de Oca, E.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Ahmed, A. R.; Sethuraman, V.; Addish, S.; Farr, G. H.; Gomez, A. E.; Rai, J.; Monstad-Rios, A. T.; Gardiner, E. M.; Karasik, D.; Maves, L.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2022-08-26
524 Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption
Bhatt, T.; Khedkar, S. U.; Dam, B.; Lall, S.; Pandey, S.; Kataria, S.; Dias, P. M.; Waskar, M.; Raut, J.; Sundaramurthy, V.; Vemula, P. K.; Ghatlia, N.; Majumdar, A.; Jamora, C.
10.1101/2022.08.26.505399 — pathology — Posted on 2022-08-26
527 Intestinal lamina propria supports acquired eTreg suppressor function
Gu, Y.; Bartolome-Casado, R.; Xu, C.; Janney, A.; Heuberger, C.; Pearson, C.; Teichmann, S.; Thornton, E. E.; Powrie, F.
10.1101/2022.08.26.505428 — immunology — Posted on 2022-08-26
528 Probabilistic axon targeting dynamics lead to individualized brain wiring
Andriatsilavo, M.; Dumoulin, A.; Dutta, S.; Stoeckli, E. T.; Hiesinger, P. R.; Hassan, B. A.
10.1101/2022.08.26.505432 — neuroscience — Posted on 2022-08-26
529 NEUROTRANSMITTER TRANSPORTER/RECEPTOR CO-EXPRESSION SHARES ORGANIZATIONAL TRAITS WITH BRAIN STRUCTURE AND FUNCTION
Hänisch, B.; Hansen, J. Y.; Bernhardt, B. C.; Eickhoff, S. B.; Dukart, J.; Misic, B.; Valk, S. L.
10.1101/2022.08.26.505274 — neuroscience — Posted on 2022-08-26
530 Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke
Staehr, C.; Giblin, J. T.; Gutierrez-Jimenez, E.; Guldbrandsen, H.; Tang, J.; Sandow, S. L.; Boas, D. A.; Matchkov, V. V.
10.1101/2022.08.26.505245 — physiology — Posted on 2022-08-26
532 SARS-CoV-2 Omicron BA.2.75 variant may be much more infective than preexisting variants
Sugano, A.; Takaoka, Y.; Kataguchi, H.; Kumaoka, M.; Ohta, M.; Kimura, S.; Araki, M.; Morinaga, Y.; Yamamoto, Y.
10.1101/2022.08.25.505217 — bioinformatics — Posted on 2022-08-26
536 Paradoxical tumor suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer
Itakura, H.; Hata, T.; Okuzaki, D.; Takeda, K.; Iso, K.; Qian, Y.; Morimoto, Y.; Adachi, T.; Hirose, H.; Yokoyama, Y.; Ogino, T.; Miyoshi, N.; Takahashi, H.; Uemura, M.; Mizushima, T.; Hinoi, T.; Mori, M.; Doki, Y.; Eguchi, H.; Yamamoto, H.
10.1101/2022.08.25.505236 — molecular biology — Posted on 2022-08-26
537 Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates
Uraki, R.; Iida, S.; Halfmann, P. J.; Yamayoshi, S.; Hirata, Y.; Iwatsuki-Horimoto, K.; Kiso, M.; Ito, M.; Furusawa, Y.; Ueki, H.; Sakai-Tagawa, Y.; Kuroda, M.; Maemura, T.; Kim, T.; Mine, S.; Kinoshita-Iwamoto, N.; Li, R.; Liu, Y.; Larson, D.; Fukushi, S.; Watanabe, S.; Maeda, K.; Wang, Z.; Ohmagari, N.; Theiler, J.; Fischer, W.; Korber, B.; Imai, M.; Suzuki, T.; Kawaoka, Y.
10.1101/2022.08.26.505450 — microbiology — Posted on 2022-08-26
538 Cholesterol-laden brain-permeable nanoparticles support long-lasting cognitive recovery and motor amelioration in the slow-progressing zQ175DN mouse model of Huntington's Disease
Birolini, G.; Valenza, M.; Ottonelli, I.; Talpo, F.; Minoli, L.; Cappelleri, A.; Bombaci, M.; Caccia, C.; Leoni, V.; Passoni, A.; Favagrossa, M.; Nucera, M. R.; Colombo, L.; Paltrinieri, S.; Bagnati, R.; Duskey, J. T.; Caraffi, R.; Vandelli, M. A.; Taroni, F.; Salmona, M.; Scanziani, E.; Biella, G.; Ruozi, B.; Tosi, G.; Cattaneo, E.
10.1101/2022.08.26.505426 — neuroscience — Posted on 2022-08-26
540 Circadian Gene Expression in Mouse Renal Proximal Tubule
Bingham, M. A.; Neijman, K.; Kikuchi, H.; Jung, H. J.; Poll, B. G.; Raghuram, V.; Park, E.; Yang, C.-R.; Chou, C.-L.; Chen, L.; Leipziger, J.; Knepper, M. A.; Dona, M.
10.1101/2022.08.26.505418 — systems biology — Posted on 2022-08-26
541 Challenges in Improving Genomic Literacy: Results from National and Regional Surveys of Genomic Knowledge, Attitudes, Concerns, and Behaviors
Jaeger, J.; Hellwig, A.; Schiavoni, E.; Brace-MacDonald, B.; Lamb, N. A.; Tumiel-Berhalter, L.; Halfon, M. S.; Vishwanath, A.; Surtees, J. A.
10.1101/2022.08.26.505444 — scientific communication and education — Posted on 2022-08-26
543 Relating enhancer genetic variation across mammals to complex phenotypes using machine learning
Kaplow, I. M.; Lawler, A. J.; Schaffer, D. E.; Srinivasan, C.; Wirthlin, M. E.; Phan, B. N.; Zhang, X.; Foley, K.; Prasad, K.; Brown, A. R.; Zoonomia Consortium, ; Meyer, W. K.; Pfenning, A. R.
10.1101/2022.08.26.505436 — genomics — Posted on 2022-08-26
544 Enhancer deregulation in TET2 Mutant Clonal Hematopoiesis is associated with increased COVID-19 related inflammation severity and mortality
Binder, M.; Lasho, T. L.; Ismail, W. M.; Ben-Crentsil, N. A.; Fernandez, J. A.; Kim, M.; Geyer, S. M.; Mazzone, A.; Finke, C. M.; Mangaonkar, A. A.; Lee, J.-H.; Hyun Kim, K.; Simon, V. A.; Rohakthar, F. R.; Munankarmy, A.; Schwager, S. M.; Harrington, J. J.; Snyder, M. R.; Droin, N. M.; Solary, E.; Robertson, K. D.; Wieben, E. D.; Padron, E.; Chia, N.; Gaspar-Maia, A.; Patnaik, M. M.
10.1101/2022.08.25.505316 — genetics — Posted on 2022-08-26
546 Effects of interspecies interactions on marine community ecosystem function
Daniels, M.; Stubbusch, A.; Held, N. A.; Schubert, O. T.; Ackermann, M.
10.1101/2022.08.26.505414 — microbiology — Posted on 2022-08-26
548 Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells
Vacchini, A.; Chancellor, A.; Yang, Q.; Spagnuolo, J.; Joss, D.; Oyas, O.; Beshirova, A.; De Gregorio, C.; Pfeffer, M.; Stelling, J.; Häussinger, D.; Lepore, M.; Mori, L.; De Libero, G.
10.1101/2022.08.26.505411 — immunology — Posted on 2022-08-26
549 Alcohol dependence modifies brain networks activated during abstinence and reaccess: a c-fos-based analysis in mice
Roland, A.; Coelho, C.; Haun, H.; Gianessi, C.; Lopez, M.; D'Ambrosio, S.; Machinski, S.; Kroenke, C.; Frankland, P.; Becker, H.; Kash, T.
10.1101/2022.08.26.505400 — neuroscience — Posted on 2022-08-26
550 A method for chronic and semi-chronic microelectrode array implantation in deep brain structures using image guided neuronavigation
Mahmoudian, B.; Dalal, H.; Lau, J. C.; Corrigan, B. W.; Barker, K.; Rankin, A.; Chen, E. C. S.; Peters, T.; Martinez-Trujillo, J. C.
10.1101/2022.08.26.505452 — neuroscience — Posted on 2022-08-26
556 The Impact of Task Context on Predicting Finger Movements in a Brain-Machine Interface
Mender, M. J.; Nason-Tomaszewski, S. R.; Temmar, H.; Costello, J. T.; Wallace, D. M.; Willsey, M. S.; Ganesh Kumar, N.; Kung, T. A.; Patil, P. G.; Chestek, C. A.
10.1101/2022.08.26.505422 — neuroscience — Posted on 2022-08-26
561 Tecomella undulata Improves Insulin Sensitivity by Attenuating Inflammation and Oxidative Stress in Experimental NASH
Srinivas, A. N.; Suresh, D.; Suvarna, D.; Pathak, P.; Giri, S.; Suman, ; Satish, S.; Chidambaram, S. B.; Kumar, D. P.
10.1101/2022.08.26.505375 — physiology — Posted on 2022-08-26
563 The Origin Of Cysteine and its Catabolism in Mammalian Tissues and Tumors
Yoon, S. J.; Combs, J. A.; Falzone, A.; Prieto-Farigua, N.; Caldwell, S.; Ackerman, H. D.; Flores, E. R.; DeNicola, G. M.
10.1101/2022.08.26.505162 — cancer biology — Posted on 2022-08-26
565 SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells
Cheng, R. Y.-H.; de Rutte, J.; Ott, A. R.; Bosler, L.; Kuo, W.-Y.; Liang, J.; Hall, B. E.; Rawlings, D. J.; Di Carlo, D.; James, R. G.
10.1101/2022.08.25.505190 — bioengineering — Posted on 2022-08-26
566 Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein
Williams, H. M.; Thorkelsson, S. R.; Vogel, D.; Milewski, M.; Busch, C.; Cusack, S.; Grunewald, K.; Quemin, E.; Rosenthal, M.
10.1101/2022.08.25.505333 — biochemistry — Posted on 2022-08-26
576 ATNr : Allometric trophic models in R
Gauzens, B.; Berti, E.; Delmas, E.; Brose, U.
10.1101/2022.08.26.505404 — ecology — Posted on 2022-08-26
577 A transcriptomic signature for single pancreatic islet leader beta cells
Chasbosseau, P.; Yong, F.; Delgadillo-Silva, L.; Young Lee, E.; Li, S.; Gandhi, N.; Lopez-Noriega, L.; Leclerc, I.; Ali, Y.; HUGHES, J.; Sladek, R.; Martinez-sanchez, A.; Rutter, G. A.
10.1101/2022.08.26.505442 — cell biology — Posted on 2022-08-26
578 Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast
Bhattacharjee, R.; Hall, A.; Mangione, M. C.; Igarashi, M. G.; Roberts-Galbraith, R. H.; Chen, J.-S.; Vavylonis, D.; Gould, K.
10.1101/2022.08.26.505417 — cell biology — Posted on 2022-08-26
580 Plasma Proteome Perturbation for CMV DNAemia in Kidney Transplantation
Sigdel, T.; Boada, P.; Kerwin, M.; Rashmi, P.; Gjertson, D.; Rossetti, M.; Sur, S.; Munar, D.; Cimino, J.; Ahn, R.; Pickering, H.; Sen, S.; Parmar, R.; Fatou, B.; Steen, H.; Schaenman, J.; Bunnapradist, S.; Reed, E.; Sarwal, M. M.; CMV Systems Immunobiology Group,
10.1101/2022.08.25.505318 — immunology — Posted on 2022-08-26
581 Subclinical Atherosclerosis is Associated with Discrepancies in BAFF and APRIL Levels and Altered Breg Potential of Precursor-like Marginal Zone B-Cells in HIV Treated Individuals
Naegele Aranguren, M.; Doyon-Laliberte, K.; El-Far, M.; Chartrand-Lefebvre, C.; Routy, J.-P.; Baril, J.-G.; Trottier, B.; Tremblay, C.; Durand, M.; Poudrier, J.; Roger, M.
10.1101/2022.08.26.505170 — immunology — Posted on 2022-08-26
582 Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation
Luda, K. M.; Kitchen-Goosen, S. M.; Ma, E. H.; Watson, M. J.; Duimstra, L. R.; Oswald, B. M.; Longo, J.; Fu, Z.; Madaj, Z.; Kupai, A.; Dickson, B. M.; Kaymak, I.; Lau, K.; Compton, S.; DeCamp, L. M.; Kelly, D. P.; Puchalska, P.; Williams, K. S.; Krawczyk, C. M.; Levesque, D.; Boisvert, F.-M.; Sheldon, R.; Rothbart, S. B.; Crawford, P. A.; Jones, R. G.
10.1101/2022.08.26.505402 — immunology — Posted on 2022-08-26
583 Through the eye to the brain: Modulating LC-mediated arousal via pupil-based neurofeedback
Meissner, S. N.; Baechinger, M.; Kikkert, S.; Imhof, J.; Missura, S.; Carro Dominguez, M.; Wenderoth, N.
10.1101/2022.08.26.505388 — neuroscience — Posted on 2022-08-26
586 Sex-specific regulation of binge drinking and affective behaviors by subcortical serotonin 5HT2c receptor-containing neurons
Flanigan, M. E.; Hon, O. J.; D'Ambrosio, S.; Boyt, K. M.; Hassanein, L.; Castle, M. E.; Haun, H. L.; Pina, M. M.; Kash, T. L.
10.1101/2022.01.28.478036 — neuroscience — Posted on 2022-08-26
587 The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions
van Beest, E. H.; Abdelwahab, M. A.; Cazemier, J. L.; Baltira, C.; Maes, M. C.; Peri, B. D.; Self, M. W.; Willuhn, I.; Roelfsema, P. R.
10.1101/2022.08.26.505381 — neuroscience — Posted on 2022-08-26
588 Beet curly top Iran virus Rep and V2 gene work as silencing suppressors through separate mechanisms
Ebrahimi, S.; Bassler, A.; Eini, O.; Yildirim, Z.; Wassenegger, M.; Krczal, G.; Uslu, V. V.
10.1101/2022.08.25.505242 — plant biology — Posted on 2022-08-26
590 Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
Polley, S.; Müschenborn, H.; Terbeck, M.; De Antoni, A.; Vetter, I. R.; Dogterom, M.; Musacchio, A.; Volkov, V. A.; Huis in 't Veld, P. J.
10.1101/2022.08.25.505310 — biochemistry — Posted on 2022-08-26
591 Ion Mobility for Unknown Metabolite Identification: Hope or Hype?
Asef, C. K.; Rainey, M.; Garcia, B. M.; Gouveia, G. J.; Shaver, A. O.; Leach, F. E.; Morse, A. M.; Edison, A. S.; McIntyre, L.; Fernandez, F.
10.1101/2022.08.26.505158 — biochemistry — Posted on 2022-08-26
593 Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice
Okur, M.; Kimura, R.; Sahbaz, B. D.; Manor, U.; Patel, J.; Andrade, L.; Puligilla, K.; Croteau, D.; Bohr, V. A.
10.1101/2022.08.25.505332 — animal behavior and cognition — Posted on 2022-08-26
595 Fighting isn't sexy in lekking Greater Sage-grouse (Centrocercus urophasianus)
Snow, S. S.; Patricelli, G. L.; Butts, C. T.; Krakauer, A. H.; Perry, A. C.; Logsdon, R.; Prum, R. O.
10.1101/2022.08.26.505294 — animal behavior and cognition — Posted on 2022-08-26
596 Dynamic DNA methylation contributes to carryover effects and beneficial acclimatization in geoduck clams
Putnam, H. M.; Trigg, S. A.; White, S. J.; Spencer, L. H.; Vadopalas, B.; Natarajan, A.; Hetzel, J.; Jaeger, E.; Soohoo, J.; Gallardo Escarate, C.; Goetz, F. W.; Roberts, S.
10.1101/2022.06.24.497506 — genomics — Posted on 2022-08-26
603 Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.
Shak, C.; Vuolo, L.; Uddin, B.; Katoh, Y.; Brown, T.; Mukhopadhyay, A. G.; Heesom, K.; Stevenson, N.; Roberts, A. J.; Nakayama, K.; Stephens, D.
10.1101/2022.03.31.486414 — cell biology — Posted on 2022-08-26
604 A network of mixed actin polarity in the leading edge of spreading cells
Chung, W.-L.; Eibauer, M.; Li, W.; Boujemaa-Paterski, R.; Geiger, B.; Medalia, O.
10.1101/2022.08.26.505326 — cell biology — Posted on 2022-08-26
606 Combined single-sample metabolomics and RNAseq reveals a hepatic pyrimidine metabolic response to acute viral infection
Madaj, Z. B.; Dahabieh, M. S.; Kamalumpundi, V.; Muhire, B.; Pettinga, D. J.; Siwicki, R. A.; Ellis, A. E.; Isaguirre, C.; Escobar Galvis, M. L.; DeCamp, L.; Jones, R. G.; Givan, S. A.; Adams, M.; Sheldon, R. D.
10.1101/2022.08.26.505340 — molecular biology — Posted on 2022-08-26
615 Progression of vascular function and blood pressure in a mouse model of Kawasaki disease
Delvecchio, M.; Alves, J. V.; Saiyid, A. Z.; Singh, S.; Galley, J. C.; Awata, W. M. C.; Bruder-Nascimento, A.; Bruder-Nascimento, T.
10.1101/2022.08.25.505303 — pharmacology and toxicology — Posted on 2022-08-26
616 Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane
Ward, A. E.; Sokovikova, D.; Waxham, N.; Heberle, F. A.; Levental, I.; Levental, K. R.; Kiessling, V.; White, J. M.; Tamm, L. K.
10.1101/2022.08.25.505328 — biophysics — Posted on 2022-08-26
618 Inventa: a computational tool to discover chemical novelty in natural extracts libraries
Quiros-Guerrero, L. M.; Nothias, L.-F.; Gaudry, A.; Marcourt, L.; Allard, P.-M.; Rutz, A.; David, B.; Ferreira, E.; Wolfender, J.-L.
10.1101/2022.08.25.505324 — bioinformatics — Posted on 2022-08-26
626 Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch
Kinsler, G.; Schmidlin, K.; Newell, D.; Eder, R.; Apodaca, S.; Petrov, D.; Geiler-Samerotte, K.
10.1101/2022.08.25.505320 — evolutionary biology — Posted on 2022-08-26
627 EukProt: a database of genome-scale predicted proteins across the diversity of eukaryotes
Richter, D. J.; Berney, C.; Strassert, J. F. H.; Poh, Y.-P.; Herman, E. K.; Munoz-Gomez, S. A.; Wideman, J. A.; Burki, F.; de Vargas, C.
10.1101/2020.06.30.180687 — evolutionary biology — Posted on 2022-08-26
629 Telomere-dependent Interleukin-1 signaling promotes immunosuppression in tumor microenvironment
Mukherjee, A. K.; Dutta, S.; Singh, A.; Sharma, S.; Roy, S. S.; Sengupta, A.; Chatterjee, M.; Vinayagamurthy, S.; Bagri, S.; Khanna, D.; Verma, M.; Soni, D.; Budharaja, A.; Bhisade, S. K.; Sengupta, V.; Perwez, A.; George, N.; Singh, A. P.; Faruq, M.; Gupta, I.; Sabarinathan, R.; Dash, D.; Chowdhury, S.
10.1101/2021.12.07.471419 — cancer biology — Posted on 2022-08-26
635 Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts
Guyomar, C.; Bousquet, C.; Ku, S.; Heumann, J.; Guilloux, G.; Gaillard, N.; Heichette, C.; Duchesne, L.; Steinmetz, M. O.; Gibeaux, R.; Chretien, D.
10.1101/2021.07.14.452321 — cell biology — Posted on 2022-08-26
636 CXCL12 in late-stage osteoblasts and osteocytes is required for load induced bone formation in mice
Cabahug-Zuckerman, P.; Liu, C.; Atria, P.; Cai, C.; Fang, E.; Qureshi, S.; Rooklin, R.; Ponce, C.; Morocho, C.; Castillo, A. B.
10.1101/2022.08.25.505279 — cell biology — Posted on 2022-08-26
637 Classification of Human Chronotype Based on fMRINetwork-Based Statistics
Mason, S. L.; Junges, L.; Woldman, W. L.; Facer-Childs, E. R.; de Campos, B. M.; Bagshaw, A. P.; Terry, J. R.
10.1101/2022.08.25.505246 — neuroscience — Posted on 2022-08-26
638 Single-cell RNA-seq reveals stepwise fate conversion of supporting cells to hair cells in the chick auditory epithelium
Matsunaga, M.; Yamamoto, R.; Kita, T.; Ohnishi, H.; Yamamoto, N.; Okano, T.; Omori, K.; Nakagawa, T.
10.1101/2022.08.25.505256 — neuroscience — Posted on 2022-08-26
639 Mixtures of large-scale dynamic functional brain network modes
Gohil, C.; Roberts, E.; Timms, R.; Skates, A.; Higgins, C.; Quinn, A.; Pervaiz, U.; van Amersfoort, J.; Notin, P.; Gal, Y.; Adaszewski, S.; Woolrich, M.
10.1101/2022.05.03.490453 — neuroscience — Posted on 2022-08-26
640 Task matters: individual MEG signatures from naturalistic and neurophysiological brain states
Colenbier, N.; Sareen, E.; del-Aguila Puntas, T.; Griffa, A.; Pellegrino, G.; Mantini, D.; Marinazzo, D.; Arcara, G.; Amico, E.
10.1101/2022.08.25.505232 — neuroscience — Posted on 2022-08-26
643 Rapid specification of human pluripotent stem cells to functional astrocytes
Lendemeijer, B.; Unkel, M.; Mossink, B.; Hijazi, S.; Sampedro, S. G.; Shpak, G.; Slump, D. E.; van den Hout, M. C. G. N.; van IJcken, W. F. J.; Bindels, E. M. J.; Hoogendijk, W. J. G.; Nadif Kasri, N.; de Vrij, F. M. S.; Kushner, S. A.
10.1101/2022.08.25.505166 — neuroscience — Posted on 2022-08-26
645 Does the brain care about averages? A simple test.
Tlaie, A.; Shapcott, K. A.; van der Plas, T.; Rowland, J. M.; Lees, R.; Keeling, J.; Packer, A.; Tiesinga, P.; Schölvinck, M.; Havenith, M. N.
10.1101/2021.11.28.469673 — neuroscience — Posted on 2022-08-26
646 Neurons protect themselves by active shrinkage upon axonal transection
Aydin, M. S.; Bay, S.; Yigit, E. N.; Ozgul, C.; Oguz, E. K.; Konuk, E. Y.; Aysit, N.; Cengiz, N.; Erdogan, E.; Him, A.; Kocak, M.; Eroglu, E.; Ozturk, G.
10.1101/2022.07.06.499034 — neuroscience — Posted on 2022-08-26
647 Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy
Khalilimeybodi, A.; Riaz, M.; Campbell, S.; Omens, J. H.; McCulloch, A. D.; Qyang, Y.; Saucerman, J. J.
10.1101/2021.08.28.458032 — systems biology — Posted on 2022-08-26
649 C4 Grasses Employ Various Strategies to Acclimate Rubisco Activase to Heat Stress
Stainbrook, S. C.; Aubuchon, L. N.; Chen, A.; Johnson, E.; Si, A.; Walton, L.; Ahrendt, A.; Jez, J. M.
10.1101/2022.08.24.505184 — plant biology — Posted on 2022-08-26
650 Dosage differences in 12-OXOPHYTODIENOATE REDUCTASE genes modulate wheat primary root growth
Gabay, G.; Wang, H.; Zhang, J.; Moriconi, J.; Burguener, G. F.; Howell, T. R.; Lukaszewski, A.; Staskawicz, B.; Cho, M.-J.; Tanaka, J.; Fahima, T.; Ke, H.; Dehesh, K.; Zhang, G.-L.; Gou, J.-Y.; Hamberg, M.; Santa Maria, G.; Dubcovsky, J.
10.1101/2022.08.25.505338 — plant biology — Posted on 2022-08-26
651 Analysis of a genetic region affecting mouse body weight
Leung, C. L. K.; Karunakaran, S.; Atser, M. G.; Innala, L.; Hu, X.; Viau, V.; Johnson, J. D.; Clee, S. M.
10.1101/2022.08.24.502873 — physiology — Posted on 2022-08-26
652 A small-molecule lycorine derivative reveals Na+/K+-ATPase α3 as an anti-obesity target
Li, L.; Zhou, Y.; Zhang, H.; Chen, D.; Chen, Z.; Li, Y.; Tian, C.; Zhang, C.; Li, C.; Chang, B.; Zeng, R.; Li, J.; Song, X.; Chen, Y.; Hao, X.
10.1101/2022.08.24.505199 — physiology — Posted on 2022-08-26
653 UltraSEQ: a universal bioinformatic platform for information-based clinical metagenomics and beyond
Gemler, B. T.; Mukherjee, C.; Howland, C.; Fullerton, P. A.; Spurbeck, R. R.; Catlin, L. A.; Smith, A.; Minard-Smith, A. T.; Bartling, C.
10.1101/2022.08.24.505213 — bioinformatics — Posted on 2022-08-26
656 HMMploidy: inference of ploidy levels from short-read sequencing data
Soraggi, S.; Rhodes, J.; Altinkaya, I.; Tarrant, O.; Balloux, F.; Fisher, M. C.; Fumagalli, M.
10.1101/2021.06.29.450340 — bioinformatics — Posted on 2022-08-26
658 Changes in Social Position Predict Survival in Bottlenose Dolphins
Rankin, R. W.; Foroughirad, V. J.; Krzyszczyk, E. B.; Frere, C. H.; Mann, J.
10.1101/2022.08.25.505273 — animal behavior and cognition — Posted on 2022-08-26
659 GATK-gCNV: A Rare Copy Number Variant Discovery Algorithm and Its Application to Exome Sequencing in the UK Biobank
Babadi, M.; Fu, J. M.; Lee, S. K.; Smirnov, A. N.; Gauthier, L. D.; Walker, M.; Benjamin, D. I.; Karczewski, K. J.; Wong, I.; Collins, R. L.; Sanchis-Juan, A.; Brand, H.; Banks, E.; Talkowski, M. E.
10.1101/2022.08.25.504851 — genomics — Posted on 2022-08-26
663 Perturbations of the T-cell immune repertoire in kidney transplant rejection
Sigdel, T.; Fields, P. A.; Liberto, J.; Damm, I.; Kerwin, M.; Hood, J.; Towfighi, P.; Sirota, M.; Robins, H.; Sarwal, M. M.
10.1101/2022.08.24.505187 — immunology — Posted on 2022-08-26
664 DISRUPTED CEREBRAL PERI-MICROVASCULAR GLYCOGEN PROMOTES CAPILLARY CONSTRICTIONS AND AGGRAVATES ISCHEMIA IN MICE
Uruk, G.; Ozcan, S. Y.; Aktas, C. C.; Taskiran-Sag, A.; Donmez-Demir, B.; Duran, J.; Guinovart, J. J.; Karatas-Kursun, H.; Dalkara, T.; Ozkan, M. Y.
10.1101/2022.08.24.505172 — neuroscience — Posted on 2022-08-26
665 An abstract categorical decision code in dorsal premotor cortex
Diaz-deLeon, G.; Alvarez, M.; Bayones, L.; Zainos, A.; Zizumbo, J.; Parra, S.; Pujalte, S.; Romo, R.; Rossi-Pool, R.; De Lafuente, V.
10.1101/2022.08.24.505180 — neuroscience — Posted on 2022-08-26
667 High-Resolution 3D Ultra-Short Echo Time MRI with Rosette k-Space Pattern for Brain Iron Content Mapping
Shen, X.; Ozen, A. C.; Monsivais, H.; Sunjar, A.; Ilbey, S.; Zheng, W.; Du, Y.; Chiew, M.; emir, u.
10.1101/2022.08.24.505201 — neuroscience — Posted on 2022-08-26
670 Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathy
Amancherla, K.; Qin, J.; Hulke, M. L.; Pfeiffer, R. D.; Agrawal, V.; Sheng, Q.; Xu, Y.; Schlendorf, K. H.; Lindenfeld, J.; Shah, R. V.; Freedman, J. E.; Tucker, N. R.; Moslehi, J. J.
10.1101/2022.08.24.504346 — systems biology — Posted on 2022-08-26
672 Defective Ca2+- dependent activation of TRPM4 channels contributes to age-related cerebral small vessel disease in Col4a1 mutant mice
Yamasaki, E.; Thakore, P.; Ali, S.; Solano, A. S.; Wang, X.; Gao, X.; Labelle-Dumais, C.; Chaumeil, M. M.; Gould, D. B.; Earley, S.
10.1101/2022.08.24.505186 — pathology — Posted on 2022-08-26
673 Increasing quantitation in spatial single-cell metabolomics by using fluorescence as ground truth
Molenaar, M. R.; Shahraz, M.; Delafiori, J.; Eisenbarth, A.; Ekelöf, M.; Rappez, L.; Alexandrov, T.
10.1101/2022.08.24.505109 — bioinformatics — Posted on 2022-08-26
674 Screening cell-cell communication in spatial transcriptomics via collective optimal transport
Cang, Z.; Zhao, Y.; Almet, A. A.; Stabell, A.; Ramos, R.; Plikus, M.; Atwood, S. X.; Nie, Q.
10.1101/2022.08.24.505185 — bioinformatics — Posted on 2022-08-26
676 The Immune Factors Driving DNA Methylation Variation in Human Blood
Bergstedt, J.; Azzou, S. A. K.; Tsuo, K.; Jaquaniello, A.; Urrutia, A.; Rotival, M.; Lin, D. T. S.; Macisaac, J. L.; Kobor, M. S.; Albert, M. L.; Duffy, D.; Patin, E.; Quintana-Murci, L.
10.1101/2021.06.23.449602 — genomics — Posted on 2022-08-26
677 1,000 ancient genomes uncover 10,000 years of natural selection in Europe
Le, M. K.; Smith, O. S.; Akbari, A.; Harpak, A.; Reich, D.; Narasimhan, V. M.
10.1101/2022.08.24.505188 — genomics — Posted on 2022-08-26
678 A statistical genetics guide to identifying HLA alleles driving complex disease
Sakaue, S.; Gurajala, S.; Curtis, M.; Luo, Y.; Choi, W.; Ishigaki, K.; Kang, J. B.; Rumker, L.; Deutsch, A. J.; Schonherr, S.; Forer, L.; LeFaive, J.; Fuchsberger, C.; Han, B.; Lenz, T. L.; de Bakker, P. I. W.; Smith, A. V.; Raychaudhuri, S.
10.1101/2022.08.24.504550 — genetics — Posted on 2022-08-26
681 Diel activity patterns of vector mosquito species in the urban environment: Implications for vector control strategies
Wilke, A. B. B.; Mhlanga, A.; Kummer, A. G.; Vasquez, C.; Moreno, M.; Petrie, W. D.; Rodriguez, A.; Vitek, C.; Hamer, G. L.; Mutebi, J.-P.; Ajelli, M.
10.1101/2022.08.24.505011 — ecology — Posted on 2022-08-26
683 Combining δ13C and δ15N from bone and dentine in marine mammal palaeoecological research: insights from toothed whales
Rey-Iglesia, A.; Wilson, T.; Routledge, J.; Skovrind, M.; Garde, E.; Heide-Jorgensen, M. P.; Szpak, P.; Lorenzen, E. D.
10.1101/2021.12.13.472362 — ecology — Posted on 2022-08-26
685 Stac1 Regulates Sensory Stimulus Induced Escape Locomotion
Linsley, J. W.; Perez, N.; Hsu, I.-U.; Yu, Y.; Jasti, N.; Waalkes, M.; Horstick, E. J.; Kuwada, J. Y.
10.1101/2022.08.24.505176 — neuroscience — Posted on 2022-08-26
688 Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults
Ertl, N.; Lawn, W.; Mokrysz, C.; Freeman, T.; Alnagger, N.; Borissova, A.; Fernandez-Vinson, N.; Lees, R.; Ofori, S.; Petrilli, K.; Trinci, K.; Viding, E.; Curran, H. V.; Wall, M. B.
10.1101/2022.08.24.505069 — neuroscience — Posted on 2022-08-26
690 Data Fusion by Matrix Completion for Exposome Target Interaction Prediction
Wang, K.; Kim, N.; Bagherian, M.; Li, K.; Chou, E.; Colacino, J. A.; Dolinoy, D. C.; Sartor, M. A.
10.1101/2022.08.24.505125 — pharmacology and toxicology — Posted on 2022-08-26
691 HepaCAM Suppresses Glioblastoma Stem Cell Invasion in the Brain
De, A.; Lattier, J. M.; Morales, J. E.; Kelly, J. R.; Zheng, X.; Chen, Z.; Sebastian, S.; Huse, J. T.; Lang, F. F.; McCarty, J. H.
10.1101/2022.08.24.504654 — cancer biology — Posted on 2022-08-26
693 spARC Recovers Human Glioma Spatial SignalingNetworks with Graph Filtering
Kuchroo, M.; Miyagishima, D.; Steach, H.; Godavarthi, A.; Takeo, Y.; Duy, P. Q.; Barak, T.; Erson-Omay, E. Z.; Youlten, S. E.; Mishra-Gorur, K.; Moliterno, J.; McGuone, D.; Gunel, M.; Krishnaswamy, S.
10.1101/2022.08.24.505139 — bioinformatics — Posted on 2022-08-26
695 Identifying climatic drivers of hybridization in Heuchereae (Saxifragaceae)
Folk, R. A.; Gaynor, M. L.; Engle-Wrye, N. J.; O'Meara, B. C.; Soltis, P. S.; Soltis, D. E.; Guralnick, R. P.; Smith, S. A.; Grady, C. J.; Okuyama, Y.
10.1101/2022.08.24.505154 — evolutionary biology — Posted on 2022-08-26
698 Organ-Specific Fuel Rewiring in Acute and Chronic Hypoxia Redistributes Glucose and Fatty Acid Metabolism
Midha, A. D.; Zhou, Y.; Queliconi, B. B.; Barrios, A. M.; Fong, C. O. Y.; Blecha, J. E.; VanBrocklin, H.; Seo, Y.; Jain, I. H.
10.1101/2022.08.25.505289 — physiology — Posted on 2022-08-26
699 Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions
Yuan, H.; Liu, K.; Condor, M.; Barrasa-Fano, J.; Louis, B.; Vandaele, J.; de Almeida, P.; Coucke, Q.; Chen, W.; Oosterwijk, E.; Xing, C.; Van Oosterwyck, H.; Kouwer, P. H. J.; Rocha, S.
10.1101/2022.08.24.505064 — biophysics — Posted on 2022-08-26
701 Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy
Chella Krishnan, K.; El Hachem, E.-J.; Carroll, L.; Vegas, A. D.; Light, C.; Cao, Y.; Pan, C.; Kaczor-Urbanowicz, K. E.; Shravah, V.; Anum, D.; Pellegrini, M.; Lee, C. F.; Seldin, M. M.; Benjamin Parker, D.; James, D. E.; Lusis, A. J.
10.1101/2022.08.24.505177 — genetics — Posted on 2022-08-26
705 The Iron Content of Human Serum Albumin Modulates the Susceptibility of Acinetobacter baumannii to Cefiderocol
Escalante, J.; Nishimura, B.; Tuttobene, M. R.; Subils, T.; Mezcord, V.; Actis, L. A.; Tolmasky, M.; Bonomo, R. A.; Ramirez, M. S.
10.1101/2022.08.24.505215 — microbiology — Posted on 2022-08-26
708 Alternative stable states, nonlinear behavior, and predictability of microbiome dynamics
Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M. S.; Yamamichi, M.; Iwayama, K.; Canarini, A.; Hayashi, I.; Fukushima, K.; Fukuda, S.; Kiers, E. T.; Toju, H.
10.1101/2022.08.23.505041 — ecology — Posted on 2022-08-26
709 Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis And Embryogenesis
Ruiz, M.; Devkota, R.; Panagaki, D.; Bergh, P.-O.; Kaper, D.; Henricsson, M.; Nik, A.; Petkevicius, K.; Hoog, J. L.; Bohlooly-Y, M.; Carlsson, P.; Boren, J.; Pilon, M.
10.1101/2021.08.12.456080 — cell biology — Posted on 2022-08-26
710 Genome-wide peptidoglycan profiling of Vibrio cholerae
Hernandez, S. B.; Alvarez, L.; Ritzl-Rinkenberger, B.; Schiffthaler, B.; Serrano, A. R.; Cava, F.
10.1101/2022.08.25.505259 — microbiology — Posted on 2022-08-26
713 Alternative stable states, nonlinear behavior, and predictability of microbiome dynamics
Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M. S.; Yamamichi, M.; Iwayama, K.; Canarini, A.; Hayashi, I.; Fukushima, K.; Fukuda, S.; Kiers, E. T.; Toju, H.
10.1101/2022.08.23.505041 — ecology — Posted on 2022-08-26
714 The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesis
Yin, Y.; Sichler, A.; Ecker, J.; Laschinger, M.; Liebisch, G.; Hoering, M.; Basic, M.; Bleich, A.; Zhang, X.-J.; Stupakov, P.; Gaertner, Y.; Lohoefer, F.; Mogler, C.; Friess, H.; Hartmann, D.; Holzmann, B.; Hueser, N.; Janssen, K.-P.
10.1101/2022.08.25.505228 — cell biology — Posted on 2022-08-26
715 A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience
Wang, C.; Wang, B.; Pandey, T.; Long, Y.; Zhang, J.; Oh, F.; Sima, J.; Guo, R.; Liu, Y. K.; Zhang, C.; Mukherjee, S.; Bassik, M. C.; Lin, W.; Deng, H.; Vale, G.; McDonald, J. G.; Shen, K.; Ma, D. K.
10.1101/2022.08.25.505359 — cell biology — Posted on 2022-08-26
716 Reprograming human fibroblasts into Sertoli cells: a tool for personalized medicine
Parivesh, A.; Delot, E.; Reyes, A.; Ryan, J.; Bhattacharya, S.; Harley, V.; Vilain, E.
10.1101/2022.08.25.505300 — cell biology — Posted on 2022-08-26
717 Vimentin intermediate filaments provide structural stability to the mammalian Golgi apparatus
Vitali, T.; Witkos, T. M.; Cutiongco, M. F.; Yan, G.; Mironov, A. A.; Swift, J.; Lowe, M.
10.1101/2022.08.25.505293 — cell biology — Posted on 2022-08-26
721 Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition
Holt, A. K.; Najumudeen, A. K.; Hoskin, A. J.; Legge, D. N.; Mortensson, E. M. H.; Flanagan, D. J.; Jones, N.; Kollareddy, M.; Collard, T. J.; Timms, P.; Sansom, O. J.; Williams, A. C.; Vincent, E. E.
10.1101/2022.08.24.505115 — cancer biology — Posted on 2022-08-26
722 MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
Zelceski, A.; Francica, P.; Lingg, L.; Mutlu, M.; Stok, C.; Liptay, M.; Alexander, J.; Baxter, J. S.; Brough, R.; Gulati, A.; Haider, S.; Raghunandan, M.; Song, F.; Sridhar, S.; Forment, J. V.; OConnor, M. J.; Davies, B. R.; van Vugt, M. A. T. M.; Krastev, D. B.; Pettitt, S. J.; Tutt, A. N. J.; Rottenberg, S.; Lord, C. J.
10.1101/2022.08.24.505108 — cancer biology — Posted on 2022-08-26
723 Choosing variant interpretation tools for clinical applications: context matters
Aguirre, J.; Padilla, N.; Özkan, S.; Riera, C.; Feliubadalo, L.; de la Cruz, X.
10.1101/2022.02.17.480823 — bioinformatics — Posted on 2022-08-26
725 The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria
Khosravi, S.; Chelius, X.; Unger, A.-K.; Frickel, J.; Sachsenheimer, T.; Luechtenborg, C.; Schieweck, R.; Bruegger, B.; Westermann, B.; Klecker, T.; Neupert, W.; Harner, M. E.
10.1101/2022.04.09.487722 — biochemistry — Posted on 2022-08-26
729 Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
Fujita, K.; Desmond, P.; Blondelle, J.; Sotak, M.; Rajan, M. R.; Clark, M.; Esteve, E.; Chan, Y.; Gu, Y.; Marrocco, V.; Dalton, N. D.; Ghassemian, M.; Do, A.; Klos, M.; Peterson, K. L.; Sheikh, F.; Cho, Y.; Borgeson, E.; Lange, S.
10.1101/2022.08.24.505098 — cell biology — Posted on 2022-08-26
730 On the therapeutic potential of MAPK4 in triple-negative breast cancer
Boudghene-Stambouli, F.; Soulez, M.; Ronkina, N.; Doerrie, A.; Kotlyarov, A.; Seternes, O.-M.; Gaestel, M.; Meloche, S.
10.1101/2022.08.24.505130 — cancer biology — Posted on 2022-08-26
731 STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway
Pencik, J.; Philippe, C.; Schlederer, M.; Pecoraro, M.; Grund-Groeschke, S.; Li, W. J.; Tracz, A.; Heidegger, I.; Lagger, S.; Trachtova, K.; Oberhuber, M.; Heitzer, E.; Osman, O.; Neubauer, H. A.; Wingelhofer, B.; Orlova, A.; Witzeneder, N.; Dillinger, T.; Redl, E.; Greiner, G.; D'Andrea, D.; Oestman, J. R.; Tangermann, S.; Hermanova, I.; Schaefer, G.; Varady, A.; Horvath, J.; Stoiber, D.; Malcolm, T. I.; Turner, S. D.; Parkes, E. E.; Hantusch, B.; Egger, G.; Rose-John, S.; Poli, V.; Jain, S.; Armstrong, C. W. D.; Hoermann, G.; Goffin, V.; Aberger, F.; Moriggl, R.; Carracedo, A.; McKinney, C.;
10.1101/2022.08.25.504915 — cancer biology — Posted on 2022-08-26
733 Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies
Yang, Y.; Ahn, J.; Edwards, N. J.; Benicky, J.; Rozeboom, A. M.; Davidson, B.; Karamboulas, C.; Nixon, K.; Ailles, L.; Goldman, R.
10.1101/2022.08.25.505356 — cancer biology — Posted on 2022-08-26
735 Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer
Pan, C.-H.; Chaika, N.; Tseng, R.; Siraj, M. A.; Chen, B.; Donnelly, K. L.; Horowitz, M.; Leiton, C. V.; Chowdhury, S.; Roa-Pena, L.; Oblein, L.; Marchenko, N.; Singh, P. K.; Shroyer, K. R.; Escobar-Hoyos, L. F.
10.1101/2022.08.24.504873 — cancer biology — Posted on 2022-08-26
740 Atypical speech production of multisyllabic words by children with developmental dyslexia
Keshavarzi, M.; M. Di Liberto, G.; Gabrielczyk, F.; Wilson, A.; Macfarlane, A.; Goswami, U.
10.1101/2022.08.24.505144 — neuroscience — Posted on 2022-08-25
742 Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
Corcoran, M.; Chernyshev, M.; Mandolesi, M.; Narang, S.; Kaduk, M.; Sundling, C.; Farnet, A.; Bernhardsson, C.; Larena, M.; Jakobsson, M.; Karlsson Hedestam, G. B.
10.1101/2022.08.25.505097 — immunology — Posted on 2022-08-25
743 Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules
Ikezoe, K.; Hidaka, N.; Manita, S.; Murakami, M.; Tsutsumi, S.; Isomura, Y.; Kano, M.; Kitamura, K.
10.1101/2022.08.24.505210 — neuroscience — Posted on 2022-08-25
745 Decorating chromatin for enhanced genome editing using CRISPR-Cas9
Chen, E.; Lin Shiao, E.; Trinidad, M.; Doost, M. S.; Colognori, D.; Doudna, J. A.
10.1101/2022.03.15.484540 — genetics — Posted on 2022-08-25
747 Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution
Kritikou, J.; Sanchez-Pascual, I.; Munoz-Miranda, J. P.; Vashist, N.; Wagner, A. K.; Zhang, X. M.; Assarsson, E.; Dominguez-Villar, M.; Yagita, H.; Garcia-Cozar, F.; Riese, P.; Harris, R. A.; Ljunggrean, H.-G.; Chambers, B.
10.1101/2022.08.25.504005 — immunology — Posted on 2022-08-25
748 SnFFPE-Seq: towards scalable single nucleus RNA-Seq of formalin-fixed paraffin-embedded (FFPE) tissue
Chung, H.; Melnikov, A.; McCabe, C.; Drokhlyansky, E.; Van Wittenberghe, N.; Magee, E. M.; Waldman, J.; Spira, A.; Chen, F.; Mazzilli, S.; Rozenblatt-Rosen, O.; Regev, A.
10.1101/2022.08.25.505257 — genomics — Posted on 2022-08-25
749 A phased, chromosome-scale genome of 'Honeycrisp' apple (Malus domestica)
Khan, A.; Carey, S. B.; Gomez, A. S.; Zhang, H.; Hargarten, H.; Hale, H.; Harkess, A.; Honaas, L.
10.1101/2022.08.24.505160 — genomics — Posted on 2022-08-25
752 Structures of human Malic Enzyme 3
Grell, T. A. J.; Mason, M.; Thompson, A. A.; Gomez-Tamayo, J. C.; Riley, D.; Wagner, M. V.; Steele, R.; Ortiz-Meoz, R. F.; Wadia, J.; Shaffer, P. L.; Tresadern, G.; Sharma, S.; Yu, X.
10.1101/2022.08.25.505315 — molecular biology — Posted on 2022-08-25
757 A molecular switch modulates assembly and host factor binding of the HIV-1 capsid
Schirra, R. T.; dos Santos, N. F.; Zadrozny, K. K.; Kucharska, I.; Ganser-Pornillos, B. K.; Pornillos, O.
10.1101/2022.08.25.505312 — microbiology — Posted on 2022-08-25
760 La revolution de l'ADN: biocompatible and biosafe DNA data storage
Maes, A.; Le Peillet, J.; Julienne, A.; Blachon, C.; Cornille, N.; Gibier, M.; Arwani, E.; Xu, Z.; Crozet, P.; Lemaire, S. D.
10.1101/2022.08.25.505104 — synthetic biology — Posted on 2022-08-25
763 Using synthetic activity to design ultra-potent antibody cocktails
Zhao, H.; Dodds, M.; Tasch, M.; Gewe, M.; Martinez, A.; Hutton, M.; Keeney, K.; Pollock, A.; Jester, B.; Khuong, N.; Zhang, M.; Ertel, S.; Brady, C.; Heinnickel, M.; Tabakh, H.; Sanjaya, N.; Cruickshank, K.; Paddock, T.; Struyvenberg, S.; Dang, J.; saveria, t.; Shanitta, C.; Fletcher, D.; sigmar, k.; Goetsch, L.; Gamble, C.; Mileto, S.; Heselpoth, R.; Lyras, D.; Behnke, C.; Fischetti, V.; Finrow, B.; Roberts, J. M.
10.1101/2021.12.21.473715 — bioengineering — Posted on 2022-08-25
764 Differential transcriptomic responses to heat stress in surface and subterranean diving beetles
Beasley-Hall, P. G.; Bertozzi, T.; Bradford, T. M.; Foster, C. S. P.; Jones, K.; Tierney, S. M.; Humphreys, W. F.; Austin, A. D.; Cooper, S. J. B.
10.1101/2021.12.12.470823 — evolutionary biology — Posted on 2022-08-25
765 GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc
Johnston, S. N.; Silagi, E. S.; Madhu, V.; Nguyen, D. H.; Shapiro, I. M.; Risbud, M. V.
10.1101/2022.07.22.501129 — cell biology — Posted on 2022-08-25
766 Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells
Lareau, C. A.; Yin, Y.; Maurer, K.; Sandor, K. D.; Yagnik, G.; Pena, J.; Crawford, J. C.; Spanjaart, A. M.; Gutierrez, J. C.; Haradvala, N. J.; Abay, T.; Stickels, R. R.; Verboon, J. M.; Liu, V.; Southard, J.; Song, R.; Li, W.; Shrestha, A.; Parida, L.; Getz, G.; Maus, M.; Li, S.; Moore, A.; Amado, R. G.; Talleur, A. C.; Thomas, P. G.; Dehghani, H.; Pertel, T.; Kundaje, A.; Gottschalk, S.; Roth, T. L.; Kersten, M. J.; Wu, C. J.; Majzner, R. G.; Satpathy, A. T.
10.1101/2022.08.12.503683 — immunology — Posted on 2022-08-25
770 snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling
Vallejo, A. F.; Harvey, K.; Wang, T.; Wise, K.; Butler, L. M.; Polo, J.; Plummer, J. T.; Swarbrick, A.; Martelotto, L. G.
10.1101/2022.08.23.505054 — cancer biology — Posted on 2022-08-25
773 PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid
Perea, V.; Cole, C.; Lebeau, J.; Dolina, V.; Baron, K. R.; Madhavan, A.; Kelly, J. W.; Grotjahn, D.; Wiseman, R. L.
10.1101/2022.02.23.481593 — cell biology — Posted on 2022-08-25
774 Distinct bile salt hydrolase substrate preferences dictate C. difficile pathogenesis
Foley, M. H.; Walker, M. E.; Stewart, A. K.; O'Flaherty, S.; Gentry, E. C.; Allen, G.; Patel, S.; Pan, M.; Beaty, V. V.; Vanhoy, M. E.; Dougherty, M. K.; McGill, S. K.; Gulati, A.; Dorrestein, P.; Baker, E. S.; Redinbo, M. R.; Barrangou, R.; Theriot, C. M.
10.1101/2022.03.24.485529 — microbiology — Posted on 2022-08-25
775 Glioblastoma is associated with extensive accelerated brain ageing
Ainslie, A. P.; Klaver, M.; Voshart, D. C.; Gerrits, E.; Eggen, B. J.; Bergink, S.; Barazzuol, L.
10.1101/2022.08.24.505089 — neuroscience — Posted on 2022-08-25
776 Evaluation of Transfer Learning Methods for Detecting Alzheimer's Disease with Brain MRI
Dhinagar, N. J.; Thomopoulos, S. I.; Rajagopalan, P.; Stripelis, D.; Ambite, J. L.; Steeg, G. V.; Thompson, P. M.
10.1101/2022.08.23.505030 — neuroscience — Posted on 2022-08-25
782 Gut microbiome signatures of Yorkshire Terrier Enteropathy during disease and remission.
Doulidis, P. G.; Galler, A. I.; Hausmann, B.; Berry, D.; Rodriguez Rojas, A.; Burgener, I. A.
10.1101/2022.08.25.505284 — microbiology — Posted on 2022-08-25
785 Co-infection of Ehrlichia with B. burgdorferi drives emergency myelopoiesis and promotes Lyme arthritis
Bonin, J. L.; Torres, S. R.; Marcinkiewicz, A. L.; Yang, X.; Pal, U.; DiSpirito, J.; Nowak, T.; Lin, Y.-P.; MacNamara, K. C.
10.1101/2022.08.23.505055 — immunology — Posted on 2022-08-25
787 Imbalance of circuit plasticity and consolidation in autism model marmosets is adjusted by oxytocin administration
Noguchi, J.; Watanabe, S.; Oga, T.; Isoda, R.; Nakagaki, K.; Sakai, K.; Sumida, K.; Hoshino, K.; Saito, K.; Miyawaki, I.; Sugano, E.; Tomita, H.; Mizukami, H.; Watakabe, A.; Yamamori, T.; Ichinohe, N.
10.1101/2022.08.24.505057 — neuroscience — Posted on 2022-08-25
790 Context-Aware Technology Mapping in Genetic Design Automation
Engelmann, N.; Schwarz, T.; Kubaczka, E.; Hochberger, C.; Koeppl, H.
10.1101/2022.08.24.505086 — synthetic biology — Posted on 2022-08-25
792 Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis
Attardo, G. M.; Benoit, J.; Michalkova, V.; Kondragunta, A.; Baumann, A.; Weiss, B.; Malacrida, A.; Scolari, F.; Aksoy, S.
10.1101/2022.08.23.504685 — physiology — Posted on 2022-08-25
793 Epigenetic memory acquired during long-term EMTinduction governs the recovery to the epithelial state
Jain, P.; Corbo, S.; Mohammad, K.; George, J. T.; Levine, H.; Toneff, M. J.; Jolly, M. K.
10.1101/2022.08.23.504814 — cancer biology — Posted on 2022-08-25
796 Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China
Palatini, U.; Alfano, N.; Lejarazu-Carballar, R.; Chen, X.; Delatte, H.; Bonizzoni, M.
10.1101/2022.08.24.505081 — genomics — Posted on 2022-08-25
799 Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism
Dolan, S. K.; Wijaya, A.; Kohlstedt, M.; Gläser, L.; Brear, P.; Silva-Rocha, R. K.; Wittmann, C.; Welch, M.
10.1101/2022.08.25.505149 — microbiology — Posted on 2022-08-25
800 Combined in vivo and in situ genome-resolved metagenomics reveals novel symbiotic nitrogen fixing interactions between non-cyanobacterial diazotrophs and microalgae
Chandola, U.; Trottier, C.; Gaudin, M.; Manirakiza, E.; Menicot, S.; Louvet, I.; Lacour, T.; Chaumier, T.; Tanaka, A.; Chaffron, S.; TIRICHINE, L.
10.1101/2022.08.25.505241 — microbiology — Posted on 2022-08-25
804 A dynamic sequence of visual processing initiated by gaze shifts
Parker, P. R. L.; Martins, D. M.; Leonard, E. S. P.; Casey, N. M.; Sharp, S. L.; Abe, E. T. T.; Smear, M. C.; Yates, J. L.; Mitchell, J. F.; Niell, C. M.
10.1101/2022.08.23.504847 — neuroscience — Posted on 2022-08-25
805 The Extremes of Normative Modelling
Fraza, C. J.; Zabihi, M.; Beckmann, C. F.; Marquand, A. F.
10.1101/2022.08.23.505049 — neuroscience — Posted on 2022-08-25
806 MicroRNA-218 instructs proper assembly of hippocampal networks
Taylor, S.; Kobayashi, M.; Vilella, A.; Tiwari, D.; Zolboot, N.; Hartzell, A.; Girgiss, C.; Abaci, Y.; De Sanctis, C.; Bellenchi, G. C.; Darnell, R. B.; Gross, C.; Zoli, M.; Berg, D. K.; Lippi, G.
10.1101/2022.08.24.505085 — neuroscience — Posted on 2022-08-25
807 Sex separation unveils the functional plasticity of the vomeronasal organ in rabbits
R Villamayor, P.; Gullon, J.; Quintela, L.; Sanchez-Quinteiro, P.; Martinez, P.; Robledo, D.
10.1101/2022.08.24.505087 — neuroscience — Posted on 2022-08-25
813 Characterization of a novel estrogen- and progesterone-responsive endometrial cancer cell line: HCI-EC-23
Rush, C. M.; Blanchard, Z.; Polaski, J. T.; Osborne, K. S.; Osby, K.; Vahrenkamp, J. M.; Yang, C.-H.; Lum, D. H.; Hagan, C. R.; Leslie, K. K.; Pufall, M. A.; Thiel, K. W.; Gertz, J.
10.1101/2022.08.25.505203 — cancer biology — Posted on 2022-08-25
814 DNA-PAINT single-particle tracking (DNA-PAINT-SPT) enables extended single-molecule studies of membrane protein interactions
Niederauer, C.; Nguyen, C.; Wang-Henderson, M.; Stein, J.; Strauss, S.; Cumberworth, A.; Stehr, F.; Jungmann, R.; Schwille, P.; Ganzinger, K. A.
10.1101/2022.08.25.503948 — biophysics — Posted on 2022-08-25
816 Annotation of biologically relevant ligands in UniProtKB using ChEBI
Coudert, E.; Gehant, S.; de Castro, E.; Pozzato, M.; Baratin, D.; Neto, T.; Sigrist, C. J. A.; Redaschi, N.; Bridge, A. J.; The UniProt Consortium,
10.1101/2022.08.19.504519 — bioinformatics — Posted on 2022-08-25
823 Alternative stable states, nonlinear behavior, and predictability of microbiome dynamics
Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M. S.; Yamamichi, M.; Iwayama, K.; Canarini, A.; Hayashi, I.; Fukushima, K.; Fukuda, S.; Kiers, T. E.; Toju, H.
10.1101/2022.08.23.505041 — ecology — Posted on 2022-08-25
824 The effect of selective logging on microclimates, arthropod abundance and the foraging behaviour of Eastern Himalayan birds
Aggarwal, K.; Chanda, R.; Rai, S.; Rai, M.; Pradhan, D. K.; Munda, B.; Tamang, B.; Biswakarma, A.; Srinivasan, U.
10.1101/2022.08.24.504948 — ecology — Posted on 2022-08-25
825 Mood variability during adolescent development and their relation to sleep and brain development
Toenders, Y. J.; van der Cruijsen, R.; Runze, J.; van de Groep, S.; Wierenga, L.; Crone, E. A.
10.1101/2022.08.23.505008 — developmental biology — Posted on 2022-08-25
826 Genomic epidemiology of the cholera outbreak in Yemen reveals the spread of a multi-drug resistance plasmid between diverse lineages of Vibrio cholerae
Lassalle, F.; Al-Shalali, S.; Al-Hakimi, M.; Njamkepo, E.; Bashir, I. M.; Dorman, M. J.; Rauzier, J.; Blackwell, G. A.; Taylor-Brown, A.; Beale, M. A.; Al-Somainy, A. A.; Al-Mahbashi, A.; Almoayed, K.; Aldawla, M.; Al-Harazi, A.; Quilici, M.-L.; Weill, F.-X.; Dhabaan, G.; Thomson, N. R.
10.1101/2022.08.24.504966 — microbiology — Posted on 2022-08-25
828 Genome-wide peptidoglycan profiling of Vibrio cholerae
Hernandez, S. B.; Alvarez, L.; Ritzl-Rinkenberger, B.; Schiffthaler, B.; Serrano, A. R.; Cava, F.
10.1101/2022.08.25.505259 — microbiology — Posted on 2022-08-25
831 A partially nested cortical hierarchy of neural states underlies event segmentation in the human brain
Geerligs, L.; Gözükara, D.; Oetringer, D.; Campbell, K.; van Gerven, M.; Güclü, U.
10.1101/2021.02.05.429165 — neuroscience — Posted on 2022-08-25
832 Restoration of β-adrenergic responsivity in the aging heart
del Villar, S. G.; Westhoff, M.; Voelker, T. L.; Dickson, E. J.; Dixon, R. E.
10.1101/2022.08.23.504979 — physiology — Posted on 2022-08-25
834 Deciphering the alphabet of disorder -- Glu and Asp act differently on local but not global properties
Roesgaard, M. A.; Lundsgaard, J. E.; Newcombe, E. A.; Jacobsen, N. L.; Pesce, F.; Lindemose, S.; Prestel, A.; Hartmann-Petersen, R.; Lindorff-Larsen, K.; Kragelund, B. B.
10.1101/2022.08.25.505250 — biophysics — Posted on 2022-08-25
835 A mathematical model of calcium signals around laser-induced epithelial wounds
Stevens, A. C.; O'Connor, J. T.; Pumford, A. D.; Page-McCaw, A.; Hutson, M. S.
10.1101/2022.08.24.505161 — biophysics — Posted on 2022-08-25
838 Vertical growth dynamics of biofilms
Bravo, P.; Ng, S. L.; MacGillivray, K. A.; Hammer, B. K.; Yunker, P. J.
10.1101/2022.08.11.503641 — biophysics — Posted on 2022-08-25
839 A Rigid Parallel-Plate Artificial Placenta Oxygenator with a Hemocompatible Blood Flow Path
Blauvelt, D. G.; Higgins, N.; De, B.; Goodin, M. S.; Wright, N.; Blaha, C.; Moyer, J.; Chui, B.; Baltazar, F.; Oishi, P.; Roy, S.
10.1101/2022.08.23.505025 — bioengineering — Posted on 2022-08-25
840 The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2
Allen, J. D.; Ivory, D.; Song, G. S.; Yong, P.; He, T.; Andrabi, R.; Burton, D.; Crispin, M.
10.1101/2022.08.24.505118 — biochemistry — Posted on 2022-08-25
841 An Aedes aegypti seryl-tRNA synthetase paralog controls bacteroidetes growth in the midgut
Silveira, G. d. O.; Talyuli, O. A. C.; Walter-Nuno, A. B.; Crnkovic, A.; Gandara, A. C. P.; Gaviraghi, A.; Bottino-Rojas, V.; Söll, D.; Polycarpo, C.
10.1101/2022.08.25.505225 — biochemistry — Posted on 2022-08-25
846 Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors
Temba, G. S.; Vadaq, N.; Kullaya, V.; Pecht, T.; Lionetti, P.; Cavalieri, D.; Schultze, J.; Kavishe, R.; Joosten, L. A.; van der Ven, A. J.; Mmbaga, B. T.; Netea, M. G.; de Mast, Q.
10.1101/2022.08.23.504992 — immunology — Posted on 2022-08-25
847 Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain
Yang, L.; Van Beek, M.; Wang, Z.; Muecksch, F.; Canis, M.; Hatziioannou, T.; Bieniasz, P. D.; Nussenzweig, M. C.; Chakraborty, A. K.
10.1101/2022.08.24.505127 — immunology — Posted on 2022-08-25
855 Identifying Optimal Neuroinflammation Treatment Using Nanoligomer Discovery Engine
Sharma, S.; Borski, C.; Hanson, J.; Garcia, M. A.; Link, C. D.; Hoeffer, C. A.; Chatterjee, A.; Nagpal, P.
10.1101/2022.08.23.505002 — neuroscience — Posted on 2022-08-25
857 Liraglutide protects against diastolic dysfunction and improves ventricular protein translation
Rutledge, C.; Redding, K.; Lopez, M.; Mullett, S.; Wendell, S.; Jurczak, M.; Goetzman, E.; Kaufman, B.
10.1101/2022.08.23.504997 — physiology — Posted on 2022-08-25
859 Development of an adenosquamous carcinoma histopathology-selective lung cancer graft model
Lähdeniemi, I. A. K.; Devlin, J. R.; Nagaraj, A. S.; Talwelkar, S.; Bao, J.; Linnavirta, N.; Seref Vujaklija, C.; Kiss, E. A.; Hemmes, A.; Verschuren, E. W.
10.1101/2022.08.23.504928 — cancer biology — Posted on 2022-08-25
860 Label-free virus-antibody interaction monitoring in real-time by common-path interferometry
Alhaddad, S.; Bey, H.; Thouvenin, O.; Boulanger, P.; Boccara, C.; Boccara, M.; Izeddin, I.
10.1101/2022.08.23.504719 — biophysics — Posted on 2022-08-25
861 Interpretable prognostic modeling of endometrial cancer
Zagidullin, B.; Pasanen, A.; Loukovaara, M.; Butzow, R.; Tang, J.
10.1101/2022.08.23.504935 — bioinformatics — Posted on 2022-08-25
869 Invasion of forested areas in Gabon (Central Africa) by the Asian tiger mosquito and the potential consequences from the One Health perspective
Obame-Nkoghe, J.; Roiz, D.; Ngangue, M.-F.; Costantini, C.; Rahola, N.; Jiolle, D.; Lehmann, D.; Makaga, L.; Ayala, D.; Kengne, P.; Paupy, C.
10.1101/2022.08.23.504969 — ecology — Posted on 2022-08-25
871 Brain Data Standards - A method for building data-driven cell-type ontologies
Tan, S. Z. K.; Kir, H.; Aevermann, B.; Gillespie, T.; Harris, N.; Hawrylycz, M.; Jorstad, N.; Lein, E.; Matentzoglu, N.; Miller, J. A.; Mollenkopf, T. S.; Mungall, C. J.; Ray, P. L.; Sanchez, R. E. A.; Staats, B.; Vermillion, J.; Yadav, A.; Zhang, Y. H.; Scheuermann, R. H.; Osumi-Sutherland, D.
10.1101/2021.10.10.463703 — neuroscience — Posted on 2022-08-25
872 High-throughput single-molecule quantification of individual base stacking energies in nucleic acids
Punnoose, J. A.; Thomas, K. J.; Chandrasekaran, A. R.; Vilcapoma, J.; Hayden, A.; Kilpatrick, K.; Vangaveti, S.; Chen, A.; Banco, T.; Halvorsen, K.
10.1101/2022.05.25.493108 — biophysics — Posted on 2022-08-25
875 Synergistic stabilization of microtubules by BUB-1, HCP-1 and CLS- 2 controls meiotic spindle assembly in C. elegans oocytes
Macaisne, N.; Bellutti, L.; Laband, K.; Edwards, F.; Pitayu-Nugroho, L.; Gervais, A.; Ganeswaran, T.; Geoffroy, H.; Maton, G.; Canman, J. C.; Lacroix, B.; Dumont, J.
10.1101/2022.08.24.505151 — cell biology — Posted on 2022-08-25
878 Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson's disease by targeting receptor interleukin-6
Pons-Espinal, M.; Blasco-Agell, L.; Fernandez-Carasa, I.; di Domenico, A.; Richaud, Y.; Mosquera, J. L.; Marruecos, L.; Espinosa, L.; Garrido, A.; Tolosa, E.; Edel, M. J.; Juan Otero, M.; Ferrer, I.; Raya, A.; Consiglio, A.
10.1101/2022.08.23.504918 — neuroscience — Posted on 2022-08-25
879 Targeting default mode network connectivity with mindfulness-based fMRI neurofeedback: A pilot study among adolescents with affective disorder history
Zhang, J.; Raya, J.; Morfini, F.; Urban, Z.; Pagliaccio, D.; Yendiki, A.; Auerbach, R. P.; Bauer, C. C. C.; Whitfield-Gabrieli, S.
10.1101/2022.08.22.504796 — neuroscience — Posted on 2022-08-25
881 Evaluation of salinity tolerance of lowland rice genotypes at the reproductive stage
Safidimanjato, R.; RANARIJAONA, H. L. T.; RASOAFALIMANANA, M.; RADANIELINA, T.; WISSUWA, M.
10.1101/2022.08.22.504861 — plant biology — Posted on 2022-08-25
884 Model Choice Metrics to Optimize Profile-QSAR Performance
He, S.; Kim, S.; McLoughlin, K. S.; Ranganathan, H.; Shi, D.; Allen, J. E.
10.1101/2022.08.22.504151 — bioinformatics — Posted on 2022-08-25
887 Data-Driven Predictions of Potential Leishmania Vectors in Latin America
Vadmal, G.; Glidden, C. K.; Han, B. A.; Carvalho, B.; Castellanos, A. A.; Mordecai, E. A.
10.1101/2022.08.22.504897 — ecology — Posted on 2022-08-25
891 Universal gut microbial relationships in the gut microbiome of wild baboons
Roche, K.; Björk, J. R.; Dasari, M.; Grieneisen, L.; Jansen, D.; Gould, T.; Gesquiere, L.; Barreiro, L.; Alberts, S. C.; Blekhman, R.; Gilbert, J.; Tung, J.; Mukherjee, S.; Archie, E. A.
10.1101/2022.08.20.504530 — ecology — Posted on 2022-08-25
892 Short prokaryotic Argonautes provide defence against invading mobile genetic elements through NAD+ depletion
Zaremba, M.; Dakineviciene, D.; Golovinas, E.; Zagorskaite, E.; Stankunas, E.; Lopatina, A.; Sorek, R.; Manakova, E.; Ruksenaite, A.; Silanskas, A.; Asmontas, S.; Grybauskas, A.; Tylenyte, U.; Jurgelaitis, E.; Grigaitis, R.; Timinskas, K.; Venclovas, C.; Siksnys, V.
10.1101/2021.12.14.472599 — molecular biology — Posted on 2022-08-25
893 Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence and late clinical metastasis in a Beclin-1-dependent manner.
Nicco, C.; Thomas, M.; Guillermet-Guibert, J.; Havard, M.; Laurent-Tchenio, F.; Doridot, L.; Dautry, F.; Batteux, F.; Tchenio, T.
10.1101/2022.05.05.490726 — cancer biology — Posted on 2022-08-25
894 Regulation of the macrolide resistance ABC-F translation factor MsrD
Fostier, C. R.; Ousalem, F.; Leroy, E. C.; Ngo, S.; Soufari, H.; Innis, C. A.; Hashem, Y.; Boel, G.
10.1101/2021.11.29.470318 — microbiology — Posted on 2022-08-25
897 Fast4DReg: Fast registration of 4D microscopy datasets
Pylvänäinen, J.; Laine, R.; Ghimire, S.; Follain, G.; Henriques, R.; Jacquemet, G.
10.1101/2022.08.22.504744 — bioinformatics — Posted on 2022-08-25
901 Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program
Jimenez, C.; Antonelli, R.; Nadal-Ribelles, M.; Devis-Jauregui, L.; Latorre, P.; Sole, C.; Masanas, M.; Molero-Valenzuela, A.; Soriano, A.; Sanchez de Toledo, J.; Llobet-Navas, D.; Roma, J.; Posas, F.; de Nadal, E.; Gallego, S.; Moreno, L.; Segura, M. F.
10.1101/2022.05.17.492122 — cancer biology — Posted on 2022-08-25
902 How to measure response diversity
Ross, S. R. P.-J.; Petchey, O. L.; Sasaki, T.; Armitage, D. W.
10.1101/2022.04.26.489626 — ecology — Posted on 2022-08-25
903 KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression
Jain, A.; Stack, O.; Ghodrati, S.; Sanchez-Conde, F. G.; Ukachukwu, C.; Salwi, S.; Jimenez-Vazquez, E. N.; Jones, D. K.
10.1101/2022.08.24.504830 — cell biology — Posted on 2022-08-25
907 Unraveling the principles of mammary gland branching morphogenesis
Lindstrom, R.; Satta, J. P.; Myllymaki, S.-M.; Lan, Q.; Trela, E.; Prunskaite-Hyyrylainen, R.; Voutilainen, M.; Kuure, S.; Vainio, S. J.; Mikkola, M. L.
10.1101/2022.08.23.504958 — developmental biology — Posted on 2022-08-25
909 Combined loss of obscurin and obscurin-like 1 in murine hearts results in impaired diastolic dysfunction, altered metabolism and deregulated mitophagy.
Fujita, K.; Desmond, P.; Blondelle, J.; Sotak, M.; Rajan, M. R.; Clark, M.; Esteve, E.; Chan, Y.; Gu, Y.; Marrocco, V.; Dalton, N. D.; Ghassemian, M.; Do, A.; Klos, M.; Peterson, K. L.; Sheikh, F.; Cho, Y.; Borgeson, E.; Lange, S.
10.1101/2022.08.24.505098 — cell biology — Posted on 2022-08-24
910 Arp2/3 inhibition switches Eps8's network associations to favour longer actin filament formation necessary for tunneling nanotubes
Henderson, J. M.; Ljubojevic, N.; Chaze, T.; Castaneda, D.; Battistella, A.; Giai Gianetto, Q.; Matondo, M.; Descroix, S.; Bassereau, P.; Zurzolo, C.
10.1101/2022.08.24.504515 — cell biology — Posted on 2022-08-24
912 p16High senescence restricts totipotent potential during somatic cell reprogramming
Grigorash, B. B.; van Essen, D.; Grosse, L.; Emelyanov, A.; Kanzler, B.; Molina, C.; Lopez, E.; Demidov, O. N.; Garrido, C.; Saccani, S.; Bulavin, D.
10.1101/2022.08.24.504108 — cell biology — Posted on 2022-08-25
914 Wild animals suppress the spread of socially-transmitted misinformation
Fahimipour, A. K.; Gil, M. A.; Celis, M. R.; Hein, G. F.; Martin, B. T.; Hein, A. M.
10.1101/2022.08.23.505022 — ecology — Posted on 2022-08-24
916 Cryo-EM Structure of a Mammalian-specific Alternative Amyloid Exon
Garcia-Pardo, J.; Bartolome-Nafria, A.; Chaves-Sanjuan, A.; Gil-Garcia, M.; Visentin, C.; Bolognesi, M.; Ricagno, S.; Ventura, S.
10.1101/2022.08.24.503855 — biochemistry — Posted on 2022-08-24
917 A genome-wide atlas of recurrent repeat expansions in human cancer
Erwin, G. S.; Gursoy, G.; Al-Abri, R.; Suriyaprakash, A.; Dolzhenko, E.; Zhu, K.; Hoerner, C. R.; White, S. M.; Ramirez, L.; Vadlakonda, A.; Vadlakonda, A.; von Kraut, K.; Park, J.; Brannon, C. M.; Sumano, D. A.; Kirtikar, R. A.; Erwin, A. A.; Metzner, T. J.; Yuen, R. K. C.; Fan, A. C.; Leppert, J. T.; Eberle, M. A.; Gerstein, M.; Snyder, M. P.
10.1101/2022.08.24.505159 — genomics — Posted on 2022-08-24
918 Site-1 Protease inhibits mitochondrial metabolism by controlling the TGF-β target gene MSS51
Mousa, M. G.; Vuppaladhadiam, L.; Kelly, M. O.; Pietka, T.; Ek, S.; Shen, K. C.; Meyer, G. A.; Finck, B. N.; Brookheart, R. T.
10.1101/2022.08.24.504591 — molecular biology — Posted on 2022-08-24
919 Antibiotic heteroresistance generated by multi-copy plasmids
Hernandez-Beltran, J.; Rodriguez-Beltran, J.; Aguilar-Luviano, B.; Velez-Santiago, J.; Mondragon-Palomino, O.; MacLean, C.; Fuentes-Hernandez, A.; San Millan, A.; Pena-Miller, R.
10.1101/2022.08.24.505173 — microbiology — Posted on 2022-08-24
920 The use of Statin-class compounds to suppress methanogenesis in lake sediment inoculated microbial fuel cells
Jayathilake, C.; Dilangani, G. P.; Bandara, S.; Nazeer, Z.; Thilini, N.; Bandara, W.; Herath, A. C.; Kyazze, G.; Fernando, E.
10.1101/2022.08.24.505145 — microbiology — Posted on 2022-08-24
921 Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes
Skovsø, S.; Overby, P.; Memar-Zadeh, J.; Lee, J.; Yang, J. C. C.; Shanina, I.; Sidarala, V.; Levi-D Ancona, E.; Zhu, J.; Soleimanpour, S. A.; Horwitz, M.; Johnson, J. D.
10.1101/2022.02.03.479027 — immunology — Posted on 2022-08-24
923 snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling
Vallejo, A. F.; Harvey, K.; Wang, T.; Wise, K.; Butler, L. M.; Polo, J.; Plummer, J. T.; Swarbrick, A.; Martelotto, L. G.
10.1101/2022.08.23.505054 — cancer biology — Posted on 2022-08-24
924 cMYC protein interactions and chromatin association in NUT carcinoma
Zee, B. M.; Alekseyenko, A. A.; Smolko, A. E.; Kang, H.; Kuroda, M. I.
10.1101/2022.04.22.489219 — cancer biology — Posted on 2022-08-24
925 Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
DeBlasi, J. M.; Falzone, A.; Caldwell, S.; Kang, Y. P.; Prieto-Farigua, N.; Prigge, J. R.; Schmidt, E. E.; Chio, I. I. C.; Karreth, F. A.; DeNicola, G. M.
10.1101/2022.08.24.504986 — cancer biology — Posted on 2022-08-24
926 Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair
Sigismondo, G.; Arseni, L.; Palacio-Escat, N.; Hofmann, T. G.; Seiffert, M.; Krijgsveld, J.
10.1101/2021.08.05.455226 — cancer biology — Posted on 2022-08-24
927 Elevated prostate androgens in African American men mediated by megalin import of testosterone and 25-hydroxyvitamin D status
Garcia, J.; Krieger, K.; Loitz, C.; Perez, L. M.; Richards, Z. A.; Helou, Y. B.; Kregel, S.; Selada, S.; Mesaros, C. A.; Gann, P.; Willnow, T. E.; Vander Griend, D.; Kittles, R.; Prins, G.; Penning, T.; Nonn, L.
10.1101/2021.11.09.467567 — cancer biology — Posted on 2022-08-24
929 Safety switch optimization enhances antibody-mediated elimination of CAR T cells
Shabaneh, T. B.; Moffett, H. F.; Stull, S. M.; Derezes, T.; Tait, L. J.; Park, S.; Riddell, S. R.; Lajoie, M. J.
10.1101/2022.08.24.505164 — bioengineering — Posted on 2022-08-24
931 Mapping the GALNT1 substrate landscape with versatile proteomics tools
Saei, A. A.; Lundstrom, S. L.; Lyu, H.; Gharibi, H.; Lu, W.; Fang, P.; Zhang, X.; Meng, Z.; Wang, J.; Gaetani, M.; Vegvari, A.; Gygi, S. P.; Zubarev, R. A.
10.1101/2022.08.24.505189 — biochemistry — Posted on 2022-08-24
935 Cell type-programmable genome editing with enveloped delivery vehicles
Hamilton, J. R.; Chen, E.; Perez, B. S.; Sandoval Espinoza, C. R.; Doudna, J. A.
10.1101/2022.08.24.505004 — genomics — Posted on 2022-08-24
937 MND1 enables repair of two-ended DNA double-strand breaks
Koob, L.; Friskes, A.; van Bergen, L.; Feringa, F. M.; van den Broek, B.; Koeleman, E. S.; Schubert, M.; Blomen, V. A.; Brummelkamp, T. R.; Krenning, L.; Medema, R. H.
10.1101/2022.08.24.505076 — cell biology — Posted on 2022-08-24
939 Experimental evaluation of environmental DNA methods for detection of a rare fish in turbid water
Holmes, A. E.; Baerwald, M. R.; Rodzen, J. A.; Schreier, B. M.; Mahardja, B.; Finger, A. J.
10.1101/2022.08.24.502857 — molecular biology — Posted on 2022-08-24
940 The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment
Sastre-Velasquez, L. E.; Dallemulle, A.; Kühbacher, A.; Baldin, C.; Alcazar-Fuoli, L.; Niedrig, A.; Müller, C.; Gsaller, F.
10.1101/2022.08.24.504767 — molecular biology — Posted on 2022-08-24
942 Triose phosphate translocator drives carbohydrates/energetic shuttling from the chloroplast in Chlamydomonas reinhardtii
Huang, W.; Krishnan, A.; Plett, A.; Meagher, M.; Linka, N.; Ren, B.; Findinier, J.; Redekop, P.; Fakhimi, N.; Xu, J.; Kim, R. G.; Karns, D. A.; Boyle, N.; Posewitz, M.; Grossman, A. R.
10.1101/2022.07.25.501471 — microbiology — Posted on 2022-08-24
944 Human anti-ACE2 monoclonal antibodies as pan-sarbecovirus prophylactic agents
Zhang, F.; Jenkins, J.; de Carvalho, R. V. H.; Nakandakari-Higa, S.; Chen, T.; Abernathy, M. E.; Nyakatura, E.; Andrew, D.; Lebedeva, I. V.; Lorenz, I. C.; Hoffmann, H.- H.; Rice, C. M.; Victora, G. D.; Barnes, C. O.; Hatziioannou, T.; Bieniasz, P. D.
10.1101/2022.08.24.505169 — microbiology — Posted on 2022-08-24
946 Energy transfer in ubiquitous rhodopsin pumps with xanthophyll antennas
Chazan, A.; Das, I.; Fujiwara, T.; Murakoshi, S.; Shihoya, W.; Rozenberg, A.; Molina-Marquez, A.; Larom, S.; Pushkarev, A.; Malakar, P.; Ruhman, S.; Hasegawa, M.; Tsukamoto, Y.; Ishizuka, T.; Konno, M.; Nagata, T.; Inoue, K.; Mizuno, Y.; Katayama, K.; Abe-Yoshizumi, R.; Kandori, H.; Leon, R. M.; Yoshizawa, S.; Sheves, M.; Nureki, O.; Beja, O.
10.1101/2022.08.24.505090 — microbiology — Posted on 2022-08-24
947 Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small 1intestinal epithelia
Sheikh, A.; Tumala, B.; Vickers, T. J.; Martin, J. C.; Rosa, B. A.; Sabui, S.; Simoes, R. D.; Mitreva, M.; Storer, C.; Tyksen, E.; Head, R. D.; Beatty, W.; Said, H. M.; Fleckenstein, J. M.
10.1101/2022.08.24.504189 — microbiology — Posted on 2022-08-24
948 The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion
Winter, S. L.; Golani, G.; Lolicato, F.; Vallbracht, M.; Thiyagarajah, K.; Ahmed, S. S.; Luechtenborg, C.; Fackler, O. T.; Bruegger, B.; Hoenen, T.; Nickel, W.; Schwarz, U. S.; Chlanda, P.
10.1101/2022.08.24.505067 — microbiology — Posted on 2022-08-24
949 Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealedby cryo-electron tomography
Kaplan, M.; Shepherd, D. C.; Vankadari, N.; Kim, K. W.; Larson, C. L.; Dutka, P.; Beare, P. A.; Krzymowski, E.; Heinzen, R. A.; Jensen, G. J.; Ghosal, D.
10.1101/2022.08.23.505044 — microbiology — Posted on 2022-08-24
950 Novel Escherichia coli genetic markers for tracking domestic wastewater contamination in environmental waters
Gomi, R.; Haramoto, E.; Wada, H.; Sugie, Y.; Ma, C.-Y.; Raya, S.; Malla, B.; Nishimura, F.; Tanaka, H.; Ihara, M.
10.1101/2022.08.23.505042 — microbiology — Posted on 2022-08-24
952 Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci
Kirsch, J. M.; Ely, S.; Stellfox, M. E.; Hullahalli, K.; Luong, P.; Palmer, K. L.; Van Tyne, D.; Duerkop, B. A.
10.1101/2022.08.24.505136 — microbiology — Posted on 2022-08-24
953 Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening
Sasi, V. M.; Ullrich, S.; Ton, J.; Fry, S. E.; Johansen-Leete, J.; Payne, R. J.; Nitsche, C.; Jackson, C. J.
10.1101/2022.08.24.505060 — biochemistry — Posted on 2022-08-24
960 Bile salt hydrolases shape the bile acid landscape and restrict C. difficile
Foley, M. H.; Walker, M. E.; Stewart, A. K.; O'Flaherty, S.; Gentry, E. C.; Allen, G.; Patel, S.; Pan, M.; Beaty, V. V.; Perkins, C.; Vanhoy, M. E.; Dougherty, M. K.; McGill, S. K.; Gulati, A.; Dorrestein, P.; Baker, E. S.; Redinbo, M. R.; Barrangou, R.; Theriot, C. M.
10.1101/2022.03.24.485529 — microbiology — Posted on 2022-08-24
961 Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?
Fraisse, C.; Le Moan, A.; Roux, C.; Dubois, G.; Daguin-Thiebaut, C.; Gagnaire, P.-A.; Viard, F.; Bierne, N.
10.1101/2022.03.22.485319 — evolutionary biology — Posted on 2022-08-24
964 Deep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots
Madsen, S.; Nelson, M. E.; Deshpande, V.; Humphrey, S. J.; Cooke, K. C.; Howell, A.; Diaz-Vegas, A.; Burchfield, J. G.; Stockli, J.; James, D. E.
10.1101/2022.08.23.504892 — molecular biology — Posted on 2022-08-24
965 The highly diverse and complex plasmid population found in Escherichia coli colonising travellers to Laos and their role in antimicrobial resistance gene carriage
Snaith, A. E.; Dunn, S. J.; Moran, R. A.; Newton, P.; Dance, D.; Davong, V.; Keunzli, E.; Kantele, A.; Corander, J.; McNally, A.
10.1101/2022.08.22.504756 — microbiology — Posted on 2022-08-24
966 In vivo and In vitro Characterization of the ClpC AAA+ ATPase of Chlamydia trachomatis
Pan, S.; Jensen, A. A.; Wood, N. A.; Henrichfreise, B.; Brötz-Oesterhelt, H.; Fisher, D. J.; Sass, P.; Ouellette, S. P.
10.1101/2022.08.22.504891 — microbiology — Posted on 2022-08-24
967 BNIP3 regulates Chikungunya virus infection independently of autophagy and cell death
Echavarria-Consuegra, L.; dinesh kumar, n.; Mauthe, M.; van de pol, d.; Reggiori, F.; Smit, J. M.
10.1101/2022.08.22.504900 — microbiology — Posted on 2022-08-24
968 MyD88-Dependent Signaling Drives Toll-Like Receptor-Induced Trained Immunity in Macrophages
Owen, A. M.; Luan, L.; Burelbach, K. R.; McBride, M. A.; Stothers, C. L.; Boykin, O. A.; Sivanesam, K.; Schaedel, J. F.; Patil, T. K.; Wang, J.; Hernandez, A.; Patil, N. K.; Sherwood, E. R.; Bohannon, J. K.
10.1101/2022.08.23.504963 — immunology — Posted on 2022-08-24
970 Gene amplification mutations originate prior to selective stress in Acinetobacter baylyi
Reams, A. B.; Herrmann, J. A.; Koprowska, A.; Winters, T. J.; Villanueva, N.; Nikityuk, V. D.; Pek, F.; Reis, E. M.; Dominguez, C. Z.; Davis, D.; McPherson, E.; Rocco, S. R.; Recendez, C.; Difuntorum, S. M.; Faeth, K.; Lopez, M. D.; Awwad, H. M.; Ghobashy, R. A.; Cappiello, L.; Neidle, E. L.; Quinones-Soto, S.
10.1101/2022.08.23.504990 — genetics — Posted on 2022-08-24
971 Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
Koudelkova, L.; Bruhova, Z.; Sztacho, M.; Pavlik, V.; Panek, D.; Gemperle, J.; Brabek, J.; Rosel, D.
10.1101/2022.08.23.504940 — cell biology — Posted on 2022-08-24
972 Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1
Cardenas-Diaz, F. L.; Liberti, D. C.; Leach, J. P.; Babu, A.; Barasch, J.; Shen, T.; Diaz-Miranda, M. A.; Zhou, S.; Ying, Y.; Morley, M. P.; Morrisey, E. E.
10.1101/2022.08.23.504977 — cell biology — Posted on 2022-08-24
974 CD73-positive cell spheroid transplantation attenuates colonic atrophy
Hisamatsu, D.; Itakura, N.; Mabuchi, Y.; Ozaki, R.; Suto, E. G.; Naraoka, Y.; Ikeda, A.; Ito, L.; Akazawa, C.
10.1101/2022.08.23.505052 — cell biology — Posted on 2022-08-24
978 The high mutational sensitivity of ccdA antitoxin is linked to codon optimality
Chandra, S.; Gupta, K.; Khare, S.; Kohli, P.; Asok, A.; Mohan, S. V.; Gowda, H.; Varadarajan, R.
10.1101/2022.01.15.476443 — molecular biology — Posted on 2022-08-24
981 Evasion of neutralizing antibodies by Omicron sublineage BA.2.75
Sheward, D. J.; Kim, C.; Fischbach, J.; Muschiol, S.; Ehling, R. A.; Björkström, N. K.; Karlsson Hedestam, G. B.; Reddy, S. T.; Albert, J.; Peacock, T. P.; Murrell, B.
10.1101/2022.07.19.500716 — immunology — Posted on 2022-08-24
982 Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Wamhoff, E.-C.; Ronsard, L.; Feldman, J.; Hauser, B. M.; Knappe, G. A.; Romanov, A.; Lam, E.; St. Denis, K.; Balazs, A. B.; Schmidt, A.; Lingwood, D.; Bathe, M.
10.1101/2022.08.16.504128 — immunology — Posted on 2022-08-24
983 A biophysical regulator of inhibitory integration and learning in mesolimbic dopamine neurons
Costa, K. M.; Hammer, N.; Knowlton, C. J.; Schwenk, J.; Mueller, T.; Schulte, D.; Fakler, B.; Canavier, C. C.; Roeper, J.
10.1101/344499 — neuroscience — Posted on 2022-08-24
984 Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Popova, D.; Gameiro-Ros, I.; Youssef, M. M.; Zalamea, P.; Morris, A. D.; Prytkova, I.; Jadali, A.; Kwan, K. Y.; Kamarajan, C.; Salvatore, J. E.; Xuei, X.; Chorlian, D. B.; Porjesz, B.; Kuperman, S.; Dick, D. M.; Goate, A.; Edenberg, H. J.; Tischfield, J. A.; Pang, Z. P.; Slesinger, P. A.; Hart, R. P.
10.1101/2022.05.24.493086 — neuroscience — Posted on 2022-08-24
988 Computational modeling and quantitative cell physiology reveal central parameters for the brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root
Grosseholz, R.; Wanke, F.; Rohr, L.; Gloeckner, N.; Rausch, L.; Scholl, S.; Scacchi, E.; Spazierer, A.-J.; Shabala, L.; Shabala, S.; Schumacher, K.; Kummer, U.; Harter, K. J. W.
10.1101/2021.04.13.439595 — plant biology — Posted on 2022-08-24
989 Long-term temporal stability of peripheral blood DNA methylation alterations in patients with inflammatory bowel disease.
Joustra, V. W.; Li Yim, A. Y. F.; Hageman, I.; Levin, E.; Adams, A.; Satsangi, J.; de Jonge, W.; Henneman, P.; D'Haens, G.
10.1101/2022.08.22.504377 — genetics — Posted on 2022-08-24
990 LSD1 controls a nuclear checkpoint in Wnt/β-Catenin signaling to regulate muscle stem cell self renewal
Mouradian, S.; Cicciarello, D.; Lacoste, N.; Berretta, F.; Le Grand, F.; Rose, N.; Schaeffer, L.; Scionti, I.
10.1101/2022.06.10.495614 — developmental biology — Posted on 2022-08-24
991 How does target lesion selection affect RECIST? A computer simulation study
Bucho, T.; Tissier, R.; Lipman, K. G.; Bodalal, Z.; Delli Pizzi, A.; Nguyen-Kim, T. D. L.; Beets-Tan, R.; Trebeschi, S.
10.1101/2022.04.14.488203 — cancer biology — Posted on 2022-08-24
996 A neural signature of reward
Chang, L. J.; Li, X.; Nguyen, K.; Ranger, M. S.; Begunova, Y.; Chen, P.-H. A.; Castrellon, j.; Samanez-Larkin, G. R.; Zald, D.; Fareri, D.; Delgado, M.; Tomova, L.
10.1101/2022.08.23.504939 — neuroscience — Posted on 2022-08-24
1000 Antibacterial Action of Gliotoxin Realized Through Interaction with Tiol-containing Proteins
Vasilchenko, A. S.; Gurina, E. V.; Drozdov, K. A.; Andreev, D.; Lebedev, E.; Vasilchenko, A. V.
10.1101/2022.08.23.504972 — microbiology — Posted on 2022-08-23
1001 Density dependent environments can select for extremes of body size
Coulson, T.; Felmy, A.; Potter, T.; Passoni, G.; Montgomery, R. A.; Gaillard, J.-M.; Hudson, P. J.; Travis, J.; Bassar, R. D.; Tuljapurkar, S. D.; Marshall, D.; Clegg, S. M.
10.1101/2022.02.17.480952 — evolutionary biology — Posted on 2022-08-23
1003 A receptor-independent signaling pathway for BDNF
Fath, J.; Brouillard, F.; Cabaye, A.; Claverie, D.; Nuss, P.; Poillerat, V.; Chwetzoff, S.; Bouceba, T.; Bouvier, E.; Salameh, M.; Molet, J.; Padilla-Ferrer, A.; Couvert, P.; Acher, F.; Golinelli-Cohen, M.-P.; Chassaing, G.; Trugnan, G.; bernard, c.; Benoliel, J.-J.; Becker, C.
10.1101/2022.08.23.504973 — cell biology — Posted on 2022-08-23
1006 Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self
Geiger, K.; Manoharan, M.; Coombs, R.; Park, C.-s.; Lee, A.; Shastri, N.; Robey, E.; Coscoy, L.
10.1101/2022.08.23.504566 — immunology — Posted on 2022-08-23
1007 Data-Driven Design of Protein-Derived Peptide Multiplexes for Biomimetic Detection of Exhaled Breath VOC Profiles
Nakano-Baker, O.; Fong, H.; Shukla, S.; Lee, R.; Cai, L.; Godin, D.; Hennig, T.; Rath, S. S.; Novosselov, I.; Dogan, S.; Sarikaya, M.; MacKenzie, J. D.
10.1101/2022.08.23.504912 — bioengineering — Posted on 2022-08-23
1008 Pathogen-specific structural features of two key players in Candida albicans morphogenetic switch
Manso, J. A.; Carabias, A.; Sarkany, Z.; de Pereda, J. M.; Pereira, P. J. B.; Macedo-Ribeiro, S.
10.1101/2022.08.23.504951 — biochemistry — Posted on 2022-08-23
1009 Temporal GWAS identifies a widely distributed putative adhesin contributing to pathogen success in Shigella spp.
Bennett, R. J.; De Silva, P. M.; Bengtsson, R. J.; Horsburgh, M. J.; Blower, T. R.; Baker, K. S.
10.1101/2022.08.23.504947 — genomics — Posted on 2022-08-23
1010 Haplotype mining panel for genetic dissection and breeding in Eucalyptus
Candotti, J.; Christie, N.; Ployet, R.; Mostert-O'Neill, M. M.; Reynolds, S. M.; Neves, L. G.; Naidoo, S.; Mizrachi, E.; Duong, T. A.; Myburg, A. A.
10.1101/2022.08.23.503551 — genetics — Posted on 2022-08-23
1011 Landscape configurations determining the genetic structure of the Yellow-Spotted Amazon River Turtle (Podocnemis unifilis) in Brazilian Amazonia
Agostini, M. A. P.; Machado, A. F.; Ritter, C. D.; Viana, M. d. N. d. S.; Monjelo, L. A. d. S.; Andrade, P. C. M.; Pantoja-Lima, J.; Pezzuti, J. C. B.; Felix-Silva, D.; de Oliveira, W. P.; Vogt, R. C.; Hrbek, T.; Farias, I. P.
10.1101/2022.08.23.504961 — molecular biology — Posted on 2022-08-23
1013 Bulinus snails in the Lake Victoria Basin in Kenya: systematics and their role as hosts for schistosomes
Babbitt, C.; Laidemitt, M. R.; Mutuku, M. W.; Oraro, P. O.; Brant, S. V.; Mkoji, G. M.; Loker, E. S.
10.1101/2022.08.22.504901 — molecular biology — Posted on 2022-08-23
1014 Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
Kumpornsin, K.; Kochakarn, T.; Yeo, T.; Luth, M.; Pearson, R. D.; Hoshizaki, J.; Schindler, K.; Mok, S.; Park, H.; Uhlemann, A.-C.; Cubel, S. M.; Franco, V.; Gomez-Lorenzo, M.; Gamo, F.-J.; Winzeler, E.; Fidock, D. A.; Chookajorn, T.; Lee, M. C.
10.1101/2022.08.23.504974 — microbiology — Posted on 2022-08-23
1016 A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
Hsieh, E.; Janssens, D. H.; Paddison, P. J.; Browne, E. P.; Henikoff, S.; Ohainle, M.; Emerman, M.
10.1101/2022.08.23.504195 — microbiology — Posted on 2022-08-23
1017 Inflammatory CD4/CD8 double positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology
Hess, N. J.; Turicek, D. P.; Riendeau, J.; McIlwain, S. J.; Contreras Guzman, E.; Nadiminti, K.; Hudson, A.; Callander, N. S.; Skala, M. C.; Gumperz, J. E.; Hematti, P.; Capitini, C. M.
10.1101/2022.01.11.475845 — immunology — Posted on 2022-08-23
1019 Optimizing E. coli as a formatotrophic platform for bioproduction via the reductive glycine pathway
Kim, S.; Giraldo, N. D.; Rainaldi, V.; Machens, F.; Collas, F.; Kubis, A.; Kensy, F.; Bar-Even, A.; Lindner, S. N.
10.1101/2022.08.23.504942 — synthetic biology — Posted on 2022-08-23
1021 Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Differentiation of Aortic Valve Cells Through STAT5
Cuevas, R. A.; Hortells, L.; Chu, C.; Wong, R.; Crane, A.; Boufford, C.; Regan, C.; Moorhead, W.; Bashline, M.; Parwal, A.; Parise, A.; Gurkar, A.; Bruemmer, D.; Sembrat, J.; Sultan, I.; Gleason, T.; Billaud, M.; St. Hilaire, C.
10.1101/2022.08.23.504425 — pathology — Posted on 2022-08-23
1022 New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance
Klein-Rodewald, T.; Micklich, K.; Sanz-Moreno, A.; Tost, M.; Calzada-Wack, J.; Adler, T.; Klaften, M.; Sabrautzki, S.; Aigner, B.; Kraiger, M.; Gailus-Durner, V.; Fuchs, H.; German Mouse Clinic Consortium, ; Gruender, A.; Pahl, H.; Wolf, E.; Hrabe de Angelis, M.; Rathkolb, B.
10.1101/2022.08.23.504938 — cancer biology — Posted on 2022-08-23
1023 Why are G-quadruplexes good at preventing protein aggregation?
Litberg, T. J.; Sannapureddi, R. K. R.; Huang, Z.; Son, A.; Sathyamoorthy, B.; Horowitz, S.
10.1101/2022.08.23.504968 — biophysics — Posted on 2022-08-23
1026 Cryo-EM structure and functional landscape of an RNA polymerase ribozyme
McRae, E. K. S.; Wan, C. J. K.; Kristoffersen, E. L.; Hansen, K.; Gianni, E.; Gallego, I.; Curran, J. F.; Attwater, J.; Holliger, P.; Andersen, E. S.
10.1101/2022.08.23.504927 — biochemistry — Posted on 2022-08-23
1027 Mucosal gene expression in response to SARS-CoV-2 is associated with early viral load.
Rajagopala, S. V.; Strickland, B. A.; Pakala, S. B.; Kimura, K. S.; Shilts, M. H.; Rosas-Salazar, C.; Brown, H. M.; Freeman, M. H.; Wessinger, B. C.; Gupta, V.; Phillips, E.; Mallal, S. A.; Turner, J. H.; Das, S. R.
10.1101/2022.08.23.504908 — genomics — Posted on 2022-08-23
1028 An outbreak of SARS-CoV-2 in big hairy armadillos (Chaetophractus villosus) associated with Gamma variant in Argentina three months after being undetectable in humans
Lucero Arteaga, F. E.; Nabaes Jodar, M.; Mondino, M.; Portu, A.; Boeris, M.; Jolly, A.; Jar, A. M.; Mundo, S. L.; Castro, E.; Alvarez, D.; Torres, C.; Viegas, M.; Bratanich, A.
10.1101/2022.08.23.503528 — microbiology — Posted on 2022-08-23
1029 Oxidative reactions catalyzed by hydrogen peroxide produced by Streptococcus pneumoniae and other Streptococci Cause the Release and Degradation of Heme from Hemoglobin
Alibayov, B.; Scasny, A.; Khan, F.; Creel, A.; Smith, P.; Jop Vidal, A. G.; Fitisemanu, F. M.; Teresita Padilla-Benavides, T.; Weiser, J. N.; Vidal, J. E.
10.1101/2022.08.23.504964 — microbiology — Posted on 2022-08-23
1030 A living conductive marine biofilm engineered to sense and respond to small molecules
Bird, L. J.; Leary, D.; Hervey, J.; Compton, J.; Phillips, D.; Tender, L.; Voigt, C.; Glaven, S.
10.1101/2022.08.23.504934 — microbiology — Posted on 2022-08-23
1033 Engineering of NEMO as calcium indicators with ultra-high dynamics and sensitivity
Li, J.; Shang, Z.; Chen, J.-H.; Gu, W.; Yao, L.; Yang, X.; Sun, X.; Wang, L.; Hou, T.; Wang, S.-Q.; Xing, D.; Gill, D. L.; Hou, L.; Zhou, Y.; Tang, A.-H.; Zhang, X.; Wang, Y.
10.1101/2022.08.23.504677 — synthetic biology — Posted on 2022-08-23
1034 The Skeletal Muscle Circadian Clock Regulates Titin Splicing Through RBM20
Riley, L.; Zhang, X.; Douglas, C.; Mijares, J.; Hammers, D.; Wolff, C. A.; Wood, N. B.; Olafson, H.; Du, P.; Labeit, S.; Previs, M. J.; T. Wang, E.; Esser, K. A.
10.1101/2021.05.27.445953 — physiology — Posted on 2022-08-23
1036 Nanoparticle-mediated CRISPR base editing rescues Kir7.1 function relevant to ocular channelopathy
Kabra, M.; Shahi, P. K.; Wang, Y.; Sinha, D.; Spillane, A.; Newby, G. A.; Saxsena, S.; Abdeen, A. A.; Edwards, K.; Thiesen, C.; Gamm, D.; Liu, D. R.; Gong, S. S.; Saha, K.; Pattnaik, B. R.
10.1101/2022.07.12.499808 — genetics — Posted on 2022-08-23
1037 Application of stable isotopes to study movement ecology and diet variation in a migratory songbird
Contina, A.; Pierce, A. K.; Yanco, S. W.; Bridge, E. S.; Kelly, J. F.; Wunder, M. B.
10.1101/2021.07.10.451926 — ecology — Posted on 2022-08-23
1039 Spatio-temporal summation of perimetric stimuli in healthy observers
Montesano, G.; Mulholland, P.; Garway-Heath, D. F.; Evans, J.; Ometto, G.; Crabb, D. P.
10.1101/2022.08.10.503485 — neuroscience — Posted on 2022-08-23
1040 Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks
El Hady, A.; Takahashi, D. Y.; Sun, R.; Boyd-Meredith, T.; Zhang, Y.; Charles, A.; Brody, C.
10.1101/2022.01.29.478327 — neuroscience — Posted on 2022-08-23
1044 A Non-invasive, Biomarker Assay for Detecting Chronic Wasting Disease Pathology in White-tailed Deer
Bradley, R. D.; Roberts, E. K.; Worsham, A. E.; Ashton, M. N.; Wright, E. A.; Saleh, N.; Hardy, D. M.
10.1101/2022.07.20.500695 — molecular biology — Posted on 2022-08-23
1045 Nuclear lamina strain states revealed by intermolecular force biosensor
Danielsson, B. E.; Abraham, B. G.; Mantyla, E.; Cabe, J. I.; Mayer, C. R.; Rekonen, A.; Ek, F.; Conway, D. E.; Ihalainen, T. O.
10.1101/2022.03.07.483300 — biophysics — Posted on 2022-08-23
1046 A Genetic History of Continuity and Mobility in the Iron Age Central Mediterranean
Moots, H. M.; Antonio, M. L.; Sawyer, S.; Spence, J. P.; Oberreiter, V.; Weiss, C. L.; Lucci, M.; Cherifi, Y. M. S.; La Pastina, F.; Genchi, F.; Praxmarer, E.; Zagorc, B.; Cheronet, O.; Özdogan, K. T.; Demetz, L.; Amrani, S.; Candilio, F.; De Angelis, D.; Gasperetti, G.; Fernandes, D.; Gao, Z.; Fantar, M.; Coppa, A.; Pritchard, J. K.; Pinhasi, R.
10.1101/2022.03.13.483276 — genomics — Posted on 2022-08-23
1048 The Translation Initiation Factor Homolog, eif4e1c, Regulates Cardiomyocyte Metabolism and Proliferation During Heart Regeneration
Rao, A.; Lyu, B.; Lubertozzi, A.; Jahan, I.; Tedeschi, F.; Jankowsky, E.; Carstens, B. C.; Poss, K. D.; Baskin, K.; Goldman, J. A.
10.1101/2022.08.15.502524 — developmental biology — Posted on 2022-08-23
1049 Atlasing white matter and grey matter joint contributions to resting-state networks in the human brain
Nozais, V.; Forkel, S. J.; Petit, L.; Corbetta, M.; Thiebaut de Schotten, M.; joliot, m.
10.1101/2022.01.10.475690 — neuroscience — Posted on 2022-08-23
1050 QuNex -- An Integrative Platform forReproducible Neuroimaging Analytics
Ji, J. L.; Demsar, J.; Fonteneau, C.; Tamayo, Z.; Pan, L.; Kraljic, A.; Matkovic, A.; Purg, N.; Helmer, M.; Warrington, S.; Harms, M. P.; Sotiropoulos, S.; Murray, J. D.; Anticevic, A.; Repovs, G.
10.1101/2022.06.03.494750 — neuroscience — Posted on 2022-08-23
1051 Coordinated Head Direction Representations in Mouse Anterodorsal Thalamic Nucleus and Retrosplenial Cortex
van der Goes, M.-S. H.; Voigts, J.; Newman, J. P.; Toloza, E. H. S.; Brown, N. J.; Murugan, P.; Harnett, M. T.
10.1101/2022.08.20.504604 — neuroscience — Posted on 2022-08-23
1054 Establishing farm dust as a useful viral metagenomic surveillance matrix
Kwok, K. T. T.; de Rooij, M. M. T.; Messink, A. B.; Wouters, I.; Smit, L. A. M.; Cotten, M.; Heederik, D.; Koopmans, M.; Phan, M. V.
10.1101/2021.03.09.434704 — evolutionary biology — Posted on 2022-08-23
1056 Isolation and characterization of SARS-CoV-2 in Kenya
Makio, A.; Irekwa, R. M.; Munyao, M. M.; Njoroge, C. W.; Rotich, P. K.; Nyandwaro, T. T.; Yego, J. J.; Mwangi, A. W.; Kimotho, J. H.; Tanui, R.; Rutto, V.; Nzou, S. M.
10.1101/2022.08.22.504904 — molecular biology — Posted on 2022-08-23
1058 The efficiency of Grignard Pure™ to inactivate airborne SARS-CoV-2 surrogate
Desai, G.; Ramachandran, G.; Goldman, E.; Galione, A.; Lal, A.; Choueiri, T. K.; Fay, A.; Jordan, W.; Schaffner, D. W.; Caravanos, J.; Grignard, E.; Mainelis, G.
10.1101/2022.08.19.504307 — microbiology — Posted on 2022-08-23
1065 Phenotypic and transcriptional features of the Araliaceae species under distinct light environments
Niu, Y.; Zhang, Y.; Wang, X.; Wang, Z.; Yang, J.; Wang, Y.; Zhang, W.; Song, Z.; Li, L.
10.1101/2022.08.22.504876 — ecology — Posted on 2022-08-23
1068 Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus
Adams, C.; Carbaugh, D. L.; Sho, B.; Ng, T.-S.; Castillo, I.; Bhowmik, R.; Segovia-Chumbez, B.; Ana C. Puhl, A. C. P.; Graham, S.; diehl, s.; Lazear, H.; de Silva, A. M.; Lok, S.-m.; Premkumar, L.
10.1101/2022.08.22.504902 — microbiology — Posted on 2022-08-23
1072 The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism: a cross-species study in vivo
Wiest, C.; Torrecillos, F.; Pogosyan, A.; Bange, M.; Muthuraman, M.; Groppa, S.; Hulse, N.; Hasegawa, H.; Ashkan, K.; Baig, F.; Morgante, F.; Pereira, E.; Mallet, N.; Magill, P.; Brown, P.; Sharott, A.; Tan, H.
10.1101/2022.08.23.504923 — neuroscience — Posted on 2022-08-23
1075 Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression
Lowe, S.; Barriga, F. M.; Tsanov, K. M.; Ho, Y. J.; Sohail, N.; Zhang, A.; Baslan, T.; Wuest, A. N.; Del Priore, I.; Meskauskaite, B.; Livshits, G.; Alonso-Curbelo, D.; Simon, J.; Chaves-Perez, A.; Bar-Sagi, D.; Iacobuzio-Donahue, C. A.; Notta, F.; Chaligne, R.; Sharma, R.; Pe'er, D.
10.1101/2022.08.22.504793 — cancer biology — Posted on 2022-08-23
1076 The ecology of cancer prevalence across species: Cancer prevalence is highest in desert species and high trophic levels
Kapsetaki, S. E.; Compton, Z.; Rupp, S. M.; Garner, M. M.; Duke, E. G.; Boddy, A. M.; Harrison, T. M.; Aktipis, A.; Maley, C. C.
10.1101/2022.08.23.504890 — cancer biology — Posted on 2022-08-23
1083 Fast4DReg: Fast registration of 4D microscopy datasets
Pylvänäinen, J.; Laine, R.; Ghimire, S.; Follain, G.; Henriques, R.; Jacquemet, G.
10.1101/2022.08.22.504744 — bioinformatics — Posted on 2022-08-23
1087 Readout of histone methylation by Trim24 locally restricts chromatin opening by p53
Isbel, L.; Iskar, M.; Durdu, S.; Grand, R. S.; Weiss, J.; Hietter-Pfeiffer, E.; Kozicka, Z.; Michael, A.; Burger, L.; Thomä, N. H.; Schübeler, D.
10.1101/2022.08.23.504916 — genomics — Posted on 2022-08-23
1088 Mutations in the SmAPRR2 transcription factor suppressing chlorophyll pigmentation in the eggplant fruit peel are key drivers of a diversified colour palette
Arrones, A.; Mangino, G.; Alonso, D.; Plazas, M.; Prohens, J.; Portis, E.; Barchi, L.; Giuliano, G.; Vilanova, S.; Gramazio, P.
10.1101/2022.08.23.504925 — genetics — Posted on 2022-08-23
1090 DNA methylation in clonal Duckweed lineages (Lemna minor L.) reflects current and historical environmental exposures.
Van Antro, M.; Prelovsek, S.; Ivanovic, S.; Gawehns, F.; Wagemaker, N. C. A. M.; Mysara, M.; Horemans, N.; Vergeer, P.; Verhoeven, K.
10.1101/2022.08.23.504803 — evolutionary biology — Posted on 2022-08-23
1093 Beyond mean fitness: demographic stochasticity and resilience matter at tree species climatic edges.
Guyennon, A.; Reineking, B.; Salguero-Gomez, R.; Dahlgren, J.; Lehtonen, A.; Ratcliffe, S.; Ruiz-Benito, P.; Zavala, M. A.; Kunstler, G.
10.1101/2022.08.22.504487 — ecology — Posted on 2022-08-23
1094 Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation
Palframan, S. L.; Mahmud, M. T.; Tan, K. S.; Grinter, R.; Xin, V.; Dunstan, R. A.; Micati, D.; Kerr, G.; McMurrick, P. J.; Smith, A.; Abud, H.; Nguyen, T. N.; Lazarou, M.; Kleifeld, O.; Lithgow, T.; Cover, T. L.; Gabriel, K.; Gorrell, R. J.; Kwok, T.
10.1101/2022.08.22.504206 — molecular biology — Posted on 2022-08-23
1096 Multiplex genome engineering in Clostridium beijerinckii NCIMB 8052 using CRISPR-Cas12a
Patinios, C.; de Vries, S. T.; Diallo, M.; Lanza, L.; Verbrugge, P. L. J. V. Q.; Lopez-Contreras, A. M.; van der Oost, J.; Weusthuis, R. A.; Kengen, S. W. M.
10.1101/2022.08.22.504755 — microbiology — Posted on 2022-08-23
1099 Peripheral Myeloid-Derived Suppressor Cells are good biomarkers of the efficacy of Fingolimod in Multiple Sclerosis
Camacho-Toledano, C.; Machin-Diaz, I.; Calahorra, L.; Cabanas, M.; Otaegui, D.; Castillo-Trivino, T.; Villar, L. M.; Costa-Frossard, L.; Comabella, M.; Midaglia, L.; Garcia-Dominguez, J. M.; Garcia-Arocha, J.; Ortega, M. C.; Clemente, D.
10.1101/2022.08.22.504792 — immunology — Posted on 2022-08-23
1100 Single-cell functional genomics of natural killer cell evasion in blood cancers
Dufva, O.; Gandolfi, S.; Huuhtanen, J.; Dashevsky, O.; Saeed, K.; Klievink, J.; Nygren, P.; Bouhlal, J.; Lahtela, J.; Näätänen, A.; Ghimire, B.; Hannunen, T.; Ellonen, P.; Duan, H.; Theodoropoulos, J.; Laajala, E.; Härkönen, J.; Pölönen, P.; Heinäniemi, M.; Yamano, S.; Shirasaki, R.; Barbie, D.; Roth, J. A.; Romee, R.; Sheffer, M.; Lähdesmäki, H.; Lee, D. A.; De Matos Simoes, R.; Kankainen, M.; Mitsiades, C. S.; Mustjoki, S.
10.1101/2022.08.22.504722 — immunology — Posted on 2022-08-23
1101 An Alzheimer's disease patient-derived olfactory cell model identifies gene expression changes associated with cognition
Rantanen, L. M.; Bitar, M.; Lampinen, R.; Stewart, R.; Quek, H.; Oikari, L. E.; Cuni-Lopez, C.; Sutharsan, R.; Thillaiyampalam, G.; Iqbal, J.; Russell, D.; Penttilä, E.; Löppönen, H.; Lehtola, J.-M.; Saari, T.; Hannonen, S.; Koivisto, A. M.; Haupt, L. M.; Mackay-Sim, A.; Cristino, A. S.; Kanninen, K. M.; White, A. R.
10.1101/2022.08.22.504884 — neuroscience — Posted on 2022-08-23
1104 Effects of Aging on Cortical Representations of Continuous Speech
Karunathilake, I. M. D.; Dunlap, J. L.; Perera, J.; Presacco, A.; Decruy, L.; Anderson, S.; Kuchinsky, S. E.; Simon, J. Z.
10.1101/2022.08.22.504825 — neuroscience — Posted on 2022-08-23
1105 Co-fluctuations of neural activity define intra-V1 networks related to perceptual organization
Valdes-Sosa, M. J.; Ontivero-Ortega, M.; Iglesias-Fuster, J.; Lage-Castellanos, A.; Galan-Garcia, L.; Valdes-Sosa, P. A.
10.1101/2022.08.22.504869 — neuroscience — Posted on 2022-08-23
1106 TAOK2β represses translation via phosphorylation of eEF2 and ameliorates exaggerated protein synthesis in a mouse model of 16p11.2 microdeletion-driven autism
Henis, M.; Rucker, T.; Scharrenberg, R.; Richter, M.; Baltussen, L.; Meka, D. P.; Schwanke, B.; Neelagandan, N.; Daaboul, D.; Murtaza, N.; Krisp, C.; Harder, S.; Schluter, H.; Kneussel, M.; Hermans-Borgmeyer, I.; de Wit, J.; Singh, K. K.; Duncan, K. E.; de Anda, F. C.
10.1101/2022.08.22.504812 — neuroscience — Posted on 2022-08-23
1109 The DC1 domain protein BINUCLEATE POLLEN is required for pollen development in Arabidopsis thaliana
Arias, L. A.; D'Ippolito, S.; Frik, J.; Amigo, N.; Marchetti, M. F.; Casalongue, C. A.; Pagnussat, G. C.; Fiol, D. F.
10.1101/2022.03.17.484815 — plant biology — Posted on 2022-08-23
1111 On the evolution of the plant phytochrome chromophore
Frascogna, F.; Ledermann, B.; Hartmann, J.; Perez Patallo, E.; Hofmann, E.; Frankenberg-Dinkel, N.
10.1101/2022.08.22.504806 — plant biology — Posted on 2022-08-23
1112 SPEX: A modular end-to-end analytics tool for spatially resolved omics of tissues
Pechuan Jorge, X.; Li, X.; Risom, T.; Zubkov, A.; Tabatsky, E.; Prilipko, A.; Ye, X.; Shi, Z.; Nowicka, m.; Peale, F.; Hibar, D.; Ziai, J.; Jesudason, R.; Orlova, D.
10.1101/2022.08.22.504841 — bioinformatics — Posted on 2022-08-23
1115 Metabolic independence drives gut microbialcolonization and resilience in health and disease
Watson, A. R.; Fuessel, J.; Veseli, I.; DeLongchamp, J. Z.; Silva, M.; Trigodet, F.; Lolans, K.; Shaiber, A.; Fogarty, E.; Runde, J. M.; Quince, C.; Yu, M. K.; Soylev, A.; Morrison, H. G.; Lee, S. T. M.; Kao, D.; Rubin, D. T.; Jabri, B.; Louie, T.; Eren, A. M.
10.1101/2021.03.02.433653 — microbiology — Posted on 2022-08-23
1118 Stereoretentive Post-Translational Protein Editing
Fu, X.; Yuan, Y.; Jha, A.; Levin, N.; Giltrap, A. M.; Ren, J.; Mamalis, D.; Mohammed, S.; Davis, B. G.
10.1101/2022.08.22.504816 — synthetic biology — Posted on 2022-08-23
1120 Allometric equation for the commonest palm in the Central Congo Peatlands, Raphia laurentii De Wild.
Bocko, Y. E.; Panzou, G. J. L.; Dargie, G. C.; Mampouya, Y. E. W.; Mbemba, M.; Loumeto, J. J.; Lewis, S. L.
10.1101/2022.08.22.503797 — ecology — Posted on 2022-08-23
1121 Metabolic enhancement of mammalian developmental pausing
van der Weijden, V. A.; Stoetzel, M.; Fauler, B.; Iyer, D. P.; Shahraz, M.; Meierhofer, D.; Rulands, S.; Alexandrov, T.; Mielke, T.; Bulut-Karslioglu, A.
10.1101/2022.08.22.504730 — developmental biology — Posted on 2022-08-23
1122 Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity
Ahmadzadeh, K.; Pereira, M.; Vanoppen, M.; Bernaerts, E.; Ko, J.-H.; Mitera, T.; Maksoudian, C.; Manshian, B. B.; Soenen, S.; Rose, C. D.; Matthys, P.; Wouters, C.; Behmoaras, J.
10.1101/2022.08.22.504763 — cell biology — Posted on 2022-08-23
1123 Cell-surface protein YwfG of Lactococcus lactis binds to α-1,2-linked mannose
Tsuchiya, W.; Fujimoto, Z.; Inagaki, N.; Nakagawa, H.; Tanaka, M.; Kimoto-Nira, H.; Yamazaki, T.; Suzuki, C.
10.1101/2022.08.19.504583 — microbiology — Posted on 2022-08-23
1124 Imbalanced immune response and dysregulation of neural functions underline fatal opportunistic encephalitis caused by astrovirus
Maximova, O. A.; Weller, M. L.; Krogmann, T.; Sturdevant, D. E.; Ricklefs, S.; Virtaneva, K.; Martens, C.; Wollenberg, K.; Minai, M.; Moore, I. N.; Sauter, C. S.; Barker, J. N.; Lipkin, I.; Seilhean, D.; Nath, A.; Cohen, J. I.
10.1101/2022.08.20.504643 — microbiology — Posted on 2022-08-23
1125 A Trypanosoma cruzi Antigen and Epitope Atlas: deep characterization of antibody specificities in Chagas Disease patients across the Americas
Ricci, A. D.; Bracco, L. E.; Ramsey, J. M.; Nolan, M. S.; Lynn, M. K.; Altcheh, J.; Ballering, G.; Torrico, F.; Kesper, N.; Villar, J. C.; Marco, J. D.; Aguero, F.
10.1101/2022.08.19.504544 — immunology — Posted on 2022-08-23
1126 The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins
Xu, R.; Lou, Y.; Tidu, A.; Bulet, P.; Heinekamp, T.; Martin, F.; Brakhage, A. A.; Li, Z.; Liegois, S.; Ferrandon, D.
10.1101/2022.08.18.504437 — immunology — Posted on 2022-08-23
1127 Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20
Preiss, N. K.; Kamal, Y.; Williams, O. M.; Li, C.; Kolling, F. W.; Trask, H. W.; Usherwood, Y.-K.; Cheng, C.; Frost, H. R.; Usherwood, E. J.
10.1101/2022.08.22.504726 — immunology — Posted on 2022-08-23
1130 The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
Lima, K.; Pereira-Martins, D. A.; de Miranda, L. B. L.; Coelho-Silva, J. L.; Leandro, G. d. S.; Weinhauser, I.; Cavaglieri, R. d. C.; de Leal, A. M.; da Silva, W. F.; Lange, A. P. A. d. L.; Velloso, E. D. R. P.; Griessinger, E.; Hilberink, J. R.; Huls, G.; Schuringa, J. J.; Rego, E. M.; Machado-Neto, J. A.
10.1101/2022.08.20.504641 — pharmacology and toxicology — Posted on 2022-08-23
1136 Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products
Nash, B.; Gregory, W. F.; White, R. R.; Protasio, A.; Gygi, S. P.; Selkirk, M. E.; Weekes, M. P.; Artavanis-Tsakonas, K.
10.1101/2022.08.23.504907 — cell biology — Posted on 2022-08-23
1137 Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells
Gujar, M. R.; Gao, Y.; Teng, X.; Deng, Q.; Tan, Y. S.; Toyama, Y.; Wang, H.
10.1101/2022.08.22.504877 — cell biology — Posted on 2022-08-23
1138 Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function
Culley, M. K.; Mehta, M.; Zhao, J.; Perk, D.; Tai, Y. Y.; Tang, Y.; Shiva, S.; Rabinovitch, M.; Gu, M.; Bertero, T.; Chan, S. Y.
10.1101/2022.08.22.504849 — cell biology — Posted on 2022-08-23
1140 First-in-human evaluation of cutaneous innate and adaptive immunomodulation by mosquito bites
Guerrero, D.; Vo, H. T. M.; Lon, C.; Bohl, J. A.; Nhik, S.; Chea, S.; Man, S.; Sreng, S.; Pacheco, A. R.; Ly, S.; Sath, R.; Lay, S.; Misse, D.; Huy, R.; Leang, R.; Kry, H.; Valenzuela, J. G.; Oliveira, F.; Cantaert, T.; Manning, J. E.
10.1101/2022.04.25.489145 — immunology — Posted on 2022-08-23
1146 Melanization of Candida auris is Associated with Alteration of Extracellular pH
Smith, D. F. Q.; Mudrak, N. J.; Zamith-Miranda, D.; Honorato, L.; Nimrichter, L.; Chrissian, C.; Smith, B.; Gerfen, G. J.; Stark, R. E.; Nosanchuk, J. D.; Casadevall, A.
10.1101/2022.07.14.500134 — microbiology — Posted on 2022-08-22
1147 Predicting Dementia Severity by Merging Anatomical and Diffusion MRI with Deep 3D Convolutional Neural Networks
Chattopadhyay, T.; Singh, A.; Joshy, N. A.; Thomopoulos, S. I.; Nir, T. M.; Zheng, H.; Nourollahimoghadam, E.; Gupta, U.; Steeg, G. V.; Jahanshad, N.; Thompson, P.
10.1101/2022.08.22.504801 — neuroscience — Posted on 2022-08-22
1150 AI-guided screen identifies probucol-mediated mitophagy enhancement through modulation of lipid droplets
Moskal, N.; Visanji, N. P.; Gorbenko, O.; Narasimhan, V.; Tyrrell, H.; Nash, J.; Lewis, P. N.; McQuibban, G. A.
10.1101/2022.05.18.492560 — neuroscience — Posted on 2022-08-22
1151 Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM
Boyle, E. A.; Goldberg, G.; Schmok, J. C.; Burgado, J.; Izidro Layng, F.; Grunwald, H. A.; Balotin, K. M.; Cuoco, M. S.; Chang, K.-C.; Ecklu-Mensah, G.; Arakaki, A. K. S.; Ahmed, N.; Garcia Arceo, X.; Jagannatha, P.; Pekar, J.; Iyer, M.; DASL Alliance, ; Yeo, G. W.
10.1101/2021.12.05.471284 — scientific communication and education — Posted on 2022-08-22
1153 A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors
Krup, A. L.; Winchester, S.; Ranade, S.; Agrawal, A.; Devine, W. P.; Sinha, T.; Choudhary, K.; Dominguez, M.; Thomas, R.; Black, B. L.; Srivastava, D.; Bruneau, B.
10.1101/2022.08.22.504863 — developmental biology — Posted on 2022-08-22
1156 Loss of chromosome Y in primary tumors
Qi, M.; Pang, J.; Mitsiades, I.; Lane, A.; Rheinbay, E.
10.1101/2022.08.22.504831 — cancer biology — Posted on 2022-08-22
1158 StORF-Reporter: Finding Genes between Genes
Dimonaco, N. J.; Aubrey, W.; Kenobi, K.; Clare, A.; Creevey, C. J.
10.1101/2022.03.31.486628 — bioinformatics — Posted on 2022-08-22
1160 Reproductive state switches the valence of male urinary pheromones in female mice
Miller, C. H.; Reichard, T. M.; Yang, J.; Carlson-Clarke, B.; Vogt, C. C.; Warden, M. R.; Sheehan, M. J.
10.1101/2022.08.22.504866 — animal behavior and cognition — Posted on 2022-08-22
1162 A view of the pan-genome of domesticated cowpea (Vigna unguiculata Walp.)
Liang, Q.; Munoz-Amatriain, M.; Shu, S.; Lo, S.; Wu, X.; Carlson, J. W.; Davidson, P.; Goodstein, D. M.; Phillips, J.; Janis, N. M.; Lee, E. J.; Liang, C. N.; Morrell, P. L.; Farmer, A. D.; Xu, P.; Close, T. J.; Lonardi, S.
10.1101/2022.08.22.504811 — genomics — Posted on 2022-08-22
1163 Suction feeding of West African lungfish (Protopterus annectens): An XROMM analysis of jaw mechanics, cranial kinesis, and hyoid mobility.
Gartner, S. M.; Whitlow, K. R.; Laurence-Chasen, J. D.; Kaczmarek, E. B.; Granatosky, M. C.; Ross, C. F.; Westneat, M. W.
10.1101/2022.05.30.493759 — evolutionary biology — Posted on 2022-08-22
1165 Endogenous RNAi silences a burgeoning sex chromosome arms race
Vedanayagam, J.; Lin, C.-J.; Papareddy, R.; Nodine, M. D.; Flynt, A. S.; Wen, J.; Lai, E. C.
10.1101/2022.08.22.504821 — evolutionary biology — Posted on 2022-08-22
1169 Disentangling temporal associations in marine microbial networks
Deutschmann, I. M.; Krabberod, A. K.; Latorre, F.; Delage, E.; Marrase, C.; Balague, V.; Gasol, J. M.; Massana, R.; Eveillard, D.; Chaffron, S.; Logares, R.
10.1101/2021.07.13.452187 — microbiology — Posted on 2022-08-22
1172 Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function
Molendijk, J.; Blazev, R.; Mills, R.; Ng, Y.-K.; Watt, K. I.; Chau, D.; Gregorevic, P.; Crouch, P. J.; Hilton, J. B.; Lisowski, L.; Zhang, P.; Reue, K.; Lusis, A. J.; Hudson, J. E.; James, D. E.; Seldin, M. M.; Parker, B. L.
10.1101/2022.08.22.504871 — systems biology — Posted on 2022-08-22
1176 Continuous Fish Muscle Cell Line with Capacity for Myogenic and Adipogenic-like Phenotypes
Saad, M. K.; Yuen, J. S.; Joyce, C. M.; Li, X.; Lim, T.; Wolfson, T. L.; Wu, J.; Laird, J.; Vissapragada, S.; Calkins, O. P.; Ali, A.; Kaplan, D. L.
10.1101/2022.08.22.504874 — bioengineering — Posted on 2022-08-22
1177 Fast and Accurate Kinship Estimation Using Sparse SNPs in Relatively Large Database Searches
Snedecor, J.; Fennell, T.; Stadick, S.; Homer, N.; Antunes, J.; Stephens, K.; Holt, C.
10.1101/2022.08.22.504804 — genomics — Posted on 2022-08-22
1178 Genome-wide analysis of Structural Variants in Parkinson's Disease using Short-Read Sequencing data
Billingsley, K. J.; Ding, J.; jerez, p. a.; illarionova, a.; Makarious, M. B.; moore, a.; vitale, d.; reed, x.; Hernandez, D.; Torkamani, A.; Ryten, M.; Hardy, J.; Chia, R.; Scholz, S. W.; Traynor, B.; Dalgard, C. L.; ehrlich, d.; Tanaka, T.; Ferrucci, L.; Beach, T.; Serrano, G. E.; Quinn, J.; Bubb, V.; Collins, R. L.; Zhao, X.; Walker, M.; Pierce-Hoffman, E.; Brand, H.; Talkowski, M.; Casey, B.; Cookson, M. R.; Markham, A.; Nalls, M. A.; Mahmoud, M.; Sedlazeck, F.; Blauwendraat, C.; Gibbs, R.; Singleton, A.
10.1101/2022.08.22.504867 — genetics — Posted on 2022-08-22
1179 Local adaptation of host-species specific gut microbiota
Sprockett, D. D.; Price, J. D.; Juritsch, A. F.; Schmaltz, R. J.; Real, M. V. F.; Goldman, S.; Sheehan, M. J.; Ramer-Tait, A. E.; Moeller, A. H.
10.1101/2022.08.22.504808 — evolutionary biology — Posted on 2022-08-22
1181 Structural and functional insights into the type III-E CRISPR-Cas immunity
Liu, X.; Zhang, L.; Wang, H.; Xiu, Y.; Huang, L.; Gao, Z.; Li, N.; Li, F.; Xiong, W.; Gao, T.; Zhang, Y.; Yang, M.; Feng, Y.
10.1101/2022.08.22.504715 — molecular biology — Posted on 2022-08-22
1184 Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
Traughber, c.; deshpande, G.; neupane, k.; Khan, M.; McMullen, M. R.; Swaidani, S.; Opoku, E.; Muppals, S.; Smith, J.; Nagy, L.; Gulshan, K.
10.1101/2022.08.22.504854 — cancer biology — Posted on 2022-08-22
1186 Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo
Wong, J. Y. K.; Kirberger, S. E.; Qiu, R.; Ekanayake, A. I.; Kelich, P.; Sarkar, S.; Alvizo-Paez, E. R.; Miao, J.; Kalhor-Monfared, S.; Dwyer, J. J.; Nuss, J. M.; Lin, Y.-S.; Macauley, M. S.; Vukovic, L.; Pomerantz, W. C. K.; Derda, R.
10.1101/2022.08.22.504611 — biochemistry — Posted on 2022-08-22
1187 The butterfly effect: mutational bias of SARS-CoV-2 affects its pattern of molecular evolution on synonymous and nonsynonymous levels
Voronka, A.; Efimenko, B.; Oreshkov, S.; Franco, M.; Fleischmann, Z.; Yurov, V.; Trufanova, A.; Timonina, V.; Ree, N.; Penfrat, E.; Junier, T.; Agranovsky, A.; Khrapko, K.; Gunbin, K.; Fellay, J.; Popadin, K.
10.1101/2022.08.22.504819 — evolutionary biology — Posted on 2022-08-22
1189 Detection of Frog virus 3 via the system integrating RPA-CRISPR/Cas12a-SPM with deep learning
Lei, Z.; Lian, L.; Zhang, L.; Wei, J.; Liu, C.; Liu, H.; Liu, Y.; Zhai, S.; Zhong, X.; Gul, I.; Yuan, X.; Dong, Y.; Zhang, H.; Wang, C.; Zhang, C.; Xing, X.; Yu, D.; He, Q.; Qin, P.
10.1101/2022.08.22.504785 — molecular biology — Posted on 2022-08-22
1195 RNA Immunoprecipitation and Sequencing of Isolated RNAs (RIP-SIR) Identifies Endogenous miRNA-Target Interactions
Wells, J.; SRIVASTAVA, A.; Maser, R. S.; Kesharwani, R.; Sarsani, V. K.; Daigle, S. L.; Lynch, R. P.; Munger, H. J.; Doty, R.; Saxl, R. L.; Bult, C. J.
10.1101/2022.08.22.504764 — molecular biology — Posted on 2022-08-22
1198 The absence of gastrointestinal redox dyshomeostasis in the brain-first rat model of Parkinson's disease induced by bilateral intrastriatal 6-hydroxydopamine
Homolak, J.; Joja, M.; Grabaric, G.; Schiatti, E.; Virag, D.; Babic Perhoc, A.; Knezovic, A.; Osmanovic Barilar, J.; Salkovic-Petrisic, M.
10.1101/2022.08.22.504759 — neuroscience — Posted on 2022-08-22
1199 Cortical interneuron development is affected in leukodystrophy 4H
Dooves, S.; Kok, L. M. L.; Holmes, D. B.; Breeuwsma, N.; Breur, M.; Bugiani, M.; Wolf, N.; Heine, V. M.
10.1101/2022.08.22.504736 — neuroscience — Posted on 2022-08-22
1200 A highly polymorphic effector protein promotes fungal virulence through suppression of plant-associated Actinobacteria
Snelders, N.; Boshoven, J.; Song, Y.; Schmitz, N.; Lorencini Fiorin, G.; Roevenich, H.; van den Berg, G.; Torres, D.; Faino, L.; Seidl, M. F.; Thomma, B.
10.1101/2022.08.22.504754 — plant biology — Posted on 2022-08-22
1202 Photophysical studies at cryogenic temperature reveal a novel photoswitching mechanism of rsEGFP2
Mantovanelli, A. M. R.; Glushonkov, O.; Adam, V.; Wulffele, J.; Thedie, D.; Byrdin, M.; Gregor, I.; Nevskyi, O.; Enderlein, J.; Bourgeois, D.
10.1101/2022.08.22.504779 — biophysics — Posted on 2022-08-22
1206 Long-term temporal stability of peripheral blood DNA methylation alterations in patients with inflammatory bowel disease.
Joustra, V. W.; Li Yim, A. Y. F.; Hageman, I.; Levin, E.; Adams, A.; Satsangi, J.; de Jonge, W.; Henneman, P.; D'Haens, G.
10.1101/2022.08.22.504377 — genetics — Posted on 2022-08-22
1207 Epigenetic variations are landmarks of freshwater adaptation in threespine sticklebacks
Golden, A.; Starshin, A.; Mazur, A.; Mugue, N.; Kaplun, D.; Artemov, A.; Khrameeva, E.; Prokhortchouk, E.
10.1101/2022.08.22.504457 — evolutionary biology — Posted on 2022-08-22
1209 Miltefosine attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice.
Traughber, C. A.; Iacano, A. J.; Khan, M. R.; Nepane, K.; Opoku, E.; Nunn, T.; Sangwan, N.; Hazen, S. L.; Smith, J.; Gulshan, K.
10.1101/2022.08.22.504848 — cell biology — Posted on 2022-08-22
1213 Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021
Molina-Mora, J. A.; Reales-Gonzalez, J.; Camacho, E.; Duarte-Martinez, F.; Tsukayama, P.; Soto-Garita, C.; Brenes, H.; Cordero-Laurent, E.; Ribeiro Dos Santos, A.; Guedes Salgado, C.; Santos Silva, C.; Santana De Souza, J.; Nunes, G.; Negri, T.; Vidal, A.; Oliveira, R.; Oliveira, G.; Munoz-Medina, J. E.; Salas-Lais, A. G.; Mireles-Rivera, G.; Sosa, E.; Turjanski, A.; Monzani, M. C.; Carobene, M. G.; Remes Lenicov, F.; Schottlender, G.; Fernandez Do Porto, D. A.; Kreuze, J. F.; Sacristan, L.; Guevara-Suarez, M.; Cristancho, M.; Campos-Sanchez, R.; Herrera-Estrella, A.
10.1101/2022.08.19.504579 — microbiology — Posted on 2022-08-22
1214 Epithelial antigen presentation controls commensal-specific intraepithelial T-cells in the gut
Brabec, T.; Schwarzer, M.; Kovacova, K.; Dobesova, M.; Schierova, D.; Brezina, J.; Pacakova, I.; Srutkova, D.; Ben-Nun, O.; Goldfarb, Y.; Splichalova, I.; Kolar, M.; Abramson, J.; Filipp, D.; Dobes, J.
10.1101/2022.08.21.504672 — immunology — Posted on 2022-08-22
1215 Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming
Soler Palacios, B.; Villares, R.; Lucas, P.; Rodriguez Frade, J. M.; Cayuela, A.; Piccirillo, J. G.; Delgado Gestoso, D.; Risco, C.; Corrales, F.; Sorzano, C. O. S.; Martinez, N.; Conesa, J. J.; Iborra, F. J.; Mellado, M.
10.1101/2022.08.22.504729 — immunology — Posted on 2022-08-22
1220 ISCB RSG-Spain and highlights from the VIII Spanish Student Symposium in Bioinformatics and Computational Biology in 2021
Rivero, I.; Gorines-Cordero, G. J.; Rubio-Rodriguez, L. A.; Soler-Saez, I.; Perpina-Clerigues, C.; Garcia, A.; Monzon, S.; Hernandez-Beeftink, T.
10.1101/2022.08.19.504447 — scientific communication and education — Posted on 2022-08-22
1222 CIPK-B is essential for salt stress signalling in Marchantia polymorpha
Tansley, C.; Houghton, J.; Rose, A. M. E.; Witek, B.; Payet, R. D.; Wu, T.; Miller, J. B.
10.1101/2022.08.22.504506 — plant biology — Posted on 2022-08-22
1224 Immunohistochemical diagnosis of Trypanosoma vivax in experimentally infected sheep tissues
do Nascimento, L. F. N.; de Cristo, T. G.; Salbego, F. Z.; Casagrande, R. A.; Bittar, J. F. F.; Miletti, L. C.
10.1101/2022.08.22.504753 — pathology — Posted on 2022-08-22
1227 Individual risk attitudes arise from noise in neurocognitive magnitude representations
Barretto Garcia, M.; de Hollander, G.; Grueschow, M.; Polania, R.; Woodford, M.; Ruff, C.
10.1101/2022.08.22.504413 — neuroscience — Posted on 2022-08-22
1229 Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19
Fraga-Silva, T. F.; Cipriano, U. G.; Fumagalli, M. J.; Correa, G. F.; Fuzo, C. A.; Mestriner, F. L. A. C.; Becari, C.; Teixeira-Carvalho, A.; Coelho-dos-Reis, J.; Menegueti, M. G.; Figueiredo, L. T. M.; Martins-Filho, O. A.; Dias-Baruffi, M.; Auxiliadora-Martins, M.; Tostes, R. C.; Bonato, V. L. D.
10.1101/2022.08.22.504760 — immunology — Posted on 2022-08-22
1231 Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer
Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.
10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-08-22
1232 A specialized mRNA translation circuit instated in pluripotency presets the competence for cardiogenesis in humans
Bartsch, D.; Kalamkar, K.; Ahuja, G.; Bazzi, H.; Papantonis, A.; Clamer, M.; Lackmann, J.-W.; Mendjan, S.; Kurian, L.
10.1101/2021.04.12.439420 — developmental biology — Posted on 2022-08-22
1238 Fear and foraging in the ecosystem size spectrum generate diversity in fish life histories
Kindsvater, H. K.; Juan Jorda, M. J.; Dulvy, N. K.; Horswill, C.; Matthiopoulos, J.; Mangel, M.
10.1101/2022.08.20.504655 — ecology — Posted on 2022-08-22
1239 Extracellular vesicle-mediated promotion of myogenic differentiation is dependent on dose, collection media composition, and isolation method
Hanson, B.; Conceicao, M.; Lomonosova, Y.; Mager, I.; Puri, P. L.; EL Andaloussi, S.; Wood, M. J. A.; Roberts, T. C.
10.1101/2022.08.22.504734 — cell biology — Posted on 2022-08-22
1240 Alpha-synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinsons disease
Martin-Lopez, E.; GREER, C. A.; Chandra, S.; D J, V.; Liberia, T.; Meller, S. J.; Harmon, L. E.; Hsu, R. M.; Han, K.; Yucel, B.
10.1101/2022.08.19.504562 — neuroscience — Posted on 2022-08-22
1243 Physiological and functional heterogeneity in the mouse locus coeruleus
Tortorelli, L.; Mcburney-Lin, J.; Garad, M.; Megemont, M.; Riccomagno, M. M.; Yang, H.
10.1101/2022.08.19.504582 — neuroscience — Posted on 2022-08-22
1244 Analysis of Kinetic of eyelids of little owl Athene noctua
Mahmoud, F.; Shawki, N. A.; Abdel-Mageed, A. M.; Al-Nefeiy, F.
10.1101/2022.08.20.504636 — zoology — Posted on 2022-08-22
1245 scPerturb: Information Resource for Harmonized Single-Cell Perturbation Data
Peidli, S.; Green, T. D.; Shen, C.; Gross, T.; Min, J.; Taylor-King, J.; Marks, D.; Luna, A.; Bluthgen, N.; Sander, C.
10.1101/2022.08.20.504663 — systems biology — Posted on 2022-08-22
1246 Increasing the sensitivity, recovery, and integrality of spatially resolved proteomics by LCM-MTA
Gu, L.; Li, X. M.; Li, Z. Y.; Wang, Q. Q.; Zheng, K.; Yu, G. Y.; Dai, C. Q.; Li, J. Q.; Zhao, B. P.; Zhang, H. P.; He, Q. Z.; Zhang, W.; Li, C.; Wang, H.
10.1101/2022.08.21.504675 — systems biology — Posted on 2022-08-22
1247 PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma
Yan, S.; Peng, B.; Kan, S.; Shao, G.; Xiahou, Z.; Tang, X.; Chen, Y.-x.; Dong, M.-Q.; Liu, X.; Xu, X.; Li, J.
10.1101/2022.08.21.504716 — cancer biology — Posted on 2022-08-22
1249 Genomic and transcriptional profiling stratifies VQ myeloma lines into two clusters with distinct risk signatures and drug responses
Flietner, E.; Yu, M.; Rajagopalan, A.; Zhou, Y.; Feng, Y.; Veltri, A.; Lasho, T.; Wen, Z.; Sun, Y.; Patnaik, M. M.; Callander, N. S.; Asimakopoulos, F.; Wang, D.; Zhang, J.
10.1101/2022.08.21.504657 — cancer biology — Posted on 2022-08-22
1251 Extending and improving metagenomic taxonomic profiling with uncharacterized species with MetaPhlAn 4
Blanco-Miguez, A.; Beghini, F.; Cumbo, F.; McIver, L. J.; Thompson, K. N.; Zolfo, M.; Manghi, P.; Dubois, L.; Huang, K. D.; Thomas, A. M.; Piccinno, G.; Piperni, E.; Puncochar, M.; Valles-Colomer, M.; Tett, A.; Giordano, F.; Davies, R.; Wolf, J.; Berry, S. E.; Spector, T. D.; Franzosa, E. A.; Pasolli, E.; Asnicar, F.; Huttenhower, C.; Segata, N.
10.1101/2022.08.22.504593 — bioinformatics — Posted on 2022-08-22
1253 Long-term effect of forest harvesting on boreal species assemblages under climate change
Bouderbala, I.; Labadie, G.; Beland, J.-M.; Tremblay, J. A.; Boulanger, Y.; Hebert, C.; Desrosiers, P.; Allard, A.; Fortin, D.
10.1101/2022.08.21.504664 — ecology — Posted on 2022-08-22
1255 The Ecosystem Integrity Index: a novel measure of terrestrial ecosystem integrity with global coverage
Hill, S. L. L.; Fajardo, J.; Maney, C.; Harfoot, M.; Harrison, M.; Guaras, D.; Jones, M.; Oliva, M. J.; Danks, F.; Hughes, J.; Burgess, N. D.
10.1101/2022.08.21.504707 — ecology — Posted on 2022-08-22
1257 Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse
Ribeiro, T. A.; Breznik, J. A.; Kennedy, K. M.; Yeo, E.; Kennelly, B. K. E.; Jazwiec, P. A.; Patterson, V. S.; Bellissimo, C. J.; Anhe, F. F.; Schertzer, J. D.; Bowdish, D. M. E.; Sloboda, D. M.
10.1101/2022.08.20.504644 — developmental biology — Posted on 2022-08-22
1258 Differentiation of human induced pluripotent stem cells into cortical neural stem cells
Neaverson, A.; Andersson, M. H. L.; Arshad, O. A.; Foulser, L.; Goodwin-Trotman, M.; Hunter, A.; Newman, B.; Patel, M.; Roth, C.; Thwaites, T.; Kilpinen, H.; Hurles, M. E.; Day, A.; Gerety, S. S.
10.1101/2022.08.19.504404 — developmental biology — Posted on 2022-08-22
1262 Visual projection neuron convergence and compensation in developing sensorimotor circuits in the Drosophila optic glomeruli
McFarland, B. W.; Jang, H.; Smolin, N.; Godenschwege, T. A.; Nern, A.; Kurmangaliyev, Y. Z.; von Reyn, C. R.
10.1101/2022.08.20.504653 — neuroscience — Posted on 2022-08-22
1263 Robin's Viewer: Using Deep-Learning Predictions to Assist EEG Annotation
Weiler, R.; Diachenko, M.; Juarez-Martinez, E.; Avramiea, A.-E.; Bloem, P.; Linkenkaer-Hansen, K.
10.1101/2022.08.07.503090 — neuroscience — Posted on 2022-08-22
1265 Coordinated Head Direction Representations in Mouse Anterodorsal Thalamic Nucleus and Retrosplenial Cortex
van der Goes, M.-S. H.; Voigts, J.; Newman, J. P.; Toloza, E. H. S.; Brown, N. J.; Murugan, P.; Harnett, M. T.
10.1101/2022.08.20.504604 — neuroscience — Posted on 2022-08-22
1266 Cortical Betz cells analogue in songbirds utilizes Kv3.1 to generate ultranarrow spikes
Zemel, B.; Nevue, A.; Tavares, L. E. S.; Dadostin, A.; Lovell, P.; Jin, D. Z.; Mello, C.; von Gersdorff, H.
10.1101/2022.08.22.504741 — neuroscience — Posted on 2022-08-22
1269 Natriuretic peptides protect against apoptosis and increase cGMP around cardiomyocyte mitochondria
Calamera, G.; Ndongson-Dongmo, B.; Arunthavarajah, D.; Ovesen, M.; Kim, C.; Levy, F. O.; Andressen, K. W.; Moltzau, L. R.
10.1101/2022.08.22.504735 — pharmacology and toxicology — Posted on 2022-08-22
1276 Microneurography as a Minimally Invasive Method to Assess Target Engagement During Neuromodulation
Verma, N.; Knudsen, B.; Gholston, A.; Skubal, A.; Settell, M.; Trevathan, J.; Blanz, S.; Frank, J.; Ludwig, K.
10.1101/2022.08.19.504592 — bioengineering — Posted on 2022-08-22
1277 Mechanistic Insight into AP-Endonuclease 1 Cleavage of Abasic Sites at Stalled Replication Forks
Hoitsma, N. M.; Norris, J.; Khoang, T.; Kaushik, V.; Antony, E.; Hedglin, M.; Freudenthal, B.
10.1101/2022.08.22.504733 — biochemistry — Posted on 2022-08-22
1282 Seasonal polyphenism underlies the origin of a sterile caste in aphids
Uematsu, K.; Kutsukake, M.; Yang, M.-M.; Shigenobu, S.; Shibao, H.; Fukatsu, T.
10.1101/2022.08.19.501651 — evolutionary biology — Posted on 2022-08-22
1283 Herbarium records provide reliable phenology estimates in the understudied tropics
Park, D. S.; Lyra, G. M.; Ellison, A. M.; Maruyama, R.; Torquato, D.; Asprino, R. C.; Cook, B.; Davis, C. C.
10.1101/2022.08.19.504574 — ecology — Posted on 2022-08-22
1285 Host-directed therapy with 2-Deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2
Wali, L.; Karbiener, M.; Chou, S.; Kovtunyk, V.; Adonyi, A.; Goesler, I.; Contreras, X.; Stoeva, D.; Blaas, D.; Stoeckl, J.; Kreil, T. R.; Gualdoni, G. A.; Gorki, A.-D.
10.1101/2022.05.24.493068 — microbiology — Posted on 2022-08-22
1286 Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors
Wu, X.; Manske, M. K.; Ruan, G.; Witter, T. L.; Nowakowski, K. E.; Abeykoon, J. P.; Tang, X.; Yu, Y.; Gwin, K. A.; Wu, A.; Taupin, V.; Bhardwaj, V.; Paludo, J.; Dasari, S.; Dong, H.; Ansell, S. M.; Badley, A. D.; Schellenberg, M.; Witzig, T. E.
10.1101/2021.12.02.470978 — immunology — Posted on 2022-08-22
1287 Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Park, Y.-J.; Pinto, D.; Walls, A. C.; Liu, Z.; De Marco, A.; Benigni, F.; Zatta, F.; Silacci-Fregni, C.; Bassi, J.; Sprouse, K. R.; Addetia, A.; Bowen, J. E.; Stewart, C.; Giurdanella, M.; Saliba, C.; Guarino, B.; Schmid, M.; Franko, N.; Logue, J.; Dang, H. V.; di Iulio, J.; Rivera, W.; Schnell, G.; Rajesh, A.; Zhou, J.; Farhat, N.; Kaiser, H.; Montiel-Ruiz, M.; Noack, J.; Lempp, F.; Janer, J.; Abdelnabi, R.; Maes, P.; Ferrari, P.; Ceschi, A.; Giannini, O.; de Melo, G.; Kergoat, L.; Bourhy, H.; Neyts, J.; Soriagha, L.; Purcell, L.; Snell, G.; Whelan, S.; Lanzavecchia, A.; Virgin, H.; Piccoli,
10.1101/2022.05.08.491108 — immunology — Posted on 2022-08-22
1290 Sex-dependent role of hypocretin/orexin neurons in social behavior
Dawson, M.; Terstege, D. J.; Jamani, N.; Pavlov, D.; Tsutsui, M.; Bugescu, R.; Epp, J. R.; Leinninger, G. M.; Sargin, D.
10.1101/2022.08.19.504565 — neuroscience — Posted on 2022-08-22
1295 SODAR: enabling, modeling, and managing multi-omics integration studies
Nieminen, M.; Stolpe, O.; Kuhring, M.; Weiner, J.; Pett, P.; Beule, D.; Holtgrewe, M.
10.1101/2022.08.19.504516 — bioinformatics — Posted on 2022-08-22
1296 Annotation of biologically relevant ligands in UniProtKB using ChEBI
Coudert, E.; Gehant, S.; de Castro, E.; Pozzato, M.; Baratin, D.; Neto, T.; Sigrist, C. J. A.; Redaschi, N.; Bridge, A. J.; The UniProt Consortium,
10.1101/2022.08.19.504519 — bioinformatics — Posted on 2022-08-22
1297 Development of a multi-sensor integrated midbrain organoid-on-a-chip platform for studying Parkinson's disease
Spitz, S.; Bolognin, S.; Brandauer, K.; Fuessl, J.; Schuller, P.; Schobesberger, S.; Jordan, C.; Schaedl, B.; Grillari, J.; Wanzenboeck, H. D.; Mayr, T.; Harasek, M.; Schwamborn, J. C.; Ertl, P.
10.1101/2022.08.19.504522 — bioengineering — Posted on 2022-08-22
1298 Prosocial behavior in adult mice is sex-dependent
Misiolek, K.; Klimczak, M.; Chroszcz, M.; Szumiec, L.; Bryksa, A.; Przyborowicz, K.; Rodriguez Parkitna, J.; Harda, Z.
10.1101/2022.08.19.504492 — animal behavior and cognition — Posted on 2022-08-22
1299 Deciphering the Evolutionary History of Complex Rearrangements in Head and Neck Cancer Patients Using Multi-Omic Approach
Chae, J.; Lee, J. S.; Park, J.; Lee, D.-S.; Park, W. S.; Clock, B.; Dixon, J.; Jung, Y.-S.; Hong, D.
10.1101/2022.08.19.504509 — genomics — Posted on 2022-08-22
1303 Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.
Alfaro-Vargas, P.; Bastos-Salas, A.; Munoz-Arrieta, R.; Pereira-Reyes, R.; Redondo-Solano, M.; Fernandez, J.; Mora-Villalobos, A.; Lopez-Gomez, J. P.
10.1101/2022.08.20.504666 — microbiology — Posted on 2022-08-22
1307 The Image Data Explorer: interactive exploration of image-derived data
Muller, C.; Serrano-Solano, B.; Sun, Y.; Tischer, C.; Heriche, J.-K.
10.1101/2022.04.27.489647 — cell biology — Posted on 2022-08-22
1308 Temporal regulation of ZBTB16 expression by glucocorticoids alters human cortical neurogenesis
Krontira, A. C.; Cruceanu, C.; Kyrousi, C.; Dony, L.; Link, M. H.; Kappelmann, N.; Poehlchen, D.; Roeh, S.; Sportelli, V.; Woelfel, B.; Koedel, M.; Sauer, S.; Rex-Haffner, M.; Labeur, M.; Cappello, S.; Binder, E. B.
10.1101/2022.08.21.504700 — neuroscience — Posted on 2022-08-22
1309 Texture Coding In Higher Order Somatosensory Cortices
Long, K. H.; Greenspon, C. M.; van Driesche, A.; Lieber, J. D.; Bensmaia, S. J.
10.1101/2022.08.19.504511 — neuroscience — Posted on 2022-08-22
1313 Spatial compartmentalization of signalling imparts source-specific functions on secreted factors
Rossi, F. M.; Groppa, E.; Martini, P.; Derakhshan, N.; Theret, M.; Ritso, M.; Tung, L. W.; Wang, Y. X.; Soliman, H.; Hamer, M. S.; Stankiewicz, L.; Eisner, C.; Le Neve, E.; Chang, C.; Yi, L.; Yuan, J.; Kong, S.; Weng, C.; Adams, J.; Chang, L.; Peng, A.; Blau, H. M.; Romualdi, C.
10.1101/2022.08.20.504649 — cell biology — Posted on 2022-08-21
1319 Resistance of Musa balbisiana accessions of the Philippines to banana bunchy top virus
Perez, N. A. M.; Dela Cueva, F. M.; Benjamin, A. F. A.; Yanos, L. A.; Gueco, L. S.; Thomas, J. E.
10.1101/2022.08.20.504392 — pathology — Posted on 2022-08-21
1324 Assessment of AI-based Protein Structure Prediction for the NLRP3 Target
Yin, J.; Lei, J.; Yu, J.; Cui, W.; Zhou, Y.; Feng, H.; Deng, J.; Su, W.; Kuai, L.
10.1101/2021.11.05.467381 — biochemistry — Posted on 2022-08-21
1327 Weak parent-of-origin expression bias: is this imprinting?
Edwards, C. A.; Watkisnon, W. M. D.; Telerman, S. B.; Hulsmann, L. C.; Hamilton, R. S.; Ferguson-Smith, A. C.
10.1101/2022.08.21.504536 — genomics — Posted on 2022-08-21
1328 Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
Gomez, G. A.; Rundle, C.; Xing, W.; Kesavan, C.; Pourteymoor, S.; Lewis, R. E.; Powell, D. R.; Mohan, S.
10.1101/2022.08.21.504689 — genetics — Posted on 2022-08-21
1332 Universal gut microbial relationships in the gut microbiome of wild baboons
Roche, K.; Björk, J. R.; Dasari, M.; Grieneisen, L.; Jansen, D.; Gould, T.; Gesquiere, L.; Barreiro, L.; Alberts, S. C.; Blekhman, R.; Gilbert, J.; Tung, J.; Mukherjee, S.; Archie, E. A.
10.1101/2022.08.20.504530 — ecology — Posted on 2022-08-21
1334 Tetraploidy-linked sensitization to CENP-E inhibition in human cells
Yoshizawa, K.; Matsura, A.; Shimada, M.; Ishida-Ishihara, S.; Yamamoto, T.; Yaguchi, K.; Kawamoto, E.; Kuroda, T.; Matsuo, K.; Tamaoki, N.; Sakai, R.; Mishra, M.; Uehara, R.
10.1101/2022.08.21.504625 — cell biology — Posted on 2022-08-21
1335 Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway
Valdes-Torres, P.; Campos, D.; Bhakta, M.; Galan-Jurado, P. E.; Durant-Archibold, A. A.; Gonzalez Santamaria, J.
10.1101/2022.08.20.504652 — microbiology — Posted on 2022-08-21
1336 Defence systems provide synergistic anti-phage activity in E. coli
Wu, Y.; van den Hurk, A.; Aparicio-Maldonado, C.; Kushwaha, S. K.; King, C. M.; Todeschini, T. C.; Clokie, M. R. J.; Millard, A. M.; Gencay, Y. E.; Nobrega, F. L.
10.1101/2022.08.21.504612 — microbiology — Posted on 2022-08-21
1337 Extant hybrids of RNA viruses and viroid-like elements
Forgia, M.; Navarro, B.; Daghino, S.; Cervera, A.; Gisel, A.; Perotto, S.; Aghayeva, D. N.; Akinyuwa, M. F.; Gobbi, E.; Zheludev, I. N.; Edgar, R. C.; Chikhi, R. C.; Turina, M.; Babaian, A.; Di Serio, F.; de la Pena, M.
10.1101/2022.08.21.504695 — microbiology — Posted on 2022-08-21
1339 3D reconstruction of the cerebellar germinal layer reveals intercytoplasmic connections between developing granule cells
Cordero Cervantes, D.; Khare, H.; Wilson, A. M.; Mendoza, N. D.; Coulon--Mahdi, O.; Lichtman, J. W.; Zurzolo, C.
10.1101/2022.08.21.504684 — neuroscience — Posted on 2022-08-21
1340 Engineering Pseudomonas putida KT2440 for chain length tailored free fatty acid and oleochemical production
Valencia, L. E.; Incha, M. R.; Schmidt, M.; Pearson, A. N.; Thompson, M. G.; Roberts, J.; Mehling, M.; Yin, K.; Sun, N.; Oka, A.; Shih, P. M.; Blank, L. M.; Gladden, J.; Keasling, J. D.
10.1101/2022.08.20.504671 — synthetic biology — Posted on 2022-08-21
1342 Dynamic Disulfide Bond Topologies in von-Willebrand-Factor's C4-Domain Undermine Platelet Binding
Kutzki, F.; Butera, D.; Lay, A. J.; Maag, D. M.; Chiu, J.; Woon, H.-G.; Kubar, T.; Elstner, M.; Aponte-Santamaria, C.; Hogg, P.; Graeter, F.
10.1101/2022.08.20.504523 — biophysics — Posted on 2022-08-21
1347 Discovery, Structure, and Function of Filamentous 3-Methylcrotonyl-CoA Carboxylase
Hu, J. J.; Lee, J. K. J.; Liu, Y.-T.; Yu, C.; Huang, L.; Aphasizheva, I.; Aphasizhev, R.; Zhou, Z. H.
10.1101/2022.08.19.504621 — molecular biology — Posted on 2022-08-21
1348 T cell migration requires ion and water influx to regulate actin polymerization
de Boer, L.; Melgrati, S.; Vanes, L.; Biggs O'May, J.; Hayward, D.; Koechl, R.; Tybulewicz, V.
10.1101/2022.03.16.484584 — immunology — Posted on 2022-08-21
1352 Variations in Atlantic water influx and sea-ice cover drive taxonomic and functional shifts in Arctic marine bacterial communities
Priest, T.; von Appen, W.-J.; Oldenburg, E.; Popa, O.; Torres-Valdes, S.; Bienhold, C.; Metfies, K.; Fuchs, B.; Amann, R.; Boetius, A.; Wietz, M.
10.1101/2022.08.12.503524 — microbiology — Posted on 2022-08-21
1354 Reading instruction causes changes in category-selective visual cortex
Yeatman, J. D.; Caffarra, S.; Clark, M.; Ender, S. M.; Gijbels, L.; Joo, S. J.; Kubota, E. C.; Kuhl, P. K.; Larson, E.; McCloy, D. R.; O'Brien, G.; Peterson, E. R.; Takada, M. E.; Taulu, S.
10.1101/2022.02.02.477919 — neuroscience — Posted on 2022-08-21
1358 Effects of global change on animal biodiversity in boreal forest landscape: an assemblage dissimilarity analysis
Bouderbala, I.; Labadie, G.; Beland, J.-M.; Boulanger, Y.; Hebert, C.; Desrosiers, P.; Allard, A.; Fortin, D.
10.1101/2022.01.31.477297 — ecology — Posted on 2022-08-21
1359 A crosstalk between hepcidin and IRE/IRP pathways controls ferroportinexpression and determines serum iron levels in mice
Charlebois, E.; Fillebeen, C.; Katsarou, A.; Rabinovich, A.; Wisniewski, K.; Venkataramani, V.; Michalke, B.; Velentza, A.; Pantopulos, K.
10.1101/2021.10.29.466457 — immunology — Posted on 2022-08-20
1361 Inhibition-Dominated Rich-Club Shapes Dynamics in Cortical Microcircuits
Hafizi, H.; Nigam, S.; Barnathan, J.; Ren, N.; Stevenson, I.; Masmanidis, S. C.; Newman, E. L.; Sporns, O.; Beggs, J.
10.1101/2021.05.07.443074 — neuroscience — Posted on 2022-08-20
1362 A personalizable autonomous neural mass model of epileptic seizures
Lopez-Sola, E.; Sanchez-Todo, R.; Lleal, E.; Köksal-Ersöz, E.; Yochum, M.; Makhalova, J.; Mercadal, B.; Guasch-Morgades, M.; Salvador, R.; Lozano-Soldevilla, D.; Modolo, J.; Bartolomei, F.; Wendling, F.; Benquet, P.; Ruffini, G.
10.1101/2021.12.24.474090 — neuroscience — Posted on 2022-08-20
1363 Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Berthiaume, A.-A.; Schmid, F.; Stamenkovic, S.; Santos, V.; Nielson, C.; Weber, B.; Majesky, M.; Shih, A.
10.1101/2022.04.28.489881 — neuroscience — Posted on 2022-08-21
1364 FAMetA: a mass isotopologue-based tool for the comprehensive analysis of fatty acid metabolism
Alcoriza-Balaguer, M. I.; Garcia-Canaveras, J. C.; Benet, M.; Juan Vidal, O.; Lahoz, A.
10.1101/2022.05.11.491462 — systems biology — Posted on 2022-08-20
1367 Commensal Neisseria species share immune suppressive mechanisms with Neisseria gonorrhoeae
Zhu, W.; Cardenas-Alvarez, M. X.; Tomberg, J.; Little, M.; Duncan, J. A.; Nicholas, R.
10.1101/2022.08.19.504588 — microbiology — Posted on 2022-08-20
1369 Evaluation of KRASG12C Inhibitor Responses in Novel Murine KRASG12C Lung Cancer Cell Line Models
Sisler, D. J.; Hinz, T. K.; Le, A. T.; Kleczko, E. K.; Nemenoff, R. A.; Heasley, L. E.
10.1101/2022.08.19.504555 — cancer biology — Posted on 2022-08-20
1370 H3K36M provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
Ko, E. K.; Anderson, A.; Zou, J.; Huang, S.; Cho, S.; Alawi, F.; Prouty, S.; Lee, V.; Ge, K.; Seykora, J. T.; Capell, B. C.
10.1101/2022.08.19.504575 — cancer biology — Posted on 2022-08-20
1375 The Nematode Oscheius tipulae as A Genetic Model for Programmed DNA Elimination
Dockendorff, T. C.; Estrem, B.; Reed, J.; Simmons, J. R.; Bahrami Zadegan, S.; Zagoskin, M. V.; Terta, V.; Seaberry, E.; Wang, J.
10.1101/2022.08.19.504554 — genetics — Posted on 2022-08-20
1377 Molecular evolution and inheritance pattern of Sox gene family among Bovidae
Akinyemi, M. O.; Adegbaju, M. S.; Grytsay, A.; Osaiyuwu, O. H.; Finucan, J.; Ogunade, I. M.; Peters, S. O.; Thomas, B. N.; Morenikeji, O. B.
10.1101/2022.08.19.504581 — evolutionary biology — Posted on 2022-08-20
1380 Diversity, composition, altitude, and seasonality of high-altitude windborne migrating mosquitoes in the Sahel: Implications for disease transmission
Yaro, A. S.; Linton, Y.-M.; Diallo, M.; Sanogo, Z. L.; Samake, D.; Ousman, Y.; Kouam, C.; Krajacich, B. J.; Faiman, R.; Bamou, R.; Woo, J.; Chapman, J.; Reynolds, D. R.; Lehmann, T.
10.1101/2022.08.19.504620 — ecology — Posted on 2022-08-20
1381 The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left-right asymmetry in the gut by promoting receptor endocytosis
Lai, Y.-T.; Sasamura, T.; Kuroda, J.; Maeda, R.; Nakamura, M.; Hatori, R.; Ishibashi, T.; Taniguchi, K.; Ooike, M.; Taguchi, T.; Nakazawa, N.; Hozumi, S.; Okumura, T.; Aigaki, T.; Inaki, M.; Matsuno, K.
10.1101/2022.08.20.504629 — developmental biology — Posted on 2022-08-20
1382 Discovery, Structure, and Function of Filamentous 3-Methylcrotonyl-CoA Carboxylase
Hu, J. J.; Lee, J. K. J.; Liu, Y.-T.; Yu, C.; Huang, L.; Aphasizheva, I.; Aphasizhev, R.; Zhou, H.
10.1101/2022.08.19.504621 — molecular biology — Posted on 2022-08-20
1384 In vitro and in vivo activity of Gepotidacin against drug-resistant mycobacterial infections
Ahmad, M. N.; Garg, T.; Singh, S.; Shukla, R.; VK, R.; Kaur, P.; Chopra, S.; Dasgupta, A.
10.1101/2022.08.19.504542 — microbiology — Posted on 2022-08-20
1385 A shift in the pathotype diversity and complexity of Phytophthora sojae, causal agent of root and stem rot of soybean, in Brazil
Batista, I. C. A.; Silva, M. P. C.; Silva Junior, A. L.; Arriagada, M. P. G.; Camargo, M. P.; Figueiredo, A.; Hora Junior, B. T.; Mizubuti, E. S. G.
10.1101/2022.08.19.504165 — microbiology — Posted on 2022-08-20
1390 Biochemically validated structural model of the 15-subunit IFT-B complex
Petriman, N. A.; Loureiro-Lopez, M.; Taschner, M.; Zacharia, N. K.; Georgieva, M. M.; Boegholm, N.; Mourao, A.; Russell, R. B.; Andersen, J. S.; Lorentzen, E.
10.1101/2022.08.20.504624 — biochemistry — Posted on 2022-08-20
1392 Emerging fish pathogens Lactococcus petauri and L. garvieae in Nile tilapia (Oreochromis niloticus) farmed in Brazil.
Egger, R. C.; Rosa, J. C. C.; Padua, S. B.; Barbosa, F. O.; Zerbini, M. T.; Tavares, G. C.; Figueiredo, H. C. P.
10.1101/2022.08.19.504548 — microbiology — Posted on 2022-08-20
1394 Cryo-EM structures and binding of mouse ACE2 to SARS-CoV-2 variants of concern
Ni, D.; Turelli, P.; Beckert, B.; Nazarov, S.; Uchikawa, E.; Myasnikov, A.; Pojer, F.; Trono, D.; Stahlberg, H.; Lau, K.
10.1101/2022.08.19.504450 — immunology — Posted on 2022-08-20
1395 Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling
Rubio, K.; Romero, A.; Sarvari, P.; Guenther, S.; Mehta, A.; Bassaly, B.; Braubach, P.; Dobreva, G.; Wygrecka, M.; Gattenloehner, S.; Braun, T.; Tresch, A.; Graumann, J.; Barreto, G.
10.1101/2022.08.16.504078 — cancer biology — Posted on 2022-08-20
1400 Autophagy regulates ARF7 degradation to facilitate root branching
Ebstrup, E.; Ansboel, J.; Chevalier, J.; Clemmens, P.; Rodriguez, E.
10.1101/2022.08.19.504407 — plant biology — Posted on 2022-08-20
1408 Mitigating pseudoreplication and bias in resource selection functions with autocorrelation-informed weighting
Alston, J. M.; Fleming, C. H.; Kays, R.; Streicher, J. P.; Downs, C. T.; Ramesh, T.; Calabrese, J. M.
10.1101/2022.04.21.489059 — ecology — Posted on 2022-08-20
1410 N-myc Downstream Regulated Gene 1 (NDRG1) functions as a molecular switch for cellular adaptation to hypoxia
Park, J. S.; Gabel, A. M.; Kassir, P.; Kang, L.; Chowdhary, P. K.; Osei-Ntansah, A.; Tran, N. D.; Viswanathan, S.; Canales, B.; Ding, P.; Lee, Y.-S.; Brewster, R.
10.1101/2021.09.10.459675 — developmental biology — Posted on 2022-08-20
1412 Gigaxonin is required for intermediate filament transport
Renganathan, B.; Zewe, J. P.; Cheng, Y.; Kittisopikul, M.; Opal, P.; Ridge, K. M.; Gelfand, V. I.
10.1101/2022.08.19.504572 — cell biology — Posted on 2022-08-20
1414 The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou, I. P.; Cunha, P. P.; Minogue, E.; Nicolet, B.; Guislain, A.; Jorgensen, C.; Zandhuis, N. D.; Barbieri, L.; Bargiela, D.; Nathanael, D.; Tyrakis, P.; Palazon, A.; Wolkers, M.; Johnson, R. S.
10.1101/2022.08.18.504372 — immunology — Posted on 2022-08-20
1418 An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer
Noguchi, Y.; Suzuki, T.; Matsutani, K.; Sakakibara, R.; Nakahigashi, R.; Adachi, M.; Nishikawa, T.; Abe, H.
10.1101/2021.09.12.459881 — zoology — Posted on 2022-08-20
1419 FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice
Calubag, M. F.; Ademi, I.; Yeh, C.-Y.; Babygirija, R.; Bhoopat, A. M.; Sonsalla, M. M.; Green, C. L.; Pak, H. H.; Lamming, D.
10.1101/2022.07.29.501882 — physiology — Posted on 2022-08-20
1420 Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
Gil Vazquez, E.; Nasreddin, N.; Valbuena, G. N.; Mulholland, E. J.; Belnoue-Davis, H. L.; Eggington, H.; Schenck, R. O.; Wouters, V. M.; Wirapati, P.; Gilroy, K.; Lannagan, T. R. M.; Flanagan, D. J.; Najumudeen, A. K.; Omwenga, S.; McCorry, A. M. B.; Easton, A.; Koelzer, V. H.; East, J. E.; Morton, D.; Trusolino, L.; Maughan, T.; Campbell, A. D.; Loughrey, M. B.; Dunne, P. D.; Tsantoulis, P.; Huels, D. J.; Tejpar, S.; Sansom, O.; Leedham, S. J.
10.1101/2022.06.11.495729 — cancer biology — Posted on 2022-08-20
1421 A spatial map of human macrophage niches links tissue location with function
Matusiak, M.; Hickey, J. W.; Luca, B.; Lu, G.; Kidzinski, L.; Shu, S.; Colburg, D. R. C.; Phillips, D. J.; Brubaker, S. W.; Charville, G. W.; Shen, J.; Nolan, G. P.; Newman, A. M.; West, R. B.; van de Rijn, M.
10.1101/2022.08.18.504434 — cancer biology — Posted on 2022-08-20
1422 GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Cordova, R.; Misra, J.; Amin, P. H.; Klunk, A. J.; Damayanti, N. P.; Carlson, K. R.; Elmendorf, A. J.; Hyeong-Geug, K.; Mirek, E. T.; Elzey, B. D.; Miller, M. J.; Dong, X. C.; Cheng, L.; Anthony, T. G.; Pili, R.; Wek, R. C.; Staschke, K. A.
10.1101/2022.06.17.496598 — cancer biology — Posted on 2022-08-20
1424 Mapping the landscape of genetic dependencies in chordoma
Sharifnia, T.; Wawer, M. J.; Goodale, A.; Lee, Y.; Kazachkova, M.; Dempster, J. M.; Muller, S.; Levy, J.; Freed, D. M.; Sommer, J.; Kalfon, J.; Vazquez, F.; Hahn, W. C.; Root, D. E.; Clemons, P. A.; Schreiber, S. L.
10.1101/2022.08.17.504193 — cancer biology — Posted on 2022-08-20
1430 The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats
Munro, D.; Wang, T.; Chitre, A. S.; Polesskaya, O.; Ehsan, N.; Gao, J.; Chen, H.; Gusev, A.; Solberg Woods, L. C.; Saba, L. M.; Palmer, A. A.; Mohammadi, P.
10.1101/2022.04.07.487560 — genetics — Posted on 2022-08-20
1431 Modelling the spatiotemporal spread of beneficial alleles using ancient genomes
Muktupavela, R. A.; Petr, M.; Segurel, L.; Korneliussen, T. S.; Novembre, J.; Racimo, F.
10.1101/2021.07.21.453231 — evolutionary biology — Posted on 2022-08-20
1432 Autophagy is associated with survival and resiliency of fibroblasts in long-term decaying post-mortem parenchymal tissue
McAndrews, K.; McGrail, D. J.; Gansmo, L. B.; Che, S. P. Y.; Chakravarti, D.; LeBleu, V.; Kalluri, R.
10.1101/2022.08.18.504466 — cell biology — Posted on 2022-08-20
1435 Dynamic Phosphorylation Regulates Eukaryotic Translation Initiation Factor 4A Activity During the Cell Cycle
Sahoo, A.; Zollo, R. A.; Shen, S.; Ashraf, M.; Nelson, S.; Koudelka, G. B.; Qu, J.; Barbi, J.; Walker, S. E.
10.1101/2022.08.14.503931 — molecular biology — Posted on 2022-08-20
1437 Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti
Saucereau, Y.; Wilson, T. H.; Tang, M. C. , K.; Moncrieffe, M. C.; Hardwick, S. W.; Chirgadze, D. Y.; Soares, S. G.; Marcaida, M. J.; Gay, N. J.; Gangloff, M.
10.1101/2021.09.06.459066 — immunology — Posted on 2022-08-20
1438 Metabolic activity organizes olfactory representations
Qian, W. W.; Wei, J. N.; Sanchez-Lengeling, B.; Lee, B. K.; Luo, Y.; Vlot, M.; Dechering, K.; Peng, J.; Gerkin, R. C.; Wiltschko, A. B.
10.1101/2022.07.21.500995 — neuroscience — Posted on 2022-08-20
1443 Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import.
Nashed, S.; El Barbry, H.; Benchouaia, M.; Dijoux-Marechal, A.; Ruiz Gutierrez, N.; Gaulier, L.; Chevreux, G.; Le Crom, S.; Palancade, B.; Devaux, F.; Laine, E.; Garcia, M.
10.1101/2022.08.19.504527 — genomics — Posted on 2022-08-19
1448 Perpendicular Shear Stresses Drive Transmural Helical Remodeling in Engineered Human Ventricular Models
Williams, N. P.; Beussman, K. M.; Foster, J. R.; Rhodehamel, M.; Williams, C. A.; Tsui, J. H.; Smith, A. S. T.; Mack, D. L.; Murry, C. E.; Sniadecki, N. J.; Kim, D.-H.
10.1101/2022.08.18.504345 — bioengineering — Posted on 2022-08-19
1449 Developmental rules of primate dental evolution align microevolution with macroevolution
Machado, F. A.; Mongle, C. S.; Slater, G.; Penna, A.; Wisniewski, A.; Soffin, A.; Dutra, V.; Uyeda, J. C.
10.1101/2022.08.19.504140 — evolutionary biology — Posted on 2022-08-19
1450 MDC1 counteracts restrained replication fork restart and its loss causes chemoresistance in BRCA1/2-deficient mammary tumors
Liptay, M.; Barbosa, J. S.; Gogola, E.; Duarte, A. A.; Dibitetto, D.; Schmid, J. A.; Klebic, I.; Mutlu, M.; Siffert, M.; Francica, P.; Salguero, I.; Ven, M. v. d.; Korte-Grimmerink, R. d.; Jackson, S. P.; Jonkers, J.; Lopes, M.; Rottenberg, S.
10.1101/2022.08.18.504391 — molecular biology — Posted on 2022-08-19
1452 The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
Bauer, L.; Rijsbergen, L.; Leijten, L.; Benavides, F. F. W.; Noack, D.; Lamers, M. M.; Haagmans, B. L.; de Vries, R. D.; de Swart, R. L.; van Riel, D.
10.1101/2022.08.19.504520 — microbiology — Posted on 2022-08-19
1455 Evolution of giant pandoravirus from small icosahedral viruses revealed by CRISPR/Cas9
Bisio, H.; Legendre, M.; Giry, C.; Philippe, N.; Alempic, J.-M.; Jeudy, S.; Abergel, C.
10.1101/2022.08.18.504477 — microbiology — Posted on 2022-08-19
1456 Group A Streptococcus antibiotic tolerance in necrotizing fasciitis
Keller, N.; Boumasmoud, M.; Andreoni, F.; Tarnutzer, A.; von Matt, M.; Scheier, T. C.; Gomez-Mejia, A.; Huemer, M.; Marques-Maggio, E.; Schuepbach, R. A.; Mairpady-Shambat, S.; Brugger, S. D.; Zinkernagel, A. S.
10.1101/2022.08.19.504414 — microbiology — Posted on 2022-08-19
1457 Immunopeptidomics-based design of highly effective mRNA vaccine formulations against Listeria monocytogenes
Mayer, R. L.; Verbeke, R.; Asselman, C.; Aernout, I.; Gul, A.; Eggermont, D.; Boucher, K.; Thery, F.; Maia, T. M.; Demol, H.; Gabriels, R.; Martens, L.; Becavin, C.; De Smedt, S.; Vandekerckhove, B.; Lentacker, I.; Impens, F.
10.1101/2022.08.19.504521 — immunology — Posted on 2022-08-19
1458 β1-adrenergic receptor on pyramidal neurons of mPFC regulates METH-preferred behaviors in METH-sired male mice
Zheng, Y.; Li, Z.; Wen, J.; Chen, W.; Guo, H.; Cheng, Z.; Hu, T.; Zhang, Y.; Zhao, Z.; Cai, Q.; Ge, F.; Fan, Y.; Liu, D.; Guan, X.
10.1101/2022.08.19.504512 — neuroscience — Posted on 2022-08-19
1460 Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment
Chiorazzi, M.; Martinek, J.; Krasnick, B.; Zheng, Y.; Robbins, K. J.; Qu, R.; Kaufmann, G.; Skidmore, Z.; Henze, L. A.; Brosecke, F.; Adonyi, A.; Zhao, J.; Shan, L.; Sefik, E.; Mudd, J.; Bi, Y.; Goedegebuure, S. P.; Griffith, M.; Griffith, O.; Oyedeji, A.; Fertuzinhos, S.; Garcia-Milian, R.; Boffa, D.; Detterbeck, F.; Dhanasopon, A.; Blasberg, J.; Judson, B.; Gettinger, S.; Politi, K.; Kluger, Y.; Palucka, A. K.; Fields, R.; Flavell, R. A.
10.1101/2022.08.19.503502 — cancer biology — Posted on 2022-08-19
1461 The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition
Subbalakshmi, A. R.; Sahoo, S.; Manjunatha, P.; Goyal, S.; Kasiviswanathan, V. A.; M, Y.; R, S.; McMullen, I.; Somarelli, J.; Jolly, M. K.
10.1101/2022.08.19.504435 — cancer biology — Posted on 2022-08-19
1463 SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks
Bravo Gonzalez-Blas, C.; De Winter, S.; Hulselmans, G.; Hecker, N.; Matetovici, I.; Christiaens, V.; Poovathingal, S.; Wouters, J.; Aibar, S.; Aerts, S.
10.1101/2022.08.19.504505 — bioinformatics — Posted on 2022-08-19
1464 The CD103-XCR1 axis mediates the recruitment of immunoregulatory dendritic cells after traumatic injury
Lokwani, R.; Ngo, T. B.; DeStefano, S.; Adusei, K. M.; Bhuiyan, M.; Josyula, A.; Faust, M.; Lin, A.; Karkanitsa, M.; Fathi, P.; Sadtler, K.
10.1101/2022.08.19.504399 — bioengineering — Posted on 2022-08-19
1465 Structural analyses of the plant PRT6-UBR box in the Cys-Arg/N-degron pathway and insights into the plant submergence response
Kim, L.; Lin, C.-C.; Lin, T.-J.; Cao, Y.-C.; Chen, M.-C.; Chou, M.-Y.; Lin, W.-H.; Kim, M.; Wu, J.-L.; Shih, M.-C.; Song, H. K.; Ho, M.-C.
10.1101/2022.08.19.504472 — biochemistry — Posted on 2022-08-19
1467 SARS-CoV-2 Airway Infection Results in Time-dependent Sensory Abnormalities in a Hamster Model
Serafini, R. A.; Frere, J. J.; Zimering, J.; Giosan, I. M.; Pryce, K. D.; Golynker, I.; Panis, M.; Ruiz, A.; tenOever, B.; Zachariou, V.
10.1101/2022.08.19.504551 — neuroscience — Posted on 2022-08-19
1469 Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women
Aziz, N. H. A.; Salker, M. S.; Lankapalli, A. K.; Shafiee, M. N.; Kocak, E.; Shekhar, S. P.; Khalid, O.; Kasim, N. M.; Kalok, A.; Fuad, N. A.; Ossowski, S.; Casadei, N.; Deutsche COVID-19 OMICS Initiative (DeCOI), ; Brucker, S. Y.; Riess, O.; Singh, Y.
10.1101/2022.08.18.504053 — immunology — Posted on 2022-08-19
1471 The impact of alpha-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells
hourfar, h.; Aliakbari, F.; Rahimi Aqdam, S.; Nayeri, Z.; Bardania, H. B.; Otzen, D. E.; Morshedi, D.
10.1101/2022.08.18.504449 — neuroscience — Posted on 2022-08-19
1473 Genetically encoded sensors for measuring histamine release both in vitro and in vivo
Dong, H.; Li, M.; Yan, Y.; Qian, T.; Lin, Y.; Ma, X.; Vischer, H. F.; Liu, C.; Li, G.; Wang, H.; Leurs, R.; Li, Y.
10.1101/2022.08.19.504485 — neuroscience — Posted on 2022-08-19
1475 Acquisition and processing methods of whole-brain layer-fMRI VASO and BOLD: The Kenshu dataset.
Koiso, K.; Mueller, A. K.; Akamatsu, K.; Dresbach, S.; Wiggins, C. J.; Gulban, O. F.; Goebel, R.; Miyawaki, Y.; Poser, B.; Huber, L.
10.1101/2022.08.19.504502 — neuroscience — Posted on 2022-08-19
1476 First Record of Aedes (Stegomyia) albopictus (Diptera: Culicidae) in the state of Acre, Brazil
Rocha, R.; Cardoso, A.; de Souza, J.; Pereira, E.; de Amorim, M.; Souza, M. S.; Medeiros, C.; Monteiro, M. F.; Meneguetti, D.; de Paula, M.; Brilhante, A.; Camara, T. L.
10.1101/2022.08.18.504440 — zoology — Posted on 2022-08-19
1477 Survival of mineral-bound peptides into the Miocene
Demarchi, B.; Mackie, M.; Li, Z.; Deng, T.; Collins, M. J.; Clarke, J.
10.1101/2022.08.19.502663 — paleontology — Posted on 2022-08-19
1482 A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets
Creason, A. L.; Watson, C.; Gu, Q.; Persson, D.; Sargent, L. L.; Chen, Y.-A.; Lin, J.-R.; Sivagnanam, S.; Wünnemann, F.; Nirmal, A. J.; Chin, K.; Feiler, H. S.; Coussens, L. M.; Schapiro, D.; Grüning, B. A.; Sorger, P. K.; Sokolov, A.; Goecks, J.
10.1101/2022.08.18.504436 — bioinformatics — Posted on 2022-08-19
1483 CausalCell: applying causal discovery to single-cell analyses
Wen, Y.; Huang, J.; Zhang, H.; Guo, S.; Elyahu, Y.; Monsonego, A.; Ding, Y.; ZHU, H.
10.1101/2022.08.19.504494 — bioinformatics — Posted on 2022-08-19
1484 Implications of taxonomic bias for microbial differential-abundance analysis
McLaren, M. R.; Nearing, J. T.; Willis, A. D.; Lloyd, K. G.; Callahan, B. J.
10.1101/2022.08.19.504330 — bioinformatics — Posted on 2022-08-19
1486 Computational investigation of IP3 diffusion
Ornelas Guevara, R.; Gil, D.; Voorsluijs, V.; Dupont, G.
10.1101/2022.08.19.504488 — biochemistry — Posted on 2022-08-19
1489 NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naive pluripotent stem cells
Maskalenka, K.; Alagoz, G.; Krueger, F.; Wright, J.; Rostovskaya, M.; Nakhuda, A.; Bendall, A.; Krueger, C.; Walker, S.; Scally, A.; Rugg-Gunn, P.
10.1101/2022.08.18.504441 — developmental biology — Posted on 2022-08-19
1494 Cell-associated Transcriptional Alterations in the Retinal of Alzheimer's Disease
Ngolab, J.; Mark, A.; Buchanan, J.; Korouri, S.; Preissl, S.; Rosenthal, S. B.; Wang, A.; Fisch, K. M.; Rissman, R. A.
10.1101/2022.08.18.502974 — neuroscience — Posted on 2022-08-19
1495 Egocentric value maps of the near-body environment
Bufacchi, R. J.; Somervail, R.; Fitzpatrick, A. M.; Caminiti, R.; Iannetti, G. D.
10.1101/2022.08.18.504456 — neuroscience — Posted on 2022-08-19
1502 Genome-wide DNA methylation profiles in smoking discordant and concordant monozygotic twin pairs
van Dongen, J.; Willemsen, G.; BIOS Consortium, ; de Geus, E. J. C.; Boomsma, D. I.; Neale, M. C.
10.1101/2022.08.17.504357 — genomics — Posted on 2022-08-19
1504 Disentangling the effects of eutrophication and natural variability on macrobenthic communities across French coastal lagoons
Jones, A. G.; Schaal, G.; Boye, A.; Creemers, M.; Derolez, V.; Desroy, N.; Fiandrino, A.; Mouton, T. L.; Simier, M.; Smith, N.; Ouisse, V.
10.1101/2022.08.18.504439 — ecology — Posted on 2022-08-19
1512 Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape
Witte, L.; Baharani, V.; Schmidt, F.; Wang, Z.; Cho, A.; Raspe, R.; Guzman-Cardozo, M. C.; Muecksch, F.; Gaebler, C.; Caskey, M.; Nussenzweig, M. C.; Hatziioannou, T.; Bieniasz, P. D.
10.1101/2022.08.17.504313 — microbiology — Posted on 2022-08-19
1516 Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo
Graf, J.; Rahmati, V.; Majoros, M.; Witte, O. W.; Geis, C.; Kiebel, S. J.; Holthoff, K.; Kirmse, K.
10.1101/2021.05.28.446133 — neuroscience — Posted on 2022-08-19
1517 A spatial map of human macrophage niches links tissue location with function
Matusiak, M.; Hickey, J. W.; Luca, B.; Lu, G.; Kidzinski, L.; Shu, S.; Colburg, D. R. C.; Phillips, D. J.; Brubaker, S. W.; Charville, G. W.; Shen, J.; Nolan, G. P.; Newman, A. M.; West, R. B.; van de Rijn, M.
10.1101/2022.08.18.504434 — cancer biology — Posted on 2022-08-19
1518 DNA capture and loop extrusion dynamics by cohesin-NIPBL
Kaur, P.; Shi, z.; Lu, X.; Zhang, H.; Finkelstein, I. J.; Tao, Y. J.; Yu, H.; Wang, H.
10.1101/2022.08.18.504320 — biophysics — Posted on 2022-08-19
1519 Androgen receptor condensates as drug targets
Basu, S.; Martinez-Cristobal, P.; Pesarrodona, M.; Frigole-Vivas, M.; Szulc, E.; Lewis, M.; Banuelos, A.; Sanchez-Zarzalejo, C.; Bielskute, S.; Zhu, J.; Garcia-Cabau, C.; Batlle, C.; Mateos, B.; Biesaga, M.; Escobedo, A.; Bardia, L.; Verdaguer, X.; Ruffoni, A.; Mawji, N. R.; Wang, J.; Tam, T.; Brun-Heath, I.; Ventura, S.; Meierhofer, D.; Garcia, J.; Robustelli, P.; Stracker, T. H.; Sadar, M. D.; Riera, A.; Hnisz, D.; Salvatella, X.
10.1101/2022.08.18.504385 — biochemistry — Posted on 2022-08-19
1520 Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM
Saotome, K.; Dudgeon, D.; Colotti, K.; Moore, M. J.; Jones, J.; Zhou, Y.; Rafique, A.; Yancopoulos, G. D.; Murphy, A. J.; Lin, J. C.; Olson, W. C.; Franklin, M. C.
10.1101/2022.08.18.504455 — biochemistry — Posted on 2022-08-19
1521 zDHHC5 expression is increased in cardiac hypertrophy and reduced in heart failure but this does not correlate with changes in substrate palmitoylation
Main, A.; Boguslavskyi, A.; Howie, J.; Kuo, C.-w. S.; Rankin, A.; Burton, F. L.; Smith, G. L.; Hajjar, R.; Baillie, G. S.; Campbell, K. S.; Shattock, M. J.; Fuller, W.
10.1101/2022.08.19.504400 — biochemistry — Posted on 2022-08-19
1523 Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
Muthaiyan Shanmugam, M.; Chaudhuri, J.; Sellegounder, D.; Sahu, A. K.; Guha, S.; Chamoli, M.; Hodge, B.; Roberts, C.; Lithgow, G.; Sarpong, R.; Kapahi, P.
10.1101/2022.08.18.504374 — genetics — Posted on 2022-08-19
1525 Habitat suitability modeling of Himalayan Monal and Koklass Pheasant in Western Himalayas and Hindukush, Pakistan
Nadeem, M. S.; Jameel, M. A.; Kabir, M. S.; Mahmood, T. S.; Akrim, F.; Aslam, S. S.; Awan, M. N.; Khan, M. F.; Anjum, M. Z.; Khan, M. A.
10.1101/2022.08.17.504340 — ecology — Posted on 2022-08-19
1526 Myosin-X recruits lamellipodin to filopodia tips
Miihkinen, M.; Popovic, A.; Ghimire, S.; Saup, R.; Grönloh, M.; Ball, N.; Goult, B. T.; Ivaska, J.; Jacquemet, G.
10.1101/2022.08.17.504298 — cell biology — Posted on 2022-08-19
1530 Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging
Zhao, X.; Yan, X.; Contrepois, K.; Vallania, F.; Ellenberger, M.; Kashiwagi, C. M.; Gagnon, S. D.; Siebrand, C. J.; Cabruja, M.; Traber, G. M.; McKay, A.; Hornburg, D.; Khatri, P.; Snyder, M. P.; Zare, R. N.; Brunet, A.
10.1101/2022.08.18.503095 — molecular biology — Posted on 2022-08-19
1531 Formation of sulfoquinovosyl diacylglycerol by acylation of sulfoquinovosyl glycerol
Cuevas-Rivas, J. Y.; Rodriguez-Terrones, D.; Gonzalez-Silva, N.; Moreno-Ocampo, A.; Guerrero, G.; Bergstrom, E.; Thomas-Oates, J. E.; Geiger, O.; Lopez-Lara, I. M.
10.1101/2022.08.18.504050 — microbiology — Posted on 2022-08-19
1532 Attention Deficit Hyperactivity Disorder and the gut microbiome: An ecological perspective
Cickovski, T.; Mathee, K.; Aguirre, G.; Tatke, G.; Hermaida, A.; Narasimhan, G.; Stollstorff, M.
10.1101/2022.08.17.504352 — microbiology — Posted on 2022-08-19
1536 A human RNA ligase that operates via auto- and RNA-AMPylation
Yuan, Y.; Stumpf, F. M.; Schlor, L. A.; Schmidt, O. P.; Huber, L. B.; Frese, M.; Hoellmueller, E.; Scheffner, M.; Stengel, F.; Diederichs, K.; Marx, A.
10.1101/2022.07.18.500566 — biochemistry — Posted on 2022-08-19
1537 A syntenin inhibitor blocks endosomal entry of SARS-CoV-2 and a panel of RNA viruses
Lindqvist, R.; Benz, C.; Sereikaite, V.; Maassen, L.; Laursen, L.; Jemth, P.; Stromgaard, K.; Ivarsson, Y.; Overby, A. K.
10.1101/2022.08.18.504268 — biochemistry — Posted on 2022-08-19
1538 Production of photocurrent and hydrogen gas from intact plant leaves.
Shlosberg, Y.; Meirovitch, M.; Yehezkeli, O.; Schuster, G.; Adir, N.
10.1101/2021.09.19.460952 — bioengineering — Posted on 2022-08-19
1539 Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury
Chen, X.; Lu, W.; Zuo, Y.; Ye, J.; Li, X.; Wu, Z.; Jin, S.; Cai, W.; Abdelrahman, Z.; Zhang, T.; Yu, B.; Gu, X.; Chen, Z.; Wang, X.
10.1101/2022.07.01.498514 — bioengineering — Posted on 2022-08-19
1540 Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells
Yao, M.; Tijore, A. S.; Cheng, D.; Li, J. V.; Hariharan, A.; Martinac, B.; Tran Van Nhieu, G.; Cox, C. D.; Sheetz, M.
10.1101/2020.03.09.972307 — cell biology — Posted on 2022-08-19
1541 Transient interactions drive the lateral clustering of Cadherin-23 on membrane
Srinivas, C. S.; Singaraju, G. S.; Kaur, V.; Das, S.; Ghosh, S. K.; Sagar, A.; Kumar, A.; Bhatia, T.; Rakshit, S.
10.1101/2022.01.09.475209 — cell biology — Posted on 2022-08-19
1542 Functional organization of social perception in the human brain
Santavirta, S.; Karjalainen, T.; Nazari-Farsani, S.; Hudson, M.; Putkinen, V.; Seppala, K.; Sun, L.; Glerean, E.; Hirvonen, J.; Karlsson, H. K.; Nummenmaa, L.
10.1101/2021.12.17.473175 — neuroscience — Posted on 2022-08-19
1543 Golgi localized Arl15 regulates cargo transport, cell adhesion and motility
Sharma, P.; Venkatesh, P. H.; Paddillaya, N.; Shah, N.; BR, R.; Dakua, A.; Penmatsa, A.; Balasubramanian, N.; Gundiah, N.; Setty, S. R. G.
10.1101/2022.08.18.504432 — cell biology — Posted on 2022-08-19
1545 Autophagy is associated with survival and resiliency of fibroblasts in long-term decaying post-mortem parenchymal tissue
McAndrews, K.; McGrail, D. J.; Gansmo, L. B.; Che, S. P. Y.; Chakravarti, D.; LeBleu, V.; Kalluri, R.
10.1101/2022.08.18.504466 — cell biology — Posted on 2022-08-18
1547 Multiomic investigation of sugarcane mosaic virus resistance in sugarcane
Pimenta, R. J. G.; Aono, A. H.; Burbano, R. C. V.; da Silva, M. F.; Anjos, I. A.; Landell, M. G. d. A.; Goncalves, M. C.; Pinto, L. R.; de Souza, A. P.
10.1101/2022.08.18.504288 — plant biology — Posted on 2022-08-18
1552 Single-Cell Transcriptome Analyses Reveal the Cell Diversity and Developmental Features of Human Gastric and Metaplastic Mucosa
Tsubosaka, A.; Komura, D.; Katoh, H.; Kakiuchi, M.; Onoyama, T.; Yamamoto, A.; Abe, H.; Seto, Y.; Ushiku, T.; Ishikawa, S.
10.1101/2022.05.22.493006 — genomics — Posted on 2022-08-18
1554 p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin
Maeso-Alonso, L.; Alonso-Olivares, H.; Martinez-Garcia, N.; Lopez-Ferreras, L.; Villoch-Fernandez, J.; Puente-Santamaria, L.; Colas-Algora, N.; Fernandez-Corona, A.; Lorenzo-Marcos, M. E.; Jimenez, B.; Holmgren, L.; Wilhelm, M.; Millan, J.; del Peso, L.; Claesson-Welsh, L.; Marques, M. M.; Marin, M. C.
10.1101/2022.03.03.482832 — cell biology — Posted on 2022-08-18
1556 Transplantation Elicits a Clonally Diverse CD8+ T Cell Response That is Comprised of Potent CD43+ Effectors
Cohen, G.; Kallarakal, M.; Jayaraman, S.; Ibukun, F. I.; Tong, K. P.; Orzolek, L. D.; Larman, H. B.; Krummey, S.
10.1101/2022.05.21.492934 — immunology — Posted on 2022-08-18
1559 Reliable energy-based antibody humanization and stabilization
Tennenhouse, A.; Khmelnitsky, L.; Yeshaya, N.; Noronha, A.; Lindzen, M.; Khalaila, R.; Zaretsky, I.; Fridmann Sirkis, Y.; Galon-Wolfenson, Y.; Abramson, J.; Yarden, Y.; Fass, D.; Fleishman, S. J.
10.1101/2022.08.14.503891 — bioengineering — Posted on 2022-08-18
1562 E. faecalis acquires resistance to antimicrobials and insect immunity via common mechanisms
Wadhawan, A.; Simoes da Silva, C. J.; Nunes, C. D.; Edwards, A. M.; Dionne, M. S.
10.1101/2022.08.17.504265 — microbiology — Posted on 2022-08-18
1563 Supraorbital whiskers act as wind-antennae in rat anemotaxis
Mugnaini, M.; Mehrotra, D.; Davoine, F.; Sharma, V.; Mendes, A. R.; Brecht, M.; Clemens, A. M.
10.1101/2022.08.18.504295 — neuroscience — Posted on 2022-08-18
1566 Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest
Lin, A.; shadrin, a.; van der Meer, D.; Hindley, G.; Cheng, W.; Sonderby, I. E.; Bahrami, S.; S OConnell, K.; Rahman, Z.; Parker, N.; B Smeland, O.; Fan, C.; Holland, D.; Dale, A.; Andreassen, O.; Frei, O.
10.1101/2022.08.18.504383 — bioinformatics — Posted on 2022-08-18
1569 A new haplotype-resolved turkey genome to enable turkey genetics and genomics research
Barros, C. P.; Derks, M. F.; Mohr, J.; Wood, B.; Crooijmans, R. P.; Megens, H.-J.; Bink, M. C.; Groenen, M. A.
10.1101/2022.08.18.504375 — genomics — Posted on 2022-08-18
1570 Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases
Diamond, K. M.; Burtner, A. E.; Siddiqui, D.; Alvarado, K.; Leake, S. L.; Rolfe, S.; Zhang, C.; Kwon, R. Y.; Maga, A. M.
10.1101/2022.08.18.504429 — genetics — Posted on 2022-08-18
1572 Single cell atlas of Xenoturbella bocki highlights the limited cell-type complexity of a non-vertebrate deuterostome lineage
Robertson, H.; Sebe-Pedros, A.; Saudemont, B.; Loe Mie, Y.; Zakrzewski, A.; Grau-Bove, X.; Mailhe, M.-P.; Schiffer, P.; Telford, M. J.; Marlow, H.
10.1101/2022.08.18.504214 — evolutionary biology — Posted on 2022-08-18
1578 An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors
Singh, R.; Rossini, V.; Stockdale, S. R.; Saiz-Gonzalo, G.; Hanrahan, N.; D' Souza, T.; Clooney, A.; Draper, L. A.; Hill, C.; Nally, K.; Shanahan, F.; Andersson-Engels, S.; Melgar, S.
10.1101/2022.08.18.504384 — immunology — Posted on 2022-08-18
1579 Macrophage-Based iNos Reporter Reveals Polarization and Reprogramming in the Context of Breast Cancer
Mas-Rosario, J. A.; Medor, J. D.; Jeffway, M. I.; Martinez-Montes, J. M.; Farkas, M. E.
10.1101/2022.08.18.504212 — immunology — Posted on 2022-08-18
1580 The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Johnson, R. S.; Foskolou, I. P.; Cunha, P. P.; Minogue, E.; Nicolet, B.; Guislain, A.; Jorgensen, C.; Zandhuis, N. D.; Barbieri, L.; Bargiela, D.; Nathanael, D.; Tyrakis, P.; Palazon, A.; Wolkers, M.
10.1101/2022.08.18.504372 — immunology — Posted on 2022-08-18
1583 Neural sequences in primate prefrontal cortex encode working memory in naturalistic environments
Roussy, M.; Busch, A.; Luna, R.; Leavitt, M.; Mofrad, M. H.; Gulli, R. A.; Corrigan, B.; Minac, J.; Sachs, A. J.; Palaniyappan, L.; Muller, L. W.; Martinez-Trujillo, J. C.
10.1101/2022.08.18.504406 — neuroscience — Posted on 2022-08-18
1585 Navigating Multiple Environments with Emergent Grid Cell Remapping
Schoyen, V. S.; Pettersen, M. B.; Holzhausen, K.; Malthe-Sorensen, A.; Lepperod, M. E.
10.1101/2022.08.18.504379 — neuroscience — Posted on 2022-08-18
1587 Independent synaptic inputs to motor neurons driving antagonist muscles
Borzelli, D.; Vieira, T. D. M. M.; Botter, A.; Gazzoni, M.; Lacquaniti, F.; d'Avella, A.
10.1101/2022.08.18.504426 — neuroscience — Posted on 2022-08-18
1590 BCAA catabolism drives adipogenesis via an intermediate metabolite and promotes subcutaneous adipose tissue expansion during obesity
Shao, J.; Liu, Y.; Zhang, X.; Shu, L.; Yu, J.; Yang, S.; Gao, C.; Wang, C.; Cao, N.; Zhou, M.; Chi, R.; Chen, M.; Liu, C.; Wang, J.; Zhang, W.; Liu, R.; Wang, J.; Wang, W.; Ning, G.; Yang, X.; Wang, Y.; Sun, H.
10.1101/2022.08.18.504380 — physiology — Posted on 2022-08-18
1591 The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice
Nagy, N.; Kaber, G.; Haddock, N.; Hargil, A.; Rajadas, J.; Malhotra, S.; Unger, M.; Frymoyer, A.; Bollyky, P.
10.1101/2022.08.18.504417 — pharmacology and toxicology — Posted on 2022-08-18
1592 Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath Tumors
Farouk Sait, S.; Tang, K.-h.; Angus, S.; Brown, R.; Sun, D.; Xie, X.; Iltis, C.; Lien, M.; Socci, N.; Bale, T.; Davis, C.; Dixon, S. A. H.; Zhang, C.; Clapp, D. W.; Neel, B. G.; Parada, L. F.
10.1101/2022.08.18.504317 — cancer biology — Posted on 2022-08-18
1593 Charge neutralization of the active site glutamates does not limit substrate binding and transport by EmrE
Spreacker, P. J.; Brousseau, M.; Hisao, G. S.; Soltani, M.; Davis, J.; Henzler-Wildman, K. A.
10.1101/2022.08.17.503475 — biophysics — Posted on 2022-08-18
1594 Assembling highly repetitive Xanthomonas TALomes using Oxford Nanopore sequencing
Erkes, A.; Grove, R.; Zarkovic, M.; Krautwurst, S.; Koebnik, R.; Morgan, R. D.; Wilson, G. G.; Hölzer, M.; Marz, M.; Boch, J.; Grau, J.
10.1101/2022.08.17.504259 — bioinformatics — Posted on 2022-08-18
1596 Prevalence and heterogeneity of antibiotic-resistant genes in Orientia tsutsugamushi and other rickettsial genomes
Rao, R. S. P.; Ghate, S. D.; Shastry, R. P.; Kurthkoti, K.; Suravajhala, P.; Patil, P.; Shetty, P.
10.1101/2022.08.17.504356 — bioinformatics — Posted on 2022-08-18
1598 Parallel molecular computation on digital data stored in DNA
Wang, B.; Wang, S. S.; Chalk, C.; Ellington, A.; Soloveichik, D.
10.1101/2022.08.17.504328 — bioengineering — Posted on 2022-08-18
1605 Unbiased intestinal single cell transcriptomics reveals previously uncharacterized enteric nervous system populations in larval zebrafish
Kuil, L. E.; Kakiailatu, N.; Windster, J. D.; Bindels, E.; Zink, J. T. M.; van der Zee, G.; Hofstra, R. M. W.; Shepherd, I. T.; Melotte, V.; Alves, M. M.
10.1101/2022.08.11.503619 — developmental biology — Posted on 2022-08-18
1607 Genetic and lipidomic identification of tuberculostearic acid as a controller of mycobacterial membrane compartmentalization
Prithviraj, M.; Kado, T.; Mayfield, J. A.; Young, D. C.; Huang, A. D.; Motooka, D.; Nakamura, S.; Siegrist, M. S.; Moody, D. B.; Morita, Y. S.
10.1101/2022.08.17.504266 — microbiology — Posted on 2022-08-18
1609 Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.
Palmer, W. H.; Leaton, L. A.; Campos Codo, A.; Hume, P. S.; Crute, B.; Stone, M.; van Bokhoven, A.; Tobin, R. P.; McCarter, M.; Janssen, W. J.; Roest, J.; Zhu, S.; Petersen, J.; Vivian, J. P.; Rossjohn, J.; Trowsdale, J.; Getahun, A.; Cambier, J.; Loh, L.; Norman, P. J.
10.1101/2022.08.17.503789 — immunology — Posted on 2022-08-18
1610 Uncovering brain tissue architecture across scales with super-resolution light microscopy
Michalska, J. M.; Lyudchik, J.; Velicky, P.; Korinkova, H.; Watson, J. F.; Cenameri, A.; Sommer, C.; Venturino, A.; Roessler, K.; Czech, T.; Siegert, S.; Novarino, G.; Jonas, P.; Danzl, J. G.
10.1101/2022.08.17.504272 — neuroscience — Posted on 2022-08-18
1611 A PATHWAY FOR T3 SIGNALING IN THE BRAIN TO IMPROVE THE VARIABLE EFFECTIVENESS OF THERAPY WITH L-T4
Salas-Lucia, F.; Fekete, C.; Sinko, R.; Egri, P.; Rada, K.; Ruska, Y.; Bocco, B.; Fonseca, T. L.; Gereben, B.; Bianco, A. C.
10.1101/2022.08.17.504300 — neuroscience — Posted on 2022-08-18
1613 Single-cell Atlas of Human Fetal Cerebellum Decoding Medulloblastoma Origin and Oncogenesis
Luo, Z.; Xia, M.; Shi, W.; Zhao, C.; Wang, J.; Xin, D.; Dong, X.; Xiong, Y.; Zhang, F.; Berry, K.; Ogurek, S.; Liu, X.; Rao, R.; Xing, R.; Wu, L. M. N.; Cui, S.; Xu, L.; Lin, Y.; Li, H.; Ma, W.; Tian, S.; Xie, Q.; Zhang, L.; Xin, M.; Wang, X.; Yue, F.; Zheng, H.; Liu, Y.; Gilbertson, R.; Millen, K.; Ma, J.; Zhou, W.; Tayler, M. D.; Lu, R.
10.1101/2022.08.17.504304 — cancer biology — Posted on 2022-08-18
1614 Mapping the landscape of genetic dependencies in chordoma
Sharifnia, T.; Wawer, M. J.; Goodale, A.; Lee, Y.; Kazachkova, M.; Dempster, J. M.; Muller, S.; Levy, J.; Freed, D. M.; Sommer, J.; Kalfon, J.; Vazquez, F.; Hahn, W. C.; Root, D. E.; Clemons, P. A.; Schreiber, S. L.
10.1101/2022.08.17.504193 — cancer biology — Posted on 2022-08-18
1615 Cancer tissue of origin constrains the growth and metabolism of metastases
Sivanand, S.; Gultekin, Y.; Winter, P.; Vermeulen, S. Y.; Do, B. T.; Danai, L. V.; Tchourine, K.; Crowder, K.; Kunchok, T.; Lau, A. N.; Darnell, A. M.; Morita, S.; Duda, D. G.; Aguirre, A.; Wolpin, B. M.; Lewis, C. A.; Vitkup, D.; Shalek, A. K.; Vander Heiden, M. G.
10.1101/2022.08.17.504141 — cancer biology — Posted on 2022-08-18
1616 Wochenende - modular and flexible alignment-based shotgun metagenome analysis
Rosenboom, I.; Scheithauer, T.; Friedrich, F. C.; Poertner, S.; Hollstein, L.; Pust, M.-M.; Sifakis, K.; Wehrbein, T.; Rosenhahn, B.; Wiehlmann, L.; Chhatwal, P.; Tuemmler, B.; Davenport, C. F.
10.1101/2022.03.18.484377 — bioinformatics — Posted on 2022-08-18
1617 promor: a comprehensive R package for label-free proteomics data analysis and predictive modeling
Ranathunge, C.; Patel, S. S.; Pinky, L.; Correll, V. L.; Semmes, O. J.; Armstrong, R. K.; Combs, C. D.; Nyalwidhe, J. O.
10.1101/2022.08.17.503867 — bioinformatics — Posted on 2022-08-18
1618 Identification of divergent botulinum neurotoxin homologs in Paeniclostridium ghonii
Wei, X.; Wentz, T.; Lobb, B.; Mansfield, M. J.; Zhen, W.; Tan, H.; Wu, Z.; Pellett, S.; Dong, M.; Doxey, A. C.
10.1101/2022.08.17.504336 — bioinformatics — Posted on 2022-08-18
1620 Oxygen kinetics during CXL using symmetrically and asymmetrically pulsed UV-irradiation
Komninou, M. A.; Nambiar, M. H.; Frueh, B. E.; Enzmann, V.; Buechler, P.; Seiler, T. G.
10.1101/2022.08.17.504256 — bioengineering — Posted on 2022-08-18
1621 Comparison of progressive hold and progressive response schedules of reinforcement.
Alvarez-Sekely, C. S.; Toscano-Zapien, A. L.; Salles-Ize, P.; Lopez-Guzman, M. A.; Velaquez-Martinez, D.
10.1101/2022.08.17.504276 — animal behavior and cognition — Posted on 2022-08-18
1626 End-to-end multimodal 3D imaging and machine learning workflow for non-destructive phenotyping and diagnosis of trunk diseases
Fernandez, R.; Le Cunff, L.; Merigeaud, S.; Verdeil, J.-L.; Perry, J.; Larignon, P.; Spilmont, A.-S.; Chatelet, P.; Cardoso, M.; Goze-Bac, C.; Moisy, C.
10.1101/2022.06.09.495457 — plant biology — Posted on 2022-08-18
1627 Multiomic investigation of sugarcane mosaic virus resistance in sugarcane
Pimenta, R. J. G.; Aono, A. H.; Burbano, R. C. V.; da Silva, M. F.; Anjos, I. A.; Landell, M. G. d. A.; Goncalves, M. C.; de Souza, A. P.
10.1101/2022.08.18.504288 — plant biology — Posted on 2022-08-18
1628 Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity
Arroyo, J. P.; Terker, A. S.; Zuchowski, Y.; Watts, J. A.; Bock, F.; Meyer, C.; Luo, W.; Kapp, M. E.; Gould, E. R.; Miranda, A. X.; Jiang, M.; Vanacore, R.; Hammock, E.; Wilson, M.; Zent, R.; Zhang, M.-Z.; Bhave, G.; Harris, R. C.
10.1101/2022.05.13.491898 — physiology — Posted on 2022-08-18
1630 Cryo-EM complex structure of active GPR75 with a nanobody
Lv, Z.; He, Y.; Xiang, Y.; Li, J.; Meng, F.; Zhao, H.; Guo, H.; He, D.; Wang, Y.; Zhuo, W.; Liu, Y.; Ni, X.; Heng, J.
10.1101/2022.08.18.503988 — biophysics — Posted on 2022-08-18
1631 Thermal modulation of skin friction at the fingertip
Filingeri, D.; Worsley, P. R.; Bader, D. L.; Martinez, D. M.; Rykaczewski, K.
10.1101/2022.08.18.504401 — biophysics — Posted on 2022-08-18
1632 Single molecule long-read real-time amplicon-based sequencing of CYP2D6: a proof-of-concept with hybrid haplotypes
Dong, R.; Thamilselvan, M.; Hu, X.; Carvalho Henriques, B.; Wang, Y.; Wallace, K.; Sivapalan, S.; Buchner, A.; Yavorskyy, V.; Martens, K.; Maier, W.; Henigsberg, N.; Hauser, J.; Cattaneo, A.; Mors, O.; Rietschel, M.; Pfeffer, G.; Aitchison, K. J.
10.1101/2022.08.17.503990 — genomics — Posted on 2022-08-18
1633 Genetic and ecological drivers of molt in a migratory bird
Contina, A.; Bossu, C.; Allen, D. C.; Wunder, M. B.; Ruegg, K. C.
10.1101/2022.08.17.504285 — ecology — Posted on 2022-08-18
1634 The centromere/kinetochore is assembled through CENP-C oligomerization
Hara, M.; Ariyoshi, M.; Sano, T.; Nozawa, R.-s.; Shinkai, S.; Onami, S.; Jansen, I.; Hirota, T.; Fukagawa, T.
10.1101/2022.08.17.504347 — cell biology — Posted on 2022-08-18
1635 A Panel of Diverse Klebsiella pneumoniae Clinical Isolates for Research and Development
Martin, M. J.; Stribling, W. C.; Ong, A. C.; Maybank, R. A.; Kwak, Y. I.; Rosado-Mendez, J. A.; Preston, L.; Lane, K. F.; Julius, M.; Jones, A. R.; Hinkle, M. K.; Waterman, P. E.; Lesho, E.; Lebreton, F.; Bennett, J. W.; McGann, P.
10.1101/2022.08.17.504361 — microbiology — Posted on 2022-08-18
1636 Insane in the vembrane: filtering and transforming VCF/BCF files
Hartmann, T. F.; Schröder, C.; Kuthe, E.; Lähnemann, D.; Köster, J.
10.1101/2022.08.17.504106 — bioinformatics — Posted on 2022-08-18
1640 Simultaneous transcriptome and proteome profiling in a single mouse oocyte with a deep single-cell multi-omics approach
Jiang, Y.-R.; Zhu, L.; Cao, L.-R.; Wu, Q.; Chen, J.-B.; Wang, Y.; Wu, J.; Zhang, T.-Y.; Wang, Z.-L.; Guan, Z.-Y.; Xu, Q.-Q.; Fan, Q.-X.; Shi, S.-W.; Wang, H.-F.; Pan, J.-Z.; Fu, X.; Wang, Y.-C.; Fang, Q.
10.1101/2022.08.17.504335 — cell biology — Posted on 2022-08-18
1645 Chromosome-level genome of the three-spot damselfish, Dascyllus trimaculatus
Roberts, M. B.; Schultz, D. T.; Gatins, R.; Escalona, M.; Bernardi, G.
10.1101/2022.08.16.504202 — genomics — Posted on 2022-08-18
1646 Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir
Iketani, S.; Mohri, H.; Culbertson, B.; Hong, S. J.; Duan, Y.; Luck, M. I.; Annavajhala, M. K.; Guo, Y.; Sheng, Z.; Uhlemann, A.-C.; Goff, S. P.; Sabo, Y.; Yang, H.; Chavez, A.; Ho, D. D.
10.1101/2022.08.07.499047 — microbiology — Posted on 2022-08-18
1649 Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling
Rubio, K.; Romero, A.; Sarvari, P.; Guenther, S.; Mehta, A.; Bassaly, B.; Braubach, P.; Dobreva, G.; Wygrecka, M.; Gattenloehner, S.; Braun, T.; Tresch, A.; Graumann, J.; Barreto, G.
10.1101/2022.08.16.504078 — cancer biology — Posted on 2022-08-18
1654 Transcriptional and translational profiling in yeast reveals the use of diverse genome decoding mechanisms to generate functionally distinct proteoforms
Fenton, D. A.; Swirski, M.; O'Connor, P. B.; Kiniry, S. J.; Michel, A. M.; Kufel, J.; Baranov, P. V.; Morrissey, J. P.
10.1101/2022.03.25.485750 — genomics — Posted on 2022-08-18
1656 A DNase T6SS effector requires its MIX domain for secretion
Fridman, C. M.; Jana, B.; Ben-Yaakov, R.; Bosis, E.; Salomon, D.
10.1101/2022.05.04.489851 — microbiology — Posted on 2022-08-18
1659 Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging
Richter, A.; Soch, J.; Kizilirmak, J. M.; Fischer, L.; Schütze, H.; Assmann, A.; Behnisch, G.; Feldhoff, H.; Knopf, L.; Raschick, M.; Schult, A.; Seidenbecher, C. I.; Yakupov, R.; Düzel, E.; Schott, B. H.
10.1101/2022.02.04.479169 — neuroscience — Posted on 2022-08-18
1661 Loss of LRP1 in adult neural stem cells impairs migration to ischemic lesions
Dietert, K.; Mahesula, S.; Hegde, S.; Verschelde, J.; Reed, P.; Sprague, S.; Kokovay, E.; Sayre, N. L.
10.1101/2022.08.17.504194 — neuroscience — Posted on 2022-08-18
1664 A mechanism of uncompetitive inhibition of the serotonin transporter
Bhat, S.; Elkasaby, A.; Kasture, A.; Boytsov, D.; Reichelt, J. B.; Hummel, T.; Sucic, S.; Pifl, C.; Freissmuth, M.; Sandtner, W.
10.1101/2022.08.11.503588 — pharmacology and toxicology — Posted on 2022-08-18
1668 Haplogenomes of Eucalyptus urophylla and E. grandis
Lötter, A.; Duong, T.; Candotti, J.; Mizrachi, E.; Wegrzyn, J. L.; Myburg, A. A.
10.1101/2022.08.17.501336 — genomics — Posted on 2022-08-18
1671 Mapping Cellular Response to Destabilized Transthyretin Reveals Cell- and Amyloidogenic Protein-Specific Signatures
Ghosh, S.; Villacorta-Martin, C.; Lindstrom-Vautrin, J.; Kenney, D.; Golden, C. S.; Edwards, C. V.; Sanchorawala, V.; Connors, L. H.; Giadone, R. M.; Murphy, G. J.
10.1101/2022.08.17.504308 — cell biology — Posted on 2022-08-18
1673 RNA-triggered protein cleavage and cell death by the RNA-guided type III-E CRISPR-Cas nuclease-protease complex
Kato, K.; Okazaki, S.; Schmitt-Ulms, C.; Jiang, K.; Zhou, W.; Ishikawa, J.; Isayama, Y.; Adachi, S.; Nishizawa, T.; Makarova, K. S.; Koonin, E. V.; Abudayyeh, O.; Gootenberg, J. S.; Nishimasu, H.
10.1101/2022.08.17.504292 — molecular biology — Posted on 2022-08-18
1675 mNGS Investigation of Single Ixodes pacificus Ticks Reveals Diverse Microbes, Viruses, and a Novel mRNA-like Endogenous Viral Elements
Martyn, C.; Hayes, B.; Lauko, D.; Mithun, E.; Castaneda, G.; Bosco-Lauth, A.; Kistler, A.; Pollard, K.; Chou, S.
10.1101/2022.08.17.504163 — microbiology — Posted on 2022-08-18
1676 The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus
James, J.; Bhat, S.; Walsh, S. K.; Karunarathna, H. M. T. K.; Sadeyen, J.-R.; Chang, P.; Sealy, J. E.; Mahmood, S.; Mollett, B.; Slomka, M. J.; Brookes, S. M.; Iqbal, M.
10.1101/2022.08.17.504359 — microbiology — Posted on 2022-08-18
1677 Sex-specific T cell exhaustion drives differential immune responses in glioblastoma
Lee, J.; Nicosia, M.; Silver, D. J.; Li, C.; Bayik, D.; Watson, D. C.; Lauko, A.; Johnson, S.; McGraw, M.; Grabowski, M.; Kish, D.; Desai, A.; Goodman, W.; Cameron, S.; Okada, H.; Valujskikh, A.; Fairchild, R. L.; Ahluwalia, M. S.; Lathia, J. D.
10.1101/2022.08.17.503211 — immunology — Posted on 2022-08-18
1678 A microbiota-derived metabolite instructs peripheral efferocytosis
Saavedra, P. H. V.; Trzeciak, A.; Wang, Z.; Rojas, W. S.; Zago, G.; Docampo, M. D.; Verter, J. G.; van den Brink, M. R. M.; Lucas, C. D.; Anderson, C. J.; Rudensky, A. Y.; Perry, J. S. A.
10.1101/2022.08.17.504322 — immunology — Posted on 2022-08-18
1680 Spatiotemporal patterns of sleep spindle activity in human anterior thalamus and cortex
Bernhard, H.; Schaper, F. L. W. V. J.; Janssen, M. L. F.; Gommer, E. D.; Jansma, B. M.; Van Kranen-Mastenbroek, V.; Rouhl, R. P. W.; Weerd, P. d.; Reithler, J.; Roberts, M. J.; DBS studygroup,
10.1101/2022.03.25.485812 — neuroscience — Posted on 2022-08-18
1683 Identification of minor alleles associated with lodging in tef (Eragrostis tef)
Ben-Zeev, S.; Hellwig, T.; Demeile, M.; Barak, V.; Vorobyova, S.; Hubner, S.; Saranga, Y.
10.1101/2022.03.17.484745 — plant biology — Posted on 2022-08-18
1684 Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition
Winkler, R.; Mägdefrau, A.-S.; Piskor, E.-M.; Kleemann, M.; Beyer, M.; Linke, K.; Hansen, L.; Schaffer, A.-M.; Hoffmann, M. E.; Poepsel, S.; Heyd, F.; Beli, P.; Möröy, T.; Mahboobi, S.; Krämer, O. H.; Kosan, C.
10.1101/2021.06.01.445760 — cancer biology — Posted on 2022-08-18
1685 Cryo-EM structure of the RADAR supramolecular anti-phage defense complex
Duncan-Lowey, B.; Tal, N.; Johnson, A. G.; Rawson, S.; Mayer, M. L.; Doron, S.; Millman, A.; Melamed, S.; Fedorenko, T.; Kacen, A.; Amitai, G.; Sorek, R.; Kranzusch, P. J.
10.1101/2022.08.17.504323 — biochemistry — Posted on 2022-08-18
1687 Purification of Human β and γ Actin from Budding Yeast
Haarer, B. K.; Pimm, M. L.; deJong, E. P.; Henty-Ridilla, J. L.; Amberg, D.
10.1101/2022.08.17.504301 — biochemistry — Posted on 2022-08-18
1688 Recently evolved combination of unique sulfatase and amidase genes enables bacterial degradation of the wastewater micropollutant acesulfame worldwide
Bonatelli, M. L.; Rohwerder, T.; Popp, D.; Liu, Y.; Akay, C.; Schultz, C.; Liao, K.-P.; Ding, C.; Reemtsma, T.; Adrian, L.; Kleinsteuber, S.
10.1101/2022.08.17.504299 — microbiology — Posted on 2022-08-18
1690 High-sensitivity vision restoration via ectopic expression of chimeric rhodopsin in mice
Katada, Y.; Yoshida, K.; Serizawa, N.; Kobayashi, K.; Negishi, K.; Hideyuki, O.; Kandori, H.; Tsubota, K.; Kurihara, T.
10.1101/2020.09.17.301523 — neuroscience — Posted on 2022-08-18
1693 Testing for phylogenetic signal in single-cell RNA-seq data
Moravec, J. C.; Lanfear, R.; Spector, D.; Diermeier, S.; Gavryushkin, A.
10.1101/2021.01.07.425804 — cancer biology — Posted on 2022-08-17
1694 Public exams may decrease anxiety and deepen critical thinking
Wiggins, B.; Lily, L.; Busch, C.; Ngwenyama, T.; Landys, M.; Shlichta, J. G.; Shi, T.
10.1101/2022.04.15.488479 — scientific communication and education — Posted on 2022-08-17
1698 N-myc Downstream Regulated Gene 1 (NDRG1) functions as a molecular switch for cellular adaptation to hypoxia
Park, J. S.; Gabel, A. M.; Kassir, P.; Kang, L.; Chowdhary, P. K.; Osei-Ntansah, A.; Tran, N. D.; Viswanathan, S.; Canales, B.; Ding, P.; Lee, Y.-S.; Brewster, R.
10.1101/2021.09.10.459675 — developmental biology — Posted on 2022-08-17
1699 The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1
Santos, J. C.; Dametto, M.; Masson, A. P.; Faca, V. M.; Bonacin, R.; Donadi, E. A.; Passos, G. A.
10.1101/2021.08.24.457565 — immunology — Posted on 2022-08-17
1700 Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Popova, D.; Gameiro-Ros, I.; Youssef, M. M.; Zalamea, P.; Morris, A. D.; Prytkova, I.; Jadali, A.; Kwan, K. Y.; Kamarajan, C.; Salvatore, J. E.; Xuei, X.; Chorlian, D. B.; Porjesz, B.; Kuperman, S.; Dick, D. M.; Goate, A.; Edenberg, H. J.; Tischfield, J. A.; Pang, Z. P.; Slesinger, P. A.; Hart, R. P.
10.1101/2022.05.24.493086 — neuroscience — Posted on 2022-08-17
1701 Active licking shapes cortical taste coding.
Neese, C.; Bouaichi, C. G.; Needham, T.; Bauer, M.; Bertram, R.; Vincis, R.
10.1101/2022.05.13.491862 — neuroscience — Posted on 2022-08-17
1702 Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome
Chen, M.; Cavinato, C.; Hansen, J.; Tanaka, K.; Ren, P.; Hassab, A.; Li, D. S.; Joshua, E.; Tellides, G.; Iyengar, R.; Humphrey, J. D.; Schwartz, M. A.
10.1101/2022.08.16.504169 — pathology — Posted on 2022-08-17
1703 Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
Gosselin, M. R.; Mournetas, V.; Borczyk, M.; Verma, S.; Occhipinti, A.; Rog, J.; Bozycki, L.; Korostynski, M.; Robson, S.; Angione, C.; Pinset, C.; Gorecki, D. C.
10.1101/2021.08.24.457331 — pathology — Posted on 2022-08-17
1704 Optimal gap-affine alignment in O(s) space
Marco-Sola, S.; Eizenga, J. M.; Guarracino, A.; Paten, B.; Garrison, E.; Moreto, M.
10.1101/2022.04.14.488380 — bioinformatics — Posted on 2022-08-17
1705 PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, A. U.; Karapetsas, A.; Nirujogi, R. S.; Chatterjee, D.; Phung, T. K.; Wightman, M.; Gourlay, R.; Morrice, N.; Mathea, S.; Knapp, S.; Alessi, D. R.
10.1101/2022.06.09.495448 — biochemistry — Posted on 2022-08-17
1708 Modelling Instantaneous Firing Rate of DBS Target Neuronal Ensembles in Basal Ganglia and Thalamus
Tian, Y.; Murphy, M. J. H.; Steiner, L. A.; Kalia, S.; Hodaie, M.; Lozano, A.; Hutchison, W. D.; Popovic, M.; Milosevic, L.; Lankarany, M.
10.1101/2022.06.28.497834 — neuroscience — Posted on 2022-08-17
1711 Loss of function variants in DNAJB4 cause a myopathy with early respiratory failure
Weihl, C. C.; Topf, A.; Bengoechea, R.; Duff, J.; Charlton, R.; Garcia, S. K.; Alsaman, A.; Hernandez-Lain, A.; VaronaFranco, L.; Ponce Sanchez, M. E.; Beecroft, S. J.; Goulee, H.; Daw, J.; Bhadra, A.; True, H.; Inoue, M.; Findlay, A.; Laing, N.; Olive, M.; Ravenscroft, G.; Straub, V.
10.1101/2022.07.31.502226 — genetics — Posted on 2022-08-17
1714 A rapid and efficient learning rule for biological neural circuits
Sezener, E.; Grabska-Barwinska, A.; Kostadinov, D.; Beau, M.; Krishnagopal, S.; Budden, D.; Hutter, M.; Veness, J.; Botvinick, M.; Clopath, C.; Hausser, M.; Latham, P.
10.1101/2021.03.10.434756 — neuroscience — Posted on 2022-08-17
1716 End-to-end multimodal 3D imaging and machine learning workflow for non-destructive phenotyping and diagnosis of trunk diseases
Fernandez, R.; Le Cunff, L.; Merigeaud, S.; Verdeil, J.-L.; Perry, J.; Larignon, P.; Spilmont, A.-S.; Chatelet, P.; Cardoso, M.; Goze-Bac, C.; Moisy, C.
10.1101/2022.06.09.495457 — plant biology — Posted on 2022-08-17
1717 Trapped pore waters in the open proton channel HV1
Boytsov, D.; Brescia, S.; Chaves, G.; Koefler, S.; Hannesschlaeger, C.; Siligan, C.; Goessweiner-Mohr, N.; Musset, B.; Pohl, P.
10.1101/2022.05.09.491141 — biophysics — Posted on 2022-08-17
1719 Dual role of Pectin Methyl Esterase activity in the regulation of plant cell wall biophysical properties.
Gallemi Rovira, M.; Montesinos, J. C.; Zarevski, N.; Pribyl, J.; Skladal, P.; Hannezo, E.; Benkova, E.
10.1101/2022.06.14.495617 — cell biology — Posted on 2022-08-17
1720 Epigenetic-focused CRISPR/Cas9 screen identifies ASH2L as a regulator of glioblastoma cell survival
Ozyerli-Goknar, E.; Kala, E. Y.; Aksu, A. C.; Bulut, I.; Cingoz, A.; Nizamuddin, S.; Biniossek, M.; Seker-Polat, F.; Morova, T.; Aztekin, C.; Kung, S. H. A.; Syed, H.; Tuncbag, N.; Gonen, M.; Philpott, M.; Cribbs, A. P.; Acilan, C.; Lack, N. A.; Onder, T. T.; Timmers, H. T. M.; Bagci-Onder, T.
10.1101/2022.08.17.504245 — cancer biology — Posted on 2022-08-17
1721 E. faecalis acquires resistance to antimicrobials and insect immunity via common mechanisms
Wadhawan, A.; Simoes da Sliva, C. J.; Nunes, C. D.; Edwards, A. M.; Dionne, M. S.
10.1101/2022.08.17.504265 — microbiology — Posted on 2022-08-17
1724 PHFinder: Assisted detection of point heteroplasmy in Sanger sequencingchromatograms
Suarez-Menendez, M.; Rivera-Leon, V.; Robbins, J.; Berube, M.; Palsboll, P. J.
10.1101/2022.08.17.501710 — bioinformatics — Posted on 2022-08-17
1727 AICAR prevents doxorubicin-induced heart failure in rats by ameliorating cardiac atrophy and improving fatty acid oxidation
Choksey, A.; Thackray, B. D.; Ball, V.; Hong Tuan Ha, L.; Sharma, E.; Kennedy, B. W.; Carter, R. D.; Broxholme, J.; Murphy, M. P.; Heather, L. C.; Tyler, D. J.; Timm, K. N.
10.1101/2022.08.17.504253 — biochemistry — Posted on 2022-08-17
1728 Dimeric G-quadruplex motifs determine a large fraction of strong replication origins in vertebrates
Poulet-Benedetti, J.; Tonnerre-Doncarli, C.; Valton, A.-L.; Laurent, M.; Gerard, M.; Barinova, N.; Parisis, N.; Massip, F.; Picard, F.; Prioleau, M.-N.
10.1101/2022.08.17.504255 — genomics — Posted on 2022-08-17
1730 ΔNp63 controls stemness and inflammation in the adult epidermis
Alexandrova, E. M.; Eyermann, C. E.; Chen, X.; Somuncu, O. S.; Li, J.; Joukov, A. N.; Chen, J.
10.1101/2022.08.17.504172 — cell biology — Posted on 2022-08-17
1731 The deubiquitylase USP31 controls the Chromosomal Passenger Complex and spindle dynamics
Bertsoulaki, E.; Glover, H. L.; Gomes-Neto, J. I.; Pizer, B.; Maiato, H.; Urbe, S.; Clague, M. J.
10.1101/2022.08.17.504168 — cell biology — Posted on 2022-08-17
1732 CRISPR interference for Sequence-Specific Regulation of Fibroblast Growth Factor Receptor A in Schistosoma mansoni
Du, X.; McManus, D. P.; French, J. D.; Collinson, N.; Sivakumaran, H.; MacGregor, S. R.; Fogarty, C. E.; Jones, M. K.; You, H.
10.1101/2022.08.17.504262 — molecular biology — Posted on 2022-08-17
1733 Mammalian N1-adenosine PARylation is a reversible DNA modification
Musheev, M. U.; Schomacher, L.; Basu, A.; Han, D.; Krebs, L.; Scholz, C.; Niehrs, C.
10.1101/2022.08.17.504244 — molecular biology — Posted on 2022-08-17
1734 Clostridioides difficile PCR ribotype 151 is polyphyletic and includes pathogenic isolates from cryptic clade C-II with mono-toxin pathogenicity loci that can escape routine diagnostics
Ducarmon, Q. R.; van der Bruggen, J.-T.; Harmanus, C.; Sanders, I. M. J. G.; Daenen, L. G. M.; Fluit, A. C.; Vossen, R. H. A. M.; Kloet, S. L.; Kuijper, E. J.; Smits, W. K.
10.1101/2022.08.17.504118 — microbiology — Posted on 2022-08-17
1736 Differential global distribution of marine picocyanobacteria gene clusters reveals distinct niche-related adaptive strategies
Dore, H.; Guyet, U.; Leconte, J.; Farrant, G. K.; Alric, B.; Ratin, M.; Ostrowski, M.; Ferrieux, M.; Brillet-Gueguen, L.; Hoebeke, M.; Siltanen, J.; Le Corguille, G.; Corre, E.; Wincker, P.; Scanlan, D. J.; Eveillard, D.; Partensky, F.; Garczarek, L.
10.1101/2022.08.17.504260 — microbiology — Posted on 2022-08-17
1740 Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: a Bayesian latent class analysis
Calvo-Urbano, B.; Leger, E.; Gabain, I.; De Dood, C. J.; Diouf, N. D.; Borlase, A.; Rudge, J. W.; Corstjens, P. L. A. M.; Sene, M.; Van Dam, G. J.; Walker, M.; Webster, J. P.
10.1101/2022.08.17.504243 — pathology — Posted on 2022-08-17
1742 The nanomechanical fingerprint of colorectal-derived peritoneal metastasis
Lorenc, E.; Varinelli, L.; Chighizola, M.; Brich, S.; Pisati, F.; Guaglio, M.; Baratti, D.; Deraco, M.; Gariboldi, M.; Podesta, A.
10.1101/2022.08.17.504271 — biophysics — Posted on 2022-08-17
1746 Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Wamhoff, E.-C.; Ronsard, L.; Feldman, J.; Hauser, B. M.; Knappe, G. A.; Romanov, A.; Lam, E.; St. Denis, K.; Balazs, A. B.; Schmidt, A.; Lingwood, D.; Bathe, M.
10.1101/2022.08.16.504128 — immunology — Posted on 2022-08-17
1751 Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism
Alfaro Nunez, A. J.; Dittner, C.; Becker, J.; Loft, A.; Mhamane, A.; Maida, A.; Georgiadi, A.; Tsokanos, P.; Klepac, K.; Molocea, E.; Merahbi, R.; Motzler, K.; Geppert, J.; Karikari, R.; Szendroedi, J.; Feuchtinger, A.; Hofmann, S.; Melchior, F.; Herzig, S.
10.1101/2022.08.17.504229 — physiology — Posted on 2022-08-17
1760 Direct access to millions of mutations by Whole Genome Sequencing of an oilseed rape mutant population
Jhingan, S.; Kumar, A.; Harloff, H.-J.; Dreyer, F.; Abbadi, A.; Beckmann, K.; Obermeier, C.; Jung, C.
10.1101/2022.08.17.504237 — genomics — Posted on 2022-08-17
1761 Convergent evolution of skim feeding in baleen whales
Dutoit, L.; Mitchell, K. J.; Dussex, N.; Kemper, C. M.; Larsson, P.; Dalen, L.; Rawlence, N. J.; Marx, F. G.
10.1101/2022.08.16.504064 — evolutionary biology — Posted on 2022-08-17
1763 Four decades of phenology in an alpine amphibian: trends, stasis and climatic drivers
Lenzi, O.; Grossenbacher, K.; Zumbach, S.; Luescher, B.; Althaus, S.; Schmocker, D.; Recher, H.; Thoma, M.; Ozgul, A.; Schmidt, B. R.
10.1101/2022.08.16.503739 — ecology — Posted on 2022-08-17
1766 Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms
Moyo-Gwete, T.; Scheepers, C.; Makhado, Z.; Kgagudi, P.; Mzindle, N. B.; Ziki, R.; Madzorera, S.; Manamela, N. P.; Ayres, F.; Lambson, B. E.; Richardson, S. I.; Morris, L.; Moore, P. L.
10.1101/2022.08.17.504233 — immunology — Posted on 2022-08-17
1767 Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy: A new mechanism for motor neuron degeneration.
Cutrupi, A. N.; Narayanan, R. K.; Perez-siles, G.; Grosz, B. R.; Lai, K.; Boyling, A.; Ellis, M.; Lin, R. C.; Neumann, B.; Mao, D.; Uesugi, M.; Nicholson, G. A.; Vucic, S.; Saporta, M. A.; Kennerson, M. L.
10.1101/2022.08.16.504208 — neuroscience — Posted on 2022-08-17
1768 Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
Schiff, H. C.; Kogan, J. F.; Isaac, M.; Czarnecki, L. A.; Fontanini, A.; Maffei, A.
10.1101/2022.08.16.504203 — neuroscience — Posted on 2022-08-17
1771 Internal states as a source of subject-dependent movement variability and their representation by large-scale networks
Breault, M. S.; Sacre, P.; Fitzgerald, Z. B.; Gale, J. T.; Cullen, K. E.; Gonzalez-Martinez, J. A.; Sarma, S. V.
10.1101/2022.08.16.504130 — neuroscience — Posted on 2022-08-17
1772 Deep learning for satellite image forecasting of vegetation greenness
Kladny, K.-R. W.; Milanta, M.; Mraz, O.; Hufkens, K.; Stocker, B. D.
10.1101/2022.08.16.504173 — plant biology — Posted on 2022-08-17
1773 Driving forces behind remorin nanodomain formation in anionic lipid membranes
Legrand, A.; Cava, D. G.; Jolivet, M.-D.; Decossas, M.; Lambert, O.; Bayle, V.; Jaillais, Y.; Loquet, A.; Germain, V.; Boudsocq, M.; Habenstein, B.; Velez, M.; MONGRAND, S.
10.1101/2022.08.16.501454 — plant biology — Posted on 2022-08-17
1774 Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma
Gopal, R. K.; Vantaku, V. R.; Panda, A.; Reimer, B.; Rath, S.; To, T.-L.; Fisch, A. S.; Cetinbas, M.; Livneh, M.; Calcaterra, M. J.; Gigliotti, B.; Pierce, K.; Clish, C. B.; Dias-Santagata, D.; Sadow, P. M.; Wirth, L. J.; Daniels, G. H.; Sadreyev, R.; Calvo, S.; Parangi, S.; Mootha, V.
10.1101/2022.08.16.504041 — cancer biology — Posted on 2022-08-17
1775 Exogenous sequences in tumors and immune cells (exotic): a tool for estimating the microbe abundances in tumor RNAseq data
Hoyd, R.; Wheeler, C.; Liu, Y.; Singh, M. S. J.; Muniak, M.; Denko, N.; Carbone, D. P.; Xiaokui, M.; Spakowicz, D.
10.1101/2022.08.16.503205 — cancer biology — Posted on 2022-08-17
1776 Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid
Frank, A. R.; Li, V.; Shelton, S. D.; Kim, J.; Stott, G. M.; Neckers, L.; Xie, Y.; Williams, N. S.; Mishra, P.; McFadden, D. G.
10.1101/2022.08.16.504162 — cancer biology — Posted on 2022-08-17
1778 Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness
Bachas, S.; Rakocevic, G.; Spencer, D.; Sastry, A. V.; Haile, R.; Sutton, J. M.; Kasun, G.; Stachyra, A.; Gutierrez, J. M.; Yassine, E.; Medjo, B.; Blay, V.; Kohnert, C.; Stanton, J. T.; Brown, A.; Tijanic, N.; McCloskey, C.; Viazzo, R.; Consbruck, R.; Carter, H.; Levine, S.; Abdulhaqq, S.; Shaul, J.; Ventura, A. B.; Olson, R. S.; Yapici, E.; Meier, J.; McClain, S.; Weinstock, M.; Hannum, G.; Schwartz, A.; Gander, M.; Spreafico, R.
10.1101/2022.08.16.504181 — bioinformatics — Posted on 2022-08-17
1781 Genome-Wide Association Study Finds Multiple Loci Associated with Intraocular Pressure in HS Rats
Fowler, S.; Wang, T.; Munro, D.; Kumar, A.; Chitre, A. S.; Hollingsworth, T.; Martinez, A. G.; St.Pierre, C. L.; Bimschleger, H.; Gao, J.; Cheng, R.; Mohammadi, P.; Chen, H.; Palmer, A. A.; Polesskaya, O.; Jablonski, M. M.
10.1101/2022.08.16.503865 — genomics — Posted on 2022-08-17
1783 Transcriptome-Wide Gene-Gene Interaction Association Study Elucidates Pathways and Functional Enrichment of Complex Traits
Evans, L. M.; Arehart, C. A.; Grotzinger, A. D.; Mize, T. J.; Brasher, M. S.; Stitzel, J. A.; Ehringer, M. A.; Hoeffer, C. A.
10.1101/2022.08.16.504187 — genetics — Posted on 2022-08-17
1786 Modulation of adaptive immune responses by Akkermansia muciniphila is restricted to an early life window in NOD mice
Maddux, S.; Lubin, J.-B. A.; Green, J.; Flores, J.; Rozich, I.; Duranova, T.; Planet, P. J.; Silverman, M. A.
10.1101/2022.08.16.504185 — immunology — Posted on 2022-08-17
1789 Systematic Analysis and Model of Fibroblast Senescence Transcriptome
Scanlan, R.-L.; Pease, L.; O'Keefe, H.; Shanley, D.; Wordsworth, J.
10.1101/2022.08.16.504144 — systems biology — Posted on 2022-08-17
1791 Multimodal Assessment of Non-Alcoholic Fatty Liver Disease with Transmission-Reflection Optoacoustic Ultrasound
Lafci, B.; Hadjihambi, A.; Konstantinou, C.; Herraiz, J. L.; Pellerin, L.; Burton, N. C.; Dean-Ben, X. L.; Razansky, D.
10.1101/2022.08.16.504139 — bioinformatics — Posted on 2022-08-17
1792 Probe set selection for targeted spatial transcriptomics
Kuemmerle, L. B.; Luecken, M. D.; Firsova, A. B.; Barros de Andrade e Sousa, L.; Strasser, L.; Heumos, L.; Mekki, I. I.; Mahbubani, K. T.; Sountoulidis, A.; Balassa, T.; Kovacs, F.; Horvath, P.; Piraud, M.; Erturk, A.; Samakovlis, C.; Theis, F. J.
10.1101/2022.08.16.504115 — bioinformatics — Posted on 2022-08-17
1793 Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering
Liu, C. C.; Greenwald, N. F.; Kong, A.; McCaffrey, E. F.; Leow, K. X.; Mrdjen, D.; Angelo, M.
10.1101/2022.08.16.504171 — bioinformatics — Posted on 2022-08-17
1796 Estimating sequence diversity of prion protein gene (PRNP) in Portuguese populations of two cervid species: red deer and fallow deer.
Pereira, J. C.; Goncalves-Anjo, N.; Orge, L.; Pires, M.; Rocha, S.; Figueira, L.; Matos, A. C.; Silva, J.; Mendonca, P.; Carvalho, P.; Tavares, P.; Lima, C.; Alves, A.; Esteves, A.; Pinto, M. L.; Pires, I.; Gama, A.; Sargo, R.; Silva, F.; Seixas, F.; Vieira-Pinto, M.; Bastos, E.
10.1101/2022.08.16.504133 — genetics — Posted on 2022-08-17
1799 Homeodomain-less MEIS1 suppresses CUL3-dependent ATOH1 degradation to regulate cerebellar granule cell development
Owa, T.; Shiraishi, R.; Adachi, T.; Miytashita, S.; Ichijo, K.; Nishioka, T.; Taya, S.; Kaibuchi, K.; Hoshino, M.
10.1101/2022.08.17.504235 — cell biology — Posted on 2022-08-17
1800 Red blood cell lingering modulates hematocrit distribution in the microcirculation
Rashidi, Y.; Simionato, G.; Zhou, Q.; John, T.; Kihm, A.; Bendaoud, M.; Krueger, T.; Bernabeu, M. O.; Kaestner, L.; Laschke, M. W.; Menger, M. D.; Wagner, C.; Darras, A.
10.1101/2022.08.16.504126 — biophysics — Posted on 2022-08-17
1801 Non-invasive fecal DNA yields whole genome and metagenomic data for species conservation
de Flamingh, A.; Ishida, Y.; Pecnerova, P.; Vilchis, S.; Siegismund, H.; van Aarde, R.; Malhi, R.; Roca, A.
10.1101/2022.08.16.504190 — genomics — Posted on 2022-08-17
1805 Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy
Majd, H.; Amin, S.; Ghazizadeh, Z.; Cesiulis, A.; Arroyo, E.; Lankford, K.; Farahvashi, S.; Chemel, A. K.; Okoye, M.; Scantlen, M. D.; Tchieu, J.; Calder, E. L.; LeRouzic, V.; Arab, A.; Goodarzi, H.; Pasternak, G.; Kocsis, J. D.; Chen, S.; Studer, L.; Fattahi, F.
10.1101/2022.08.16.504209 — developmental biology — Posted on 2022-08-17
1806 An examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells
Manchanda, Y.; Bitsi, S.; Chen, S.; Broichhagen, J.; Bernardino de la Serna, J.; Jones, B.; Tomas, A.
10.1101/2022.08.17.504231 — cell biology — Posted on 2022-08-17
1808 Detecting anomalous content in dairy with whole metagenome sequencing
Haiminen, N.; Beck, K. L.; Agarwal, A.; Carrieri, A.-P.; Kawas, B.; Wiedmann, M.; Ganda, E.
10.1101/2022.08.16.504221 — microbiology — Posted on 2022-08-17
1809 Leaf side determines the relative importance of dispersal versus host filtering in the phyllosphere microbiome
Smets, W.; Chock, M. K.; Walsh, C. M.; Vanderburgh, C. Q.; Kau, E.; Lindow, S. E.; Fierer, N.; Koskella, B.
10.1101/2022.08.16.504148 — microbiology — Posted on 2022-08-17
1811 In Situ Microwave Fixation to Define the Terminal Rodent Brain Metabolome
Juras, J. A.; Webb, M. B.; Young, L. E. A.; Markussen, K. H.; Hawkinson, T. R.; Buoncristiani, M. D.; Bolton, K. E.; Coburn, P. T.; Wiliams, M. I.; Sun, L. P.; Sanders, W. C.; Bruntz, R. C.; Conroy, L. R.; Wang, C.; Gentry, M. S.; Smith, B. N.; Sun, R. C.
10.1101/2022.08.16.504166 — biochemistry — Posted on 2022-08-17
1814 The genome of a vestimentiferan tubeworm (Ridgeia piscesae) provides insights into its adaptation to a deep-sea environment
Wang, M.; Ruan, L.; Liu, M.; Liu, Z.; He, J.; Zhang, L.; Wang, Y.; Shi, H.; Chen, M.; Yang, F.; Zeng, R.; He, J.; Guo, C.; Chen, J.
10.1101/2022.08.16.504205 — genomics — Posted on 2022-08-17
1816 A gradient border model for cell fate decisions at the neural plate border
Thiery, A.; Buzzi, A. L.; Hamrud, E.; Cheshire, C.; Luscombe, N.; Briscoe, J.; Streit, A.
10.1101/2022.02.15.480567 — developmental biology — Posted on 2022-08-17
1819 Engineering bacterial blight-resistant plants through CRISPR/Cas9-targeted editing of the MeSWEET10a promoter in cassava
Wang, Y.; Geng, M.; Pan, R.; Zhang, T.; Lu, X.; Zhen, X.; Che, Y.; Li, R.; Liu, J.; Chen, Y.; Guo, J.; Yao, Y.
10.1101/2022.03.02.482644 — plant biology — Posted on 2022-08-17
1821 Analysis of the complete genome sequence for Halococcus dombrowskii ATCC BAA-364T
Lim, S. W.; Maurais, E. G.; Farwell, A. C.; Barber, N.; Olsen, A. J.; Shalygina, K. F.; Omeragic, M.; Fedorov, E. A.; MacLea, K. S.
10.1101/2022.08.16.504008 — genomics — Posted on 2022-08-17
1822 Transient interactions drive the lateral clustering of Cadherin-23 on membrane
Srinivas, C. S.; Singaraju, G. S.; Das, S.; Sagar, A.; Kumar, A.; Rakshit, S.
10.1101/2022.01.09.475209 — cell biology — Posted on 2022-08-17
1823 Reaction-diffusion patterning of DNA-based artificial cells
Leathers, A.; Walczak, M.; Brady, R. A.; Al Samad, A.; Kotar, J.; Booth, M. J.; Cicuta, P.; Di Michele, L.
10.1101/2022.03.24.485404 — synthetic biology — Posted on 2022-08-16
1824 DeepST: A versatile graph contrastive learning framework for spatially informed clustering, integration, and deconvolution of spatial transcriptomics
Long, Y.; Ang, K. S.; Li, M.; Chong, K. L. K.; Sethi, R.; Zhong, C.; Xu, H.; Ong, Z.; Sachaphibulkij, K.; Chen, A.; Li, Z.; Fu, H.; Wu, M.; Lim, H. K. L.; Liu, L.; Chen, J.
10.1101/2022.08.02.502407 — bioinformatics — Posted on 2022-08-16
1826 Human activities impact microbial communities of Amazon Mangroves
da Costa, G. M.; Costa, S. d. S.; Barauna, R. A.; Castilho, B. P.; Pinheiro, I. C.; da Silva, A. L. d. C.; Silva, A. P. S.; dos Santos, A. K. C. R.; das Gracas, D. A.
10.1101/2022.08.03.501699 — genetics — Posted on 2022-08-16
1831 Alterations of pulmonary surfactant function by e-cigarette vapour
Graham, E.; McCaig, L.; Shui-Kei Lau, G.; Tejura, A.; Cao, A.; Zuo, Y. Y.; Veldhuizen, R.
10.1101/2022.08.16.501319 — biophysics — Posted on 2022-08-16
1834 Nudibranch predation boosts sponge silicon cycling
Lopez-Acosta, M.; Potel, C.; Gallinari, M.; F. Perez, F.; Leynaert, A.
10.1101/2022.08.16.504137 — ecology — Posted on 2022-08-16
1835 Proteome capacity constraints favor respiratory ATP generation
Shen, Y.; Dinh, H. V.; Cruz, E.; Call, C. M.; Baron, H.; Ryseck, R.-P.; Pratas, J.; Subramanian, A.; Fatma, Z.; Weilandt, D.; Dwaraknath, S.; Xiao, T.; Hendry, J. I.; Tran, V.; Yang, L.; Yoshikuni, Y.; Zhao, H.; Maranas, C. D.; Wuhr, M.; Rabinowitz, J. D.
10.1101/2022.08.10.503479 — systems biology — Posted on 2022-08-16
1839 Facilitating CG simulations with MAD: theMArtini Database Server
Hilpert, C.; Beranger, L.; Souza, P. C. T.; Vainikka, P. A.; Nieto, V.; Marrink, S. J.; Monticelli, L.; Launay, G.
10.1101/2022.08.03.502585 — biophysics — Posted on 2022-08-16
1840 ATG9 vesicles comprise the seed membrane of mammalian autophagosomes
Olivas, T. J.; Wu, Y.; Yu, S.; Luan, L.; Choi, P.; Nag, S.; De Camilli, P.; Gupta, K.; Melia, T. J.
10.1101/2022.08.16.504143 — cell biology — Posted on 2022-08-16
1849 Plankton energy flows using a global size-structured and trait-based model
Negrete-Garcia, G.; Luo, J. Y.; Long, M. C.; Lindsay, K.; Levy, M.; Barton, A. D.
10.1101/2022.02.01.478546 — biochemistry — Posted on 2022-08-16
1853 Influenza A virus reassortment in mammals gives rise to genetically distinct within-host sub-populations
Ganti, K.; Bagga, A.; Carnaccini, S.; Ferreri, L. M.; Geiger, G.; Caceres, J.; Seibert, B. A.; Li, Y.; Wang, L.; Kwon, T.; Li, Y.; Morozov, I.; Ma, W.; Richt, J. A.; Perez, D. R.; Koelle, K.; Lowen, A. C.
10.1101/2022.02.08.479600 — microbiology — Posted on 2022-08-16
1860 Merlin Tumor Suppressor Function is Regulated by PIP2-Mediated Dimerization
Hennigan, R. F.; Thomson, C. S.; Ratner, N.; Nassar, N.; Stachowski, K.
10.1101/2021.11.11.468247 — cancer biology — Posted on 2022-08-16
1861 Towards a structurally resolved human protein interaction network
Burke, D. F.; Bryant, P.; Barrio-Hernandez, I.; Memon, D.; Pozzati, G.; Shenoy, A.; Zhu, W.; Dunham, A. S.; Albanese, P.; Keller, A.; Scheltema, R. A.; Bruce, J. B.; Leitner, A.; Kundrotas, P.; Beltrao, P.; Elofsson, A.
10.1101/2021.11.08.467664 — bioinformatics — Posted on 2022-08-16
1866 Exposure of Greenlandic Inuit and South African VhaVenda men to the persistent DDT metabolite is associated with an altered sperm epigenome at regions implicated in paternal epigenetic transmission and developmental disease - a cross-sectional study
Lismer, A.; Shao, X.; Dumargne, M.-C.; Lafleur, C.; Lambrot, R.; Chan, D.; Toft, G.; Bonde, J. P.; MacFarlane, A.; Bornman, R.; Aneck-Hahn, N.; Patrick, S.; Bailey, J.; de Jager, C.; Dumeaux, V.; Trasler, J.; Kimmins, S.
10.1101/2022.08.15.504029 — genomics — Posted on 2022-08-16
1867 Capped nascent RNA sequencing reveals novel therapy-responsive enhancers in prostate cancer
Cotter, K. A.; Shah, S. R.; Paramo, M. I.; Lou, S.; Yao, L.; Rubin, P. D.; Chen, Y.; Gerstein, M.; Rubin, M.; Yu, H.
10.1101/2022.04.08.487666 — genomics — Posted on 2022-08-16
1869 RGG-motif proteins regulate mRNA translation upon genotoxic stress
Roy, R.; Mohanan, G.; Malka-Mahieu, H.; Biswas, A.; Labbe, C.; Vagner, S.; Rajyaguru, P. I.
10.1101/2022.07.12.499753 — cell biology — Posted on 2022-08-16
1872 Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data Fusion
Lotter, L. D.; Kohl, S. H.; Gerloff, C.; Bell, L.; Niephaus, A.; Kruppa, J. A.; Dukart, J.; Schulte-Rüther, M.; Reindl, V.; Konrad, K.
10.1101/2022.07.26.501562 — neuroscience — Posted on 2022-08-16
1875 Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome
chen, m.; Cavinato, C.; Hansen, J.; Tanaka, K.; ren, p.; Hassab, A.; li, d. s.; Joshuao, E.; Tellides, G.; Iyengar, R.; Humphrey, J. D.; Schwartz, M.
10.1101/2022.08.16.504169 — pathology — Posted on 2022-08-16
1876 Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Hsu, P. P.; Do, B. T.; Vermeulen, S. Y.; Wang, Z.; Hirz, T.; Aziz, N.; Replogle, J. M.; Abbott, K. L.; Block, S.; Darnell, A. M.; Ferreira, R.; Milosevic, J. T.; Schmidt, D. R.; Chidley, C.; Su, X. A.; Harris, I. S.; Weissman, J. S.; Cheloufi, S.; Sykes, D. B.; Vander Heiden, M. G.
10.1101/2022.08.16.503984 — cancer biology — Posted on 2022-08-16
1877 Kokiri: Random Forest-Based Cohort Comparison and Characterization
Eckelt, K.; Adelberger, P.; Bauer, M. J.; Zichner, T.; Streit, M.
10.1101/2022.08.16.503622 — bioinformatics — Posted on 2022-08-16
1878 A guide to sampling design for GPS-based studies of animal societies
He, P.; Klarevas-Irby, J. A.; Papageorgiou, D.; Christensen, C.; Strauss, E. D.; Farine, D. R.
10.1101/2022.01.29.478280 — animal behavior and cognition — Posted on 2022-08-16
1881 Characterization of an Eye Field-like State during Optic Vesicle Organoid Development
Owen, L. J.; Rainger, J.; Bengani, H.; Kilanowski, F.; FitzPatrick, D. R.; Papanastasiou, A. S.
10.1101/2022.08.16.504119 — developmental biology — Posted on 2022-08-16
1883 Genetic variations in G-Quadruplex forming sequences affect the transcription of human disease-related genes
Lorenzatti, A.; Piga, E. J.; Gismondi, M.; Binolfi, A.; Margarit, E.; Calcaterra, N. B.; Armas, P.
10.1101/2022.08.16.503999 — molecular biology — Posted on 2022-08-16
1884 Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation
Saragovi, A.; Zheng, X.; Abramovich, I.; Cohen-Daniel, L.; Zhuoning, L.; Raifer, H.; Omar, I.; Swisa, A.; Kuchersky, M.; Drori, A.; Marini, F.; Toker, O.; Somech, R.; Schmidl, C.; Hendrickson, R. C.; Gottlieb, E.; Huber, M.; Berger, M.
10.1101/2022.08.16.504136 — immunology — Posted on 2022-08-16
1885 Regulation of Macrophage IFNγ-Stimulated Gene Expression by the Transcriptional Coregulator CITED1
Subramani, A.; Hite, M. E. L.; Kondee, H.; Millican, G. E.; McClelland, E. E.; Seipelt-Thiemann, R. L.; Nelson, D. E.
10.1101/2022.08.16.504142 — immunology — Posted on 2022-08-16
1891 Copy-number dosage regulates telomere maintenance and disease-associated pathways in neuroblastoma
Burkert, M.; Blanc, E.; Thiessen, N.; Weber, C.; Toedling, J.; Monti, R.; Dombrowe, V. M.; de Biase, M. S.; Kaufmann, T. L.; Haase, K.; Waszak, S. M.; Eggert, A.; Beule, D.; Schulte, J. H.; Ohler, U.; Schwarz, R. F.
10.1101/2022.08.16.504100 — genomics — Posted on 2022-08-16
1893 Analysis of the complete genome sequence for Halococcus dombrowskii ATCC BAA-364T
Lim, S. W.; Maurais, E. G.; Farwell, A. C.; Barber, N.; Olsen, A. J.; Shalygina, K. F.; Omeragic, M.; Fedorov, E. A.; MacLea, K. S.
10.1101/2022.08.16.504008 — genomics — Posted on 2022-08-16
1896 Leveraging prior biological knowledge improves prediction of tocochromanols in maize grain
Tanaka, R.; Wu, D.; Li, X.; Tibbs-Cortes, L. E.; Wood, J. C.; Magallanes-Lundback, M.; Bornowski, N.; Hamilton, J. P.; Vaillancourt, B.; Li, X.; Deason, N. T.; Schoenbaum, G. R.; Buell, C. R.; DellaPenna, D.; Yu, J.; Gore, M. A.
10.1101/2022.08.16.502005 — genetics — Posted on 2022-08-16
1898 A novel batokine Breg controls adipose thermogenesis and glucose homeostasis
Chen, Q.; Huang, L.; Pan, D.; Hu, K.; Li, R.; Zhu, L. J.; Guertin, D.; Wang, Y.-X.
10.1101/2022.08.16.504121 — cell biology — Posted on 2022-08-16
1899 Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects
Kulcsar, P. I.; Talas, A.; Ligeti, Z.; Toth, E.; Rakvacs, Z.; Vegi, V. L.; Krausz, S. L.; Huszar, K.; Welker, E.
10.1101/2022.08.16.504097 — molecular biology — Posted on 2022-08-16
1900 PPAR-γ regulates the effector function of human TH9 cells by promoting glycolysis
Bertschi, N. L.; Steck, O.; Luther, F.; Bazzini, C.; von Meyenn, L.; Felser, A.; Keller, I.; Friedli, O.; Freigang, S.; Begre, N.; Lamos, C.; Gabutti, M. P.; Benzaquen, M.; Laimer, M.; Simon, D.; Nuoffer, J.-M.; Schlapbach, C.
10.1101/2022.08.16.503972 — immunology — Posted on 2022-08-16
1901 Posteromedial cortical networks encode visuomotor prediction errors.
Takeuchi, R. F.; Ito, K. N.; Ueda, R.; Yamaguchi, M.; Osakada, F.
10.1101/2022.08.16.504075 — neuroscience — Posted on 2022-08-16
1902 The RSK-RPS6 axis controls the preconditioning effect and induces spinal cord regeneration
Decourt, C.; Schaeffer, J.; Blot, B.; Paccard, A.; Excoffier, B.; Pende, M.; Nawabi, H.; Belin, S.
10.1101/2022.08.16.502928 — neuroscience — Posted on 2022-08-16
1908 Plasma membrane nanodeformations promote actin polymerisation through CIP4/CDC42 recruitment and regulate type II IFN signaling
Ledoux, B.; Zanin, N.; Yang, J.; Coster, C.; Dupont-Gillain, C.; Alsteens, D.; Morsomme, P.; Renard, H.-F.
10.1101/2022.08.16.504113 — cell biology — Posted on 2022-08-16
1910 Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells
Liu, C. S. C.; Mandal, T.; Biswas, P.; Hoque, M. A.; Bandopadhyay, P.; Sinha, B. P.; Sarif, J.; D'Rozario, R.; Sinha, D. K.; Sinha, B.; Ganguly, D.
10.1101/2022.08.16.504114 — immunology — Posted on 2022-08-16
1911 In-vivo Measurement of Radio Frequency Electric Fields in Mice Brain
Yaghmazadeh, O.; Schoenhardt, S.; Sarabandi, A.; Sabet, A.; Sabet, K.; Safari, F.; Alon, L.; Buzsaki, G.
10.1101/2022.08.16.504138 — biophysics — Posted on 2022-08-16
1912 Synchronicity of viral shedding in molossid bat maternity colonies
Hoarau, A. O. G.; Köster, M.; Dietrich, M.; Le Minter, G.; Joffrin, L.; Ramanantsalama, R. V.; Mavingui, P.; Lebarbenchon, C.
10.1101/2022.08.16.504085 — ecology — Posted on 2022-08-16
1914 The post-translational modification SUMO affects TDP-43 phase separation, compartmentalization, and aggregation in a zebrafish model
Maurel, C.; Scherer, N. M.; Hogan, A.; Vidal-Itriago, A.; Don, E. K.; Radford, R.; Chapman, T.; Cull, S.; Vourch, P.; Chung, R.; Lee, A.; Morsch, M.
10.1101/2022.08.14.503569 — molecular biology — Posted on 2022-08-16
1916 Exploring therapeutic strategies for Infantile Neuronal Axonal Dystrophy (INAD/PARK14)
Lin, G.; Tepe, B.; McGrane, G.; Tipon, R. C.; Croft, G.; Panwala, L.; Hope, A.; Liang, A. J.; Zuo, Z.; Wang, L.; Bellen, H. J.
10.1101/2022.08.16.504080 — neuroscience — Posted on 2022-08-16
1917 A mouse model of insomnia with sleep apnea
Masubuchi, S.; Yano, T.; Koatsu, K.; Ikegami, K.; Nakamura, W.; Ota, A.; Karnan, S.; Takeuchi, K.; Yoshitaka, H.; Todo, T.; Shiomi, T.
10.1101/2022.08.16.503987 — physiology — Posted on 2022-08-16
1918 DeepGAMI: Deep biologically guided auxiliary learning for multimodal integration and imputation to improve phenotype prediction
Chandrashekar, P. B.; Wang, J.; Hoffman, G. E.; He, C.; Jin, T.; Alatkar, S.; Khullar, S.; Bendl, J.; Fullard, J. F.; Roussos, P.; Wang, D.
10.1101/2022.08.16.504101 — bioinformatics — Posted on 2022-08-16
1920 A key residue of plant ABC transporter modulates access path geometry and phenylpropanoid substrate selectivity
Pakuła, K.; Sequeiros-Borja, C.; Biała-Leonhard, W.; Pawela, A.; Banasiak, J.; Bailly, A.; Radom, M.; Geisler, M.; Brezovsky, J.; Jasinski, M.
10.1101/2022.08.16.503940 — biochemistry — Posted on 2022-08-16
1924 Delta-Omicron recombinant escapes therapeutic antibody neutralization
Duerr, R.; Zhou, H.; Tada, T.; Dimartino, D.; Marier, C.; Zappile, P.; Wang, G.; Plitnick, J.; Griesemer, S.; Girardin, R. C.; Machowski, J.; Bialosuknia, S.; Lasek-Nesselquist, E.; Hong, S. L.; Baele, G.; Dittman, M.; Ortigoza, M. B.; Prasad, P. J.; McDonough, K.; Landau, N.; St. George, K.; Heguy, A.
10.1101/2022.04.06.487325 — microbiology — Posted on 2022-08-16
1925 Melatonin suppression does not automatically alter sleepiness, vigilance, sensory processing, or sleep
Blume, C.; Niedernhuber, M.; Spitschan, M.; Slawik, H. C.; Meyer, M. P.; Bekinschtein, T.; Cajochen, C.
10.1101/2022.04.12.488023 — neuroscience — Posted on 2022-08-16
1926 Selecting better biocatalysts by complementing recoded bacteria
Rubini, R.; Jansen, S. C.; Beekhuis, H.; Rozeboom, H. J.; Mayer, C.
10.1101/2022.08.16.504095 — synthetic biology — Posted on 2022-08-16
1928 Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells
Liu, Z.; Krstic, A.; Neve, A.; Rauch, N.; Wynne, K.; Cassidy, H.; McCann, A.; Kavanagh, E.; McCann, B.; Blanco, A.; Rauch, J.; Kolch, W.
10.1101/2022.08.16.504086 — cancer biology — Posted on 2022-08-16
1929 Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling
Rubio, K.; Romero, A.; Sarvari, P.; Guenther, S.; Mehta, A.; Bassaly, B.; Braubach, P.; Dobreva, G.; Wygrecka, M.; Gattenloehner, S.; Braun, T.; Tresch, A.; Graumann, J.; Barreto, G.
10.1101/2022.08.16.504078 — cancer biology — Posted on 2022-08-16
1932 Identification of cell barcodes from long-read single-cell RNA-seq with BLAZE
You, Y.; Prawer, Y. D. J.; Paoli-Iseppi, R. D.; Hunt, C. P. J.; Parish, C. L.; Shim, H.; Clark, M. B.
10.1101/2022.08.16.504056 — bioinformatics — Posted on 2022-08-16
1934 3D RNA-scaffolded wireframe origami
Parsons, M. F.; Allan, M. F.; Li, S.; Shepherd, T. R.; Ratanalert, S.; Zhang, K.; Pullen, K. M.; Chiu, W.; Rouskin, S.; Bathe, M.
10.1101/2022.08.15.504019 — bioengineering — Posted on 2022-08-16
1937 The emergence of variants with increased fitness accelerates the slowdown of genome sequence heterogeneity in the SARS-CoV-2 coronavirus
Oliver, J. L.; Bernaola-Galvan, P.; Perfectti, F.; Gomez-Martin, C.; Castiglione, S.; Raia, P.; Verdu, M.; Moya, A.
10.1101/2022.05.26.493529 — genomics — Posted on 2022-08-16
1938 The emergence of high-fitness variants accelerates the decay of genome heterogeneity in the coronavirus
Oliver, J. L.; Bernaola-Galvan, P.; Perfectti, F.; Gomez-Martin, C.; Castiglione, S.; Raia, P.; Verdu, M.; Moya, A.
10.1101/2021.11.06.467547 — genomics — Posted on 2022-08-16
1940 Species-specific traits mediate avian demographic responses under past climate change
Germain, R. R.; Feng, S.; Chen, G.; Graves, G.; Tobias, J.; Rahbek, C.; Lei, F.; Fjeldsa, J.; Hosner, P.; Gilbert, M. T. P.; Zhang, G.; Nogues-Bravo, D.
10.1101/2022.08.16.504093 — evolutionary biology — Posted on 2022-08-16
1941 Disease decreases variation in host community structure in an old-field grassland
Grunberg, R. L.; Halliday, F. W.; Heckman, R. W.; Joyner, B. N.; O'Keeffe, K. R.; Mitchell, C. E.
10.1101/2022.08.15.503989 — ecology — Posted on 2022-08-16
1942 Four decades of phenology in an alpine amphibian: trends, stasis and climatic drivers
Lenzi, O.; Grossenbacher, K.; Zumbach, S.; Luescher, B.; Althaus, S.; Schmocker, D.; Recher, H.; Thoma, M.; Ozgul, A.; Schmidt, B. R.
10.1101/2022.08.16.503739 — ecology — Posted on 2022-08-16
1944 Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium
Pydyn, N.; Kadluczka, J.; Major, P.; Hutsch, T.; Woloszyn, K.; Malczak, P.; Radkowiak, D.; Budzynski, A.; Miekus, K.; Jura, J.; Kotlinowski, J.
10.1101/2022.08.16.504094 — molecular biology — Posted on 2022-08-16
1946 Optimized Quantification of Intrahost Viral Diversity in SARS-CoV-2 and Influenza Virus Sequence Data
Roder, A.; Johnson, K. E.; Knoll, M.; Khalfan, M.; Wang, B.; Schultz-Cherry, S.; Banakis, S.; Kreitman, A.; Mederos, C.; Youn, J.-H.; Mercado, R.; Wang, W.; Ruchnewitz, D.; Samanovic, M. I.; Mulligan, M. J.; Laessig, M.; Luksza, M.; Das, S.; Gresham, D.; Ghedin, E.
10.1101/2021.05.05.442873 — microbiology — Posted on 2022-08-16
1950 ENGRAILED-1 transcription factor exerts a paracrine neurotrophic activity on adult spinal cord α-motoneurons.
Leboeuf, M.; Vargas-Abonce, S. E.; Peze-Hedsieck, E.; Dupont, E.; Jimenez-Alonso, L.; MOYA, K. L.; Prochiantz, A.
10.1101/2022.08.16.504081 — neuroscience — Posted on 2022-08-16
1951 Temporal dynamics of oscillatory brain activity during the observation of communicative interactions between point-light agents
Friedrich, E. V. C.; Zillekens, I.; Biel, A. L.; O'Leary, D.; Singer, J.; Seegenschmiedt, E. V.; Sauseng, P.; Schilbach, L.
10.1101/2022.08.16.504090 — neuroscience — Posted on 2022-08-16
1952 High-resolution eye-tracking via digital imaging of Purkinje reflections
Wu, R.-J.; Clark, A. M.; Cox, M.; Intoy, J.; Jolly, P.; Zhao, Z.; Rucci, M.
10.1101/2022.08.16.504076 — neuroscience — Posted on 2022-08-16
1955 Intrinsic disorder in CENP-ACse4 tail and its chaperone facilitates synergistic association for kinetochore stabilization
Shukla, S.; Bhattacharya, A.; Agarwal, P.; Malik, N.; Duraisamy, K.; Sri Rangan, N.; Hosur, R. V.; kumar, A.
10.1101/2022.08.15.504061 — biophysics — Posted on 2022-08-16
1958 A comparative study of two grasswren species reveals strong genetic divergence between a peninsula and mainland population
Gibson Vega, A.; Hall, M. L.; Ridley, A.; Cowen, S. J.; Slender, A. L.; Burbidge, A. H.; Louter, M.; Kennington, W. J.
10.1101/2022.08.15.503954 — genetics — Posted on 2022-08-16
1961 Multiplex PCR Assay for Clade-typing Salmonella Enteritidis
Gallichan, S.; Perez-Sepulveda, B. M.; Feasey, N.; Hinton, J.; Thomas, J.; Smith, A. M.
10.1101/2022.08.12.503823 — molecular biology — Posted on 2022-08-16
1963 ARAX: a graph-based modular reasoning tool for translational biomedicine
Glen, A. K.; Ma, C.; Mendoza, L.; Womack, F.; Wood, E. C.; Sinha, M.; Acevedo, L.; Kvarfordt, L. G.; Peene, R. C.; Liu, S.; Hoffman, A. S.; Roach, J. C.; Deutsch, E. W.; Ramsey, S. A.; Koslicki, D.
10.1101/2022.08.12.503810 — bioinformatics — Posted on 2022-08-16
1965 The IgH Eμ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
Martin, O.; Thomas, M.; Marquet, M.; Garot, A.; Brousse, M.; Bender, S.; Carrion, C.; Choi, J. E.; Vuong, B.; Gearhart, P.; Maul, R.; Le Noir, S.; Pinaud, E.
10.1101/2022.08.15.503996 — immunology — Posted on 2022-08-16
1966 The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: A two-pronged meta-analysis
Chye, S.; Chembila Valappil, A.; Wright, D. J.; Frank, C.; Shearer, D. A.; Tyler, C. J.; Diss, C. E.; Mian, O.; Tillin, N.; Bruton, A. M.
10.1101/2022.05.23.493106 — neuroscience — Posted on 2022-08-16
1967 Masculinization of the X-chromosome in aphid soma and gonads
Jaquiery, J.; Simon, J.-C.; Robin, S.; Richard, G.; Peccoud, J.; Boulain, H.; Legeai, F.; Tanguy, S.; Prunier-Leterme, N.; Letrionnaire, G.
10.1101/2021.08.13.453080 — evolutionary biology — Posted on 2022-08-16
1968 ALLOPURINOL BLOCKS AORTIC ANEURYSM IN A MOUSE MODEL OF MARFAN SYNDROME VIA REDUCING AORTIC OXIDATIVE STRESS
Rodriguez-Rovira, I.; Arce, C.; Rycke, K. d.; Perez, B.; Carretereo, A.; Arbones, M.; Teixido-Tura, G.; Gomez-Cabrera, M. C.; Campuzano, V.; Jimenez-Altayo, F.; Egea, G.
10.1101/2021.10.13.464182 — pathology — Posted on 2022-08-16
1971 Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities
Hegazy, A. N.; Peine, C.; Niesen, D.; Panse, I.; Vainshtein, Y.; Kommer, C.; Zhang, Q.; Brunner, T. M.; Peine, M.; Froehlich, A.; Ishaque, N.; Marek, R. M.; Zhu, J. J.; Hoefer, T.; Loehning, M.
10.1101/2022.08.14.503916 — immunology — Posted on 2022-08-16
1974 Cardiac adenylyl cyclase type 8 overexpression increases locomotor activity in mice by modulating EEG-gamma oscillations
Agrimi, J.; Menicucci, D.; Qu, J.-H.; Mackey, C.; Laurino, M.; Hasnain, L.; McDevit, R. A.; Tarasova, Y. S.; Tarasov, K. V.; Hoover, D. B.; Gemignani, A.; Paolocci, N.; Lakatta, E. G.
10.1101/2021.07.19.452502 — physiology — Posted on 2022-08-16
1980 The circulating phageome reflects bacterial infections
Haddock, N. L.; Barkal, L. J.; Ram-Mohan, N.; Kaber, G.; Chiu, C. Y.; Bhatt, A. S.; Yang, S.; Bollyky, P.
10.1101/2022.08.15.504009 — microbiology — Posted on 2022-08-15
1981 Syncytial nerve net in a ctenophore sheds new light on the early evolution of nervous systems
Burkhardt, P.; Medhus, A.; Digel, L.; Naumann, B.; Soto-Angel, J. J.; Nordmann, E.-L.; Sachkova, M.; Kittelmann, M.
10.1101/2022.08.14.503905 — evolutionary biology — Posted on 2022-08-15
1985 Compartment-Specific Measurement of Small Molecule Accumulation into Diderm Bacteria
Ongwae, G. M.; Lepori, I.; Chordia, M. D.; Dalesandro, B. E.; Apostolos, A. J.; Siegrist, M. S.; Pires, M. M.
10.1101/2022.05.05.489932 — microbiology — Posted on 2022-08-15
1986 Outer membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes
White, J. B.; Silale, A.; Feasey, M. C.; Heunis, T.; Zhu, Y.; Zheng, H.; Gajbhiye, A.; Firbank, S.; Basle, A.; Trost, M.; Bolam, D. N.; Ranson, N. A.; van den Berg, B.
10.1101/2022.08.15.503959 — microbiology — Posted on 2022-08-15
1987 Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-cells in the Context of HIV-1 infection
Doyon-Laliberte, K.; Aranguren, M.; Byrns, M.; Chagnon-Choquet, J.; Paniconi, M.; Routy, J.-P.; Tremblay, C.; Quintal, M.-C.; Brassard, N.; Kaufmann, D. E.; Poudrier, J.; Roger, M.
10.1101/2022.08.15.504021 — immunology — Posted on 2022-08-15
1991 Steroidal glycoalkaloids contribute to anthracnose resistance in Solanum lycopersicum
Fabian, M. L.; Zhang, C.; Sun, J.; Price, N. P.; Chen, P.; Clarke, C. R.; Jones, R. W.; Stommel, J. R.
10.1101/2022.08.08.503224 — plant biology — Posted on 2022-08-15
1992 Genetic silencing of AKT induces melanoma cell death
Parkman, G. L.; Turapov, T.; Kircher, D. A.; Burnett, W. J.; Stehn, C. M.; O'Toole, K. T.; Flaherty, R.; Elmer, R. C.; Culver, K. M.; Foth, M.; Andtbacka, R.; Lum, D. H.; Judson-Torres, R. L.; VanBrocklin, M. W.; Holmen, S. L.; McMahon, M.
10.1101/2022.08.15.504039 — cancer biology — Posted on 2022-08-15
1993 FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
Wilde, B. R.; Chakraborty, N.; Matulionis, N.; Ueno, D.; Hernandez, S.; Esplin, E. D.; Ouyang, K.; Nykamp, K.; Shuch, B.; Christofk, H. R.
10.1101/2022.08.15.504023 — cancer biology — Posted on 2022-08-15
1996 Deep Learning-based Phenotype Imputation on Population-scale Biobank Data Increases Genetic Discoveries
An, U.; Pazokitoroudi, A.; Alvarez, M.; Huang, L.; Bacanu, S.; Schork, A. J.; Kendler, K.; Pajukanta, P.; Flint, J.; Zaitlen, N.; Cai, N.; Dahl, A.; Sankararaman, S.
10.1101/2022.08.15.503991 — bioinformatics — Posted on 2022-08-15
1997 Enhanced capillary pumping using open-channel capillary trees with integrated paper pads
Lee, J. J.; Berthier, J.; Dostie, A. M.; Khor, J. W.; Tokihiro, J. C.; Tu, W.-c.; Theberge, A. B.; Berthier, E.
10.1101/2022.07.15.500252 — bioengineering — Posted on 2022-08-15
1998 Recombination between heterologous human acrocentric chromosomes
Guarracino, A.; Buonaiuto, S.; Potapova, T.; Rhie, A.; Koren, S.; Rubinstein, B.; Fischer, C.; Human Pangenome Reference Consortium, ; Gerton, J. L.; Phillippy, A. M.; Colonna, V.; Garrison, E.
10.1101/2022.08.15.504037 — genomics — Posted on 2022-08-15
1999 A single-cell massively parallel reporter assay detects cell type specific cis-regulatory activity
Zhao, S.; Hong, C. K.; Myers, C. A.; Granas, D. M.; White, M. A.; Corbo, J. C.; Cohen, B. A.
10.1101/2021.11.11.468308 — genomics — Posted on 2022-08-15
2000 Exposure of Greenlandic Inuit and South African VhaVenda men to the persistent DDT metabolite is associated with an altered sperm epigenome at regions implicated in paternal epigenetic transmission and developmental disease - a cross-sectional study
Lismer, A.; Shao, X.; Dumargne, M.-C.; Lafleur, C.; Lambrot, R.; Chan, D.; Toft, G.; Bonde, J. P.; MacFarlane, A.; Bornman, R.; Aneck-Hahn, N.; Patrick, S.; Bailey, J.; de Jager, C.; Dumeaux, V.; Trasler, J.; Kimmins, S.
10.1101/2022.08.15.504029 — genomics — Posted on 2022-08-15
2001 Metatranscriptomics reveals a shift in microbial community composition and function during summer months in a coastal marine environment
Sutherland, B. J. G.; Finke, J. F.; Saunders, R.; Warne, S.; Schulze, A. D.; Strohm, J. H. T.; Chan, A. M.; Suttle, C. A.; Miller, K. M.
10.1101/2022.01.21.477286 — genetics — Posted on 2022-08-15
2005 Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells
Zhong, L.; Gordillo, M.; Wang, X.; Qin, Y.; Huang, Y.; Soshnev, A.; Kumar, R.; Nanjangud, G.; James, D.; Allis, C. D.; Evans, T.; Carey, B.; Wen, D.
10.1101/2022.08.12.503780 — developmental biology — Posted on 2022-08-15
2006 Cell Senescence-Independent Ageing of Human Skin
Wordsworth, J.; Fullard, N.; Welsh, C.; Maltman, V.; Bascom, C.; Tasseff, R.; Isfort, R.; Costello, L.; Scanlan, R.; Przyborski, S.; Shanley, D.
10.1101/2022.08.15.504045 — molecular biology — Posted on 2022-08-15
2008 Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster
Port, J. R.; Morris, D. H.; Yinda, C. K.; Riopelle, J. C.; Avanzato, V. A.; Holbrook, M. G.; Schukz, J. E.; Saturday, T. A.; Bushmaker, T.; Barbian, K.; Russel, C. A.; Perry-Gottschalk, R.; Shaia, C. I.; Martens, C.; Lloyd-Smith, J. O.; Fischer, R. J.; Munster, V. J.
10.1101/2022.08.15.504010 — microbiology — Posted on 2022-08-15
2013 Negative legacy effects of past forest use on plant diversity in semi-natural grasslands on ski slopes
Yaida, Y. A.; Nagai, T.; Oguro, K.; Katsuhara, K. R.; Uchida, K.; Kenta, T.; Ushimaru, A.
10.1101/2022.08.11.503702 — plant biology — Posted on 2022-08-15
2015 Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
Okuma, H.; Hord, J. M.; Chandel, I.; Anderson, M. E.; Venzke, D.; Walimbe, A. S.; Joseph, S.; Gastel, Z.; Hara, Y.; Saito, F.; Matsumura, K.; Campbell, K. P.
10.1101/2022.08.09.502851 — biochemistry — Posted on 2022-08-15
2018 Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms
Cedillo, L.; Li, S.; Ahsan, F.; Stuhr, N. L.; Zhou, Y.; Zhang, Y.; Adedoja, A.; Murphy, L. M.; Yerevanian, A.; Emans, S.; Dao, K.; Li, Z.; Peterson, N. D.; Watrous, J.; Jain, M.; Das, S.; Pukkila-Worley, R.; Curran, S. P.; Soukas, A. A.
10.1101/2021.09.02.457410 — genetics — Posted on 2022-08-15
2019 Spatial scales of competition and a growth-motility tradeoff interact to determine bacterial coexistence
Kuhn, T.; Mamin, M.; Bindschedler, S.; Bshary, R.; Estoppey, A.; Gonzalez, D.; Palmieri, F.; Junier, P.; Richter, X.-Y. L.
10.1101/2022.01.05.474435 — ecology — Posted on 2022-08-15
2021 HSV-1 exploits host heterochromatin for egress
Lewis, H. C.; Kelnhofer-Millevolte, L. E.; Brinkley, M. R.; Arbach, H. E.; Arnold, E. A.; Ramachandran, S.; Avgousti, D. C.
10.1101/2022.05.31.494218 — microbiology — Posted on 2022-08-15
2022 Design and construction of 3D-printed devices to investigate active and passive bacterial dispersal on hydrated surfaces
Kuhn, T.; Buffi, M.; Bindschedler, S.; Chain, P.; Gonzalez, D.; Stanley, C.; Wick, L.; Junier, P.; Richter, X.-Y. L.
10.1101/2022.05.16.492069 — microbiology — Posted on 2022-08-15
2024 A Deep Redox Proteome Profiling Workflow and Its Application to Skeletal Muscle of a Duchene Muscular Dystrophy Model
Day, N. J.; Zhang, T.; Gaffrey, M.; Zhao, R.; Fillmore, T.; Moore, R. J.; Rodney, G. G.; Qian, W.
10.1101/2022.08.15.504013 — biochemistry — Posted on 2022-08-15
2027 Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars
Lawrence, A.-L. E.; Berger, R. P.; Hill, D. R.; Huang, S.; Yadagiri, V. K.; Bons, B.; Fields, C.; Knight, J. S.; Wobus, C. E.; Spence, J. R.; Young, V. B.; Abuaita, B. H.; O'Riordan, M. X.
10.1101/2022.08.09.503428 — immunology — Posted on 2022-08-15
2033 Hedgehog signaling acts as cell fate determinant during adult tissue repair
Norris, A. M.; Johnson, C. D.; Zhou, L. Y.; Appu, A.; McKellar, D. W.; Cosgrove, B. D.; Kopinke, D.
10.1101/2022.08.15.504012 — developmental biology — Posted on 2022-08-15
2048 Wenzhou shrimp virus 8 (WZV8) diagnosis by unique inclusions in shrimp hepatopancreatic E-cells and by RT-PCR
Srisala, J.; Thaiue, D.; Saguanrut, P.; Taengchaiyaphum, S.; Flegel, T. W.; Sritunyalucksana, K.
10.1101/2022.08.15.504032 — zoology — Posted on 2022-08-15
2050 Principles of metabolome conservation in animals
Liska, O.; Boross, G.; Rocabert, C.; Szappanos, B.; Tengölics, R.; Papp, B.
10.1101/2022.08.15.503737 — systems biology — Posted on 2022-08-15
2051 Identifying predictors of survival in patients with leukemia using single-cell mass cytometry and machine learning
Kleftogiannis, D.; Tislevoll, B. S.; Hellesoy, M.; Gullaksen, S.-E.; van der Meer, N.; Griessinger, E.; Motzfeldt, I. K. F.; Fagerholt, O.; Lenartova, A.; Floisand, Y.; Schuringa, J. J.; Gjertsen, B. T.; Jonassen, I.
10.1101/2022.08.13.503587 — cancer biology — Posted on 2022-08-15
2052 Quantitative reconstitution of yeast RNA processing bodies
Currie, S. L.; Xing, W.; Muhlrad, D.; Decker, C. J.; Parker, R.; Rosen, M. K.
10.1101/2022.08.13.503854 — biophysics — Posted on 2022-08-15
2054 Clonal evolution during metastatic spread in high-risk neuroblastoma
Gundem, G.; Levine, M. F.; Roberts, S. S.; Cheung, I. Y.; Medina-Matrinez, J. S.; Feng, Y.; Arango-Ossa, J. E.; Chadoutaud, L.; Rita, M.; Asimomitis, G.; Zhou, J.; You, D.; Bouvier, N.; Spitzer, B.; Solit, D. B.; Dela Cruz, F.; LaQuaglia, M. P.; Kushner, B.; Modak, S.; Shukla, N.; Iacobuzio-Donahue, C.; Kung, A. L.; Cheung, N.-K.; Papaemmanuil, E.
10.1101/2022.08.15.503973 — genomics — Posted on 2022-08-15
2058 Urotensin II-Related Peptides, Urp1 and Urp2, Control Zebrafish Spine Morphology
Bearce, E. A.; Irons, Z. H.; O'Hara-Smith, J. R.; Kuhns, C. J.; Fisher, S. I.; Crow, W. E.; Grimes, D. T.
10.1101/2022.08.13.503856 — developmental biology — Posted on 2022-08-15
2059 CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis
Stylianou, P.; Rushwan, S.; Wang, W.; Miah, M. A.; Darweesh, O.; Mackinnon, A.; Roach, K. M.; Hitchman, C. J.; Gonchar, O.; Thorpe, S.; Harris, C.; Haigh, R.; Richards, D. F.; Snetkov, V.; Beasley, J.; Cleary, S. J.; Barer, M. R.; Ward, J. P.; Rooney, C.; McCaughan, F.; Bradding, P. H.; Beale, R.; Knight, M. M.; Sethi, T.; Gooptu, B.
10.1101/2022.08.12.503154 — cell biology — Posted on 2022-08-15
2060 pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells
Farahani, P. E.; Yang, X.; Mesev, E.; Fomby, K.; Bashor, C.; Nelson, C. M.; Toettcher, J. E.
10.1101/2022.08.13.503850 — cell biology — Posted on 2022-08-15
2061 Single-cell analysis of non-alcoholic fatty livers identifies a role for the constitutive androstane receptor
Coassolo, L.; Liu, T.; Jung, Y.; Taylor, N. P.; Zhao, M.; Charville, G. W.; Nissen, S. B.; Yki-Jarvinen, H.; Altman, R. B.; Svensson, K. J.
10.1101/2022.08.15.504026 — cell biology — Posted on 2022-08-15
2064 SIRT-1 connects autophagy and release of virus-containing vesicles during picornavirus infection
Jassey, A.; Logue, J.; Weston, S.; Wagner, M. A.; Galitska, G.; Miller, K. A.; Frieman, M. B.; Jackson, W. T.
10.1101/2022.08.12.503821 — microbiology — Posted on 2022-08-15
2067 The gut microbiome and child mental health: a population-based study
Kraaij, R.; Schuurmans, I. K.; Radjabzadeh, D.; Tiemeier, H.; Dinan, T. G.; Uitterlinden, A. G.; Hillegers, M.; Jaddoe, V. W. V.; Duijts, L.; Moll, H.; Rivadeneira, F.; Medina-Gomez, C.; Jansen, P.; Cecil, C.
10.1101/2022.08.15.502771 — microbiology — Posted on 2022-08-15
2068 Evasion of Neutralizing Antibody Response by the SARS-CoV-2 BA.2.75 Variant
Qu, P.; Evans, J. P.; Zheng, Y.-M.; Carlin, C.; Saif, L. J.; Oltz, E. M.; Xu, K.; Gumina, R. J.; Liu, S.-L.
10.1101/2022.08.14.503921 — microbiology — Posted on 2022-08-15
2069 Distribution and abundance of tetraether lipid cyclization genes in terrestrial hot springs reflects pH
Blum, L. N.; Colman, D. R.; Eloe-Fadrosh, E. A.; Kellom, M.; Boyd, E. S.; Zhaxybayeva, O.; Leavitt, W. D.
10.1101/2022.08.15.504015 — microbiology — Posted on 2022-08-15
2070 Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans
Gervais, N. C.; La Bella, A. A.; Wensing, L. F.; Acquaviva, V.; Best, M.; Sharma, J.; Uthayakumar, D.; Chavez, A.; Santiago-Tirado, F.; Flores-Mireles, A. L.; Shapiro, R. S.
10.1101/2022.08.15.501889 — microbiology — Posted on 2022-08-15
2071 STAT3 signaling in B cells controls germinal center zone organization and recycling
Fike, A. J.; Chodisetti, S. B.; Wright, N. E.; Bricker, K. N.; Domeier, P. D.; Maienschein-Cline, M.; Rosenfeld, A. M.; Luckenbill, S. A.; Weber, J. L.; Choi, N. M.; Luning Prak, E. T.; Mandal, M.; Clark, M. R.; Rahman, Z. S. M.
10.1101/2022.08.12.503811 — immunology — Posted on 2022-08-15
2072 Intrinsic Activity Develops Along a Sensorimotor-Association Cortical Axis in Youth
Sydnor, V. J.; Larsen, B.; Seidlitz, J.; Adebimpe, A.; Alexander-Bloch, A.; Bassett, D. S.; Bertolero, M. A.; Cieslak, M.; Covitz, S.; Fan, Y.; Gur, R. E.; Gur, R. C.; Mackey, A. P.; Moore, T. M.; Roalf, D. R.; Shinohara, R. T.; Satterthwaite, T. D.
10.1101/2022.08.15.503994 — neuroscience — Posted on 2022-08-15
2073 Single session of rTMS enhances brain metastability and intrinsic ignition
Bharath, R. D.; Bhardwaj, S.; Panda, R.; Stezin, A.; Khokhar, S. K.; Prasad, S.; Tyagi, V.; Kamble, N.; Kumar, K.; M, N.; Yadav, R.; Annen, J.; Udupa, K.; Kashyap, R.; Laureys, S.; Deco, G.; Pal, P. K.
10.1101/2022.08.14.503887 — neuroscience — Posted on 2022-08-15
2075 High throughput analysis of vacuolar acidification
Zhang, C.; Balutowski, A.; Feng, Y.; Calderin, J. D.; Fratti, R. A.
10.1101/2022.08.13.503847 — biochemistry — Posted on 2022-08-15
2076 The Spike protein of SARS-coV2 19B (S) clade mirrors critical features of viral adaptation and coevolution
Hussein, B. K.; Ibrahium, O. M.; Alamin, M. F.; Ahmed, L. A. M.; Abuswar, S. A. E.; Abdelraheem, M. H.; Ibrahim, M. E.
10.1101/2022.08.12.503822 — evolutionary biology — Posted on 2022-08-15
2077 A gradient border model for cell fate decisions at the neural plate border
Thiery, A.; Buzzi, A. L.; Hamrud, E.; Cheshire, C.; Luscombe, N.; Briscoe, J.; Streit, A.
10.1101/2022.02.15.480567 — developmental biology — Posted on 2022-08-15
2081 Multispecies phase diagram of biofilm architectures reveals biophysical principles of biofilm development
Jeckel, H.; Diaz-Pascual, F.; Skinner, D. J.; Song, B.; Jimenez Siebert, E.; Jelli, E.; Vaidya, S.; Dunkel, J.; Drescher, K.
10.1101/2021.08.06.455416 — microbiology — Posted on 2022-08-15
2082 Soil protists can actively redistribute beneficial bacteria along Medicago truncatula roots
Hawxhurst, C. J.; Micciulla, J. L.; Bridges, C. M.; Shor, M.; Gage, D. J.; Shor, L. M.
10.1101/2021.06.16.448774 — microbiology — Posted on 2022-08-15
2083 Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord
Nakamura, Y.; Kurabe, M.; Matsumoto, M.; Sato, T.; Miyashita, S.; Hoshina, K.; Kamiya, Y.; Tainaka, K.; Matsuzawa, H.; Ohno, N.; Ueno, M.
10.1101/2022.08.15.501844 — neuroscience — Posted on 2022-08-15
2084 Cortical distribution of neurofilaments associates with pathological hallmarks and MRI measures of atrophy and diffusivity in Parkinson's disease
Frigerio, I.; Laansma, M. A.; Lin, C.-P.; Hermans, E. J.; Bouwman, M. M.; Bol, J. G.; Galis-de Graaf, Y.; Hepp, D. H.; Rozemuller, A. J.; Barkhof, F.; van de Berg, W. D.; Jonkman, L. E.
10.1101/2022.08.10.503440 — neuroscience — Posted on 2022-08-15
2087 ENVIROME-WIDE ASSOCIATIONS ENHANCE MULTI-YEAR GENOME-BASED PREDICTION OF HISTORICAL WHEAT BREEDING DATA
Costa-Neto, G.; Crespo-Herrera, L.; Fradgley, N.; Gardner, K.; Bentley, A. R.; Dreisigacker, S.; Fritsche-Neto, R.; Montesinos-Lopez, O.; Crossa, J.
10.1101/2022.08.14.503901 — genetics — Posted on 2022-08-15
2090 Acai (Euterpe precatoria Mart. Arecaceae) from the Northern Region of Bolivia is not contaminated with Trypanosoma cruzi
Rollano-Penaloza, O. M.; Roque-Marca, N.; Penarrieta, M.; Mollinedo, P.; Rodriguez, C.; Larrea-Alcazar, D.
10.1101/2022.08.15.503748 — ecology — Posted on 2022-08-15
2091 Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules
Pahl, A.; Schoelermann, B.; Rusch, M.; Dow, M.; Hedberg, C.; Nelson, A.; Sievers, S.; Waldmann, H.; Ziegler, S.
10.1101/2022.08.15.503944 — cell biology — Posted on 2022-08-15
2094 Loss of retinogeniculate synaptic function in the DBA/2J mouse model of glaucoma.
Smith, J. C.; Zhang, K. Y.; Sladek, A.; Thompson, J.; Bierlein, E. R.; Bhandari, A.; Van Hook, M. J.
10.1101/2022.08.15.503974 — neuroscience — Posted on 2022-08-15
2095 Hierarchical unimodal processing within the primary somatosensory cortex during a bimodal detection task
Parra, S.; Diaz, H.; Zainos, A.; Alvarez, M.; Zizumbo, J.; Pujalte, S.; Bayones, L.; Romo, R.; Rossi-Pool, R.
10.1101/2022.08.12.503802 — neuroscience — Posted on 2022-08-15
2096 Development and validation of PainFace, a software platform that simplifies and standardizes mouse grimace analyses
McCoy, E. S.; Park, S. K.; Patel, R. P.; Ryan, D. F.; Mullen, Z. J.; Nesbitt, J. J.; Lopez, J. E.; Taylor-Blake, B.; Krantz, J. L.; Hu, W.; Garris, R. L.; Lima, L. V.; Sotocinal, S. G.; Austin, J.-S.; Kashlan, A. D.; Jimenez, J. A.; Shah, S.; Trocinski, A. K.; Vanden, K. A.; Major, R. M.; Bazick, H. O.; Klein, M. R.; Mogil, J. S.; Wu, G.; Zylka, M. J.
10.1101/2022.08.12.503790 — neuroscience — Posted on 2022-08-15
2097 A Role for Steroid 5α-reductase 1 in Vascular Remodelling During Endometrial Decidualisation
Shaw, I. W.; Kirkwood, P. M.; Rebourcet, D.; Cousins, F. L.; Ainslie, R. J.; Livingstone, D. E. W.; Smith, L. B.; Saunders, P. T. K.; Gibson, D. A.
10.1101/2022.05.30.493728 — physiology — Posted on 2022-08-15
2098 Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT
Olsen, K. S.; Jadi, O.; Dexheimer, S.; Bortone, D.; Vensko, S. P.; Bennett, S.; Tang, H.; Diiorio, M.; Saran, T.; Dingfelder, D.; Zhu, Q.; Wang, Y.; Haiman, C. A.; Pooler, L.; Sheng, X. P.; Webb, A.; Pasquini, M. C.; McCarthy, P. L.; Spellman, S. R.; Weimer, E.; Hahn, T.; Sucheston-Campbell, L.; Armistead, P.; Vincent, B.
10.1101/2022.08.12.503667 — cancer biology — Posted on 2022-08-15
2099 Solid/liquid coexistence during aging of FUS condensates
Shen, Y.; Chen, A.; Wang, W.; Shen, Y.; Ruggeri, F. S.; Aime, S.; Wang, Z.; Qamar, S. S.; Espinosa, J. R.; Garaizar Suarez, A.; St George-Hyslop, P.; Collepardo-Guevara, R.; Weitz, D.; Vigolo, D.; Knowles, T.
10.1101/2022.08.15.503964 — biophysics — Posted on 2022-08-15
2100 Identification, characterization of Apyrase (APY) gene family in rice (Oryza sativa) and analysis of the expression pattern under various stress conditions
Chowdhury, A. T.; Hasan, M. N.; Bhuiyan, F. H.; Islam, M. Q.; Rahaman, M. M.; Nayon, M. R. W.; Hoque, H.; Jewel, N. A.; Ashrafuzzaman, M.; Prodhan, S. H.
10.1101/2022.08.12.503798 — bioinformatics — Posted on 2022-08-15
2102 Reliable energy-based antibody humanization and stabilization
Tennenhouse, A.; Khmelnitsky, L.; Yeshaya, N.; Noronha, A.; Lindzen, M.; Khalaila, R.; Zaretsky, I.; Fridmann Sirkis, Y.; Galon-Wolfenson, Y.; Abramson, J.; Yarden, Y.; Fass, D.; Fleishman, S. J.
10.1101/2022.08.14.503891 — bioengineering — Posted on 2022-08-15
2103 Expression QTLs in single-cell sequencing data
Gewirtz, A. D.; Townes, F. W.; Engelhardt, B. E.
10.1101/2022.08.14.503915 — genomics — Posted on 2022-08-15
2104 CGIAR BARLEY BREEDING TOOLBOX: A diversity panel to facilitate breeding and genomic research in the Developing World
Bouhlal, O.; Visioni, A.; Verma, R. P. S.; Kandil, M.; Gyawali, S.; Capettini, F.; Sanchez-Garcia, M.
10.1101/2022.08.13.502796 — genetics — Posted on 2022-08-15
2109 Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome
Althammer, F.; Wimmer, M.; Krabichler, Q.; Kueppers, S.; Schimmer, J.; Froehlich, H.; Doetsch, L.; Kirchner, M. K.; Stern, J. E.; Charlet, A.; Grinevich, V.; Schaaf, C. P.
10.1101/2022.08.15.503958 — neuroscience — Posted on 2022-08-15
2110 A Cellular Positioning System to Probe Morphological Heterogeneity Among Mouse CA3 Hippocampal Pyramidal Neurons
Handwerk, C. J.; Bland, K. M.; Brett, C. A.; Denzler, C. J.; Kalinowski, A. R.; Swinehart, B. D.; Rodriguez, H. V.; Cook, H. N.; Vidal, G. S.
10.1101/2022.08.12.503761 — neuroscience — Posted on 2022-08-15
2113 A Novel Framework for In-vivo Diffusion Tensor Distribution MRI of the Human Brain
Magdoom, K. N.; Avram, A. V.; Sarlls, J. E.; Gasbarra, D. E.; Basser, P. J.
10.1101/2022.08.15.503969 — neuroscience — Posted on 2022-08-15
2114 Extending Janus lectins architecture: characterization and application to protocells
Notova, S.; Siukstaite, L.; Rosato, F.; Vena, F.; Audfray, A.; Bovin, N.; Landemarre, L.; Roemer, W.; Imberty, A.
10.1101/2022.08.15.503968 — synthetic biology — Posted on 2022-08-15
2116 Destabilized 3UTR ARE therapeutically degrades ERBB2 in drug-resistant ERBB2+ cancer models
Awah, C.; Glemaud, Y.; Levine, F.; Yang, K.; Ansary, A.; Dong, F.; Ash, L.; Zhang, J.; Weiser, D.; Ogunwobi, O. O.
10.1101/2022.08.14.503914 — cancer biology — Posted on 2022-08-15
2118 Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancer
Fathi, M.; Martinez-Paniagua, M.; Rezvan, A.; Montalvo, M. J.; Mohanty, V.; Chen, K.; Mani, S. A.; Varadarajan, N.
10.1101/2022.08.13.503860 — cancer biology — Posted on 2022-08-15
2122 Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds
Wang, Y. J.; Valotteau, C.; Aimard, A.; Villanueva, L.; Kostrz, D.; Follenfant, M.; Strick, T.; Chames, P.; Rico, F.; Gosse, C.; Limozin, L.
10.1101/2022.08.14.503897 — biophysics — Posted on 2022-08-15
2123 Learning representations for image-based profiling of perturbations
Moshkov, N.; Bornholdt, M.; Benoit, S.; McQuin, C.; Smith, M.; Goodman, A.; Senft, R.; Han, Y.; Babadi, M.; Horvath, P.; Cimini, B. A.; Carpenter, A. E.; Singh, S.; Caicedo, J. C.
10.1101/2022.08.12.503783 — bioinformatics — Posted on 2022-08-15
2125 IRIS: Integrated Retinal Functionality in Image Sensors
Yin, Z.; Kaiser, M. A.-A.; Camara, L. O.; Camarena, M.; Parsa, M.; Jacob, A.; Schwartz, G.; Jaiswal, A.
10.1101/2022.08.14.503909 — bioengineering — Posted on 2022-08-15
2128 Itinerant lifestyle and congregation of lesser kestrels in West Africa
Lopez-Ricaurte, L.; Vansteelant, W. M. G.; Hernandez-Pliego, J.; Garcia-Silveira, D.; Casado, S.; Garces-Toledano, F.; Martinez-Dalmau, J.; Ortega, A.; Rodriguez-Moreno, B.; Bustamante, J.
10.1101/2022.08.12.503182 — animal behavior and cognition — Posted on 2022-08-15
2129 Genomics of secondarily temperate adaptation in the only non-Antarctic icefish
Rivera-Colon, A. G.; Rayamajhi, N.; Minhas, B. F.; Madrigal, G.; Bilyk, K. T.; Yoon, V.; Hüne, M.; Gregory, S.; Cheng, C.- H. C.; Catchen, J. M.
10.1101/2022.08.13.503862 — genomics — Posted on 2022-08-15
2132 Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD
Dahl, A.; Thompson, M.; An, U.; Krebs, M. D.; Appadurai, V.; Border, R.; Bacanu, S.-A.; Werge, T.; Flint, J.; Schork, A. J.; Sankararaman, S.; Kendler, K.; Cai, N.
10.1101/2022.08.15.503980 — genetics — Posted on 2022-08-15
2133 Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies
Cicconardi, F.; Milanetti, E.; Pinheiro de Castro, E. C.; Mazo-Vargas, A.; Belleghem, S. M.; Ruggieri, A. A.; Rastas, P.; Hanly, J. J.; Evans, E.; Jiggins, C. D.; McMillan, W. O.; Papa, R.; di Marino, D.; Martin, A.; Montgomery, S. H.
10.1101/2022.08.12.503723 — evolutionary biology — Posted on 2022-08-15
2136 Worldwide late-Quaternary population declines in extant megafauna are due to Homo sapiens rather than climate
Bergman, J.; Pedersen, R. O.; Lundgren, E. J.; Lemoine, R. T.; Monsarrat, S.; Schierup, M. H.; Svenning, J.-C.
10.1101/2022.08.13.503826 — evolutionary biology — Posted on 2022-08-15
2140 TRIAC disrupts cerebral thyroid hormone action via a negative feedback loop and heterogenous distribution among organs
Yamauchi, I.; Hakata, T.; Ueda, Y.; Sugawa, T.; Omagari, R.; Teramoto, Y.; Nakayama, S. F.; Nakajima, D.; Kubo, T.; Inagaki, N.
10.1101/2022.08.12.502299 — ecology — Posted on 2022-08-15
2146 The Translation Initiation Factor Homolog, eif4e1c, Regulates Cardiomyocyte Metabolism and Proliferation During Heart Regeneration
Rao, A.; Lyu, B.; Lubbertozzi, A.; Jahan, I.; Tedeschi, F.; Jankowsky, E.; Carstens, B. C.; Poss, K. D.; Baskin, K.; Goldman, J. A.
10.1101/2022.08.15.502524 — developmental biology — Posted on 2022-08-15
2147 Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish
LeBleu, V. S.; Dai, J.; Tsutakawa, S.; MacDonald, B. A.; Alge, J. L.; Sund, M.; Xie, L.; Sugimoto, H.; Tainer, J.; Zon, L. I.; Kalluri, R.
10.1101/2022.08.14.503918 — developmental biology — Posted on 2022-08-15
2148 DNA methylation age studies of humpback whales
Horvath, S.; Haghani, A.; Zoller, J. Z.; Fei, Z.; Berube, M.; Robbins, J.
10.1101/2022.08.15.503952 — developmental biology — Posted on 2022-08-15
2149 Proteome-scale induced proximity screens reveal highly potent protein degraders and stabilizers
Poirson, J.; Dhillon, A.; Cho, H.; Lam, M. H. Y.; Alerasool, N.; Lacoste, J.; Mizan, L.; Taipale, M.
10.1101/2022.08.15.503206 — molecular biology — Posted on 2022-08-15
2150 Outer membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes
van den Berg, B.; White, J. B.; Silale, A.; Feasey, M. C.; Heunis, T.; Zhu, Y.; Zheng, H.; Gajbhiye, A.; Firbank, S.; Basle, A.; Trost, M.; Bolam, D. N.; Ranson, N. A.
10.1101/2022.08.15.503959 — microbiology — Posted on 2022-08-15
2152 Structural principles of B-cell antigen receptor assembly
Dong, Y.; Pi, X.; Bartels-Burgahn, F.; Saltukoglu, D.; Liang, Z.; Yang, J.; Zheng, Y.; Alt, F. W.; Reth, M.; Wu, H.
10.1101/2022.08.13.503858 — immunology — Posted on 2022-08-15
2154 Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities
Hegazy, A. N.; Peine, C.; Niesen, D.; Panse, I.; Vainshtein, Y.; Kommer, C.; Zhang, Q.; Brunner, T. M.; Peine, M.; Froehlich, A.; Ishaque, N.; Marek, R. M.; Zhu, J. J.; Hoefer, T.; Loehning, M.
10.1101/2022.08.14.503916 — immunology — Posted on 2022-08-15
2155 IgG derived dendritic cells can induce production of IL-17 by T cells in multiple sclerosis
Pournasrolla, N.; Ahmadi, E.; Siroos, S.; Nourizadeh, M.; Harirchian, M. H.; Izad, M.
10.1101/2022.08.15.503963 — immunology — Posted on 2022-08-15
2158 Cellular Mechanisms Underlying Embryonic Retinal Waves
Voufo, C.; Chen, A. Q.; Smith, B. E.; Feller, M. B.; Tiriac, A.
10.1101/2022.08.14.503889 — neuroscience — Posted on 2022-08-15
2161 Localized network hyperconnectivity leads to hyperexcitability after injury
Ghiasvand, S.; Ibne Ferdous, Z.; Buczak, M.; Hasan, M. F.; Berdichevsky, Y.
10.1101/2022.08.14.503888 — neuroscience — Posted on 2022-08-15
2163 Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimers disease hallmarks
Dave, N.; Judd, J. M.; Decker, A.; Winslow, W.; Sarette, P.; Espinosa, O. V.; Sandler, J. A.; Bilal, A.; Tallino, S.; McDonough, I.; Blackwood, E.; Glembotski, C.; Karr, T.; Velazquez, R.
10.1101/2022.08.14.503929 — neuroscience — Posted on 2022-08-15
2164 A neural mechanism for conserved value computations integrating information and rewards
Bromberg-Martin, E. S.; Feng, Y.-Y.; Ogasawara, T.; White, J. K.; Zhang, K.; Monosov, I. E.
10.1101/2022.08.14.503903 — neuroscience — Posted on 2022-08-15
2167 Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
Kiel, C.; Ternet, C.; Catozzi, S.; Junk, P.; Oliviero, G.; Sevrin, T.; Wynne, K.
10.1101/2022.08.15.503960 — systems biology — Posted on 2022-08-15
2168 Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging
Karakaslar, E. O.; Katiyar, N.; Hasham, M.; Youn, A.; Sharma, S.; Chung, C.-h.; Marches, R.; Korstanje, R.; Banchereau, J.; Ucar, D.
10.1101/2022.08.15.503978 — systems biology — Posted on 2022-08-15
2170 A desert green alga that thrives at extreme high-light intensities using a unique photoin-hibition protection mechanism
Levin, G.; Yasmin, M.; Simanowitz, M. C.; Meir, A.; Tadmor, Y.; Hirschberg, J.; Adir, N.; Schuster, G.
10.1101/2022.08.14.503881 — plant biology — Posted on 2022-08-15
2172 A 4-bp natural deletion of maize Na+/H+ exchanger gene alters maize salt stress tolerance
Luo, M.; Zhao, Y.; Zhang, Y.; Zhang, R.; Cai, M.; Zhang, P.; Du, D.; Li, J.; Xing, J.; Sun, X.; Duan, M.; Lu, X.; Xue, Y.; Liu, Y.; Wang, F.; Lu, B.; Wang, Y.; Wang, R.; Song, W.; Zhao, J.
10.1101/2022.08.14.503892 — plant biology — Posted on 2022-08-15
2174 An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle
Yang, L.; Arbona, R. J. R.; Smith, C.; Banks, K. M.; Thomas, V. K.; Palmer, L.; Evans, T.; Hurtado, R.
10.1101/2022.08.14.503722 — physiology — Posted on 2022-08-15
2175 Time-of-day defines the efficacy of NAD+ to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clock
Escalante-Covarrubias, Q.; Mendoza-Viveros, L.; Gonzalez-Suarez, M.; Becerril-Perez, F.; Pacheco-Bernal, I.; Carreno-Vazquez, E.; Mass-Sanchez, P.; Bustamante-Zepeda, M.; Orozco-Solis, R.; Aguilar-Arnal, L.
10.1101/2022.08.12.503453 — physiology — Posted on 2022-08-15
2177 Molecular characterization reveals subclasses of 1q gain in intermediate-risk Wilms tumors
van Belzen, I. A.; van Tuil, M.; Badloe, S.; Strengman, E.; Janse, A.; Verwiel, E. T.; van der Leest, D. F.; de Vos, S.; Baker-Hernandez, J. L.; Groenendijk, A.; de Krijger, R.; Kerstens, H. H.; Drost, J.; van den Heuvel-Eibrink, M. M.; Tops, B. B.; Holstege, F. C.; Kemmeren, P.; Hehir-Kwa, J. Y.
10.1101/2022.08.12.503742 — cancer biology — Posted on 2022-08-15
2179 Characterizing nanometric thin films with far-field light
Klimovsky, H.; Shavit, O.; Julien, C.; Olevsko, I.; Hamode, M.; Abulafia, Y.; Suaudeau, H.; Armand, V.; Oheim, M.; Salomon, A.
10.1101/2022.08.15.503956 — biophysics — Posted on 2022-08-15
2183 Aldy 4: An efficient genotyper and star-allele caller for pharmacogenomics
Hari, A.; Zhou, Q.; Gonzaludo, N.; Harting, J.; Scott, S. A.; Sahinalp, C.; Numanagic, I.
10.1101/2022.08.11.503701 — bioinformatics — Posted on 2022-08-15
2184 Capturing the Hierarchically Assorted Modules of Protein Interaction in the Organized Nucleome
Dai, S.; Liu, S.; Zhou, C.; Yu, F.; Zhu, G.; Zhang, W.; Deng, H.; Burlingame, A.; Yu, W.; Wang, T.; Li, N.
10.1101/2022.08.14.503837 — bioinformatics — Posted on 2022-08-15
2189 An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues
Li, N. T.; Wu, N. C.; Cao, R.; Cadavid, J. L.; Latour, S.; Lu, X.; Zhu, Y.; Mijalkovic, M.; Roozitalab, R.; McGuigan, A. P.
10.1101/2022.08.14.503643 — bioengineering — Posted on 2022-08-15
2190 SIC50: Determination of IC50 by an optimized Sobel operator and a vision transformer
Wang, Y.; Zhang, W.; Yip, H.; Qu, C.; Hu, H.; Chen, X.; Lee, T.; Yang, X.; Yang, B.; Kumar, P.; Lee, S. Y.; Casimiro, J.; Zhang, J.; Lam, K. S.; Wang, A.
10.1101/2022.08.12.503661 — bioengineering — Posted on 2022-08-15
2198 Remote sensing-based forest modeling reveals positive effects of functional diversity on productivity at local spatial scale
Schneider, F. D.; Longo, M.; Paul-Limoges, E.; Scholl, V. M.; Schmid, B.; Morsdorf, F.; Pavlick, R. P.; Schimel, D. S.; Schaepman, M. E.; Moorcroft, P. R.
10.1101/2022.08.11.503677 — ecology — Posted on 2022-08-15
2200 Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells
Wen, D.; Zhong, L.; Gordillo, M.; Wang, X.; Qin, Y.; Huang, Y.; Soshnev, A.; Kumar, R.; Nanjangud, G.; James, D.; Allis, C. D.; Evans, T.; Carey, B.
10.1101/2022.08.12.503780 — developmental biology — Posted on 2022-08-15
2206 L-Fucose is a candidate monosaccharide neuromodulator and mitigates Alzheimer's synaptic deficits
Di Lucente, J.; Tena, J.; Mendiola, U. R.; Chen, X.; Lebrilla, C. B.; Maezawa, I.; Jin, L.-W.
10.1101/2022.08.11.503673 — neuroscience — Posted on 2022-08-15
2207 Diversity of Ganglion Cell Responses to Saccade-like Image Shifts in the Primate Retina
Nitsche, S.; Khani, M. H.; Karamanlis, D.; Erol, Y. C.; Zapp, S. J.; Mietsch, M.; Protti, D. A.; Rozenblit, F.; Gollisch, T.
10.1101/2022.08.12.503725 — neuroscience — Posted on 2022-08-15
2208 Negative legacy effects of past forest use on plant diversity in semi-natural grasslands on ski slopes
Yaida, Y. A.; Nagai, T.; Oguro, K.; Katsuhara, K. R.; Uchida, K.; Kenta, T.; Ushimaru, A.
10.1101/2022.08.11.503702 — plant biology — Posted on 2022-08-15
2209 Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
Gayoso, A.; Weiler, P.; Lotfollahi, M.; Klein, D.; Hong, J.; Streets, A. M.; Theis, F. J.; Yosef, N.
10.1101/2022.08.12.503709 — bioinformatics — Posted on 2022-08-15
2212 DUnet: A deep learning guided protein-ligand binding pocket prediction
Wang, X.; Zhao, B.; Yang, P.; Tan, Y.; Ma, R.; Rao, S.; Du, J.; Chen, J.; Zhou, J.; Liu, S.
10.1101/2022.08.11.503579 — bioinformatics — Posted on 2022-08-15
2213 A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes
Wilder, C.; Lefaudeux, D.; Mathenge, R.; Kishimoto, K.; Zuniga Munoz, A.; Nguyen, M. A.; Meyer, A. S.; Cheng, Q. J.; Hoffmann, A.
10.1101/2022.08.11.503561 — immunology — Posted on 2022-08-15
2214 Modeling and Simulation of Rat Non-Barrel Somatosensory Cortex. Part I: Modeling Anatomy
Reimann, M. W.; Bolanos Puchet, S.; Egas Santander, D.; Courcol, J.-D.; Arnaudon, A.; Coste, B.; Delemontex, T.; Devresse, A.; Dictus, H.; Dietz, A.; Ecker, A.; Favreau, C.; Ficarelli, G.; Gevaert, M.; Hernando, J. B.; Herttuainen, J.; Isbister, J. B.; Kanari, L.; Keller, D.; King, J. G.; Kumbhar, P.; Lapere, S.; Lazovskis, J.; Lu, H.; Ninin, N.; Pereira, F.; Planas, J.; Pokorny, C.; Riquelme, J. L.; Romani, A.; Shi, Y.; Smith, J. P.; Sood, V.; Srivastava, M.; Van Geit, W.; Vanherpe, L.; Wolf, M.; Levi, R.; Hess, K.; Schürmann, F.; Muller, E. B.; Ramaswamy, S.; Markram, H.
10.1101/2022.08.11.503144 — neuroscience — Posted on 2022-08-15
2216 Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids
Mapelli, L.; Dubochet, O.; Tedesco, M.; Sciacca, G.; Ottaviani, A.; Monteverdi, A.; Battaglia, C.; Tritto, S.; Cardot, F.; Surbled, P.; Schildknecht, J.; Gandolfo, M.; Imfeld, K.; Cervetto, C.; Marcoli, M.; D'Angelo, E.; Maccione, A.
10.1101/2022.08.11.503595 — neuroscience — Posted on 2022-08-15
2217 Tensor Image Registration Library: Automated Deformable Registration of Stand-Alone Histology Images to Whole-Brain Post-Mortem MRI Data
Huszar, I. N.; Pallebage-Gamarallage, M.; Bangerter-Christensen, S.; Brooks, H.; Fitzgibbon, S.; Foxley, S.; Hiemstra, M.; Howard, A. F.; Jbabdi, S.; Kor, D. Z.; Leonte, A.; Mollink, J.; Smart, A.; Tendler, B. C.; Turner, M. R.; Ansorge, O.; Miller, K. L.; Jenkinson, M.
10.1101/2022.08.11.503605 — neuroscience — Posted on 2022-08-15
2221 Reprogramming of lactate metabolism is linked to the oncogenesis of the virus-induced leukemia
Toyoda, K.; Yasunaga, J.-i.; Arima, Y.; Tsujita, K.; Tanaka, A.; Hussein, O.; Sonoda, M.; Watanabe, M.; Shichijo, T.; Kurita, D.; Nakashima, K.; Yamada, K.; Miyoshi, H.; Ohshima, K.; Matsuoka, M.
10.1101/2022.08.12.503711 — cancer biology — Posted on 2022-08-15
2222 Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis
Gonzalez-Munoz, T.; Di Giannatale, A.; Garcia-Silva, S.; Santos, V.; Sanchez-Redondo, S.; Savini, C.; Grana-Castro, O.; Blanco, C.; Pisapia, D. J.; Peralto, J. L.; Romagosa Perez-Portabella, C.; Alaggio, R.; Benassi, M. S.; Pazzaglia, L.; Scotlandi, K.; Ratner, N.; Yohay, K.; Theuer, C. P.; Peinado, H.
10.1101/2022.08.12.503580 — cancer biology — Posted on 2022-08-15
2223 Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Alber, A. B.; Marquez, H. A.; Ma, L.; Kwong, G.; Thapa, B. R.; Villacorta-Martin, C.; Lindstrom-Vautrin, J.; Bawa, P.; Luo, Y.; Ikonomou, L.; Shi, W.; Kotton, D. N.
10.1101/2022.08.12.502651 — developmental biology — Posted on 2022-08-15
2224 Asparagine starvation suppresses histone demethylation through iron depletion
Zhang, J.; Jiang, J.; Srivastava, S.; Liu, S.; Seim, G.; Zhong, M.; Cao, S.; Dave, U.; Kapur, R.; Mosley, A. L.; Zhang, C.; Wan, J.; Fan, J.
10.1101/2022.08.14.503884 — cell biology — Posted on 2022-08-15
2225 The P681H mutation in the Spike glycoprotein escapes IFITM restriction and is necessary for type I interferon resistance in the SARS-CoV-2 alpha variant
Lista, M. J.; Winstone, H.; Wilson, H.; Dyer, A.; Pickering, S.; Galao, R. P.; De Lorenzo, G.; Cowton, V.; Furnon, W.; Suarez, N. M.; Orton, R.; Palmirini, M.; Patel, A. H.; Snell, L. B.; Nebbia, G.; Swanson, C. M.; Neil, S. J.
10.1101/2022.08.11.503706 — microbiology — Posted on 2022-08-15
2227 Huntingtin-KIF1A-mediated axonal transport of synaptic vesicle precursors influences synaptic transmission and motor skill learning in mice
Vitet, H.; Bruyere, J.; Xu, H.; Brocard, J.; Abada, Y.-S.; Delatour, B.; Scaramuzzino, C.; Venance, L.; Saudou, F.
10.1101/2022.08.14.503885 — neuroscience — Posted on 2022-08-15
2228 Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells
Chang, L.; Ran, Y.; Auferkorte, O.; Butz, E.; Hueser, L.; Haverkamp, S.; Euler, T.; Schubert, T.
10.1101/2022.08.11.503581 — neuroscience — Posted on 2022-08-15
2232 Katdetectr: utilising unsupervised changepoint analysis for robust kataegis detection
Hazelaar, D. M.; van Riet, J.; Hoogstrate, Y.; Lolkema, M. P.; van de Werken, H. J. G.
10.1101/2022.07.11.499364 — bioinformatics — Posted on 2022-08-15
2239 Retrograde Control of Cytosolic Translation Targets Synthesis of Plastid Localized Proteins and Nuclear Responses for Efficient Light Acclimation.
Moore, M.; Smith, A. B.; Wesemann, C.; Schmidtpott, S.; Wegener, M.; Farooq, M. A.; Ganguly, D. R.; Seidel, T.; Pogson, B. J.; Dietz, K.-J.
10.1101/2021.02.18.431817 — plant biology — Posted on 2022-08-15
2240 A systems approach reveals species differences in hepatic stress response capacity
Russomanno, G.; Sison-Young, R.; Livoti, L. A.; Coghlan, H.; Jenkins, R. E.; Kunnen, S. J.; Fisher, C. P.; Reddyhoff, D.; Gardner, I.; Rehman, A. H.; Fenwick, S. W.; Jones, A. R.; Vermeil De Conchard, G.; Simonin, G.; Bertheux, H.; Weaver, R.; Liguori, M. J.; Clausznitzer, D.; Stevens, J. L.; Goldring, C. E.; Copple, I. M.
10.1101/2022.04.13.488145 — pharmacology and toxicology — Posted on 2022-08-15
2247 The addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neurons
Montalban, E.; Walle, R.; Castel, J.; Ansoult, A.; Hassouna, R.; Foppen, E.; Fang, X.; Hutelin, Z.; Mickus, S.; Perszyk, E. E.; Petitbon, A.; Berthelet, J.; Rodrigues-Lima, F.; Cebrian-Serrano, A.; Gangarossa, G.; Martin, C.; Trifileff, P.; Bosch-Bouju, C.; Small, D. M.; Luquet, S. H.
10.1101/2022.08.12.503577 — neuroscience — Posted on 2022-08-15
2248 Tissue-Like 3D Standard and Protocols for Microscope Quality Management
Abrams, B.; Pengo, T.; Deagle, R. C.; Vuillemin, N.; Wee, T. L.; Callahan, L. M.; Smith, M. A.; Kubow, K. E.; Girard, A.-M.; Rappoport, J. Z.; Bayles, C. J.; Cameron, L. A.; Cole, R.; Brown, C. M.
10.1101/2022.08.14.503777 — cell biology — Posted on 2022-08-15
2249 Intratumoral heterogeneity and clonal evolution induced by HPV integration
Akagi, K.; Symer, D. E.; Mahmoud, M.; Jiang, B.; Goodwin, S.; Wangsa, D.; Li, Z.; Xiao, W.; Dunn, J. D.; McCombie, R.; Ried, T.; Coombes, K. R.; Sedlazeck, F. J.; Gillison, M. L.
10.1101/2022.08.11.503647 — cancer biology — Posted on 2022-08-14
2250 High-Dose Paclitaxel and its Combination with CSF1R Inhibitor in Polymeric Micelles for Chemoimmunotherapy of Triple Negative Breast Cancer
Lim, C.; Hwang, D.; Yazdimamaghani, M.; Atkins, H. M.; Hyun, H.; Shin, Y.; Ramsey, J. D.; Perou, C. M.; Sokolsky-Papkov, M.; Kabanov, A.
10.1101/2022.08.12.503695 — cancer biology — Posted on 2022-08-14
2251 An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome
Liu, S.; Ezran, C.; Wang, M. F. Z.; Li, Z.; The Tabula Microcebus Consortium, ; Long, J. Z.; De Vlaminck, I.; Wang, S.; Kuo, C.; Epelbaum, J.; Terrien, J.; Krasnow, M. A.; Ferrell, J. E.
10.1101/2021.12.13.472243 — genomics — Posted on 2022-08-14
2252 Human Satellite 1 (HSAT1) analysis provides novel evidence of pericentromeric transcription
Lopes, M.; Louzada, S.; Ferreira, D.; Verissimo, G.; Eleuterio, D.; Gama-Carvalho, M.; Chaves, R.
10.1101/2022.08.11.503625 — genomics — Posted on 2022-08-14
2256 Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis
Puttock, E. H.; Tyler, E. J.; Manni, M.; Maniati, E.; Butterworth, C.; Peerani, E.; Hirani, P.; Gauthier, V.; Liu, Y.; Maniscalco, G.; Rajeeve, V.; Cutillas, P.; Trevisan, C.; Pozzobon, M.; Lockley, M.; Rastrick, J.; Laubli, H.; White, A.; Pearce, O. M. T.
10.1101/2022.08.11.503568 — cancer biology — Posted on 2022-08-14
2261 rRNA depletion for holobiont metatranscriptome profiling across demosponges
Vargas, S.; Rivera-Vicens, R. E.; Eitel, M.; Buettner, G.; Woerheide, G.
10.1101/2022.08.12.503726 — genomics — Posted on 2022-08-14
2262 An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer
Jacob, J.; Francisco, L. E.; Chatterjee, T.; Liang, Z.; Subramanian, S.; Liu, Q. J.; Rowe, J. H.; Carmon, K. S.
10.1101/2022.08.11.503187 — cancer biology — Posted on 2022-08-14
2263 A guidance into the fungal metabolomic abyss: Network analysis for revealing relationships between exogenous compounds and their outputs
Meena, M. G.; Lane, M. J.; Tannous, J.; Carrell, A. A.; Abraham, P. E.; Giannone, R. J.; Ane, J.-M.; Keller, N. P.; Labbe, J. L.; Kainer, D.; Jacobson, D. A.; Rush, T. A.
10.1101/2022.08.11.503656 — systems biology — Posted on 2022-08-14
2269 Prediction of quality-control degradation signals in yeast proteins
Johansson, K. E.; Mashahreh, B.; Hartmann-Petersen, R.; Ravid, T.; Lindorff-Larsen, K.
10.1101/2022.04.06.487301 — bioinformatics — Posted on 2022-08-14
2271 Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin
Nguyen, T. N.; Sawa-makarska, J.; Khuu, G.; Lam, W. K.; Adriaenssens, E.; Fracchiolla, D.; Shoebridge, S.; Padman, B. S.; Skulsuppaisarn, M.; Lindblom, R. S. J.; Martens, S.; Lazarou, M.
10.1101/2022.08.14.503930 — cell biology — Posted on 2022-08-15
2273 Sex-specificity of the C. elegans metabolome
Burkhardt, R. N.; Artyukhin, A. B.; Aprison, E. Z.; Curtis, B. J.; Fox, B. W.; Ludewig, A. H.; Chaturbedi, A.; Panda, O.; Wrobel, C. J.; Lee, S. S.; Ruvinsky, I.; Schroeder, F. C.
10.1101/2022.08.11.503636 — bioinformatics — Posted on 2022-08-14
2275 Drought and flooding resistances of maize germplasm are compared and evaluated using a multivariate analysis method
Wang, G. Y.; Ahmad, S.; Wang, Y.; Wang, B. W.; Huang, J. H.; Jahan, M. S.; Zhou, X. B.; Shi, C. Q.
10.1101/2022.08.11.503629 — physiology — Posted on 2022-08-14
2276 Pleiotropic roles for mycobacterial DinB2 in frameshift and substitution mutagenesis
Dupuy, P.; Ghosh, S.; Adefisayo, O.; Bean, J.; Gupta, R.; Shuman, S.; Glickman, M.
10.1101/2022.08.14.503212 — microbiology — Posted on 2022-08-14
2277 Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa
Weber, B. S.; Carfrae, L. A.; Woods, J. J.; Klobucar, K.; Bigham, N. P.; MacNair, C.; Lyn Raivio, T.; Wilson, J. J.; Brown, E. D.
10.1101/2022.08.11.503708 — microbiology — Posted on 2022-08-14
2281 The cognitive basis of intracranial self-stimulation of midbrain dopamine neurons
Millard, S. J.; Hoang, I. B.; Greer, Z.; O'Connor, S. L.; Wassum, K. M.; James, M. H.; Barker, D. J.; Sharpe, M. J.
10.1101/2022.08.11.503670 — neuroscience — Posted on 2022-08-14
2282 Single-molecule sequencing of animal mitochondrial genomes reveals chloroplast-like architecture and repeat-mediated recombination
Sharbrough, J.; Bankers, L.; Cook, E.; Fields, P. D.; Jalinsky, J.; McElroy, K. E.; Neiman, M.; Logsdon, J. M.; Boore, J. L.
10.1101/2022.08.11.503648 — evolutionary biology — Posted on 2022-08-14
2287 Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region
Rosing, J.; Doyle, A.; Brinda, A.; Blumenfeld, M.; Lecy, E.; Spencer, C.; Dao, J.; Krieg, J.; Wilmerding, L. K.; Sullivan, D.; Best, S.; Mohanty, B.; Wang, J.; Johnson, L. A.; Vitek, J. L.; Johnson, M. D.
10.1101/2022.04.28.489769 — neuroscience — Posted on 2022-08-14
2290 Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion
Ni, R.; Straumann, N.; Fazio, S.; Dean-Ben, X. L.; Louloudis, G.; Keller, C.; Razansky, D.; Ametamey, S.; Mu, L.; Nombela-Arrieta, C.; Klohs, J.
10.1101/2022.08.11.503550 — neuroscience — Posted on 2022-08-14
2296 Genomic databanks and targeted assays help characterise domestic mosquito incursions
Schmidt, T. L.; Endersby-Harshman, N.; Kurucz, N.; Pettit, W.; Krause, V.; Ehlers, G.; Muzari, O.; Currie, B. J.; Hoffmann, A. A.
10.1101/2022.01.19.477022 — genomics — Posted on 2022-08-14
2298 A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma
Chen, D.; Varanasi, S. K.; Hara, T.; Traina, K.; McDonald, B.; Farsakoglu, Y.; Clanton, J.; Xu, S.; Mann, T. H.; Du, V.; Chung, H. K.; Xu, Z.; Tripple, V.; Casillas, E.; Ma, S.; O Connor, C.; Yang, Q.; Zheng, Y.; Hunter, T.; Lemke, G.; Kaech, S. M.
10.1101/2022.08.12.502093 — immunology — Posted on 2022-08-14
2301 The high-resolution in vivo measurement of replication fork velocity and pausing
Huang, D.; Johnson, A. E.; Sim, B. S.; Lo, T.; Merrikh, H.; Wiggins, P. A.
10.1101/2022.08.13.503874 — biophysics — Posted on 2022-08-14
2309 IL-12/18/21 pre-activation enhances the anti-tumor efficacy of expanded γδT cells and overcomes resistance to anti-PD-L1 treatment
Liu, H.; Teo, H. Y.; Song, Y.; Yong, K. S. M.; Liu, Y.; Mei, Y.; Hanafi, Z. B.; Zhu, Y.; Gascoigne, N. R. J.; Chen, Q.
10.1101/2022.08.11.503563 — immunology — Posted on 2022-08-13
2311 Widespread perturbation of ETS factor binding sites in cancer
Pro, S. C.; Hook, H.; Bray, D.; Berenzy, D.; Moyer, D.; Yin, M.; Labadorf, A. T.; Tewhey, R.; Siggers, T.; Bass, J. I. F.
10.1101/2022.08.10.503516 — cancer biology — Posted on 2022-08-13
2315 Dendritic cell-Natural Killer cell Crosstalk Modulates T cell activation in Response to Influenza A Viral Infection
Harvey, A. G.; Graves, A. M.; Uppalapati, C. K.; Matthews, S. M.; Rosenberg, S.; Fagerlie, M. H.; Guinan, J.; Lopez, B.; Kronstad, L. M.
10.1101/2022.08.12.503177 — immunology — Posted on 2022-08-13
2317 Spatio-temporal summation of perimetric stimuli in healthy observers
Montesano, G.; Mulholland, P.; Garway-Heath, D. F.; Evans, J.; Ometto, G.; Crabb, D. P.
10.1101/2022.08.10.503485 — neuroscience — Posted on 2022-08-13
2318 A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical venules
Shaked, I.; Foo, C.; Liu, R.; Cui, Y.; Ji, X.; Broggini, T.; Mächler, P.; Sundd, P.; Devor, A.; Friedman, B.; Kleninfeld, D.
10.1101/2022.08.10.503527 — neuroscience — Posted on 2022-08-13
2321 A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma
Pozniak, J.; Pedri, D.; Landeloos, E.; Van Herck, Y.; Antoranz, A.; Karras, P.; Nowosad, A.; Makhzami, S.; Bervoets, G.; Dewaele, M.; Vanwynsberghe, L.; Cinque, S.; Kint, S.; Vandereyken, K.; Voet, T.; Vernaillen, F.; Annaert, W.; Lambrechts, D.; Boecxstaens, V.; van den Oord, J.; Bosisio, F.; Leucci, E.; Rambow, F.; Bechter, O.; Marine, J.-C.
10.1101/2022.08.11.502598 — cancer biology — Posted on 2022-08-13
2322 Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma
Gaglia, G.; Burger, M.; Ritch, C. C.; Rammos, D.; Dai, Y.; Crossland, G. E.; Tavana, S. Z.; Warchol, S.; Jaeger, A. M.; Naranjo, S.; Coy, S.; Johnson, A.; Krueger, R.; Lin, J.-R.; Pfister, H.; Sorger, P. K.; Jacks, T.; Santagata, S.
10.1101/2022.08.11.503237 — cancer biology — Posted on 2022-08-13
2327 Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis
Lara-Astiaso, D.; Goni-Salaverri, A.; Mendieta-Esteban, J.; Narayan, N.; Del Valle, C.; Gross, T.; Giotopoulos, G.; Navarro-Alonso, M.; Zazpe, J.; Marchese, F.; Torrea, N.; Calvo, I. A.; Lopez, C.; Alignani, D.; Lopez, A.; Saez, B.; Taylor-King, J. P.; Prosper, F.; Fortelny, N.; Huntly, B. J. P.
10.1101/2022.08.11.503571 — genomics — Posted on 2022-08-13
2329 Seasonal polyphenism of wing colors and its influence on sulphur butterfly diversification
Fenner, J.; Ficarrotta, V.; Colombara, A.; Smith, H.; Evans, K.; Range, R. C.; Counterman, B. A.
10.1101/2022.08.10.503521 — evolutionary biology — Posted on 2022-08-13
2331 A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma
Chen, D.; Varanasi, S. K.; Hara, T.; Traina, K.; McDonald, B.; Farsakoglu, Y.; Clanton, J.; Xu, S.; Mann, T. H.; Du, V.; Chung, H. K.; Xu, Z.; Tripple, V.; Casillas, E.; Ma, S.; O Connor, C.; Yang, Q.; Zheng, Y.; Hunter, T.; Lemke, G.; Kaech, S. M.
10.1101/2022.08.12.502093 — immunology — Posted on 2022-08-13
2333 Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex
Shelchkova, N. D.; Downey, J. E.; Greenspon, C. M.; Okorokova, E. V.; Sobinov, A. R.; Verbaarschot, C.; He, Q.; Sponheim, C.; Tortolani, A. F.; Moore, D. D.; Kaufman, M. T.; Lee, R. C.; Satzer, D.; Gonzalez-Martinez, J.; Warnke, P. C.; Miller, L. E.; Boninger, M. L.; Gaunt, R.; Collinger, J.; Hatsopoulos, N.; Bensmaia, S. J.
10.1101/2022.08.10.503543 — neuroscience — Posted on 2022-08-13
2338 Genetic architecture and evolution of color variation in American black bears
Puckett, E. E.; Davis, I. S.; Harper, D. C.; Wakamatsu, K.; Battu, G.; Belant, J. L.; Beyer, D. E.; Carpenter, C.; Crupi, A. P.; Davidson, M.; DePerno, C. S.; Forman, N.; Fowler, N. L.; Garshelis, D. L.; Gould, N.; Gunther, K.; Haroldson, M.; Ito, S.; Kocka, D.; Lackey, C.; Leahy, R.; Lee-Roney, C.; Lewis, T.; Lutto, A.; McGowan, K.; Olfenbuttel, C.; Orlando, M.; Platt, A.; Pollard, M. D.; Ramaker, M.; Reich, H.; Sajecki, J. L.; Sell, S. K.; Strules, J.; Thompson, S.; van Manen, F.; Whitman, C.; Williamson, R.; Winslow, F.; Kaelin, C.; Marks, M.; Barsh, G.
10.1101/2022.08.12.503788 — evolutionary biology — Posted on 2022-08-13
2341 Emergence and clonal expansion of Vibrio aestuarianus lineages pathogenic for oysters in Europe
Mesnil, A.; Jacquot, M.; Garcia, C.; Tourbiez, D.; Canier, L.; Bidois, A.; Degremont, L.; Cheslett, D.; Geary, M.; Vetri, A.; Roque, A.; Furones, D.; Garden, A.; Orozova, P.; Arzul, I.; Sicard, M.; Charriere, G.; Destoumieux-Garzon, D.; Travers, M.-A.
10.1101/2022.04.04.486953 — microbiology — Posted on 2022-08-13
2344 Ageing in a collective: The impact of ageing individuals on social network structure
Siracusa, E. R.; Pereira, A. S.; Bohr Brask, J.; Negron-Del Valle, J. E.; Phillips, D.; Cayo Biobank Research Unit, ; Platt, M. L.; Higham, J. P.; Snyder-Mackler, N.; Brent, L. J. N.
10.1101/2022.08.10.503309 — animal behavior and cognition — Posted on 2022-08-13
2346 K978C CFTR restores essential epithelial function with greater efficiency than wildtype CFTR when expressed in CF airway cells.
Woodall, M. N. J.; Tarran, R.; Lee, R. E.; Anfishi, H.; Prins, S.; Counsell, J.; Vergani, P.; Hart, S. L.; Baines, D.
10.1101/2022.08.10.503368 — molecular biology — Posted on 2022-08-13
2349 A Structural Connectivity Atlas of Limbic Brainstem Nuclei
Levinson, S.; Miller, M.; Iftekhar, A.; Arriola, D.; Hazany, S.; Avecillas-Chasin, J.; Kuhn, T.; Horn, A.; Bari, A. A.
10.1101/2022.08.10.503282 — neuroscience — Posted on 2022-08-13
2352 Tip-links serve as force-pass filter to fulfil the role of gating-springs
Arora, N.; Hazra, J. P.; Roy, S.; Bhati, G. K.; Gupta, S.; Chaudhuri, A.; Sagar, A.; RAKSHIT, S.
10.1101/2022.08.10.503460 — biophysics — Posted on 2022-08-13
2353 FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
Chen, D.; Wosztyl, A.; Mullapudi, V.; Bali, S.; Vacquer-Alicea, J.; Melhem, S.; Seelaar, H.; Van Swieten, J.; Diamond, M. I.; Joachimiak, L. A.
10.1101/2022.08.11.503511 — biophysics — Posted on 2022-08-13
2354 Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics
Sun, Y.; Jack, K.; Ercolani, T.; Sangar, D.; Hosszu, L. L.; Collinge, J.; Bieschke, J.
10.1101/2022.08.10.503301 — biophysics — Posted on 2022-08-13
2356 Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editing
Chen, L.; Zhang, S.; Xue, N.; Hong, M.; Zhang, X.; Zhang, D.; Yang, J.; Bai, S.; Huang, Y.; Meng, H.; Wu, H.; Luan, C.; Zhu, B.; Ru, G.; Liu, M.; Liu, M.; Cheng, Y.; Yi, C.; Song, G.; Wang, L.; Li, D.
10.1101/2022.08.12.503700 — bioengineering — Posted on 2022-08-13
2362 Combination therapy of glycation lowering compounds reduces caloric intake, improves insulin sensitivity and extends lifespan.
Wimer, L.; Kaneshiro, K. R.; Ramirez, J.; Contreras, M. V.; Shanmugam, M.; Gaffney, D.; Singh, P.; Beck, J.; Sellegounder, D.; Newman, J.; Galligan, J.; Koliwad, S.; Kapahi, P.
10.1101/2022.08.10.503411 — molecular biology — Posted on 2022-08-13
2363 Reliable multiplex generation of pooled induced pluripotent stem cells for genetic testing
Smullen, M.; Reichert, J. M.; Dawes, P.; Wang, Q.; Readhead, B.; Church, G.; Lim, E. T.; Chan, Y.
10.1101/2022.08.10.500520 — molecular biology — Posted on 2022-08-13
2366 EEG signature of breaks in embodiment in VR
Porssut, T.; Iwane, F.; Chavarriaga, R.; Blanke, O.; Millan, J. d. R.; Boulic, R.; Herbelin, B.
10.1101/2022.08.10.502929 — neuroscience — Posted on 2022-08-13
2368 Local brain oscillations and inter-regional connectivity differentially serve sensory and expectation effects on pain
Bott, F. S.; Nickel, M. M.; Hohn, V. D.; May, E. S.; Gil Avila, C.; Tiemann, L.; Gross, J.; Ploner, M.
10.1101/2022.08.10.503459 — neuroscience — Posted on 2022-08-13
2370 Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates
Watson, Z.; Knudson, I.; Ward, F. R.; Miller, S. J.; Cate, J. H.; Schepartz, A.; Abramyan, A. M.
10.1101/2022.08.13.503842 — synthetic biology — Posted on 2022-08-13
2375 Intratumoral heterogeneity and clonal evolution induced by HPV integration
Akagi, K.; Symer, D. E.; Mahmoud, M.; Jiang, B.; Goodwin, S.; Wangsa, D.; Li, Z.; Xiao, W.; Dunn, J. D.; McCombie, R.; Ried, T.; Coombes, K. R.; Sedlazeck, F. J.; Gillison, M. L.
10.1101/2022.08.11.503647 — cancer biology — Posted on 2022-08-13
2376 DeepIFC: virtual fluorescent labeling of blood cells in imaging flow cytometry data with deep learning
Timonen, V. A.; Kerkela, E.; Impola, U.; Penna, L.; Partanen, J.; Kilpivaara, O.; Arvas, M.; Pitkanen, E.
10.1101/2022.08.10.503433 — bioinformatics — Posted on 2022-08-13
2377 Detecting isoform-level allelic imbalance accounting for inferential uncertainty
Wu, E.; Singh, N. P.; Choi, K.; Zakeri, M.; Vincent, M.; Churchill, G. A.; Ackert-Bicknell, C. L.; Patro, R.; Love, M. I.
10.1101/2022.08.12.503785 — bioinformatics — Posted on 2022-08-13
2378 Cortical distribution of neurofilaments associates with pathological hallmarks and MRI measures of atrophy and diffusivity in Parkinson's disease
Frigerio, I.; Laansma, M. A.; Lin, C.-P.; Hermans, E. J.; Bouwman, M. M.; Bol, J. G.; Galis-de Graaf, Y.; Hepp, D. H.; Rozemuller, A. J.; Barkhof, F.; van de Berg, W. D.; Jonkman, L. E.
10.1101/2022.08.10.503440 — neuroscience — Posted on 2022-08-13
2381 Klarigi: Characteristic Explanations for Semantic Data
Slater, L. T.; Williams, J. A.; Schofield, P. N.; Russell, S.; Pendleton, S. C.; Karwath, A.; Fanning, H.; Ball, S.; Hoehndorf, R. T.; Gkoutos, G. V.
10.1101/2021.06.14.448423 — bioinformatics — Posted on 2022-08-13
2382 Dynamics of hinged wings in strong upward gusts
Stevenson, J. P.; Cheney, J. A.; Usherwood, J. R.; Bomphrey, R. J.; Windsor, S. P.
10.1101/2022.08.05.502962 — bioengineering — Posted on 2022-08-13
2383 Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM
Cong, Y.; Liu, C.; Jin, M.; Wang, S.; Han, W.; Zhao, Q.; Wang, Y.; Xu, C.; Diao, L.; Yin, Y.; Peng, C.; Bao, L.; Wang, Y.
10.1101/2022.08.08.503128 — biochemistry — Posted on 2022-08-13
2385 Cardiomyocyte adenyl cyclase 8 overexpression increases locomotor activity in mice by modulating EEG-gamma oscillations
Agrimi, J.; Menicucci, D.; Qu, J.-H.; Mackey, C.; Laurino, M.; Hasnain, L.; McDevit, R. A.; Tarasova, Y. S.; Tarasov, K. V.; Hoover, D. B.; Gemignani, A.; Paolocci, N.; Lakatta, E. G.
10.1101/2021.07.19.452502 — physiology — Posted on 2022-08-13
2386 Flexible perceptual encoding by discrete gamma events
Perrenoud, Q.; Fonseca, A. H. d. O.; Airhart, A.; Bonanno, J.; Mao, R.; Cardin, J. A.
10.1101/2022.05.13.491832 — neuroscience — Posted on 2022-08-13
2387 Klarigi: Characteristic Explanations for Semantic Data
Slater, L. T.; Williams, J. A.; Schofield, P. N.; Russell, S.; Pendleton, S. C.; Karwath, A.; Fanning, H.; Ball, S.; Hoehndorf, R. T.; Gkoutos, G. V.
10.1101/2021.06.14.448423 — bioinformatics — Posted on 2022-08-13
2390 Environmentally induced changes in genetic variance align with selection rather than plasticity
Walter, G. M.; Terranova, D.; Clark, J.; Cozzolino, S.; Cristaudo, A.; Hiscock, S. J.; Bridle, J. R.
10.1101/2021.02.08.430333 — evolutionary biology — Posted on 2022-08-13
2394 Metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks
Godbersen, G. M.; Klug, S.; Wadsak, W.; Pichler, V.; Raitanen, J.; Rieckmann, A.; Stiernman, L.; Cocchi, L.; Breakspear, M.; Hacker, M.; Lanzenberger, R.; Hahn, A.
10.1101/2022.08.12.503715 — neuroscience — Posted on 2022-08-12
2396 Phylogenomics revealed migration routes and adaptive radiation timing of Holarctic malaria vectors of the Maculipennis group
Yurchenko, A. A.; Naumenko, A.; Artemov, G.; Karagodin, D. A.; Hodge, J. M.; Velichevskaya, A.; Kokhanenko, A.; Bondarenko, S.; Abai, M. R.; Kamali, M.; Gordeev, M. I.; Moskaev, A. V.; Caputo, B.; Aghayan, S. A.; Baricheva, E. M.; Stegniy, V. N.; Sharakhova, M. V.; Sharakhov, I. V.
10.1101/2022.08.10.503503 — evolutionary biology — Posted on 2022-08-12
2402 ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation
Zhang, S.; Huang, Y.; Yang, F.; HE, L.; Li, Y.; Wan, Y. C. E.; Ding, Y.; Chan, K. M.; Xie, T.; Sun, H.; Wang, H.
10.1101/2022.08.12.503549 — cell biology — Posted on 2022-08-12
2410 Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation
West, J.; Rentzeperis, F.; Adam, C.; Bravo, R.; Luddy, K. A.; Robertson-Tessi, M.; Anderson, A. R. A.
10.1101/2022.06.03.493752 — cancer biology — Posted on 2022-08-12
2417 Metabolic adaptations underpin resistance to histone acetyltransferase inhibition
Bishop, T. R.; Subramanian, C.; Bilotta, E. M.; Garnar-Wortzel, L.; Ramos, A. R.; Zhang, Y.; Asiaban, J. N.; Ott, C. J.; Rock, C. O.; Erb, M. A.
10.1101/2022.08.12.503669 — molecular biology — Posted on 2022-08-12
2418 Phosphorylation of the Smooth Muscle Master Splicing Regulator RBPMS Regulates its Splicing Activity
Barnhart, M. D.; Yang, Y.; Nakagaki-Silva, E. E.; Hammond, T. H.; Pizzinga, M.; Gooding, C.; Stott, K.; Smith, C.
10.1101/2022.08.11.503562 — molecular biology — Posted on 2022-08-12
2420 Robust phenotypic plasticity of symbiotic organs facilitates the adaptation and evolution of deep-sea mussels
Li, M.; Chen, H.; Wang, M.; Zhong, Z.; Lian, C.; Zhou, L.; Zhang, H.; Wang, H.; Cao, L.; Li, C.
10.1101/2022.08.11.503589 — molecular biology — Posted on 2022-08-12
2421 Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells
Lareau, C. A.; Yie, Y.; Maurer, K.; Sandor, K. D.; Yagnik, G.; Pena, J.; Crawford, J. C.; Spanjaart, A. M.; Gutierrez, J. C.; Haradvala, N. J.; Abay, T.; Stickels, R. R.; Verboon, J. M.; Liu, V.; Southard, J.; Song, R.; Li, W.; Shrestra, A.; Parida, L.; Getz, G.; Maus, M.; Li, S.; Moore, A.; Amado, R. G.; Talleur, A. C.; Thomas, P. G.; Dehghani, H.; Pertel, T.; Kundaje, A.; Gottschalk, S.; Roth, T. L.; Kersten, M. J.; Wu, C. J.; Majzner, R. G.; Satpathy, A. T.
10.1101/2022.08.12.503683 — immunology — Posted on 2022-08-12
2422 Loss of Bcl6 transcriptionally alters classical dendritic cells and diminishes T follicular helper cell-inducing cDC2 in mouse spleen
Xiao, H.; Ulmert, I.; Narasimhan, H.; Kurochkin, I.; Moerbe, U.; Baumjohann, D.; Pereira, F.; Schraml, B.; Lahl, K.
10.1101/2022.08.10.503322 — immunology — Posted on 2022-08-12
2423 Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes
Hawwari, I.; Rosero, N.; Ribeiro, L. S.; Demczuk, A.; Teichmann, L. S.; Meffert, L.; Bertheloot, D.; Franklin, B. S.
10.1101/2022.08.10.503291 — immunology — Posted on 2022-08-12
2426 Thriving in the heat - Lysine acetylation stabilizes the quaternary structure of a Mega-Dalton hyperthermoactive PEP-synthase
Albanese, P.; Song, W.; Keulen, S. v.; Koendjbiharie, J.; Koh, F.; Steigenberger, B.; Vincent, T.; Konijnenberg, A.; Heck, A. J. R.; Kengen, S.; Bonvin, A. M. J. J.; Förster, F.; Scheltema, R. A.
10.1101/2022.08.11.503304 — biochemistry — Posted on 2022-08-12
2427 A role for phase separation to prevent R-loops during transcription
Thompson, V. F.; Wieland, D. R.; Mendoza-Leon, V.; Janis, H. I.; Lay, M. A.; Harrell, L. M.; Schwartz, J. C.
10.1101/2022.08.11.503633 — biochemistry — Posted on 2022-08-12
2428 Cellular, Molecular, and Enzymatic Signatures ofThrombi are Vascular Bed-Dependent
Bender, M.; Aggarwal, A.; Mix, D.; Godwin, M.; Guntupalli, S.; Nanjundappa, A.; Tefera, L.; Haddadin, I.; Bhandari, R.; Tong, M.; Baldwin, W.; Faurchild, R.; Gomes, M.; Campbell, J.; Schumick, D.; Cameron, S.
10.1101/2022.08.11.503688 — biochemistry — Posted on 2022-08-12
2429 Structure of the pre-mRNA leakage 39-kDa proteinreveals a single domain of integrated zf-C3HC and Rsm1 modules
Hashimoto, H.; Ramirez, D. H.; Lautier, O.; Pawlak, N.; Blobel, G.; PALANCADE, B.; Debler, E. W.
10.1101/2022.08.11.503642 — biochemistry — Posted on 2022-08-12
2431 Antisense oligonucleotide therapy for the common Stargardt disease type 1-causing variant in ABCA4
Kaltak, M.; de Bruijn, P.; Piccolo, D.; Lee, S.-E.; Dulla, K.; Hoogenboezem, T.; Beumer, W.; Webster, A. R.; Collin, R. W. J.; Cheetham, M. E.; Platenburg, G.; Swildens, J.
10.1101/2022.08.12.503728 — molecular biology — Posted on 2022-08-12
2435 Systematic characterization of chromodomain proteins revealsan H3K9me1/2 reader regulating aging in C. elegans
Hou, X.; Xu, M.; Zhu, C.; Gao, J.; Li, M.; Chen, X.; Sun, C.; Nashan, B.; Zang, J.; Guang, S.; Feng, X.
10.1101/2022.08.10.503448 — molecular biology — Posted on 2022-08-12
2439 Distantly related hepaciviruses share common entry factor, Claudin-1
Toon, K.; Kalemera, M. D.; Palor, M.; ROSE, N. J.; Takeuchi, Y.; Grove, J.; Mattiuzzo, G.
10.1101/2022.08.10.503556 — microbiology — Posted on 2022-08-12
2445 Variations in Atlantic water influx and sea-ice cover drive taxonomic and functional shifts in Arctic marine bacterial communities
Priest, T.; von Appen, W.-J.; Oldenburg, E.; Popa, O.; Torres-Valdes, S.; Fuchs, B.; Amann, R.; Boetius, A.; Wietz, M.
10.1101/2022.08.12.503524 — microbiology — Posted on 2022-08-12
2446 Accumulation of defense systems drives panphage resistance in Pseudomonas aeruginosa
Costa, A. R.; van den Berg, D. F.; Esser, J. Q.; Muralidharan, A.; van den Bossche, H.; Estrada Bonilla, B.; van der Steen, B. A.; Haagsma, A. C.; Nobrega, F. L.; Haas, P.-J.; Brouns, S. J.
10.1101/2022.08.12.503731 — microbiology — Posted on 2022-08-12
2448 Turnover of the extracellular polymeric matrix in an EBPR microbial community
Tomas-Martinez, S.; Zwolsman, E. J.; Merlier, F.; Pabst, M.; Lin, Y.; van Loosdrecht, M. C. M.; Weissbrodt, D. G.
10.1101/2022.08.11.503576 — microbiology — Posted on 2022-08-12
2452 Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa
Weber, B. S.; Carfrae, L. A.; Woods, J. J.; Klobucar, K.; Bigham, N. P.; MacNair, C.; Lyn Raivio, T.; Wilson, J. J.; Brown, E. D.
10.1101/2022.08.11.503708 — microbiology — Posted on 2022-08-12
2455 A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency
Yan, B.; Wang, C.; Chakravorty, S.; Zhang, Z.; Kadadi, S. D.; Zhuang, Y.; Sirit, I.; Hu, Y.; Jung, M.; Sahoo, S.; Wang, L.; Shao, K.; Anderson, N. L.; Trujillo-Ochoa, J. L.; Liu, X.; Olson, M. R.; Afzali, B.; Zhao, B.; Kazemian, M.
10.1101/2022.08.10.503552 — microbiology — Posted on 2022-08-12
2457 Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells
Stewart, C. M.; Bo, Y.; Fu, K.; Chan, M.; Kozak, R.; Apperley, K. Y.-P.; Laroche, G.; Beauchemin, A.; Kobinger, G.; Kobasa, D.; Cote, M.
10.1101/2022.08.12.503750 — microbiology — Posted on 2022-08-12
2459 Screening Avian Pathogens in Eggs from Commercial Hatcheries in Nepal- an Effective Poultry Disease Surveillance Tool
Sharma, S.; Dhital, K.; Puri, D.; Pradhan, S. M.; Rajbhandari, U.; Basnet, A.; Ghaju, S.; Manandhar, P.; Ghimire, N. U.; Shahi, M. K.; Poudel, A.; Napit, R.; Karmacharya, D.
10.1101/2022.08.11.503567 — microbiology — Posted on 2022-08-12
2460 The dissemination of Rift Valley fever virus to the eye and sensory neurons of zebrafish larvae is stat1 dependent.
ter Horst, S.; Siekierska, A.; De Meulemeester, A.-S.; Cuvry, A.; Cools, L.; Neyts, J.; de Witte, P.; Rocha-Pereira, J.
10.1101/2022.08.10.503461 — microbiology — Posted on 2022-08-12
2465 Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
Cohen, H.; Baram, N.; Fridman, C. M.; Edry-Botzer, L.; Salomon, D.; Gerlic, M.
10.1101/2022.08.11.503615 — immunology — Posted on 2022-08-12
2466 Bacterial communities of premise plumbing systems in four European cities, and their association with culturable Legionella
Scaturro, M.; Del Chierico, F.; Motro, Y.; Chaldoupi, A.; Flountzi, A.; Moran-Gilad, J.; Girolamo, A.; Koutsiomani, T.; Krogulska, B.; Lindsay, D.; Matuszewska, R.; Papageorgiou, G.; Pancer, K.; Panoussis, N.; Rota, M. C.; Uldum, S. A.; Velonakis, E.; Chaput, D. L.; Ricci, M. L.
10.1101/2022.08.12.503735 — microbiology — Posted on 2022-08-12
2467 Domestication of different varieties in the cheese-making fungus Geotrichum candidum
Bennetot, B.; Vernadet, J. P.; Perkins, V.; Hautefeuille, S.; Rodriguez de la Vega, R. C.; O'Donnell, S.; Snirc, A.; Grondin, C.; Lessard, M.-H.; Peron, A.-C.; Labrie, S.; Landaud, S.; Giraud, T.; Ropars, J.
10.1101/2022.05.17.492043 — genetics — Posted on 2022-08-12
2469 Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection
Wang, Z.; Zhou, P.; Muecksch, F.; Cho, A.; Tanfous, T. B.; Canis, M.; Witte, L.; Johnson, B.; Raspe, R.; Schmidt, F.; Bednarski, E.; DaSilva, J.; Ramos, V.; Zong, S.; Turroja, M.; Millard, K. G.; Yao, K.; Shimeliovich, I.; Dizon, J.; Kaczynska, A.; Jankovic, M.; Gazumyan, A.; Oliveira, T. Y.; Caskey, M.; Gaebler, C.; Bieniasz, P. D.; Hatziioannou, T.; Nussenzweig, M. C.
10.1101/2022.08.11.503601 — immunology — Posted on 2022-08-12
2470 SARS-CoV-2 specific plasma cells acquire the phenotype of long-lived plasma cells in the human bone marrow
Schulz, A. R.; Hirseland, H.; Diekmann, L.-M.; Reinke, S.; Hardt, S.; Niedobitek, A.; Mei, H. E.
10.1101/2022.08.11.503574 — immunology — Posted on 2022-08-12
2472 A low-cost, thermostable, cell-free protein synthesis platform for on demand production of conjugate vaccines
Warfel, K. F.; Williams, A.; Wong, D. A.; Sobol, S. E.; Desai, P.; Li, J.; Chang, Y.-F.; DeLisa, M. P.; Karim, A. S.; Jewett, M. C.
10.1101/2022.08.10.503507 — synthetic biology — Posted on 2022-08-12
2473 A multiplexed, confinable CRISPR/Cas9 gene drive propagates in caged Aedes aegypti populations
Anderson, M. A. E.; Gonzalez, E.; Edgington, M. P.; Ang, J. X. D.; Purusothaman, D.-K.; Shackleford, L.; Nevard, K.; Verkuijl, S. A. N.; Harvey-Samuel, T.; Leftwich, P. T.; Esvelt, K.; Alphey, L.
10.1101/2022.08.12.503466 — synthetic biology — Posted on 2022-08-12
2480 The emergence of high-fitness variants accelerates the decay of genome heterogeneity in the coronavirus
Oliver, J. L.; Bernaola-Galvan, P.; Perfectti, F.; Gomez-Martin, C.; Verdu, M.; Moya, A.
10.1101/2021.11.06.467547 — genomics — Posted on 2022-08-12
2482 Uncoupling from transcription protects polyadenylation site cleavage from inhibition by DNA damage
Sfaxi, R.; Biswas, B.; Boldina, G.; Cadix, M.; Servant, N.; Chen, H.; Larson, D. R.; Dutertre, M.; Robert, C.; Vagner, S.
10.1101/2022.05.26.492040 — molecular biology — Posted on 2022-08-12
2488 Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Nichols, A. L.; Blumenfeld, Z.; Luebbert, L.; Knox, H. J.; Muthusamy, A. K.; Marvin, J. S.; Kim, C. H.; Grant, S. N.; Walton, D. P.; Cohen, B. N.; Hammar, R.; Looger, L. L.; Artursson, P.; Dougherty, D. A.; Lester, H. A.
10.1101/2022.08.09.502705 — neuroscience — Posted on 2022-08-12
2492 A reductase in the lipid metabolism at cross roads between cuticular wax production and jasmonic acid-mediated defenses in maize
Liu, J.; Li, L.; Robert, C. A. M.; Li, B.; He, S.; Xiong, Z.; Chen, W.; Bi, J.; Zhai, G.; Guo, S.; Zhang, H.; Li, J.; Zhou, S.; Zhang, X.; Song, C.-P.
10.1101/2022.08.10.503514 — plant biology — Posted on 2022-08-12
2493 Vertical growth dynamics of biofilms
Bravo, P.; Ng, S. L.; MacGillivray, K. A.; Hammer, B. K.; Yunker, P. J.
10.1101/2022.08.11.503641 — biophysics — Posted on 2022-08-12
2497 Development of a novel aging clock based on chromatin accessibility
Rechsteiner, C.; Morandini, F.; Perez, K.; Praz, V.; Lopez-Garcia, G.; Hinte, L.; von Meyenn, F.; Ocampo, A.
10.1101/2022.08.11.502778 — genomics — Posted on 2022-08-12
2498 A genomic timescale for placental mammal evolution
Foley, N. M.; Mason, V. C.; Harris, A.; Bredemeyer, K. R.; Damas, J.; Lewin, H. A.; Eizirik, E.; Gatesy, J.; Zoonomia Consortium, ; Springer, M.; Murphy, W. J.
10.1101/2022.08.10.503388 — evolutionary biology — Posted on 2022-08-12
2502 No evidence that post-training D2R dopaminergic drug administration affects differential fear responding in rats
Schroyens, N.; Vercammen, L.; Ozcan, B.; Ossorio Salazar, V. A.; Zaman, J.; De Bundel, D.; Beckers, T.; Luyten, L.
10.1101/2022.02.02.478781 — neuroscience — Posted on 2022-08-12
2507 Unbaised intestinal single cell transcriptomics reveals previously uncharacterized enteric nervous system populations in larval zebrafish
Kuil, L. E.; Kakiailatu, N.; Windster, J. D.; Bindels, E.; Zink, J. T. M.; van der Zee, G.; Hofstra, R. M. W.; Shepherd, I. T.; Melotte, V.; Alves, M. M.
10.1101/2022.08.11.503619 — developmental biology — Posted on 2022-08-11
2512 A lncRNA identifies IRF8 enhancer element in negative feedback control of dendritic cell differentiation
Xu, H.; Li, Z.; Kuo, C.-C.; Goetz, K.; Look, T.; Szymanski de Toledo, M. A.; Sere, K.; Gesteira Costa Filho, I.; Zenke, M.
10.1101/2022.08.11.503623 — cell biology — Posted on 2022-08-12
2514 Npas4-mediated dopaminergic regulation of fear memory states
Ko, B.; Yoo, J.-Y.; Choi, W.; Dogan, R.; Sung, K.; Lee, S.; Um, D.; Lee, S. B.; Yoo, T.; Kim, H. J.; Beak, S. T.; Park, S. K.; Paik, S.-B.; Kim, T.-K.; Kim, J.-H.
10.1101/2022.08.11.503591 — neuroscience — Posted on 2022-08-12
2515 Sodium regulates PLC and IP3R-mediated calcium signalling in invasive breast cancer cells
James, A. D.; Unthank, K. P.; Jones, I.; Sizer, R. E.; Chawla, S.; Evans, G. J. O.; Brackenbury, W. J.
10.1101/2022.08.10.503447 — cancer biology — Posted on 2022-08-11
2517 Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth
Oberin, R.; Petautschnig, S.; Tsai, T.; Qu, Z.; Jarred, E. G.; Bildsoe, H.; Truong, T. T.; Fernando, D.; van den Buuse, M.; Gardner, D. K.; Sims, N. A.; Adelson, D. L.; Western, P. S.
10.1101/2022.08.08.503175 — developmental biology — Posted on 2022-08-11
2518 MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin
Kim, J.; Chun, Y.; Ramirez, C. B.; Hoffner, L. A.; Jung, S.; Jang, K. H.; Rubtsova, V. I.; Jang, C.; Lee, G.
10.1101/2022.08.05.502726 — cancer biology — Posted on 2022-08-11
2519 Evolutionary investigations of the biosynthetic diversity in the skin microbiome using lsaBGC
Salamzade, R.; Cheong, J. Z. A.; Sandstrom, S.; Swaney, M. H.; Stubbendieck, R. M.; Starr, N. L.; Currie, C. R.; Singh, A. M.; Kalan, L.
10.1101/2022.04.20.488953 — bioinformatics — Posted on 2022-08-11
2521 How many sirtuin genes are out there? evolution of sirtuin genes in vertebrates with a description of a new family member
Opazo, J. C.; Vandewege, M.; Hoffmann, F. G.; Zavala, K.; Melendez, C.; Luchsinger, C.; Cavieres, V.; Vargas-Chacoff, L.; Morera, F.; Burgos, P.; Tapia-Rojas, C.; Mardones, G.
10.1101/2020.07.17.209510 — evolutionary biology — Posted on 2022-08-11
2522 Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
Salomon, A.; Phyo, S. A.; Okami, N.; Heffler, J.; Robison, P.; Bogush, A. I.; Prosser, B. L.
10.1101/2021.05.26.445641 — cell biology — Posted on 2022-08-11
2523 Soil protists can actively redistribute beneficial bacteria along Medicago truncatula roots
Hawxhurst, C. J.; Micciulla, J. L.; Bridges, C. M.; Gage, D. J.; Shor, L. M.; Shor, M.
10.1101/2021.06.16.448774 — microbiology — Posted on 2022-08-11
2525 Locus coeruleus neuromelanin predicts ease of attaining and maintaining neural states of arousal
Hussain, S.; Menchaca, I.; Shalchy, M. A.; Yaghoubi, K.; langley, j.; Seitz, A.; Hu, X.; Peters, M. A. K.
10.1101/2022.03.07.483289 — neuroscience — Posted on 2022-08-11
2529 Epigenetics and island-mainland divergence in an insectivorous small mammal
Cossette, M.-L.; Stewart, D. T.; Haghani, A.; Zoller, J. A.; Shafer, A. B. A.; Horvath, S.
10.1101/2022.04.14.488253 — genomics — Posted on 2022-08-11
2531 Epigenetic Changes in Saccharomyces cerevisiae Alters the Aromatic Profile in Alcoholic Fermentation
Kong, Y.; Olejar, K. J.; On, S. L. W.; Winefield, C.; Wescombe, P. A.; Brennan, C. S.; Hider, R. N.; Chelikani, V.
10.1101/2022.08.09.503430 — microbiology — Posted on 2022-08-11
2532 The Solanum americanum pangenome and effectoromics reveal new resistance genes against potato late blight
Lin, X.; Jia, Y.; Heal, R.; Prokchorchik, M.; Sindalovskaya, M.; Olave-Achury, A.; Makechemu, M.; Fairhead, S.; Noureen, A.; Heo, J.; Witek, K.; Smoker, M.; Taylor, J.; Shrestha, R.-K.; Lee, Y. Y.; Zhang, C.; Park, S. J.; sohn, k. h.; Huang, S.; Jones, J. D.
10.1101/2022.08.11.503608 — plant biology — Posted on 2022-08-11
2533 Stratification of responses to tDCS intervention in a healthy paediatric population based on resting-state EEG profiles
Dagnino, P. C.; Braboszcz, C.; Kroupi, E.; Splittgerber, M.; Brauer, H.; Dempfle, A.; Breitling-Ziegler, C.; Prehn-Kristensen, A.; Krauel, K.; Siniatchkin, M.; Moliadze, V.; Soria-Frisch, A.
10.1101/2022.08.09.503347 — neuroscience — Posted on 2022-08-11
2535 Exercise Training Remodels Adipocyte-Specific Extracellular Matrix Proteins and Alters Innervation and Vascularization in Inguinal White Adipose Tissue (iWAT)
Nigro, P.; Vamvini, M.; Yang, J. J.; Caputo, T.; Ho, L.-L.; Papadopoulos, D.; Carbone, N. P.; Colin, R.; He, J.; Michael, H. F.; White, J. D.; Robidoux, J.; Hickner, R.; Nielsen, S.; Pedersen, B. K.; Kellis, M.; Middelbeek, R.; Goodyear, L. J.
10.1101/2022.08.09.503375 — physiology — Posted on 2022-08-11
2537 Adiponectin Reverses Beta-Cell Damage and Impaired Insulin Secretion Induced by Obesity
Munhoz, A. C.; Serna, J. D. C.; Vilas-Boas, E. A.; Caldeira da Silva, C. C.; dos Santos, T. G.; Martins, V. R.; Kowaltowski, A. J.
10.1101/2022.07.22.501128 — biochemistry — Posted on 2022-08-11
2539 The cosmopolitan appendicularian Oikopleura dioica reveals hidden genetic diversity around the globe
Masunaga, A.; Mansfield, M. J.; Tan, Y.; Liu, A. W.; Bliznina, A.; Barzaghi, P.; Hodgetts, T. L.; Ferrandez-Roldan, A.; Canestro, C.; Onuma, T.; Plessy, C.; Luscombe, N. M.
10.1101/2022.08.09.503427 — evolutionary biology — Posted on 2022-08-11
2544 Psychological mechanisms of offset analgesia: The effect of expectancy manipulation
Szikszay, T. M.; Adamczyk, W. M.; Panskus, J.; Heimes, L.; David, C.; Gouverneur, P.; Luedtke, K.
10.1101/2022.08.09.503102 — neuroscience — Posted on 2022-08-11
2545 Selective Nigrostriatal Dopamine Excess Impairs Behaviors Linked to the Cognitive and Negative Symptoms of Psychosis
Moya, N. A.; Yun, S.; Fleps, S. W.; Martin, M. M.; Nadel, J. A.; Beutler, L. R.; Zweifel, L. S.; Parker, J. G.
10.1101/2022.08.09.503421 — neuroscience — Posted on 2022-08-11
2547 Light prevents pathogen-induced aqueous microenvironments via potentiation of salicylic acid signaling
Lajeunesse, G.; Roussin-Leveillee, C.; Boutin, S.; Fortin, E.; Laforest-Lapointe, I.; Moffett, P.
10.1101/2022.08.10.503390 — plant biology — Posted on 2022-08-11
2548 The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the viral infection in Arabidopsis
Rosas-Diaz, T.; Cana-Quijada, P.; Wu, M.; Du, H.; Fernandez-Barbero, G.; Macho, A. P.; Solano, R.; Castillo, A. G.; Wang, X.-W.; Lozano-Duran, R.; Eduardo, B. R.
10.1101/2022.08.11.503596 — plant biology — Posted on 2022-08-11
2549 A rapid alkalinization factor-like peptide EaF82 impairs tapetum degeneration during pollen development
Hung, C.-Y.; Kittur, F.; Wharton, K.; Chen, J.; Umstead, M.; Burwell, D.; Thomas, M.; Qi, Q.; Zhang, J.; Oldham, C. E.; Burkey, K. O.; Xie, J. J.
10.1101/2022.08.11.503650 — plant biology — Posted on 2022-08-11
2552 Beneficial Effects of Bempedoic Acid Treatment in Polycystic Kidney Disease Cells and Mice
Hallows, K. R.; Li, H.; Saitta, B.; Sepehr, S.; Huang, P.; Pham, J.; Wang, J.; Mancino, V.; Chung, E. J. R.; Pinkosky, S. L.; Pastor-Soler, N. M.
10.1101/2022.08.09.503392 — pathology — Posted on 2022-08-11
2553 Retrotransposons facilitate tissue-specific horizontal Transfer of circulating tumor DNA
cinar, M.; Martinez-Medina, L.; Puvvula, P. K.; Arakelyan, A.; Vardarajan, B. N.; Anthony, N.; Nagaraju, G. P.; Park, D.; Feng, L.; Sheff, F.; Mosunjac, M.; Saxe, D.; Flygare, S.; Alese, O. B.; Kaufman, J.; Lonial, S.; Sarmiento, J.; Lossos, I. S.; Vertino, P. M.; Lopez, J. A.; Bernal-Mizrachi, L.
10.1101/2022.08.10.501131 — cancer biology — Posted on 2022-08-11
2559 Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis
Premkumar, T.; Paniker, L.; Kang, R.; Biot, M.; Humphrey, E.; Destain, H.; Ferranti, I.; Okulate, I.; Nguyen, H.; Kilaru, V.; Frasca, M.; Chakraborty, P.; Cole, F.
10.1101/2022.08.10.503530 — genetics — Posted on 2022-08-11
2561 Assessing the accuracy of paired and random sampling for quantifying plant-plant interactions in natural communities
Michalet, R.; Losapio, G.; Kikvidze, Z.; Brooker, R. W.; Butterfield, B. J.; Callaway, R. M.; Cavieres, L. A.; Lortie, C. J.; Pugnaire, F. I.; Schoeb, C.
10.1101/2022.08.09.503341 — ecology — Posted on 2022-08-11
2563 Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars
Lawrence, A.-L. E.; Berger, R. P.; Hill, D. R.; Huang, S.; Yadagiri, V. K.; Bons, B.; Fields, C.; Knight, J. S.; Wobus, C. E.; Spence, J. R.; Young, V. B.; Abuaita, B. H.; O'Riordan, M. X.
10.1101/2022.08.09.503428 — immunology — Posted on 2022-08-11
2566 A Genetic Variant of Fatty Acid Amide Hydrolase (FAAH) Exacerbates Hormone- Mediated Orexigenic Feeding in Mice
Balsevich, G.; Petrie, G. N.; Heinz, D. E.; Singh, A.; Aukema, R. J.; Hunker, A. C.; Vecchiarelli, H. A.; Yau, H.; Sticht, M.; Thompson, R. J.; Lee, F. S.; Zweifel, L. S.; Chelikani, P. K.; Gassen, N. C.; Hill, M. N.
10.1101/2022.08.09.503403 — neuroscience — Posted on 2022-08-11
2567 Enhancing adult neuroplasticity by epigenetic regulation of Parvalbumin-expressing GABAergic cells
Lavertu-Jolin, M.; Chattopadhyaya, B.; Chehrazi, P.; Carrier, D.; Wunnemann, F.; Leclerc, S.; Dumouchel, F.; Robertson, D.; Affia, H.; Saba, K.; Gopal, V.; Patel, A. B.; Andelfinger, G.; Pineyro, G.; Di Cristo, G.
10.1101/2022.08.09.503382 — neuroscience — Posted on 2022-08-11
2571 Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes
Lee, J. W. L.; Cowley, E. S.; Wolf, P. G.; Doden, H. L.; Murai, T.; Caicedo, K. Y. O.; Ly, L.; Sun, F.; Takei, H.; Nittono, H.; Daniel, S. L.; Cann, I.; Gaskins, R.; Anantharaman, K.; Ridlon, J. M.
10.1101/2022.08.09.503364 — biochemistry — Posted on 2022-08-11
2572 Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease
Chinthapatla, R.; Sotoudegan, M. S.; Anderson, T.; Moustafa, I. M.; Passow, K. T.; Kennelly, S. A.; Moorthy, R.; Dulin, D.; Feng, J. Y.; Harki, D. A.; Kirchdoerfer, R.; Cameron, C. E.; Arnold, J. J.
10.1101/2022.08.11.503614 — biochemistry — Posted on 2022-08-11
2574 The genetic and environmental etiology of blood-based biomarkers related to the risks of Alzheimer's Disease in a population-based sample of early old age men
Gillespie, N. A.; Rissman, R. A.; Elman, J. A.; McKenzie, R. E.; Tu, X. M.; Reynolds, C. A.; Lyons, M. J.; Eglit, G. M. L.; Neale, M. C.; Franz, C.; Kremen, W. S.
10.1101/2022.08.09.503234 — genetics — Posted on 2022-08-11
2575 Ancient DNA reveals interstadials as a driver of the common vole population dynamics during the last glacial period
Baca, M.; Popovic, D.; Lemanik, A.; Banuls-Cardona, S.; Conard, N.; Cuenca-Bescos, G.; Desclaux, E.; Fewlass, H.; Garcia, J. T.; Heckel, G.; Horacek, I.; Lebreton, L.; Garcia, J. M. L.; Luzi, E.; Markovic, Z.; Lenardic, J. M.; Murelaga, X.; Noiret, P.; Petculescu, A.; Popov, V.; Hadravova, T.; Rhodes, S.; Ridush, B.; Royer, A.; Stewart, J. R.; Stojak, J.; Talamo, S.; Knul, M. V.; Wang, X.; Wojcik, J. M.; Nadachowski, A.
10.1101/2022.08.09.503016 — evolutionary biology — Posted on 2022-08-11
2576 Sex differences in inter-individual gene expression variability across human tissues
Khodursky, S.; Jiang, C. S.; Zheng, E. B.; Vaughan, R.; Schrider, D. R.; Zhao, L.
10.1101/2022.08.09.503366 — evolutionary biology — Posted on 2022-08-11
2581 Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Brown, T. L.; Horton, E. C.; Craig, E. W.; Hewitt, M. N.; Yee, N. G.; Goo, C. E.; Fan, E. T.; Black, E. C.; Raible, D. W.; Rasmussen, J. P.
10.1101/2022.08.11.503570 — developmental biology — Posted on 2022-08-11
2582 A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters
Chaturvedi, S.; Beutler, N.; Pablo, M.; Vasen, G.; Chen, X.; Calia, G.; Buie, L.; Rodick, R.; Smith, D.; Rogers, T.; Weinberger, L.
10.1101/2022.08.10.503534 — microbiology — Posted on 2022-08-11
2583 Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein
Yang, K.; Wang, C.; Kreutzberger, A. J. B.; Ojha, R.; Kuivanen, S.; Couoh-Cardel, S.; Muratcioglu, S.; Eisen, T. J.; White, K. I.; Held, R. G.; Subramanian, S.; Marcus, K.; Pfuetzner, R. A.; Esquivies, L.; Doyle, C. A.; Kuriyan, J.; Vapalahti, O.; Balistreri, G.; Kirchhausen, T.; Brunger, A. T.
10.1101/2022.08.11.503553 — microbiology — Posted on 2022-08-11
2584 Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro
Hou, N.; Shuai, L.; Zhang, L.; Xie, X.; Tang, K.; Zhu, Y.; Yu, Y.; Zhang, W.; Tan, Q.; Zhong, G.; Wen, Z.; Wang, C.; He, X.; Huo, H.; Gao, H.; Xu, Y.; Xue, J.; Peng, C.; Zou, J.; Schindewolf, C.; Menachery, V.; Su, W.; Yuan, Y.; Shen, Z.; Zhang, R.; Yuan, S.; Yu, H.; Shi, P.-Y.; Bu, Z.; Huang, J.; Hu, Q.
10.1101/2022.08.10.503531 — microbiology — Posted on 2022-08-11
2585 Increased structural connectivity in high schizotypy
Messaritaki, E.; Foley, S.; Barawi, K.; Ettinger, U.; Jones, D. K.
10.1101/2022.05.12.491533 — neuroscience — Posted on 2022-08-11
2589 MuDoGeR: Multi-Domain Genome Recovery from metagenomes made easy
Nunes da Rocha, U.; Kasmanas, J.; Kallies, R.; Saraiva, J. P.; Brizola Toscan, R.; Stefanic, P.; Bicalho, M. F.; Correa, F. B.; Basturk, M. N.; Fousekis, E.; Barbosa, L. M. V.; Plewka, J.; Probst, A. J.; Baldrian, P.; Stadler, P. F.; CLUE-TERRA consortium,
10.1101/2022.06.21.496983 — bioinformatics — Posted on 2022-08-11
2590 Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Le-Trilling, V. T. K.; Banchenko, S.; Paydar, D.; Leipe, P. M.; Binting, L.; Lauer, S.; Graziadei, A.; Gotthold, C.; Burger, J.; Bracht, T.; Sitek, B.; Lebbink, R. J.; Malyshkina, A.; Mielke, T.; Rappsilber, J.; Spahn, C. M. T.; Voigt, S.; Trilling, M.; Schwefel, D.
10.1101/2022.05.05.490734 — biochemistry — Posted on 2022-08-11
2591 Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data
Warchol, S.; Krueger, R.; Nirmal, A. J.; Gaglia, G.; Jessup, J.; Ritch, C. C.; Hoffer, J.; Muhlich, J. L.; Burger, M.; Jacks, T. L.; Santagata, S.; Sorger, P. K.; Pfister, H.
10.1101/2022.05.09.490039 — cell biology — Posted on 2022-08-11
2594 Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis
Bumbak, F.; Pons, M.; Inoue, A.; Paniagua, J. C.; Yan, F.; Wu, H.; ROBSON, S. A.; Bathgate, R.; Scott, D. J.; Gooley, P. R.; Ziarek, J. J.
10.1101/2022.08.09.503369 — biophysics — Posted on 2022-08-11
2595 A common mechanism of Sec61 translocon inhibition by small molecules
Itskanov, S.; Wang, L.; Junne, T.; Sherriff, R.; Xiao, L.; Blanchard, N.; Shi, W. Q.; Forsyth, C.; Hoepfner, D.; Spiess, M.; Park, E.
10.1101/2022.08.11.503542 — biochemistry — Posted on 2022-08-11
2597 Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Mouse Blastocyst-derived Stem Cells
Thomas, C.; Haimson, R. B.; Zacharia, A.; Orih, P.; Shehadeh, A.; Saidemberg, D.; Kogan, N. M.; Alfandary, S.; Serruya, R.; Dagan, A.; Petit, I.; Moussaieff, A.
10.1101/2022.07.28.501839 — developmental biology — Posted on 2022-08-11
2600 Piezo1 as a force-through-membrane sensor in red blood cells.
Vaisey, G.; Banerjee, P.; North, A. J.; Haselwandter, C. A.; MacKinnon, R.
10.1101/2022.08.10.503510 — biochemistry — Posted on 2022-08-11
2612 Counting Is Almost All You Need
Akerman, O.; Louzoun, Y.; Isakov, H.; Levi, R.
10.1101/2022.08.09.501430 — immunology — Posted on 2022-08-11
2614 Enteric glia adopt an activated pro-inflammatory state in response to human and bacterial amyloids
Verstraelen, P.; Van Remoortel, S.; De Loose, N.; Verboven, R.; Garcia-Diaz Barriga, G.; Christmann, A.; Gries, M.; Tukel, C.; Ibiza Martinez, S.; Schaefer, K.-H.; Timmermans, J.-P.; De Vos, W.
10.1101/2022.08.08.503156 — neuroscience — Posted on 2022-08-11
2615 In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
Gonzalez-Sepulveda, M.; Compte, J.; Cuadros, T.; Nicolau, A.; Guillard-Sirieix, C.; Penuelas, N.; Lorente-Picon, M.; Parent, A.; Romero-Gimenez, J.; Cladera-Sastre, J. M.; Laguna, A.; Vila, M.
10.1101/2022.08.08.503142 — neuroscience — Posted on 2022-08-11
2616 Human photoreceptor cell transplants integrate into human retina organoids
Wagner, F.; Carrera, R.; Kurth, T.; Michalakis, S.; Naumann, R.; Zuzic, M.; Neumann, K.; Goureau, O.; Busskamp, V.; Karl, M. O.
10.1101/2022.08.09.500037 — neuroscience — Posted on 2022-08-11
2619 Bidirectional and reciprocal control of astrocyte free calcium by modest fluctuations in external potassium
Institoris, A.; Shin, S. S.; Weiilnger, N. L.; Gorzo, K.; Mehina, E.; Haidey, J.; MacVicar, B. A.; Gordon, G. R.
10.1101/2022.08.08.503209 — neuroscience — Posted on 2022-08-11
2620 The basolateral amygdala-anterior cingulate pathway contributes to depression and its comorbidity with chronic pain
Becker, L.; Fillinger, C.; Waegaert, R.; Hener, P.; Ayazgok, B.; Humo, M.; Journee, S. H.; Karatas, M.; Degiorgis, L.; Santin, M. d. N.; Mondino, M.; Barrot, M.; Ibrahim, E. C.; Turecki, G.; Belzeaux, R.; Veinante, P.; Harsan, L. A.; Hugel, S.; Lutz, P.-E.; Yalcin, I.
10.1101/2022.08.09.503276 — neuroscience — Posted on 2022-08-11
2622 Labeled lines for fat and sugar reward combine to promote overeating
McDougle, M.; de Araujo, A.; Vergara, M.; Yang, M.; Singh, A.; Braga, I.; Urs, N.; Warren, B.; de Lartigue, G.
10.1101/2022.08.09.503218 — neuroscience — Posted on 2022-08-11
2623 There is no fundamental trade-off between prediction accuracy and feature importance reliability
Chen, J.; Ooi, L. Q. R.; Li, J.; Asplund, C. L.; Eickhoff, S. B.; Bzdok, D.; Holmes, A. J.; Yeo, B. T. T.
10.1101/2022.08.08.503167 — neuroscience — Posted on 2022-08-11
2625 FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons
Choi, M.; Schneeberger, M.; Fan, W.; Bugde, A.; Gautron, L.; Vale, K.; Zhang, Y.; Friedman, J. M.; Mangelsdorf, D. J.; Kliewer, S. A.
10.1101/2022.08.09.502667 — neuroscience — Posted on 2022-08-11
2626 Microglia associations with brain pericytes and the vasculature are reduced in Alzheimer's disease
Morris, G. P.; Foster, C. G.; Courtney, J.-M.; Collins, J. M.; Cashion, J. M.; Brown, L. S.; Howells, D. W.; DeLuca, G. C.; Canty, A. J.; King, A. E.; Ziebell, J. M.; Sutherland, B. A.
10.1101/2022.08.08.503250 — neuroscience — Posted on 2022-08-11
2628 Exploring the adaptability and robustness of the central carbon metabolism of Mycoplasma pneumoniae
Zondervan, N.; Yus, E.; Sevin, D.; Martinez, S.; Gallo, C.; Schaap, P. J.; Lluch-Senar, M.; Serrano, L.; Martins dos Santos, V. A. P.; Suarez-Diez, M.
10.1101/2022.08.08.503180 — systems biology — Posted on 2022-08-11
2630 Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks
Lakrisenko, P.; Stapor, P.; Grein, S.; Paszkowski, Łukasz; Pathirana, D.; Fröhlich, F.; Lines, G. T.; Weindl, D.; Hasenauer, J.
10.1101/2022.08.08.503176 — systems biology — Posted on 2022-08-11
2632 Bovine polyomavirus-1 (Epsilonpolyomavirus bovis): An emerging fetal pathogen of cattle that causes renal lesions resembling polyomavirus-associated nephropathy of humans
Giannitti, F.; da Silva Silveira, C.; Bullock, H.; Beron, M.; Fernandez, S.; Benitez-Galeano, M. J.; Rodriguez-Osorio, N.; Silva-Flannery, L.; Perdomo, Y.; Cabrera, A.; Puentes, R.; Colina, R.; Ritter, J. M.; Castells, M.
10.1101/2022.08.08.503126 — pathology — Posted on 2022-08-11
2633 Centuries of genome instability and evolution in soft-shell clam transmissible cancer
Hart, S. F.; Yonemitsu, M. A.; Giersch, R. M.; Beal, B. F.; Arriagada, G.; Davis, B. W.; Ostrander, E. A.; Goff, S. P.; Metzger, M. J.
10.1101/2022.08.07.503107 — cancer biology — Posted on 2022-08-11
2635 Retrotransposons facilitates tissue specific horizontal Transfer of circulating tumor DNA
cinar, M.; Martinez-Medina, L.; Puvvula, P. K.; Arakelyan, A.; Vardarajan, B. N.; Anthony, N.; Nagaraju, G. P.; Park, D.; Feng, L.; Sheff, F.; Mosunjac, M.; Saxe, D.; Flygare, S.; Alese, O. B.; Kaufman, J.; Lonial, S.; Sarmiento, J.; Lossos, I. S.; Vertino, P. M.; Lopez, J. A.; Bernal-Mizrachi, L.
10.1101/2022.08.10.501131 — cancer biology — Posted on 2022-08-11
2636 Albumin as a probe for clathrin-independent endocytosis and transcytosis into experimental brain metastases of breast cancer.
Khan, I.; Gril, B.; Paranjape, A.; Burks, C.; Robinson, C.; Difilippantonio, S.; Biernat, W.; Bienkowski, M.; Peksa, R.; Duchnowska, R.; Jassem, J.; Brastianos, P. K.; Metellus, P.; Bialecki, E.; Woodroofe, C. C.; Wu, H.; Swenson, R.; Steeg, P. S.
10.1101/2022.08.09.503253 — cancer biology — Posted on 2022-08-11
2637 Nanoscale engagement of immune checkpoint inhibitor PD-L1 in membrane lipid rafts
Ruglioni, M.; Civita, S.; Salvadori, T.; Cristiani, S.; Carnicelli, V.; Barachini, S.; Petrini, I.; Diaspro, A.; Bianchini, P.; Storti, B.; Bizzarri, R.; Fogli, S.; Danesi, R.
10.1101/2022.08.09.503318 — biophysics — Posted on 2022-08-11
2640 CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.
Pernice, S.; Sirovich, R.; Grassi, E.; Viviani, M.; Ferri, M.; Sassi, F.; Alessandri, L.; Tortarolo, D.; Calogero, R. A.; Trusolino, L.; Bertotti, A.; Beccuti, M.; Olivero, M.; Cordero, F.
10.1101/2022.08.08.503120 — bioinformatics — Posted on 2022-08-11
2645 agoTRIBE detects miRNA-target interactions transcriptome-wide in single cells
Sekar, V.; Marmol-Sanchez, E.; Kalogeropoulos, P.; Stanicek, L.; Sagredo, E. A.; Doukoumopoulos, E.; Bonath, F.; Biryukova, I.; Friedländer, M. R.
10.1101/2022.08.10.503472 — genomics — Posted on 2022-08-11
2646 The Chromosome-based Genome of Paspalum vaginatum Provides New Insights into Salt-stress Adaptation
Liao, L.; Hu, X.; Hao, J.; Tang, M.; Ren, L.; Pan, L.; Xie, S.; Raymer, P.; Qi, P.; Chen, Z.; Wang, Z.; Luo, J.
10.1101/2022.08.08.503172 — genomics — Posted on 2022-08-11
2647 Melon pan-genome and multi-parental framework for high-resolution trait dissection
Oren, E.; Dafna, A.; Tzuri, G.; Halperin, I.; Isaacson, T.; Elakabetz, M.; Meir, A.; Saar, U.; Ohali, S.; La, T.; Romay, C.; Tadmor, Y.; Schaffer, A. A.; Buckler, E. S.; Cohen, R.; Burger, J.; Gur, A.
10.1101/2022.08.09.503186 — genetics — Posted on 2022-08-11
2652 Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth
Oberin, R.; Petautschnig, S.; Tsai, T.; Qu, Z.; Jarred, E.; Bildsoe, H.; Truong, T. T.; Fernando, D.; van den Buuse, M.; Gardner, D. K.; Sims, N. A.; Adelson, D. L.; Western, P. S.
10.1101/2022.08.08.503175 — developmental biology — Posted on 2022-08-11
2653 Indoxyl Sulfate, a Uremic Toxin, Induces Trained Immunity of Monocytes through the AhR-Dependent Arachidonic Acid Pathway
Kim, H. Y.; Kim, D. H.; Lee, S. J.; Kang, Y. J.; Kim, G.; Shin, H. M.; Lee, H.; Yoo, T.-H.; Lee, W.-W.
10.1101/2022.08.08.503143 — immunology — Posted on 2022-08-11
2654 Pattern Of Some Inflammatory Mediators Among Adult Patients With Bronchial Asthma On Corticosteroids Attending Aminu Kano Teaching Hospital, Kano, Nigeria
Hayatu, S.; Ismail, M.; Mannir, H.; Umar, L.; Gwarzo, M. Y.; Rogo, L. D.; Ibrahim, A.; Garba, N.; Danladi, S. B.; Aliyu, I. A.; Bala, J. A.; Yahaya, S. I.
10.1101/2022.08.08.503171 — immunology — Posted on 2022-08-11
2655 Resting-state aperiodic neural activity as a novel objective marker of daytime somnolence
Cross, Z. R.; Kang, T. Y.; Lushington, K.; Sarkar, P.; Singh, P.; Johnston, S.; Yeo, A.; Chatburn, A.
10.1101/2022.08.07.503118 — neuroscience — Posted on 2022-08-11
2656 A key role of the hippocampal P3 in the attentional blink
Derner, M.; Reber, T. P.; Faber, J.; Surges, R.; Mormann, F.; Fell, J.
10.1101/2022.08.08.502473 — neuroscience — Posted on 2022-08-11
2657 Taking shortcuts: Great for travel, but not for reproducible methods sections
Standvoss, K.; Kazezian, V.; Lewke, B. R.; Bastian, K.; Chidambaram, S.; Arafat, S.; Alsharif, U.; Herrera-Melendez, A.; Knipper, A.-D.; Seco, B. M. S.; Soto, N. N.; Rakitzis, O.; Steinecker, I.; van Kronenberg Till, P.; Zarebidaki, F.; Weissgerber, T. L.
10.1101/2022.08.08.503174 — neuroscience — Posted on 2022-08-11
2658 Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS/FTD
Luan, W.; Wright, A. L.; Brown-Wright, H.; Le, S.; San Gil, R.; Madrid San Martin, L.; Ling, K.; Jafar-Nejad, P.; Rigo, F.; Walker, A. K.
10.1101/2022.08.08.503119 — neuroscience — Posted on 2022-08-11
2659 The effects of ethnoracial-related stressors during pregnancy on the developing offspring brain.
Spann, M. N.; Alleyne, K.; Holland, C. M.; Davids, A.; Pierre-Louis, A.; Bang, C.; Oyeneye, V.; Kiflom, R.; Shea, E.; Cheng, B.; Peterson, B. S.; Monk, C.; Scheinost, D.
10.1101/2022.08.08.503168 — neuroscience — Posted on 2022-08-11
2661 Does phasic dopamine release cause policy updates?
Carter, F.; Cossette, M.-P.; Trujillo-Pisanty, I.; Pallikaras, V.; Breton, Y.-A.; Conover, K.; Caplan, J.; Solis, P.; Voisard, J.; Yaksich, A.; Shizgal, P.
10.1101/2022.08.08.502043 — neuroscience — Posted on 2022-08-11
2663 Deep learning-based automated lesion segmentation on mouse stroke magnetic resonance images
An, J.; Wendt, L.; Wiese, G.; Herold, T.; Rzepka, N.; Mueller, S.; Koch, S. P.; Hoffmann, C. J.; Harms, C.; Boehm-Sturm, P.
10.1101/2022.08.09.503140 — neuroscience — Posted on 2022-08-11
2664 Migratory hoverflies orientate north during spring migration
Hawkes, W.; Weston, S.; Cook, H.; Doyle, T.; Massy, R.; Jimenez-Guri, E.; Wotton Jimenez, R.; Wotton, K.
10.1101/2022.08.08.503145 — zoology — Posted on 2022-08-11
2665 Proteome capacity constraints favor respiratory ATP generation
Shen, Y.; Dinh, H. V.; Cruz, E.; Call, C. M.; Baron, H.; Ryseck, R.-P.; Pratas, J.; Subramanian, A.; Fatma, Z.; Weilandt, D.; Dwaraknath, S.; Xiao, T.; Hendry, J. I.; Tran, V.; Yang, L.; Yoshikuni, Y.; Zhao, H.; Maranas, C. D.; Wuhr, M.; Rabinowitz, J. D.
10.1101/2022.08.10.503479 — systems biology — Posted on 2022-08-11
2666 Steroidal glycoalkaloids contribute to anthracnose resistance in Solanum lycopersicum
Fabian, M. L.; Zhang, C.; Sun, J.; Price, N. P.; Chen, P.; Clarke, C. R.; Jones, R. W.; Stommel, J. R.
10.1101/2022.08.08.503224 — plant biology — Posted on 2022-08-11
2667 HSPA8 chaperone complex drives chaperone-mediated autophagy regulation in acute promyelocytic leukemia differentiation
Rafiq, S.; Mungure, I.; Niklaus, N. J.; Mueller, S.; Jacquel, A.; Robert, G.; Auberger, P.; Torbett, B. E.; Muller, S.; Tschan, M. P.; Humbert, M.
10.1101/2022.08.07.502745 — cancer biology — Posted on 2022-08-11
2668 Deciphering transcriptional networks during human cardiac development
Canac, R.; Cimarosti, B.; Girardeau, A.; Forest, V.; Olchesqui, P.; Poschmann, J.; Redon, R.; Lemarchand, P.; Gaborit, N.; Lamirault, G.
10.1101/2022.08.11.503560 — developmental biology — Posted on 2022-08-11
2671 Mechanical Stimulation Shapes the Immunoregulatory Properties of Dendritic Cells
Alraies, Z.; Rivera, C. A.; Delgado, M.-G.; Sanseau, D.; Maurin, M.; Yatim, A.; Saez, P.; Williart, A.; Gratia, M.; DeSilva, N.; Moreau, A.; Albaud, B.; Legoix, P.; Nakano, H.; Cook, D. N.; Lawrence, T.; Manel, N.; D. Moreau, H.; Nader, G. P. F.; Piel, M.; Lennon-Dumenil, A.-M.
10.1101/2022.08.09.503223 — cell biology — Posted on 2022-08-11
2673 Circadian ribosome profiling reveals a role for the Period2 upstream opening reading frame in sleep
Millius, A.; Yamada, R.; Fujishima, H.; Maeda, K.; Standley, D. M.; Sumiyama, K.; Perrin, D.; Ueda, H. R.
10.1101/2022.08.09.503391 — cell biology — Posted on 2022-08-11
2674 Macrophage migrates on alternate non-adhesive surfaces
Xing, F.; Dong, H.; Yang, J.; Fan, C.; Hou, M.; Zhang, P.; Hu, F.; Zhou, J.; Chen, L.; Pan, L.; Xu, J.
10.1101/2022.08.10.503454 — cell biology — Posted on 2022-08-11
2678 Deterministic and probabilistic fate decisions co-exist in a single retinal lineage
Nerli, E.; Kretzschmar, J.; Bianucci, T.; Rocha-Martins, M.; Zechner, C.; Norden, C.
10.1101/2022.08.11.503564 — developmental biology — Posted on 2022-08-11
2679 Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae.
Gaillard, A.-L.; Mohamad, T.; Quan, F. B.; De Cian, A.; Mosimann, C.; Tostivint, H.; Pezeron, G.
10.1101/2022.08.09.503396 — developmental biology — Posted on 2022-08-11
2680 Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Brown, T. L.; Horton, E. C.; Craig, E. W.; Hewitt, M. N.; Yee, N. G.; Goo, C. E.; Fan, E. T.; Black, E. C.; Raible, D. W.; Rasmussen, J. P.
10.1101/2022.08.11.503570 — developmental biology — Posted on 2022-08-11
2681 Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites
Hart, M. N.; Mohring, F.; Donvito, S. M.; Thomas, J. A.; Muller-Sienerth, N.; Wright, G. J.; Knuepfer, E.; Saibil, H. R.; Moon, R. W.
10.1101/2022.08.09.503398 — cell biology — Posted on 2022-08-11
2688 Cloud-controlled microscopy enables remote project-based biology education in Latinx communities in the United States and Latin America
Baudin, P. V.; Sacksteder, R.; Worthington, A. K.; Voitiuk, K.; Ly, V. T.; Hoffman, R. N.; Elliott, M. A. T.; Parks, D.; Ward, R.; Torres-Montoya, S.; Amend, F.; Montellano Duran, N.; Vargas, P. A.; Martinez, G.; Alvarado-Arnez, L. E.; Ehrlich, D.; Rosen, Y. M.; Breevoort, A.; Schouten, T.; Kurniawan, S.; Haussler, D.; Teodorescu, M.; Mostajo-Radji, M. A.
10.1101/2022.08.05.502091 — scientific communication and education — Posted on 2022-08-11
2689 Correlating viscosity and molecular crowding with fluorescent nanobeads and molecular probes: in vitro and in vivo
Lecinski, S.; Shepherd, J. W.; Bunting, K.; Dresser, L.; Quinn, S. D.; MacDonald, C.; Leake, M. C.
10.1101/2022.06.27.497768 — biophysics — Posted on 2022-08-11
2691 Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis
Premkumar, T.; Paniker, L.; Kang, R.; Biot, M.; Humphrey, E.; Destain, H.; Ferranti, I.; Okulate, I.; Nguyen, H.; Kilaru, V.; Frasca, M.; Chakraborty, P.; Cole, F.
10.1101/2022.08.10.503530 — genetics — Posted on 2022-08-11
2694 Bayesian Additive Regression Trees for Genotype by Environment Interaction Models
Sarti, D. A.; Prado, E. B.; Inglis, A.; dos Santos, A. A. L.; Hurley, C.; Moral, R. d. A.; Parnell, A.
10.1101/2021.05.07.442731 — bioinformatics — Posted on 2022-08-11
2697 Adaptive radioresistance of Enterohemorrhagic Escherichia coli O157:H7 results in genomic loss of shiga toxin-encoding prophages
Gaougaou, G.; Vincent, A. T.; Krylova, K.; Habouria, H.; Bessaiah, H.; Baraketi, A.; Veyrier, F. J.; Dozois, C. M.; Deziel, E.; Lacroix, M.
10.1101/2022.08.08.503262 — microbiology — Posted on 2022-08-11
2698 Longitudinal quantitative whole-brain microscopy reveals distinct temporal and spatial efficacies of anti-Aβ therapies
Kirschenbaum, D.; Dadgar-Kiani, E.; Catto, F.; Voigt, F.; Trevisan, C.; Bichsel, O.; Shirani, H.; Nilsson, P. K. R.; Frontzek, K.; Paganetti, P.; Helmchen, F.; Lee, J. H.; Aguzzi, A.
10.1101/2021.01.15.426090 — neuroscience — Posted on 2022-08-11
2702 PI3P dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
Ghosh, A.; Venugopal, A.; Shinde, D.; Sharma, S. M.; Krishnan, M.; Mathre, S.; Krishnan, H.; PADINJAT, R.
10.1101/2022.06.18.496676 — cell biology — Posted on 2022-08-11
2703 Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.
Khani, S.; Topel, H.; Josephrajan, A.; Larsen, B. D. M.; Tavanez, A. R. A. d. A.; Gaudry, M. J.; Leyendecker, P.; Stanic, N.; Gaziano, I.; Hansmeier, N. R.; Schmidt, E.; Klemm, P.; Vagliano, L.-M.; Engelhard, C. A.; Nielsen, S.; Jespersen, N. Z.; Rehimi, R.; Gohlke, S.; Frommolt, P.; Gnad, T.; Rada-Iglesias, A.; Pradas-Juni, M.; Schulz, T. J.; Wunderlich, F. T.; Pfeifer, A.; Jastroch, M.; Wachten, D.; Kornfeld, J.-W.
10.1101/2022.08.01.502156 — cell biology — Posted on 2022-08-11
2706 The VGNC: Expanding Standardized Vertebrate Gene Nomenclature
Jones, T. E. M.; Yates, B.; Braschi, B.; Gray, K.; Tweedie, S.; Seal, R. L.; Bruford, E. A.
10.1101/2022.08.10.503477 — genomics — Posted on 2022-08-10
2709 Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis
Premkumar, T.; Paniker, L.; Kang, R.; Biot, M.; Humphrey, E.; Destain, H.; Ferranti, I.; Okulate, I.; Nguyen, H.; Kilaru, V.; Frasca, M.; Chakraborty, P.; Cole, F.
10.1101/2022.08.10.503530 — genetics — Posted on 2022-08-10
2718 Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration
Wisdom, K. M.; Suijker, J.; van den Broek, L.; Sridharan, B.; Grandhi, T. S. P.; Cheng, A.; Lamb, M.; Titus, S. A.; Gehman, A.; Poore, D.; Shah, N.; Cheng, S.-H.; Kim, E.; Griffin, S.; Ekert, J.
10.1101/2022.08.03.502507 — bioengineering — Posted on 2022-08-10
2720 Heat inactivation of the Monkeypoxvirus
Batejat, C.; Grassin, Q.; Feher, M.; Hoinard, D.; Vanhomwegen, J.; Manuguerra, J.-C.; Leclercq, I.
10.1101/2022.08.10.502482 — microbiology — Posted on 2022-08-10
2721 Stability of SARS-CoV-2 in cold-chain transportation environments and the efficacy of disinfection measures
Peng, S.; Li, G.; Pathak, J. L.; Guo, X.; Lin, Y.; Xu, H.; Qiu, W.; Zheng, J.; Sun, W.; Hu, X.; Zhang, G.; Li, B.; Bi, X.; Dai, J.
10.1101/2022.08.09.503429 — microbiology — Posted on 2022-08-10
2722 Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages
Ren, P.; Hu, Y.; Peng, L.; Yang, L.; Suzuki, K.; Fang, Z.; Bai, M.; Zhou, L.; Feng, Y.; Xiong, Y.; Chen, S.
10.1101/2022.08.09.503414 — immunology — Posted on 2022-08-10
2724 Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Remesh, S. G.; Merz, G. E.; Britol, A. F.; Chio, U. S.; Rizo, A. N.; Pospiech, T. H.; Lui, I.; Laurie, M. T.; Glasgow, J.; Le, C. Q.; Zhang, Y.; Diwanji, D.; Hernandez, E.; Lopez, J.; Pawar, K. I.; Pourmal, S.; Smith, A. M.; Zhou, F.; QBI Coronavirus Research Group Structural Biology Consortium, ; DeRisi, J.; Kortemme, T.; Rosenberg, O. S.; Glasgow, A.; Leung, K. K.; Wells, J. A.; Verba, K. A.
10.1101/2022.08.09.503400 — biochemistry — Posted on 2022-08-10
2725 Restoration and resilience to sea level rise of a salt marsh affected by dieback events in Charleston, SC
Rolando, J. L.; Hodges, M.; Garcia, K. D.; Krueger, G.; Williams, N.; Carr, J.; Robinson, J.; George, A.; Morris, J. T.; Kostka, J. E.
10.1101/2022.04.18.488673 — ecology — Posted on 2022-08-10
2726 Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants
Jian, F.; Yu, Y.; Song, W.; Yisimayi, A.; Yu, L.; Gao, Y.; Zhang, N.; Wang, Y.; Shao, F.; Hao, X.; Xu, Y.; Jin, R.; Wang, Y.; Xie, X. S.; Cao, Y.
10.1101/2022.08.09.503384 — immunology — Posted on 2022-08-10
2729 Arabidopsis Leucine Rich Repeat-Malectin Receptor Kinases in immunity triggered by cellulose and mixed-linked glucan oligosaccharides
Martin-Dacal, M.; Fernandez-Calvo, P.; Jimenez-Sandoval, P.; Lopez, G.; Garrido-Arandia, M.; Rebaque, D.; del Hierro, I.; Torres, M. A.; Kumar, V.; Berlanga, D. J.; Melida, H.; Pacios, L. F.; Santiago, J.; Molina, A.
10.1101/2022.08.09.503277 — plant biology — Posted on 2022-08-10
2733 Semi-Self-Supervised Learning for Semantic Segmentation in Images with Dense Patterns
Najafian, K.; Ghanbari, A.; Kish, M. S.; Eramian, M.; Shirdel, G. H.; Stavness, I.; Jin, L.; Maleki, F.
10.1101/2022.08.09.503251 — plant biology — Posted on 2022-08-10
2734 1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells
Cordes, T.; Kuna, R. S.; McGregor, G. H.; Khare, S. V.; Gengatharan, J.; Muthusamy, T.; Metallo, C. M.
10.1101/2022.01.19.476986 — cancer biology — Posted on 2022-08-10
2737 Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform
Almogy, G.; Pratt, M.; Oberstrass, F.; Lee, L.; Mazur, D.; Beckett, N.; Barad, O.; Soifer, I.; Perelman, E.; Etzioni, Y.; Sosa, M.; Jung, A.; Clark, T.; Trepagnier, E.; Lithwick-Yanai, G.; Pollock, S.; Hornung, G.; Levy, M.; Coole, M.; Howd, T.; Shand, M.; Farjoun, Y.; Emery, J.; Hall, G.; Lee, S. K.; Sato, T.; Magner, R.; Low, S.; Bernier, A.; Gandi, B.; Stohlman, J.; Nolet, C.; Donovan, S.; Blumenstiel, B.; Cipicchio, M.; Dodge, S.; Banks, E.; Lennon, N.; Gabriel, S.; Lipson, D.
10.1101/2022.05.29.493900 — genomics — Posted on 2022-08-10
2739 Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico
Castelan-Sanchez, H. G.; Delaye, L.; Inward, R. P.; Dellicour, S.; Gutierrez, B.; Martinez de la Vina, N.; Pybus, O.; de Anda Jauregui, G.; Guzman, P.; Flores Garrido, M.; Fontanelli, O.; Rosales, M. H.; Meneses, A.; Olmedo-Alvarez, G.; Herrera-Estrella, A.; Boukadida, C.; Sanchez-Flores, A.; Munoz-Medina, J. E.; Comas-Garcia, A.; Gomez-Gil, B.; Zarate, S.; Taboada, B.; Lopez, S.; Arias, C. F.; Kraemer, M. U. G.; Lazcano, A.; Escalera-Zamudio, M.
10.1101/2022.07.05.498834 — evolutionary biology — Posted on 2022-08-10
2740 An optimised transformation protocol for Anthoceros agrestis and three more hornwort species
Waller, M.; Frangedakis, E.; Marron, A.; Sauret-Gueto, S.; Rever, J.; Sabbagh, C. R. R.; Hibberd, J. M.; Haseloff, J.; Renzaglia, K.; Szovenyi, P.
10.1101/2022.08.10.503456 — plant biology — Posted on 2022-08-10
2741 microbeSEG: A deep learning software tool with OMERO data management for efficient and accurate cell segmentation
Scherr, T.; Seiffarth, J.; Wollenhaupt, B.; Neumann, O.; Schilling, M. P.; Kohlheyer, D.; Scharr, H.; Nöh, K.; Mikut, R.
10.1101/2022.04.29.489998 — bioinformatics — Posted on 2022-08-10
2742 Dynamic changes in the niche and transcription trigger early murine and human pluripotent stem cell-derived liver organogenesis
Ogoke, O.; Guiggey, D.; Thompson, S.; Chiang, A.; Nguyen, T. H. A.; Berke, D.; Ott, C.; Kalinousky, A.; Shamul, C.; Chen, P.; Ross, S.; Chen, Z.; Srivastava, P.; Mahajan, S. D.; Zhao, R.; Gunawan, R.; Parashurama, N.
10.1101/2022.07.24.501313 — bioengineering — Posted on 2022-08-10
2743 Restoration and resilience to sea level rise of a salt marsh affected by dieback events in Charleston, SC
Rolando, J. L.; Hodges, M.; Garcia, K. D.; Krueger, G.; Williams, N.; Carr, J.; Robinson, J.; George, A.; Morris, J. T.; Kostka, J. E.
10.1101/2022.04.18.488673 — ecology — Posted on 2022-08-10
2744 Neural plate progenitors give rise to both anterior and posterior pituitary cells
Chen, Q.; Leshkowitz, D.; Li, H.; van Impel, A.; Schulte-Merker, S.; Amit, I.; Rizzoti, K.; Levkowitz, G.
10.1101/2022.06.12.495791 — developmental biology — Posted on 2022-08-10
2746 Impact of 100 LRRK2 variants linked to Parkinsons Disease on kinase activity and microtubule binding
Kalogeropulou, A. F.; Purlyte, E.; Tonelli, F.; Lange, S. M.; Wightman, M.; Prescott, A. R.; Padmanabhan, S.; Sammler, E.; Alessi, D. R.
10.1101/2022.04.01.486724 — neuroscience — Posted on 2022-08-10
2750 The evolution of the human DNA replication timing program
Bracci, A. N.; Dallmann, A.; Ding, Q.; Hubisz, M. J.; Caballero, M.; Koren, A.
10.1101/2022.08.09.503365 — evolutionary biology — Posted on 2022-08-10
2751 Zeb2 DNA-binding sites in neuroprogenitor cells reveal autoregulation and affirm neurodevelopmental defects, including in Mowat-Wilson Syndrome.
Birkhoff, J. C.; Korporaal, A. L.; Nowosad, K.; Brouwer, R. W. W.; Milazzo, C.; Mouratidou, L.; van den Hout, M. C. G. N.; van IJcken, W. F. J.; Huylebroeck, D.; Conidi, A.
10.1101/2021.07.06.451350 — cell biology — Posted on 2022-08-10
2752 Ultraviolet Dosage and Decontamination Efficacy was Widely Variable Across 14 UV Devices after Testing a Dried Enveloped Ribonucleic Acid Virus Surrogate for SARS-CoV-2
Buhr, T. L.; Borgers-Klonkowski, E.; Gutting, B. W.; Hammer, E. E.; Hamilton, S. M.; Huhman, B. M.; Jackson, S. L.; Kennihan, N. L.; Lilly, S. D.; Little, J. D.; Luck, B. B.; Matuczinski, E. A.; Miller, C. T.; Sides, R. E.; Yates, V. L.; Young, A. A.
10.1101/2022.01.27.478063 — microbiology — Posted on 2022-08-10
2753 Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75
Cao, Y.; Song, W.; Wang, L.; Liu, P.; Yue, C.; Jian, F.; Yu, Y.; Yisimayi, A.; Wang, P.; Wang, Y.; Zhu, Q.; Deng, J.; Fu, W.; Yu, L.; Zhang, N.; Wang, J.; Xiao, T.; An, R.; Wang, J.; Liu, L.; Yang, S.; Niu, X.; Gu, Q.; Shao, F.; Hao, X.; Jin, R.; Wang, Y.; Xie, X. S.; Wang, X.
10.1101/2022.07.18.500332 — immunology — Posted on 2022-08-10
2754 A group of Arabidopsis thaliana Leucine Rich Repeat-Malectin Receptor Kinases are required for the activation of immune responses triggered by cellulose and mixed-linked glucan oligosaccharides
Martin Dacal, M.; Fernandez-Calvo, P.; Jimenez-Sandoval, P.; Lopez, G.; Garrido-Arandia, M.; Rebaque, D.; del Hierro, I.; Torres, M. A.; Kumar, V.; Berlanga, D. J.; Melida, H.; Pacios, L. F.; Santiago, J.; Molina, A.
10.1101/2022.08.09.503277 — plant biology — Posted on 2022-08-10
2755 An optimised transformation protocol for Anthoceros agrestis and three more hornwort species
Frangedakis, E.; Sauret-Gueto, S.; Hibberd, J. M.; Haseloff, J.; Szovenyi, P.; Waller, M.; Renzaglia, K.; Rever, J.; Marron, A.; Sabbagh, C. R. R.
10.1101/2022.08.10.503456 — plant biology — Posted on 2022-08-10
2757 The microtubule-associated protein SlMAP70 interacts with SlIQD21 and regulates fruit shape formation in tomato
Bao, Z.; Guo, Y.; Deng, Y.; Zang, J.; Zhang, J.; Ouyang, B.; Qu, X.; Burstenbinder, K.; Wang, P.
10.1101/2022.08.08.503161 — plant biology — Posted on 2022-08-10
2758 Semi-Self-Supervised Learning for Semantic Segmentation in Images with Dense Patterns
Najafian, K.; Ghanbari, A.; Kish, M. S.; Eramian, M.; Shirdel, G. H.; Stavness, I.; Jin, L.; Maleki, F.
10.1101/2022.08.09.503251 — plant biology — Posted on 2022-08-10
2759 Explainable deep graph learning accurately modeling the peptide secondary structure prediction
Jiang, Y.; Wang, R.; Feng, J.; Jin, J.; Liang, S.; Li, Z.; Yu, Y.; Ma, A.; Su, R.; Zou, Q.; Ma, Q.; Wei, L.
10.1101/2022.06.09.495580 — bioinformatics — Posted on 2022-08-10
2760 Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization
Kogure, Y. S.; Muraoka, H.; Koizumi, W. C.; Gelin-alessi, R.; Godard, B.; Oka, K.; Heisenberg, C.-P.; Hotta, K.
10.1101/2021.09.21.461063 — developmental biology — Posted on 2022-08-10
2762 The Interictal Suppression Hypothesis in Focal Epilepsy: Electrographic and Structural Evaluation
Johnson, G. W.; Doss, D. J.; Morgan, V. L.; Paulo, D. L.; Cai, L. Y.; Shless, J. S.; Negi, A. S.; Gummadavelli, A.; Kang, H.; Reddy, S. B.; Naftel, R. P.; Bick, S. K.; Roberson, S. W.; Dawant, B. M.; Wallace, M. T.; Englot, D. J.
10.1101/2022.06.27.497765 — neuroscience — Posted on 2022-08-10
2763 Demes: a standard format for demographic models
Gower, G. R.; Ragsdale, A. P.; Bisschop, G.; Gutenkunst, R. N.; Hartfield, M.; Noskova, E.; Schiffels, S.; Struck, T. J.; Kelleher, J.; Thornton, K.
10.1101/2022.05.31.494112 — genetics — Posted on 2022-08-10
2766 siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos
Masuda-Ozawa, T.; Fujita, S.; Nakamura, R.; Watanabe, H.; Kuranaga, E.; Nakajima, Y.-i.
10.1101/2022.03.24.485716 — developmental biology — Posted on 2022-08-10
2770 Exotic alleles of EARLY FLOWERING 3 determine plant development and grain yield in barley
Zahn, T.; Zhu, Z.; Ritoff, N.; Krapf, J.; Junker, A.; Altmann, T.; Schmutzer, T.; Tüting, C.; Kastritis, P. L.; Babben, S.; Quint, M.; Pillen, K.; Maurer, A.
10.1101/2022.07.15.500212 — genetics — Posted on 2022-08-10
2772 Identification of GTF2IRD1 as a novel transcription factor essential for acute myeloid leukemia
Heshmati, Y.; Turkoz, G.; Dimitriou, M.; Harisankar, A.; Bostrom, J.; Cai, H.; Kadri, N.; Altun, M.; Qian, H.; Walfridsson, J.
10.1101/2022.08.09.503300 — cancer biology — Posted on 2022-08-10
2774 Human iPSC Derived Enamel Organoid Guided by Single-Cell Atlas of Human Tooth Development
Alghadeer, A.; Hanson-Drury, S.; Ehnes, D.; Zhao, Y. T.; Patni, A. P.; O'Day, D. R.; Spurrell, C. H.; Gogate, A. A.; Phal, A.; Zhang, H.; Devi, A.; Wang, Y.; Starita, L.; Doherty, D.; Glass, I. A.; Shendure, J.; Baker, D.; Regier, M. C.; Mathieu, J.; Ruohola-Baker, H.
10.1101/2022.08.09.503399 — developmental biology — Posted on 2022-08-10
2777 Dorsal Hippocampus To Nucleus Accumbens Projections Drive Reinforcement Via Activation of Accumbal Dynorphin Neurons.
Massaly, N.; Ibrahim, K. M.; Yoon, H.-J.; Sandoval, R.; Williams, S.; Frye, H.; Post, W.; Yu, W.; Idowu, O.; Zec, A.; Pathiranage, S.; Kash, T.; Moron, J. A.
10.1101/2022.08.08.503098 — neuroscience — Posted on 2022-08-10
2778 Cellular profiling of a recently-evolved social behavior
Johnson, Z. V.; Hegarty, B. E.; Gruenhagen, G. W.; Lancaster, T. J.; McGrath, P. T.; Streelman, J. T.
10.1101/2022.08.09.503380 — neuroscience — Posted on 2022-08-10
2779 A truncating mutation of Magel2 in the rat modelled for the study of Schaaf-Yang and Prader-Willi syndromes alters select behavioral and physiological outcomes
Reznik, D. L.; Yang, M. V.; Albelda de la Haza, P.; Jain, A.; Spanjaard, M.; Theiss, S.; Schaaf, C. P.; Malovannaya, A.; Strong, T. V.; Veeraragavan, S.; Samaco, R. C.
10.1101/2022.08.09.503377 — neuroscience — Posted on 2022-08-10
2780 KDM4A promotes NEPC progression through regulation of MYC expression
Mak, C. S. L.; Zhu, M.; Liang, X.; Wang, F.; Hoang, A. G.; Song, X.; Shepherd, P.; Liang, D.; Park, J.; Zhang, M.; Metzger, E.; Schule, R.; Jain, A. K.; Foster, B. A.; Lee, M. G.; Corn, P.; Logothetis, C. J.; Aparicio, A.; Navone, N.; Troncoso, P.; Zhang, J.; Lin, S.-H.; Wang, G.
10.1101/2022.05.14.491739 — cancer biology — Posted on 2022-08-09
2781 Emergence of Erythromycin Resistant Invasive Group A Streptococcus in West Virginia, United States
Powell, L. M.; Choi, S. J.; Chipman, C. E.; Grund, M. E.; LaSala, P. R.; Lukomski, S.
10.1101/2022.08.08.503263 — microbiology — Posted on 2022-08-09
2782 Goal-specific brain MRI harmonization
An, L.; Chen, J.; Chen, P.; Zhang, C.; He, T.; Chen, C.; Zhou, J. H.; Yeo, B. T. T.
10.1101/2022.03.05.483077 — neuroscience — Posted on 2022-08-09
2784 Deep learning segmentation of the nucleus basalis of Meynert on 3T MRI
Doss, D. J.; Johnson, G. W.; Narasimhan, S.; Jiang, J. W.; Gonzalez, H. F. J.; Paulo, D. L.; Lucas, A.; Davis, K. A.; Chang, C.; Morgan, V. L.; Constantinidis, C.; Dawant, B. M.; Englot, D. J.
10.1101/2022.07.02.498556 — neuroscience — Posted on 2022-08-09
2788 Klarigi: Characteristic Explanations for Semantic Data
Slater, L. T.; Williams, J. A.; Schofield, P. N.; Russell, S.; Pendleton, S. C.; Karwath, A.; Fanning, H.; Ball, S.; Hoehndorf, R. T.; Gkoutos, G. V.
10.1101/2021.06.14.448423 — bioinformatics — Posted on 2022-08-09
2790 Multivalent BARD1-nucleosome interactions facilitate H2A ubiquitylation by BRCA1/BARD1
Witus, S. R.; Tuttle, L. M.; Zelter, A.; Kermoade, K. E.; Wilburn, D. B.; Zhao, W.; Davis, T. N.; Brzovic, P.; Klevit, R. E.
10.1101/2022.08.09.503292 — biochemistry — Posted on 2022-08-09
2791 Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis
Mantri, M.; Hinchman, M. M.; McKellar, D. W.; Wang, M. F. Z.; Cross, S. T.; Parker, J. S. L.; De Vlaminck, I.
10.1101/2021.12.07.471659 — genomics — Posted on 2022-08-09
2793 ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes
Kim, D.; Naganuma, M.; Nakagawa, R.; Cong, A.; Ehara, H.; Vu, H.; Jeong, J.; Chang, J. H.; Schellenberg, M.; Sekine, S.-i.; Bunch, H.
10.1101/2022.08.09.503353 — molecular biology — Posted on 2022-08-09
2795 mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity
Pagan, A. J.; Lee, L. J.; Edwards-Hicks, J.; Moens, C. B.; Tobin, D. M.; Busch-Nentwich, E. M.; Pearce, E. L.; Ramakrishnan, L.
10.1101/2022.01.30.478369 — immunology — Posted on 2022-08-09
2796 Coxsackievirus B3 elicits a sex-specific CD8+ T cell response in female mice.
Dhalech, A. H.; Condotta, S. A.; Corn, C. M.; Richer, M. J.; Robinson, C. M.
10.1101/2022.08.09.503381 — immunology — Posted on 2022-08-09
2799 Class imbalance should not throw you off balance: Choosing the right classifiers and performance metrics for brain decoding with imbalanced data
Thölke, P.; Ramos, Y. J. M.; Abdelhedi, H.; Maschke, C.; Dehgan, A.; Harel, Y.; Kemtur, A.; Berrada, L. M.; Sahraoui, M.; Young, T.; Bellemare, A.; El Khantour, C.; Landry, M.; Pascarella, A.; Hadid, V.; Combrisson, E.; O'Byrne, J.; Jerbi, K.
10.1101/2022.07.18.500262 — neuroscience — Posted on 2022-08-09
2803 A miniaturized ultrasound transducer for monitoring full-mouth oral health: a preliminary study
Qi, B.; Hariri, A.; Khazaeinezhad, R.; Fu, L.; Li, Y.; Jin, Z.; Yim, W.; He, T.; Cheng, Y.; Zhou, J.; Jokerst, J. V.
10.1101/2022.03.31.486598 — bioengineering — Posted on 2022-08-09
2804 Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
Okuma, H.; Hord, J. M.; Chandel, I.; Anderson, M. E.; Venzke, D.; Walimbe, A. S.; Joseph, S.; Gastel, Z.; Hara, Y.; Saito, F.; Matsumura, K.; Campbell, K. P.
10.1101/2022.08.09.502851 — biochemistry — Posted on 2022-08-09
2806 Ex vivo midgut cultures of Aedes aegypti are efficiently infected by mosquito-borne alpha- and flaviviruses
Rosales Rosas, A. L.; Wang, L.; Goossens, S.; Cuvry, A.; Li, L.-H.; Santos-Ferreira, N.; Dallmeier, K.; Delang, L.
10.1101/2022.08.09.503233 — molecular biology — Posted on 2022-08-09
2812 Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation
Zeppillo, T.; Ali, H.; Wenger, S.; Murcia, F. J. L.; Gideons, E.; Signorelli, J.; Schmeisser, M. J.; Wiltfang, J.; Rhee, J.; Brose, N.; Taschenberger, H.; Krueger-Burg, D.
10.1101/2022.08.08.503083 — neuroscience — Posted on 2022-08-09
2813 Biomechanical origins of proprioceptive maps in the Drosophila leg
Mamiya, A.; Gurung, P.; Siwanowicz, I.; Sustar, A.; Chen, C.; Phelps, J. S.; Kuan, A. T.; Pacureanu, A.; Lee, W.-C. A.; Mhatre, N.; Tuthill, J. C.
10.1101/2022.08.08.503192 — neuroscience — Posted on 2022-08-09
2814 Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism
Diot, C.; Garcia-Gonzalez, A. P.; Vieira, A. F.; Walker, M.; Honeywell, M.; Doyle, H.; Ponomarova, O.; Rivera, Y.; Na, H.; Zhang, H.; Lee, M.; Olsen, C. P.; Walhout, A. J. M.
10.1101/2021.11.05.467497 — systems biology — Posted on 2022-08-09
2820 Rapid proteostasis controls monolayer integrity of quiescent endothelium
Podieh, F.; Wensveen, R.; Overboom, M. C.; Abbas, L.; Majolee, J.; Hordijk, P. L.
10.1101/2022.08.09.503297 — molecular biology — Posted on 2022-08-09
2822 Leishmania mexicana Promotes Pain-reducing Metabolomic Reprogramming In Cutaneous Lesions
Volpedo, G.; Oljuskin, T.; Cox, B.; Mercado, Y.; Askwith, C.; Azodi, N.; Gannavaram, S.; Nakhasi, H.; Satoskar, A. R.
10.1101/2022.08.09.503319 — microbiology — Posted on 2022-08-09
2825 The asthma gut microbiota influences lung inflammation in gnotobiotic mice
Wilson, N. G.; Hernandez-Leyva, A.; Rosen, A. L.; Jaeger, N.; McDonough, R. T.; Santiago-Borges, J.; Lint, M. A.; Rosen, T. R.; Tomera, C. P.; Bacharier, L. B.; Swamidass, S. J.; Kau, A. L.
10.1101/2022.08.09.502549 — microbiology — Posted on 2022-08-09
2827 Abrupt permafrost thaw triggers microbial bloom and increased activity of microbial predators
Scheel, M.; Zervas, A.; Tveit, A. T.; Rijkers, R.; Ekelund, F.; Jacobsen, C. S.; Christensen, T. R.
10.1101/2022.08.09.499897 — microbiology — Posted on 2022-08-09
2828 Hydrogen and dark oxygen drive microbial productivity in diverse groundwater ecosystems
Ruff, S. E.; Humez, P.; Hrabe de Angelis, I.; Nightingale, M.; Diao, M.; Cho, S.; Connors, L.; Kuloyo, O. O.; Seltzer, A. M.; Bowman, S.; Wankel, S.; McClain, C. N.; Mayer, B.; Strous, M.
10.1101/2022.08.09.503387 — microbiology — Posted on 2022-08-09
2831 Spike-specific CXCR3+ TFH cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination
Zhang, J.; He, R.; Liu, B.; Zheng, X.; Wu, Q.; Wen, B.; Wang, Q.; Liu, Z.; Chang, F.; Hu, Y.; Xie, T.; Liu, Y.; Chen, J.; Yang, J.; Teng, S.; Bai, T.; Peng, Y.; Liu, Z.; Peng, Y.; Huang, W. J.; Terzieva, V.; Wang, Y.; Liu, W.; Li, Y.-P.; Qu, X.
10.1101/2022.08.09.503302 — immunology — Posted on 2022-08-09
2832 From empirical to data-driven host selection: a broad-host-range expression platform to facilitate chassis screening
Mol, V. H.; Falkenberg, K. B.; De Almeida Will, A.; Pogrebnyakov, I.; Beck, C.; Skoettrup, A. L.; Nielsen, A. T.; Jensen, S. I.
10.1101/2022.08.09.503317 — synthetic biology — Posted on 2022-08-09
2833 COVID-19 pandemic responses may impact the spread of antibiotic-resistant bacteria: a modelling study
Kovacevic, A.; Smith, D. R. M.; Rahbe, E.; Novelli, S.; Henriot, P.; Temime, L.; Opatowski, L.
10.1101/2022.08.08.503267 — evolutionary biology — Posted on 2022-08-09
2834 CITED2 is a Conserved Regulator of the Uterine-Placental Interface
Kuna, M.; Dhakal, P.; Iqbal, K.; Dominguez, E. M.; Kent, L. N.; Muto, M.; Moreno-Irusta, A.; Kozai, K.; Varberg, K. M.; Okae, H.; Arima, T.; Sucov, H. M.; Soares, M. J.
10.1101/2022.06.15.496287 — developmental biology — Posted on 2022-08-09
2835 Acetylsalicylic acid and Salicylic acid inhibit SARS-CoV-2 replication in precision-cut lung slices
Geiger, N.; König, E.-M.; Oberwinkler, H.; Roll, V.; Diesendorf, V.; Faehr, S.; Obernolte, H.; Sewald, K.; Wronski, S.; Steinke, M.; Bodem, J.
10.1101/2022.08.09.503270 — microbiology — Posted on 2022-08-09
2836 Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic marks
Cassiano, L. M. G.; Silva, V. C.; Oliveira, M. S.; Prado, B. V. O.; Cardoso, C. G.; Salim, A. C. M.; Franco, G. R.; D'Almeida, V.; Francisco, S. C.; Coimbra, R. S.
10.1101/2022.08.08.503231 — immunology — Posted on 2022-08-09
2837 A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned
O'Connor, M. A.; Hawman, D. W.; Meade-White, K.; Leventhal, S.; Song, W.; Randall, S.; Archer, J.; Lewis, T. B.; Brown, B.; Iwayama, N.; Ahrens, C.; Garrison, W.; Wangari, S.; Guerriero, K. A.; Hanley, P.; Lovaglio, J.; Saturday, G.; Edlefsen, P. T.; Khandhar, A.; Feldmann, H.; Fuller, D. H.; Erasmus, J. H.
10.1101/2022.08.08.503239 — immunology — Posted on 2022-08-09
2838 Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction
Wei, F.-Y.; Inoue, A.; Ogawa, A.; Ohira, S.; Ikuta, T.; Kato, Y.; Yanagida, S.; Ishii, Y.; Kanda, Y.; Nishida, M.
10.1101/2022.08.08.503256 — pharmacology and toxicology — Posted on 2022-08-09
2841 Multi-channel deep learning with intracranial neurostimulation can localize seizure onset zones in humans
Johnson, G. W.; Cai, L. Y.; Doss, D. J.; Jiang, J. W.; Negi, A. S.; Narasimhan, S.; Paulo, D. L.; Gonzalez, H. F.; Roberson, S. W.; Bick, S. K.; Chang, C. E.; Morgan, V. L.; Wallace, M. T.; Englot, D. J.
10.1101/2022.02.28.481828 — neuroscience — Posted on 2022-08-09
2845 A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response
Xu, L.; Saunders, K. N.; Knutsdottir, H.; Chen, K.; Maues, J.; Hodgdon, C.; Roussos-Torres, E. T.; Reddy, S.; Xu, L.; Chan, I. S.
10.1101/2022.08.01.501918 — cancer biology — Posted on 2022-08-09
2848 IFT-A Structure Reveals Carriages for Membrane Protein Transport into Cilia
Hesketh, S. J.; Mukhopadhyay, A. G.; Nakamura, D.; Toropova, K.; Roberts, A. J.
10.1101/2022.08.09.503213 — cell biology — Posted on 2022-08-09
2849 Targeting Epsins by nanotherapy regulates lipid metabolism and promotes 1 ABCG1-mediated cholesterol efflux to fortify atheroma regression
Cui, K.; Gao, X.; Wang, B.; Wu, H.; Dong, Y.; Xiao, Y.; Jiang, X.; Malovichko, M. V.; Li, K.; Chan, K.; Shan, D.; Peng, Q.; Lu, Y. W.; Zhu, B.; Wong, S.; Cowan, D. B.; Linton, M. F.; Srivastava, S.; Shi, J.; Chen, K. F.; Chen, H.
10.1101/2022.08.09.503334 — cell biology — Posted on 2022-08-09
2850 Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-β Signaling Constrains Endothelial-to-Mesenchymal-Transition in Atherosclerosis
Dong, Y.; Wang, B.; Du, M.; Zhu, B.; Cui, K.; Chan, K.; Cowan, D. B.; Bhattacharjee, S.; Shan, D.; Wong, S.; Bischoff, J.; Linton, M. F.; Chen, H.
10.1101/2022.08.09.503324 — cell biology — Posted on 2022-08-09
2851 Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Bussi, C.; Heunis, T.; Pellegrino, E.; Bernard, E. M.; Bah, N.; Silva Dos Santos, M.; Santucci, P.; Aylan, B.; Rodgers, A.; Fearns, A.; Mitschke, J.; Moore, C.; MacRae, J. I.; Greco, M.; Reinheckel, T.; Trost, M.; Gutierrez, M. G.
10.1101/2022.08.09.503288 — cell biology — Posted on 2022-08-09
2855 Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic ductal adenocarcinoma
Zhang, W.; Wright, M.; Rathore, M.; Zarei, M.; Vaziri-Gohar, A.; Winter, J.; Brody, J.; Wang, R.
10.1101/2022.06.24.497507 — cancer biology — Posted on 2022-08-09
2857 Alternate response of Bacillus anthracis atxA and acpA to serum, HCO3- and CO2
Glinert, I.; Bar-David, E.; Ben-Smueal, A.; Sittner, A.; Puni, R.; Laredo, S.; Kobiler, D.; Weiss, S.; Levy, H.
10.1101/2022.02.21.481328 — microbiology — Posted on 2022-08-09
2859 Prion propagation is dependent on key amino acids in Charge cluster 2 within the prion protein
Bhamra, S. K.; Arora, P.; Manka, S. W.; Schmidt, C.; Brown, C.; Rayner, M. L.; Kloehn, P.-C.; Clarke, A. R.; Collinge, J.; Jat, P. S.
10.1101/2022.08.08.503133 — molecular biology — Posted on 2022-08-09
2860 Superficial white matter across the lifespan: volume, thickness, change, and relationship with cortical features
Schilling, K.; Archer, D. B.; Rheault, F.; Lyu, I.; Huo, Y.; Cai, L. Y.; Bunge, S.; Weiner, K. S.; Gore, J. C.; Anderson, A. W.; Landman, B. A.
10.1101/2022.07.20.500818 — neuroscience — Posted on 2022-08-09
2861 An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
Jain, K.; Marunde, M. R.; Burg, J. M.; Gloor, S. L.; Joseph, F. M.; Gillespie, Z. B.; Rodriguez, K. L.; Howard, S. A.; Popova, I. K.; Hall, N. W.; Vaidya, A.; Cooke, S. W.; Fox, G. C.; Namitz, K. E. W.; Taylor, B. C.; Weinzapfel, E. N.; Cheek, M. A.; Meiners, M. J.; Krajewski, K.; Cosgrove, M. S.; Young, N. L.; Keogh, M.-C.; Strahl, B. D.
10.1101/2022.02.28.482307 — biochemistry — Posted on 2022-08-09
2866 H3AGWAS : A portable workflow for Genome Wide Association Studies
Brandenburg, J.-T.; Clark, L.; Botha, G.; Panji, S.; Baichoo, S.; Fields, C. J.; Hazelhurst, S.
10.1101/2022.05.02.490206 — bioinformatics — Posted on 2022-08-09
2867 Clinical Viability of Magnetic Bead Implants in Muscle
Taylor, C. R.; Clark, W. H.; Clarrissimeaux, E. G.; Yeon, S. H.; Carty, M. J.; Lipsitz, S. R.; Bronson, R. T.; Roberts, T. J.; Herr, H. M.
10.1101/2022.08.01.502296 — bioengineering — Posted on 2022-08-09
2868 Prion propagation is dependent on key amino acids in Charge cluster 2 within the prion protein
Bhamra, S. K.; Arora, P.; Manka, S. W.; Schmidt, C.; Brown, C.; Rayner, M. L.; Klöhn, P.-C.; Clarke, A. R.; Collinge, J.; Jat, P. S.
10.1101/2022.08.08.503133 — molecular biology — Posted on 2022-08-09
2869 Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Ruppel, A.; Worthmuller, D.; Misiak, V.; Kelkar, M.; Wang, I.; Moreau, P.; Mery, A.; Revilloud, J.; Charras, G.; Cappello, G.; Boudou, T.; Schwarz, U. S.; Balland, M.
10.1101/2022.06.01.494332 — biophysics — Posted on 2022-08-09
2871 Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron
Lemercier, C. E.; Garenne, A.; Poulletier de Gannes, F.; El Khoueiry, C.; Arnaud-Cormos, D.; Leveque, P.; Lagroye, I.; Percherancier, Y.; Lewis, N.
10.1101/2022.04.05.487108 — neuroscience — Posted on 2022-08-09
2872 CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in Diseases
Karakulak, T.; Szklarczyk, D.; Saylan, C. C.; Moch, H.; von Mering, C.; Kahraman, A.
10.1101/2021.09.17.460795 — bioinformatics — Posted on 2022-08-09
2874 UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Vogel, A.; Arnese, R.; Gudino Carrillo, R.; Sehr, D.; Bylicki, A.; Meinhart, A.; Clausen, T.
10.1101/2022.08.08.502945 — biochemistry — Posted on 2022-08-09
2880 BDNF stimulates the retrograde pathway for axonal autophagy
Sidibe, D.; Kulkarni, V. V.; Dong, A.; Brandt Herr, J.; Maday, S.
10.1101/2022.08.08.503181 — neuroscience — Posted on 2022-08-09
2883 An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo)
Robinson, J. W.; Hemani, G.; Babaei, M. S.; Huang, Y.; Baird, D. A.; Tsai, E. A.; Chen, C.-Y.; Gaunt, T. R.; Zheng, J.
10.1101/2022.08.08.503158 — bioinformatics — Posted on 2022-08-08
2884 Bilallelic germline mutations in MAD1L1 induce a novel syndrome of aneuploidy with high tumor susceptibility
Villarroya-Beltri, C.; Osorio, A.; Torres-Ruiz, R.; Gomez-Sanchez, D.; Trakala, M.; Sanchez-Belmonte, A.; Mercadillo, F.; Pitarch, B.; Hernandez-Nunez, A.; Gomez-Caturla, A.; Rueda, D.; Perea, J.; Rodriguez-Perales, S.; Malumbres, M.; Urioste, M.
10.1101/2022.08.08.503198 — cancer biology — Posted on 2022-08-08
2885 Single-molecule tracking of Nanog and Oct4 in mouse embryonic stem cells
Okamoto, K.; Fujita, H.; Okada, Y.; Onami, S.; Shinkai, S.; Abe, K.; Fujimoto, K.; Watanabe, T. M.
10.1101/2022.08.08.503148 — biophysics — Posted on 2022-08-08
2886 Harmonin homology domains of human RTEL1 interact with replication protein A and DNA
Kumar, N.; Taneja, A.; Ghosh, M.; Rothweiler, U.; Sundaresan, N. R.; Singh, M.
10.1101/2022.08.08.503141 — biophysics — Posted on 2022-08-08
2888 Comprehensive chromatin proteomics resolves functional phases of pluripotency
Ugur, E.; de la Porte, A.; Bultmann, S.; Drukker, M.; Mann, M.; Wierer, M.; Leonhardt, H.
10.1101/2022.08.08.503208 — biochemistry — Posted on 2022-08-08
2889 UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Clausen, T.; Vogel, A.; Arnese, R.; Gudino Carrillo, R.; Sehr, D.; Bylicki, A.; Meinhart, A.
10.1101/2022.08.08.502945 — biochemistry — Posted on 2022-08-08
2890 Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C.; Plaisier, S. B.; Phung, T. N.; Silasi, M.; Perley, L.; O'Bryan, J.; Ramirez, L.; Kliman, H. J.; Wilson, M. A.
10.1101/2022.08.08.503197 — genomics — Posted on 2022-08-08
2891 Rational probe design for efficient rRNA depletion and improved metatranscriptomic analysis of human microbiomes
Tan, A.; Murugapiran, S.; Mikalauskas, A.; Koble, J.; Kennedy, D.; Hyde, F.; Ruotti, V.; Law, E.; Jensen, J.; Schroth, G. P.; Macklaim, J.; Kuersten, S.; Le Francois, B.; Gohl, D. M.
10.1101/2022.08.08.502835 — genomics — Posted on 2022-08-08
2892 Purine-rich RNA sequences in the 5'UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation
Schmidt, T.; Dabrowska, A.; Waldron, J. A.; Hodge, K.; Koulouras, G.; Gabrielsen, M.; Munro, J.; Tack, D. C.; Harris, G.; McGhee, E.; Scott, D.; Carlin, L. M.; Huang, D.; Le Quesne, J.; Zanivan, S.; Wilczynska, A.; Bushell, M.
10.1101/2022.08.08.503179 — molecular biology — Posted on 2022-08-08
2893 Dnmt3bas regulates transcriptional induction and alternative splicing of Dnmt3b
Dar, M. S.; Mensah, I. K.; McGovern, S.; He, M.; Hall, M. C.; Whitlock, H. C.; Bippus, N. E.; Ceminsky, M.; GOWHER, H.
10.1101/2022.08.08.503222 — molecular biology — Posted on 2022-08-08
2895 Implementation of the β-hydroxyaspartate cycle increases growth performance of Pseudomonas putida on the PET monomer ethylene glycol
Schada von Borzyskowski, L.; Schulz-Mirbach, H.; Troncoso Castellanos, M.; Severi, F.; Gomez Coronado, P. A.; Glatter, T.; Bar-Even, A.; Lindner, S. N.; Erb, T. J.
10.1101/2022.08.08.503134 — synthetic biology — Posted on 2022-08-08
2896 A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
Tanasa, S.; Shukla, N.; Cairo, A.; Ganji, R. S.; Mikulkova, P.; Valuchova, S.; Raxwal, V. K.; Capitao, C.; Schnittger, A.; Zdrahal, Z.; Riha, K.
10.1101/2022.08.08.503215 — plant biology — Posted on 2022-08-08
2899 Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM
Cong, Y.; Liu, C.; Jin, M.; Wang, S.; Han, W.; Zhao, Q.; Wang, Y.; Xu, C.; Diao, L.; Yin, Y.; Peng, C.; Bao, L.; Wang, Y.
10.1101/2022.08.08.503128 — biochemistry — Posted on 2022-08-08
2903 A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions
Seroussi, U.; Lugowski, A.; Wadi, L.; Lao, R. X.; Willis, A. R.; Zhao, W.; Sundby, A. E.; Charlesworth, A. G.; Reinke, A. W.; Claycomb, J. M.
10.1101/2022.08.08.502013 — molecular biology — Posted on 2022-08-08
2905 Transcriptomic cell type structures in vivo neuronal activity across multiple time scales.
Schneider, A.; Azabou, M.; McDougall-Vigier, L.; Parks, D. F.; Ensley, S.; Bhaskaran-Nair, K.; Nowakowski, T. J.; Dyer, E. L.; Hengen, K. B.
10.1101/2022.07.10.499487 — neuroscience — Posted on 2022-08-08
2911 Validation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model
Mancini, M. V.; Tandavanitj, R.; Ant, T. H.; Murdochy, S. M.; Gingell, D. D.; Setthapramote, C.; Natsrita, P.; Kohl, A.; Sinkins, S. P.; Patel, A. H.; De Lorenzo, G.
10.1101/2022.08.08.503125 — microbiology — Posted on 2022-08-08
2915 Testosterone promotes intestinal replication and dissemination of Coxsackievirus B3 in an oral inoculation mouse model
Dhalech, A. H.; Corn, C. M.; Mangale, V.; Syed, F.; Condotta, S. A.; Richer, M. J.; Robinson, C. M.
10.1101/2021.12.08.471774 — microbiology — Posted on 2022-08-08
2918 Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery
Neikirk, K.; Vue, Z.; Katti, P.; Rodriguez, B. I.; Omer, S. A.; Shao, J.; Christensen, T. A.; Garza Lopez, E.; Marshall, A.; Palavicino-Maggio, C.; Ponce, J.; Alghanem, A.; Vang, L.; Barongan, T.; Beasley, H.; Rodman, T.; Mungai, M.; Correia, M.; Exil, V.; Murray, S.; Salisbury, J. L.; Glancy, B.; Pereira, R. O.; Abel, E. D.; Hinton, A.
10.1101/2021.09.26.461841 — biophysics — Posted on 2022-08-08
2920 Quantifying the Local Adaptive Landscape of a Nascent Bacterial Community
Ascensao, J. A.; Wetmore, K. M.; Good, B. H.; Arkin, A. P.; Hallatschek, O.
10.1101/2022.02.03.475969 — evolutionary biology — Posted on 2022-08-08
2921 Structure and mechanism of the type I-G CRISPR effector
Shangguan, Q.; Graham, S.; Sundaramoorthy, R.; White, M. F.
10.1101/2022.08.08.503147 — microbiology — Posted on 2022-08-08
2924 Virological characteristics of the SARS-CoV-2 Omicron BA.2.75
Saito, A.; Tamura, T.; Zahradnik, J.; Deguchi, S.; Tabata, K.; Kimura, I.; Ito, J.; Nasser, H.; Toyoda, M.; Nagata, K.; Uriu, K.; Kosugi, Y.; Fujita, S.; Yamasoba, D.; Shofa, M.; Begum, M. M.; Oda, Y.; Suzuki, R.; Ito, H.; Nao, N.; Wang, L.; Tsuda, M.; Yoshimatsu, K.; Yamamoto, Y.; Nagamoto, T.; Asakura, H.; Nagashima, M.; Sadamasu, K.; Yoshimura, K.; Ueno, T.; Schreiber, G.; Takaori-Kondo, A.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Shirakawa, K.; Sawa, H.; Irie, T.; Takayama, K.; Matsuno, K.; Tanaka, S.; Ikeda, T.; Fukuhara, T.; Sato, K.
10.1101/2022.08.07.503115 — microbiology — Posted on 2022-08-08
2925 Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir
Iketani, S.; Mohri, H.; Culbertson, B.; Hong, S. J.; Duan, Y.; Luck, M. I.; Annavajhala, M. K.; Guo, Y.; Sheng, Z.; Uhlemann, A.-C.; Goff, S. P.; Sabo, Y.; Yang, H.; Chavez, A.; Ho, D. D.
10.1101/2022.08.07.499047 — microbiology — Posted on 2022-08-08
2926 A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations
Ou, J.; Lewandowski, E.; Hu, Y.; Lipinski, A.; Morgan, R.; Jacobs, L.; Zhang, X.; Bikowitz, M.; Langlais, P.; Tan, H.; Wang, J.; Chen, Y.; Choy, J. S.
10.1101/2022.08.06.503039 — microbiology — Posted on 2022-08-08
2927 Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Moghadasi, S. A.; Heilmann, E.; Moraes, S. N.; Kearns, F. L.; von Laer, D.; Amaro, R. E.; Harris, R.
10.1101/2022.08.07.503099 — microbiology — Posted on 2022-08-08
2929 Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity
Hirota, M.; Tamai, M.; Yukawa, S.; Taira, N.; Matthews, M. M.; Toma, T.; Seto, Y.; Yoshida, M.; Toguchi, S.; Miyagi, M.; Mori, T.; Tomori, H.; Tamai, O.; Kina, M.; Sakihara, E.; Yamashiro, C.; Miyagi, M.; Tamaki, K.; Wolf, M.; Collins, M. K.; Kitano, H.; Ishikawa, H.
10.1101/2022.08.08.503075 — immunology — Posted on 2022-08-08
2930 The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2, Necroptosis, Pyroptosis and Panoptosis
Schifanella, L.; Anderson, J.; Wieking, G.; Southern, P. J.; Antinori, S.; Galli, M.; Corbellino, M.; Lai, A.; Klatt, N.; Schacker, T.; Haase, A. T.
10.1101/2022.08.06.503050 — immunology — Posted on 2022-08-08
2935 Pericyte Heterogeneity Identified by 3D Ultrastructural Analysis of the Microvessel Wall
Abdelazim, H.; Payne, L. B.; Nolan, K.; Paralkar, K.; Bradley, V.; Kanodia, R.; Gude, R.; Ward, R.; Monavarfeshani, A.; Fox, M.; Chappell, J. C.
10.1101/2022.08.08.503052 — cell biology — Posted on 2022-08-08
2936 Inositol pyrophosphate-controlled kinetochore architecture and mitotic entry in S. pombe
Kuenzel, N. A.; Alcazar-Roman, A. R.; Saiardi, A.; Bartsch, S. M.; Daunaraviciute, S.; Fiedler, D.; Fleig, U.
10.1101/2022.08.08.503146 — cell biology — Posted on 2022-08-08
2938 True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin
Gelleri, M.; Chen, S.-Y.; Szczurek, A.; Hübner, B.; Sterr, M.; Neumann, J.; Kröger, O.; Sadlo, F.; Imhoff, J.; Markaki, Y.; Hendzel, M. J.; Cremer, M.; Cremer, T.; Strickfaden, H.; Cremer, C.
10.1101/2022.03.23.485308 — cell biology — Posted on 2022-08-08
2939 Mitochondrial uncouplers impair human sperm motility without altering ATP content
Skinner, W. M.; Petersen, N. T.; Unger, B.; Tang, S.; Tabarsi, E.; Lamm, J.; Jalalian, L.; Smith, J.; Bertholet, A. M.; Xu, K.; Kirichok, Y.; Lishko, P. V.
10.1101/2022.08.04.502752 — cell biology — Posted on 2022-08-08
2942 Macrophage Innate Training Induced by IL-4 and IL-13 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses
Lundahl, M. L.; Mitermite, M.; Ryan, D. G.; Case, S.; Williams, N. C.; Yang, M.; Lynch, R. I.; Lagan, E.; Lebre, F. M.; Gorman, A. L.; Stojkovic, B.; Bracken, A. P.; Frezza, C.; Sheedy, F. J.; Scanlan, E. M.; O'Neill, L. A.; Gordon, S. V.; Lavelle, E. C.
10.1101/2021.10.12.463833 — immunology — Posted on 2022-08-08
2943 Pyruvate carboxylation identifies Glioblastoma Stem-like Cells opening new metabolic strategy to prevent tumor recurrence
Renoult, O.; Gratas, C.; Joalland, N.; Laurent--Blond, M.; Awada, H.; Bourgeois, M.; Oliver, L.; Chiavassa, S.; Croyal, M.; Paris, F.; Pecqueur, C.
10.1101/2022.07.18.500427 — cancer biology — Posted on 2022-08-08
2944 Hypergraph factorisation for multi-tissue gene expression imputation
Torne, R. V.; Joshi, C. K.; Georgiev, D.; Dumitrascu, B.; Gamazon, E.; Lio, P.
10.1101/2022.07.31.502211 — bioinformatics — Posted on 2022-08-08
2945 scMoMaT: Mosaic integration of single cell multi-omics data using matrix trifactorization
Zhang, Z.; Sun, H.; Chen, X.; Mariappan, R.; Chen, X.; Jain, M.; Efremova, M.; Rajan, V.; Teichmann, S.; Zhang, X.
10.1101/2022.05.17.492336 — bioinformatics — Posted on 2022-08-08
2946 Avifauna recovers faster in areas less accessible to trapping in regenerating tropical forests
Sagar, H. S. S. C.; Gilroy, J. J.; Swinfield, T.; Yong, D. L.; Gemita, E.; Burivalova, Z.; Novriyanti, N.; Lee, D. C.; Janra, M. N.; Balmford, A.; Hua, F.
10.1101/2021.08.20.457106 — ecology — Posted on 2022-08-08
2947 ACTN2 mutant causes proteopathy in human iPSC-derived cardiomyocytes
Zech, A. T.; Prondzynski, M.; Singh, S. R.; Pietsch, N.; Orthey, E.; Alizoti, E.; Busch, J.; Madsen, A.; Behrens, C. S.; Meyer-Jens, M.; Mearini, G.; Lemoine, M. D.; Kraemer, E.; Mosqueira, D.; Virdi, S.; Inderbirken, D.; Depke, M.; Salazar, M. G.; Voelker, U.; Braren, I.; Pu, W. T.; Eschenhagen, T.; Hammer, E.; Schlossarek, S.; Carrier, L.
10.1101/2021.10.28.466251 — cell biology — Posted on 2022-08-08
2948 Improved neutralization of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech BNT162b2 COVID-19 vaccine boosting
Basile, K.; Rockett, R. J.; McPhie, K.; Fennell, M.; Johnson-Mackinnon, J.; Agius, J.; Fong, W.; Rahman, H.; Ko, D.; Donavan, L.; Hueston, L.; Lam, C.; Arnott, A.; Chen, S.; Maddocks, S.; O'Sullivan, M.; Dwyer, D. E.; Sintchenko, V.; Kok, J.
10.1101/2021.12.12.472252 — microbiology — Posted on 2022-08-08
2951 The mechanical stability of Tension Gauge Tethers
Liu, J.; Le, S.; Yao, M.; Huang, W.; Tio, Z.; Zhou, Y.; Yan, J.
10.1101/2022.03.11.483943 — biophysics — Posted on 2022-08-08
2952 A single cell transcriptomic and clonal analysis depicts valvulogenesis
Fahrat, B.; Bordeu, I.; Jagla, B.; Blanc, H.; Livet, J.; Simons, B. D.; Beaurepaire, E.; Puceat, M.
10.1101/2022.08.06.503022 — developmental biology — Posted on 2022-08-08
2953 A tripartite complex HIV-1 Tat-cyclophilin A-capsid protein enables Tat encapsidation that is required for HIV-1 infectivity
Schatz, M.; Marty, L.; Ounadjela, C.; Tong, P. B. V.; Cardace, I.; Mettling, C.; Milhiet, P.-E.; Costa, L.; Godefroy, C.; Pugniere, M.; Guichou, J.-F.; Mesnard, J.-M.; Blaise, M.; Beaumelle, B.
10.1101/2022.08.07.503104 — microbiology — Posted on 2022-08-08
2956 Robin's Viewer: Using Deep-Learning Predictions to Assist EEG Annotation
Weiler, R.; Diachenko, M.; Juarez-Martinez, E.; Avramiea, A.-E.; Bloem, P.; Linkenkaer-Hansen, K.
10.1101/2022.08.07.503090 — neuroscience — Posted on 2022-08-08
2962 Sensitive multimodal profiling of native DNA by transposase-mediated single-molecule sequencing
Nanda, A. S.; Wu, K.; Kasinathan, S.; Ostrowski, M. S.; Clugston, A. S.; Satpathy, A.; Sweet-Cordero, E. A.; Goodarzi, H.; Ramani, V.
10.1101/2022.08.07.502893 — genomics — Posted on 2022-08-08
2963 MiMIC analysis reveals an isoform specific role for Drosophila Musashi in follicle stem cell maintenance and escort cell function
Siddall, N. A.; Casagranda, F.; Johanson, T. M.; Dominado, N.; Heaney, J.; Sutherland, J. M.; McLaughlin, E. A.; Hime, G. R.
10.1101/2020.08.25.265769 — developmental biology — Posted on 2022-08-07
2964 Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions
Chen, J.; Hu, Z.; Sun, S.; Tan, Q.; Wang, Y.; Yu, Q.; Zong, L.; Hong, L.; Xiao, J.; Shen, T.; King, I.; Li, Y.
10.1101/2022.08.06.503062 — bioinformatics — Posted on 2022-08-07
2966 Genomic characterization of Francisella tularensis and other diverse Francisella species from complex samples
Wagner, D. M.; Birdsell, D. N.; McDonough, R. F.; Nottingham, R.; Chavet, K.; Celona, K.; Özsürekci, Y.; Öhrman, C.; Karlsson, L.; Myrtennäs, K.; Sjödin, A.; Johansson, A.; Keim, P. S.; Forsman, M.; Sahl, J. W.
10.1101/2022.08.07.503100 — genomics — Posted on 2022-08-07
2967 Allelic diversity of the pharmacogene CYP2D6 in New Zealand Maori and Pacific peoples
Hitchman, L. M.; Faatoese, A.; Merriman, T. R.; Liau, Y.; Graham, O. E. E.; Kee, P. S.; Pearson, J. F.; Fakahau, T.; Cameron, V. A.; Kennedy, M. A.; Maggo, S. D. S.
10.1101/2022.07.21.501043 — genetics — Posted on 2022-08-07
2968 Distinct subpopulations of DN1 thymocytes exhibit preferential αβ or γδ T lineage potential
Oh, S.; Liu, X.; Tomei, S.; Luo, M.; Skinner, J.; Berzins, S. P.; Naik, S. H.; Gray, D. H.; Chong, M. M.
10.1101/2022.02.25.481936 — immunology — Posted on 2022-08-07
2969 Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity
Guet-McCreight, A.; Chameh, H. M.; Mahallati, S.; Wishart, M.; Tripathy, S. J.; Valiante, T. A.; Hay, E.
10.1101/2021.11.03.467014 — neuroscience — Posted on 2022-08-07
2970 Robin's Viewer: Using Deep-Learning Predictions to Assist EEG Annotation
Weiler, R.; Diachenko, M.; Juarez-Martinez, E.; Avramiea, A.-E.; Bloem, P.; Linkenkaer-Hansen, K.
10.1101/2022.08.07.503090 — neuroscience — Posted on 2022-08-07
2971 A resource for the comparison and integration of heterogeneous microbiome networks
Hu, Z.; Kishore, D.; Wang, Y.; Birzu, G.; DeLisi, C.; Korolev, K. S.; Segre, D.
10.1101/2022.08.07.503059 — systems biology — Posted on 2022-08-07
2972 Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin
Kong, X.; Yan, W.; Sun, W.; Zhang, Y.; Yang, H. J.; Chen, M.; Chen, H.; de Vere White, R. W.; Zhang, J.; Chen, X.
10.1101/2022.08.07.503085 — cancer biology — Posted on 2022-08-07
2974 A Universal Language for Finding Mass Spectrometry Data Patterns
Jarmusch, A. K.; Aron, A. T.; Petras, D.; Phelan, V. V.; Bittremieux, W.; Acharya, D. D.; Ahmed, M. M. A.; Bauermeister, A.; Bertin, M. J.; Boudreau, P. D.; Borges, R. M.; Bowen, B. P.; Brown, C. J.; Chagas, F. O.; Clevenger, K. D.; Correia, M. S. P.; Crandall, W. J.; Crusemann, M.; Damiani, T.; Fiehn, O.; Garg, N.; Gerwick, W. H.; Gilbert, J. R.; Globisch, D.; Gomes, P. W. P.; Heuckeroth, S.; James, C. A.; Jarmusch, S. A.; Kakhkhorov, S. A.; Kang, K. B.; Kersten, R. D.; Kim, H.; Kirk, R. D.; Kohlbacher, O.; Kontou, E. E.; Liu, K.; Lizama-Chamu, I.; Luu, G. T.; Luzzatto Knaan, T.; Marty, M. T.
10.1101/2022.08.06.503000 — bioinformatics — Posted on 2022-08-07
2978 Mouse lemur transcriptomic atlas elucidates primate genes, physiology, disease, and evolution
The Tabula Microcebus Consortium, ; Ezran, C.; Liu, S.; Ming, J.; Guethlein, L. A.; Wang, M. F. Z.; Dehghannasiri, R.; Olivieri, J.; Frank, H. K.; Tarashansky, A.; Koh, W.; Jing, Q.; Botvinnik, O.; Antony, J.; Chang, S.; Pisco, A. O.; Karkanias, J.; Yang, C.; Ferrell, J. E.; Boyd, S. D.; Parham, P.; Long, J. Z.; Wang, B.; Salzman, J.; De Vlaminck, I.; Wu, A.; Quake, S. R.; Krasnow, M. A.
10.1101/2022.08.06.503035 — genetics — Posted on 2022-08-07
2979 Genetic drivers of chromosomal integron stability
Richard, E.; Darracq, B.; Littner, E.; Vit, C.; Whiteway, C.; Bos, J.; Fournes, F.; Garriss, G.; Conte, V.; Lapaillerie, D.; Parissi, V.; Rousset, F.; Skovgaard, O.; Bikard, D.; Rocha, E.; Mazel, D.; Loot, C.
10.1101/2022.08.03.502626 — genetics — Posted on 2022-08-07
2980 The evolution of two transmissible leukaemias colonizing the coasts of Europe
Bruzos, A. L.; Santamarina, M.; Garcia Souto, D.; Diaz, S.; Rocha, S.; Zamora, J.; Lee, Y.; Feas, A.; Quail, M.; Otero, I.; Valtierra, A.; Temes, J.; Castro, J.; Villanueva, A.; Costas, D.; Rodriguez, R.; Prieto, T.; Tomas, L.; Alvarino, P.; Alonso, J.; Cao, A.; Iglesias, D.; Carballal, M.; Amaral, A.; Balseiro, P.; Calado, R.; Khalfi, B.; Izagirre, U.; Montaudouin, X.; Pade, N.; Probert, I.; Ricardo, F.; Ruiz, P.; Skazina, M.; Smolarz, K.; Pasantes, J.; Villalba, A.; Ning, Z.; Ju, Y.; Posada, D.; Demeulemeester, J.; Ortega, A.; Tubio, J.
10.1101/2022.08.06.503021 — evolutionary biology — Posted on 2022-08-07
2984 A light sheet fluorescence microscopy protocol for Caenorhabditis elegans larvae and adults
Smith, J. J.; Kenny, I. W.; Wolff, C.; Cray, R.; Kumar, A.; Sherwood, D. R.; Matus, D. Q.
10.1101/2022.08.05.503008 — developmental biology — Posted on 2022-08-07
2986 Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses
Gajwani, P.; Wang, L.; Srivastava, S.; Ye, Z.; Kim, Y.-M.; Krantz, S.; Wang, D.; Tiruppathi, C.; Toth, P. T.; Rehman, J.
10.1101/2022.08.07.503084 — cell biology — Posted on 2022-08-07
2991 The glycolipid GlcCer is recruited into the viral envelope to promote phenuivirus binding to host cells
Uckeley, Z. M.; Mazelier, M.; Luechtenborg, C.; Winter, S. L.; Schad, P.; Chlanda, P.; Bruegger, B.; Lozach, P.-Y.
10.1101/2022.08.07.502911 — microbiology — Posted on 2022-08-07
2993 An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium
Kon, E.; Levy, Y.; Elia, U.; Cohen, H.; Halevy, I.; Aftalion, M.; Ezra, A.; Bar-Haim, E.; Naidu, G. S.; Diesendruck, Y.; Rotem, S.; Ad-El, N.; Goldsmith, M.; Mamroud, E.; Peer, D.; Cohen, O.
10.1101/2022.08.07.503096 — microbiology — Posted on 2022-08-07
2998 Object representation in a gravitational reference frame
Emonds, A. M.; Srinath, R.; Nielsen, K. J.; Connor, C. E.
10.1101/2022.08.06.503060 — neuroscience — Posted on 2022-08-07
3004 Fast rule switching and slow rule updating in a perceptual categorization task
Bouchacourt, F.; Tafazoli, S.; Mattar, M. G.; Buschman, T. J.; Daw, N. D.
10.1101/2022.01.29.478330 — neuroscience — Posted on 2022-08-07
3008 Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology
Daniels, L. J.; Macindoe, C.; Koutsifeli, P.; Annandale, M.; Raaijmakers, A. J. A.; Weeks, K. L.; Bell, J. R.; Janssens, J. V.; Curl, C. L.; Delbridge, L. M. D.; Mellor, K. M.
10.1101/2022.08.06.503061 — physiology — Posted on 2022-08-07
3011 Functional interplay between SWI/SNF complexes underlies BRD9 dependency in SMARCB1-mutant cancers
Mobley, R. J.; Myers, J. A.; Wills, K. M.; Malone, H. A.; Manzano, T. I.; Partridge, J. F.; Roberts, C. W. M.
10.1101/2022.08.07.503080 — cancer biology — Posted on 2022-08-07
3013 Multiplexed and millimeter-scale superresolution imaging of cells and tissue sections via prism-illumination and microfluidics-enhanced DNA-PAINT
Rames, M. J.; Kenison, J.; Heineck, D.; Civitci, F.; Szczepaniak, M.; Tao, K.; Zheng, T.; Shangguan, J.; Esener, S.; Nan, X.
10.1101/2022.08.07.503091 — biophysics — Posted on 2022-08-07
3014 Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions
Chen, J.; Hu, Z.; Sun, S.; Tan, Q.; Wang, Y.; Yu, Q.; Zong, L.; Hong, L.; Xiao, J.; King, I.; Li, Y.
10.1101/2022.08.06.503062 — bioinformatics — Posted on 2022-08-07
3015 Reference-free assembly of long-read transcriptome sequencing data with RNA-Bloom2
Nip, K. M.; Hafezqorani, S.; Gagalova, K. K.; Chiu, R.; Yang, C.; Warren, R. L.; Birol, I.
10.1101/2022.08.07.503110 — bioinformatics — Posted on 2022-08-07
3016 Modulation of cannabinoid receptor signaling by endocannabinoids
Krishna Kumar, K.; Robertson, M. J.; Thadhani, E.; Wang, H.; Suomivuori, C.-M.; Powers, A. S.; Ji, L.; Nikas, S. P.; Gerasi, M.; Vemuri, K.; Dror, R.; Inoue, A.; Makriyannis, A.; Skiniotis, G.; Kobilka, B. K.
10.1101/2022.08.06.502185 — biochemistry — Posted on 2022-08-07
3017 Development of Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors with Negligible Cytotoxicity
Almaliti, J.; Fajtova, P.; Calla, J.; LaMonte, G. M.; Feng, M.; Rocamora, F.; Ottilie, S.; Glukhov, E.; Boura, E.; Suhandynata, R. T.; Momper, J. D.; Gilson, M. K.; Winzeler, E. A.; Gerwick, W. H.; O'Donoghue, A. J.
10.1101/2022.08.06.502205 — biochemistry — Posted on 2022-08-07
3018 Prosociality in a despotic society
Bhattacharjee, D.; Cousin, E.; Pfluger, L. S.; Massen, J. J. M.
10.1101/2022.08.07.503078 — animal behavior and cognition — Posted on 2022-08-07
3019 Sensitive multimodal profiling of native DNA by transposase-mediated single-molecule sequencing
Nanda, A. S.; Wu, K.; Kasinathan, S.; Ostrowski, M. S.; Clugston, A. S.; Satpathy, A.; Sweet-Cordero, E. A.; Goodarzi, H.; Ramani, V.
10.1101/2022.08.07.502893 — genomics — Posted on 2022-08-07
3023 Rapid protein stability prediction using deep learning representations
Blaabjerg, L. M.; Kassem, M. M.; Good, L. L.; Jonsson, N.; Cagiada, M.; Johansson, K. E.; Boomsma, W.; Stein, A.; Lindorff-Larsen, K.
10.1101/2022.07.14.500157 — biophysics — Posted on 2022-08-07
3024 Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis
Cikes, D.; Leutner, M.; Cronin, S. J. - F.; Novatchkova, M.; Pfleger, L.; Klepochova, R.; Rullman, E.; Gustafsson, T.; Hagelkrueys, A.; Knauf, C.; Moro, C.; Krebs, M.; Kautzky-Willer, A.; Krssak, M.; Orthofer, M.; Penninger, J. M.
10.1101/2021.10.26.465828 — physiology — Posted on 2022-08-07
3026 Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Mouse Blastocyst-derived Stem Cells
Thomas, C.; Haimson, R. B.; Zacharia, A.; Orih, P.; Shehadeh, A.; Saidemberg, D.; Kogan, N. M.; Alfandary, S.; Serruya, R.; Dagan, A.; Petit, I.; Moussaieff, A.
10.1101/2022.07.28.501839 — developmental biology — Posted on 2022-08-07
3027 Hypergraph factorisation for multi-tissue gene expression imputation
Torne, R. V.; Joshi, C. K.; Georgiev, D.; Dumitrascu, B.; Gamazon, E.; Lio, P.
10.1101/2022.07.31.502211 — bioinformatics — Posted on 2022-08-07
3028 Rapid range shifts in African Anopheles mosquitoes over the last century
Carlson, C. J.; Bannon, E.; Mendenhall, E.; Newfield, T.; Bansal, S.
10.1101/673913 — ecology — Posted on 2022-08-07
3029 Microliter spotting and micro-colony observation: a rapid and simple approach for counting bacterial colony-forming units
Bhuyan, S.; Yadav, M.; Giri, S. J.; Begum, S.; Das, S.; Phukan, A.; Priyadarshani, P.; Sarkar, S.; Jayswal, A.; Kabyashree, K.; Kumar, A.; Mandal, M.; Ray, S. K.
10.1101/2022.01.26.477842 — microbiology — Posted on 2022-08-07
3032 Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities
Casalino, L.; Seitz, C.; Lederhofer, J.; Tsybovsky, Y.; Wilson, I. A.; Kanekiyo, M.; Amaro, R. E.
10.1101/2022.08.02.502576 — biophysics — Posted on 2022-08-07
3036 Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism
The Tabula Microcebus Consortium, ; Ezran, C.; Liu, S.; Chang, S.; Ming, J.; Botvinnik, O.; Penland, L.; Tarashansky, A.; de Morree, A.; Travaglini, K. J.; Hasegawa, K.; Sin, H.; Sit, R.; Okamoto, J.; Sinha, R.; Zhang, Y.; Karanewsky, C. J.; Pendleton, J. L.; Morri, M.; Perret, M.; Aujard, F.; Stryer, L.; Artandi, S.; Fuller, M.; Weissman, I. L.; Rando, T. A.; Ferrell, J. E.; Wang, B.; De Vlaminck, I.; Yang, C.; Casey, K. M.; Albertelli, M. A.; Pisco, A. O.; Karkanias, J.; Neff, N.; Wu, A.; Quake, S. R.; Krasnow, M. A.
10.1101/2021.12.12.469460 — genetics — Posted on 2022-08-07
3038 Synonymous codon substitutions regulate transcription and translation of an upstream gene
Rodriguez, A.; Wright, G. S.; Lundgren, T.; Moss, M. J.; Li, J.; Milenkovic, T.; Huber, P. W.; Champion, M. M.; Emrich, S.; Clark, P. L.
10.1101/2022.08.05.502938 — molecular biology — Posted on 2022-08-06
3041 Neutralization of Omicron BA.4/BA.5 and BA.2.75 by Booster Vaccination or BA.2 Breakthrough Infection Sera
Wang, X.; Ai, J.; Li, X.; Zhao, X.; Wu, J.; Zhang, H.; He, X.; Zhao, C.; Qiao, R.; Li, M.; Cui, Y.; Chen, Y.; Yang, L.; Hu, Z.; Xu, C.; Zhang, W.; Wang, P.
10.1101/2022.08.04.502716 — immunology — Posted on 2022-08-06
3042 Greater resistance to footshock punishment in female C57BL/6J mice responding for ethanol
Sneddon, E. A.; Fennell, K. A.; Bhati, S.; Setters, J. E.; Schuh, K. M.; DeMedio, J. N.; Arnold, B. J.; Monroe, S. C.; Quinn, J. J.; Radke, A. K.
10.1101/2022.08.05.502979 — neuroscience — Posted on 2022-08-06
3046 Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas
Bons, J.; Pan, D.; Shah, S.; Bai, R.; Chen-Tanyolac, C.; Wang, X.; Fels Elliott, D. R.; Urisman, A.; O'Broin, A.; Basisty, N.; Rose, J.; Sangwan, V.; Camilleri-Broet, S.; Tankel, J.; Gascard, P.; Ferri, L.; Tlsty, T. D.; Schilling, B.
10.1101/2022.08.05.503012 — cancer biology — Posted on 2022-08-06
3047 MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin
Kim, J.; Chun, Y.; Ramirez, C. B.; Hoffner, L. A.; Jung, S.; Jang, K. H.; Rubtsova, V. I.; Jang, C.; Lee, G.
10.1101/2022.08.05.502726 — cancer biology — Posted on 2022-08-06
3048 ALT in Pediatric Brain Tumors Can Occur without ATRX Mutation and is Enriched in Patients with Pathogenic Germline MMR Variants
Stundon, J. L.; Ijaz, H.; Gaonkar, K. S.; Kaufman, R. S.; Jin, R.; Karras, A.; Vaksman, Z.; Kim, J.; Miller, D. P.; Guo, Y.; Santi, M.; Li, M.; Lopez, G.; Storm, P. J.; Resnick, A. C.; Waanders, A. J.; MacFarland, S. P.; Stewart, D.; Diskin, S. J.; Rokita, J. L.; Cole, K. A.
10.1101/2022.08.05.502870 — cancer biology — Posted on 2022-08-06
3049 A unified analysis of atlas single cell data
Chen, H.; Nguyen, N. D.; Ruffalo, M.; Bar-Joseph, Z.
10.1101/2022.08.06.503038 — bioinformatics — Posted on 2022-08-06
3050 Functional Ultrasound Imaging of the Human Spinal Cord
Agyeman, K.; Lee, D. J.; Russin, J.; Kreydin, E. I.; Choi, W.; Abedi, A.; Edgerton, V. R.; Liu, C.; Christopoulos, V.
10.1101/2022.08.06.503044 — bioengineering — Posted on 2022-08-06
3054 Hepatocyte Differentiation From Mouse Liver Ductal Organoids By Transducing Four Liver-Specific Transcription Factors
Tomofuji, K.; Kondo, J.; Onuma, K.; Oyama, K.; Miyoshi, E.; Fukumitsu, K.; Ishii, T.; Hatano, E.; Inoue, M.
10.1101/2022.08.06.503031 — cell biology — Posted on 2022-08-06
3055 Microglia and astrocytes differentially endocytose exosomes facilitating alpha-Synuclein endolysosomal sorting
Pantazopoulou, M.; Alexaki, A.; Lamprokostopoulou, A.; Delis, A.; Coens, A.; Melki, R.; Pagakis, S. N.; Stefanis, L.; Vekrellis, K.
10.1101/2022.08.05.502843 — neuroscience — Posted on 2022-08-06
3056 Alcanivorax borkumensis Biofilms Enhance Oil Degradation By Interfacial Tubulation
Prasad, M.; Obana, N.; Lin, S.-Z.; Sakai, K.; Blanch-Mercader, C.; Prost, J.; Nomura, N.; Rupprecht, J.-F.; Fattaccioli, J.; Utada, A. S.
10.1101/2022.08.06.503017 — biophysics — Posted on 2022-08-06
3058 Engineering a Single Extracellular Vesicle Protein and RNA Assay (siEVPRA) via In Situ Fluorescence Microscopy in a UV Micropatterned Array
Zhang, J.; Wang, X.; Rima, X. Y.; Nguyen, L. T. H.; Huntoon, K.; Ma, Y.; Walters, N.; Kwak, K. J.; Yoon, M. J.; Lee, D.; Wang, Y.; Ha, J.; Scherler, K.; Fallen, S.; Lee, I.; Palmer, A. F.; Jiang, W.; Wang, K.; Kim, B. Y. S.; Lee, L. J.; Reategui, E.
10.1101/2022.08.05.502995 — bioengineering — Posted on 2022-08-06
3059 Dynamics of hinged wings in strong upward gusts
Stevenson, J. P.; Cheney, J. A.; Usherwood, J. R.; Bomphrey, R. J.; Windsor, S. P.
10.1101/2022.08.05.502962 — bioengineering — Posted on 2022-08-06
3060 Mouse L1s fade with age: a methylation-enforced mechanism for attenuation of L1 retrotransposition potential
Gerdes, P.; Chan, D.; Lundberg, M.; Sanchez-Luque, F. J.; Bodea, G. O.; Ewing, A. D.; Faulkner, G. J.; Richardson, S. R.
10.1101/2022.08.06.500894 — genetics — Posted on 2022-08-06
3061 Beyond variance: simple random distributions are not a good proxy for intraspecific variability in systems with environmental structure
Girard-Tercieux, C.; Vieilledent, G.; Clark, A. T.; Clark, J. S.; Courbaud, B.; Fortunel, C.; Kunstler, G.; Pelissier, R.; Rueger, N.; Marechaux, I.
10.1101/2022.08.06.503032 — ecology — Posted on 2022-08-06
3063 A single cell transcriptomic and clonal analysis depicts valvulogenesis
Fahrat, B.; Bordeau, I.; Jagla, B.; Blanc, H.; Livet, J.; Simons, B. D.; Beaurepaire, E.; Puceat, M.
10.1101/2022.08.06.503022 — developmental biology — Posted on 2022-08-06
3067 Culex tarsalis is a competent host of the insect-specific alphavirus Eilat virus (EILV)
Joseph, R. E.; Urakova, N.; Werling, K. L.; Metz, H. C.; Montanari, K.; Rasgon, J. L.
10.1101/2022.08.06.503036 — microbiology — Posted on 2022-08-06
3068 Compost Teas: market survey and microbial analysis
Legein, M.; Beeck, W. V.; Muyshondt, B.; Wuyts, K.; Samson, R.; Lebeer, S.
10.1101/2022.08.05.503013 — microbiology — Posted on 2022-08-06
3072 Multi-areal neural dynamics encode human decision making
Overton, J. A.; Moxon, K. A.; Stickle, M. P.; Peters, L. M.; Lin, J. J.; Chang, E. F.; Knight, R. T.; Hsu, M.; Saez, I.
10.1101/2022.08.05.502992 — neuroscience — Posted on 2022-08-06
3074 A key regulator with a MIF-like domain orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae
Galli, M.; Jacob, S.; Zheng, Y.; Ghezellou, P.; Gand, M.; Albuquerque, W.; Imani, J.; Allasia, V.; Coustau, C.; Spengler, B.; Keller, H.; Thines, E.; Kogel, K.-H.
10.1101/2022.08.05.502968 — plant biology — Posted on 2022-08-06
3075 Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120
Nagao, R.; Kato, K.; Hamaguchi, T.; Ueno, Y.; Tsuboshita, N.; Shimizu, S.; Furutani, M.; Ehira, S.; Nakajima, Y.; Kawakami, K.; Suzuki, T.; Dohmae, N.; Akimoto, S.; Yonekura, K.; Shen, J.-R.
10.1101/2022.08.05.501323 — plant biology — Posted on 2022-08-06
3080 matchRanges: Generating null hypothesis genomic ranges via covariate-matched sampling
Davis, E. S.; Mu, W.; Lee, S.; Dozmorov, M. H.; Love, M. I.; Phanstiel, D. H.
10.1101/2022.08.05.502985 — bioinformatics — Posted on 2022-08-06
3082 Internal calibration for opportunistic computed tomography muscle density analysis
Smith, A.; Tse, J. J.; Waungana, T. H.; Bott, K. N.; Kuczynski, M. T.; Michalski, A. S.; Boyd, S. K.; Manske, S. L.
10.1101/2022.08.05.502969 — bioengineering — Posted on 2022-08-06
3084 Chemoenzymatic Synthesis of Genetically-Encoded Multivalent Liquid N-glycan Arrays
Lin, C.-L.; Sojitra, M.; Carpenter, E. J.; Hayhoe, E. S.; Sarkar, S.; Volker, E. A.; Atrazhev, A.; Lowary, T. L.; Macauley, M. S.; Derda, R.
10.1101/2022.08.05.503005 — biochemistry — Posted on 2022-08-06
3085 MetaTiME: Meta-components of the Tumor Immune Microenvironment
Zhang, Y.; Xiang, G.; Jiang, A. Y.; Lynch, A.; Zeng, Z.; Wang, C.; Zhang, W.; Fan, J.; Kang, J.; Gu, S.; Wan, C.; Zhang, B.; Liu, X. S.; Brown, M.; Meyer, C. A.
10.1101/2022.08.05.502989 — genomics — Posted on 2022-08-06
3086 Robust genetic analysis of the X-linked anophthalmic (Ie) mouse
Hernandez-Moran, B. A.; Papanastasiou, A. S.; Parry, D.; Meynert, A.; Grimes, G.; Adams, I. R.; Trejo-Reveles, V.; Bengani, H.; Keighren, M.; Jackson, I. J.; Adams, D. J.; FitzPatrick, D. R.; Rainger, J.
10.1101/2022.08.05.502661 — genetics — Posted on 2022-08-06
3090 β1 integrin regulates alveolar epithelial cell differentiation following injury
Sucre, J. M. S.; Bock, F.; Negretti, N. M.; Benjamin, J. T.; Gulleman, P. M.; Dong, X.; Ferguson, K. T.; Jetter, C. S.; Han, W.; Liu, Y.; Kook, S.; Gokey, J.; Guttentag, S. H.; Kropski, J. A.; Blackwell, T. S.; Zent, R.; Plosa, E. J.
10.1101/2022.08.05.502988 — cell biology — Posted on 2022-08-06
3092 Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells.
Couch, A. C. M.; Solomon, S.; Marrocu, A.; Duarte, R.; Sun, Y.; Sichlinger, L.; Matuleviciute, R.; Dutan Polit, L.; Hanger, B.; Kordasti, S.; Srivastava, D. P.; Vernon, A. C.
10.1101/2022.08.05.502958 — neuroscience — Posted on 2022-08-06
3095 Evaluation of an image-derived input function for kinetic modeling of nicotinic acetylcholine receptor-binding PET ligands
Zammit, M.; Kao, C.-M.; Zhang, H. J.; Holderman, N.; Mitchell, S.; Tanios, E.; Zhang, V.; Bhuiyan, M.; Freifelder, R.; Green, W.; Mukherjee, J.; Chen, C.-T.
10.1101/2022.08.05.502975 — neuroscience — Posted on 2022-08-06
3100 A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models
Wolter, A.; Bucher, C. H.; Kurmies, S.; Schreiner, V.; Konietschke, F.; Hohlbaum, K.; Klopfleisch, R.; Loehning, M.; Thoene-Reineke, C.; Buttgereit, F.; Huwyler, J.; Jirkof, P.; Rapp, A. E.; Lang, A.
10.1101/2022.07.05.498859 — animal behavior and cognition — Posted on 2022-08-06
3101 Culture of human nasal olfactory stem cells and their extracellular vesicles as advanced therapy medicinal products
Jaloux, C.; Bonnet, M.; Vogtensperger, M.; Witters, M.; Veran, J.; Giraudo, L.; Sabatier, F.; Michel, J.; Lacroix, R.; Chareyre, C.; Legre, R.; Guiraudie Capraz, G.; Feron, F.
10.1101/2022.08.05.502926 — neuroscience — Posted on 2022-08-06
3105 Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice
Zekri, Y.; Guyot, R.; Suner, I. G.; Canaple, L.; Stein, A. G.; Petit, J. V.; Aubert, D.; Richard, S.; Flamant, F.; Gauthier, K.
10.1101/2022.08.03.502639 — genomics — Posted on 2022-08-06
3109 Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus)
Trouche, S. G.; Boutajangout, A.; Asuni, A.; Fontes, P.; Sigurdsson, E. M.; Verdier, J.-M.; Mestre Frances, N.
10.1101/2022.08.05.502918 — neuroscience — Posted on 2022-08-06
3110 Novel transient cell clusters provide a possible link between early neural activity and angiogenesis in the neonatal mouse retina
de Montigny, J.; Thorne, C.; Bhattacharya, D.; Bousoulas-Sertedakis, D.; Krishnamoorthy, V.; Rozenblit, F.; Gollisch, T.; Sernagor, E.
10.1101/2022.08.04.502860 — neuroscience — Posted on 2022-08-06
3119 Neuronal SNAP-23 scales hippocampal synaptic plasticity and memory
Huang, M.; Bin, N.-R.; Rai, J.; Ma, K.; Chow, C. H.; Eide, S.; Harada, H.; Xiao, J.; Feng, D.; Sun, H.-S.; Feng, Z.-P.; Gaisano, H. Y.; Pessin, J.; Monnier, P. P.; Okamoto, K.; Zhang, L.; Sugita, S.
10.1101/2022.08.04.502541 — neuroscience — Posted on 2022-08-06
3121 Loss of tristetraprolin activates NF-κB induced phenotypic plasticity and primes transition to lethal prostate cancer
Morel, K. L.; Hamid, A. A.; Falcon, B. G.; Singh, J. N.; Burkhart, D. L.; Kim, M.; Kim, J.; Plummer, J. T.; You, S.; Sweeney, C. J.; Ellis, L.
10.1101/2022.08.05.500896 — cancer biology — Posted on 2022-08-05
3123 Intrinsically disordered regions that drive phase separation form a robustly distinct protein class
Ibrahim, A. Y.; Khaodeuanepheng, N. P.; Amarasekara, D. L.; Correia, J. J.; Lewis, K. A.; Fitzkee, N. C.; Hough, L. E.; Whitten, S. T.
10.1101/2022.08.04.502866 — biophysics — Posted on 2022-08-06
3127 Predicting regional somatic mutation rates using DNA motifs
Liu, c.; Wang, Z.; Wang, J.; Liu, C.; Wang, M.; Ngo, V.; Wang, W.
10.1101/2022.08.04.502732 — bioinformatics — Posted on 2022-08-05
3128 Identification and prediction of Parkinson's disease subtypes and progression using machine learning in two cohorts.
Dadu, A.; Satone, V. K.; Kaur, R.; Hashemi, S. H.; Leonard, H.; Iwaki, H.; Makarious, M. B.; Billingsley, K. J.; Bandres-Ciga, S.; Sargent, L.; Noyce, A.; Daneshmand, A.; Blauwendraat, C.; Marek, K.; Scholz, S. W.; Singleton, A.; Nalls, M. A.; Campbell, R.; Faghri, F.
10.1101/2022.08.04.502846 — bioinformatics — Posted on 2022-08-06
3131 EDoF-Miniscope: pupil engineering for extended depth-of-field imaging in a fluorescence miniscope
Greene, J.; Xue, Y.; Alido, J.; Matlock, A.; Hu, G.; Kilic, K.; Davison, I. G.; Tian, L.
10.1101/2022.08.05.502947 — bioengineering — Posted on 2022-08-05
3134 A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing
Lengyel, E.; Li, Y.; Weigert, M.; Zhu, L.; Eckart, H.; Javellana, M.; Ackroyd, S.; Xiao, J.; Olalekan, S.; Glass, D.; Iyer, S.; Bilecz, A. J.; Lastra, R.; Chen, M.; Basu, A.
10.1101/2022.08.04.502826 — genomics — Posted on 2022-08-05
3135 Pollinator and host sharing lead to hybridization and introgression in Panamanian free-standing figs, but not in their pollinator wasps
Satler, J. D.; Herre, E. A.; Heath, T. A.; Machado, C. A.; Zuniga, A. G.; Jander, K. C.; Eaton, D. A. R.; Nason, J. D.
10.1101/2022.08.04.502839 — evolutionary biology — Posted on 2022-08-05
3138 Discovery of Novel Bilaterian Signaling Peptides Using Cone Snail Toxins
Koch, T. L.; Torres, J. P.; Baskin, R. P.; Salcedo, P. F.; Chase, K.; Olivera, B. M.; Safavi-Hemami, H.
10.1101/2022.08.05.502922 — evolutionary biology — Posted on 2022-08-05
3140 High Resolution Kinetic Characterization and Dynamic Mathematical Modeling of the RIG-I Signaling Pathway and the Antiviral Responses
Burkart, S. S.; Schweinoch, D.; Frankish, J.; Sparn, C.; Wuest, S.; Urban, C.; Piras, A.; Pichlmair, A.; Willemsen, J.; Kaderali, L.; Binder, M.
10.1101/2022.08.05.502818 — immunology — Posted on 2022-08-05
3141 Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
Wang, Y.-T.; Trzeciak, A.; Rojas, W. S.; Saavedra, P.; Chen, Y.-T.; Chirayil, R.; Etchegaray, J. I.; Lucas, C. D.; Puleston, D. J.; Keshari, K. R.; Perry, J. S. A.
10.1101/2022.08.04.502838 — immunology — Posted on 2022-08-05
3142 Antiretroviral treatment reveals a novel role for lysosomes in oligodendrocyte maturation
Festa, L. K.; Clyde, A. E.; Long, C. C.; Roth, L. M.; Grinspan, J. B.; Jordan-Sciutto, K. L.
10.1101/2022.08.05.502855 — neuroscience — Posted on 2022-08-05
3146 Systematic delineation of signaling and epigenomic mechanisms underlying microglia inflammatory activity in acute and chronic brain pathologies
Machado Xavier, A.; Distefano-Gagne, F.; Belhamiti, N.; Belhocine, S.; Bitarafan, S.; Falle, A.; Fiola, S.; Rivest, S.; Gosselin, D.
10.1101/2022.08.04.502805 — neuroscience — Posted on 2022-08-05
3147 Towards Detailed Cortical Maps of the Human Back with Representational Similarity Analysis
Guekos, A.; Cole, D. M.; Doerig, M. A.; Staempfli, P.; Schibli, L.; Schuetz, P. A.; Meier, M. L.
10.1101/2022.08.05.502912 — neuroscience — Posted on 2022-08-06
3149 Gonadal Hormones Impart Male-Biased Behavioral Vulnerabilities to Immune Activation via Microglial Mitochondrial Function
Bordt, E. A.; Moya, H. A.; Jo, Y. C.; Ravichandran, C. T.; Bankowski, I. M.; Ceasrine, A. M.; McDougle, C. J.; Carlezon, W. A.; Bilbo, S. D.
10.1101/2022.08.05.502953 — neuroscience — Posted on 2022-08-06
3151 Gene expression noise dynamics unveil functional heterogeneity of ageing hematopoietic stem cells
Rosales-Alvarez, R. E.; Rettkowski, J.; Herman, J. S.; Dumbovic, G.; Cabezas-Wallscheid, N.; Grun, D.
10.1101/2022.08.04.502776 — systems biology — Posted on 2022-08-05
3153 Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution
Winkler, J.; Tan, W.; Diadhiou, C. M. M.; McGinnis, C. S.; Abbasi, A.; Hasnain, S.; Durney, S.; Atamaniuc, E.; Superville, D.; Awni, L.; Lee, J. V.; Hinrichs, J. H.; Hein, M. Y.; Borja, M.; Detweiler, A.; Liu, S.-Y.; Nanjaraj, A.; Sitarama, V.; Rugo, H. S.; Neff, N.; Gartner, Z. J.; Pisco, A. O.; Goga, A.; Darmanis, S.; Werb, Z.
10.1101/2022.08.04.502697 — cancer biology — Posted on 2022-08-05
3155 Single-cell Spatial Explorer: Easy exploration of spatial and multimodal transcriptomics
PONT, F.; Cerapio, J.-P.; Gravelle, P.; Ligat, L.; Valle, C.; Sarot, E.; Perrier, M.; Lopez, F.; Laurent, C.; FOURNIE, j. j.; Tosolini, M.
10.1101/2022.08.04.502890 — bioinformatics — Posted on 2022-08-05
3158 Evaluating material-driven regeneration in a tissue engineered human in vitro bone defect model
de Wildt, B. W. M.; Cramer, E. E. A.; de Silva, L. S.; Ito, K.; Gawlitta, D.; Hofmann, S.
10.1101/2022.08.05.502914 — bioengineering — Posted on 2022-08-05
3160 A fear conditioned cue orchestrates a suite of behaviors
Chu, A.; Michel, C. B.; Gordon, N. T.; Hanrahan, K. E.; DuBois, A. M.; Williams, D. C.; McDannald, M. A.
10.1101/2022.08.05.502178 — animal behavior and cognition — Posted on 2022-08-05
3163 Choice of climate data influences current and future global invasion risks for two Phelsuma geckos
Dubos, N.; Fieldsend, T. W.; Roesch, M. A.; Augros, S.; Besnard, A.; Choeur, A.; Ineich, I.; Krysko, K.; Leroy, B.; Malone, S.; Probst, J.-M.; Raxworthy, C.; Crottini, A.
10.1101/2022.08.04.502765 — ecology — Posted on 2022-08-05
3164 Endothelial TIE1 restricts angiogenic sprouting to coordinate vein assembly in synergy with its homologue TIE2
Cao, X.; Li, T.; Xu, B.; Ding, K.; Li, W.; Shen, B.; Chu, M.; Zhu, D.; Rui, L.; Shang, Z.; Li, X.; Wang, Y.; Zheng, S.; Alitalo, K.; Liu, G.; Tang, J.; Kubota, Y.; He, Y.
10.1101/2022.08.05.502976 — developmental biology — Posted on 2022-08-05
3166 Sexual Dimorphic Metabolic and Cognitive Responses of C57BL/6 Mice to Fisetin or Dasatinib and Quercetin Cocktail Oral Treatment
Fang, Y.; Medina, D.; Stockwell, R.; McFadden, S.; Quinn, K.; Peck, M. R.; Bartke, A.; Hascup, K. N.; Hascup, E. R.
10.1101/2021.11.08.467509 — physiology — Posted on 2022-08-05
3167 Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma
Mohammed, S.; Thadathil, N.; Tran, A. L.; Van Der Veldt, M.; Georgescu, C.; Haritha, N. H.; Ohene-Marfo, P.; Oh, S.; Nicklas, E. H.; Wang, D.; Luo, W.; Janknecht, R.; Miller, B. F.; Wren, J. D.; Freeman, W.; Deepa, S. S.
10.1101/2022.08.03.502666 — cancer biology — Posted on 2022-08-05
3168 Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting tumor mutation burden
Schvartzman, J. M.; Forsyth, G. C.; Walch, H.; Chatila, W.; Santella, A.; Menghrajani, K.; Sanchez-Vega, F.; Koche, R.; Thompson, C. B.
10.1101/2022.08.04.502834 — cancer biology — Posted on 2022-08-05
3169 Thymidine rescues ATR kinase inhibition induced deoxyuridine contamination in genomic DNA, cell death, and Type 1 interferon expression
Sugitani, N.; Vendetti, F. P.; Cipriano, A. J.; Pandya, P.; Deppas, J. J.; Moiseeva, T. N.; Schamus-Haynes, S.; Wang, Y.; Palmer, D.; Osmanbeyoglu, H. U.; Bostwick, A.; Snyder, N. W.; Gong, Y.-N.; Aird, K. M.; Delgoffe, G. M.; Beumer, J. H.; Bakkenist, C. J.
10.1101/2022.02.24.481821 — cancer biology — Posted on 2022-08-05
3170 Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids
Alsaadi, A.; Artibani, M.; Hu, Z.; Wietek, N.; Morotti, M.; Gonzalez, L. S.; Alazzam, M.; Jiang, J.; Abdul, B.; Soleymani majd, H.; Blazer, L. L.; Adams, J. J.; Sidhu, S.; Brugge, J. S.; Ahmed, A. A.
10.1101/2022.08.02.502319 — cancer biology — Posted on 2022-08-05
3171 TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding
Lim, T.-Y.; Wilde, B. R.; Thomas, M. L.; Murphy, K. E.; Vahrenkamp, J. M.; Conway, M. E.; Varley, K. E.; Gertz, J.; Ayer, D. E.
10.1101/2022.08.04.502753 — cancer biology — Posted on 2022-08-05
3173 Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma
Stewart, C. E.; Guerra Garcia, M. E.; Luo, L.; Williams, N. T.; Ma, Y.; Regal, J. A.; Ghosh, D.; Sansone, P.; Oldham, M.; Deland, K.; Becher, O. J.; Kirsch, D. G.; Reitman, Z. J.
10.1101/2022.08.05.502656 — cancer biology — Posted on 2022-08-05
3175 Collective polarization dynamics in gonococcal colonies
Hennes, M.; Bender, N.; Cronenberg, T.; Welker, A.; Maier, B.
10.1101/2022.08.04.502895 — biophysics — Posted on 2022-08-05
3181 Single-molecule fluorescence microscopy demonstrates fast dynamics of the variant surface glycoprotein coat on living trypanosomes
Schwebs, M.; Paul, T.; Glogger, M.; Forster, L.; Morriswood, B.; Tessmar, J.; Groll, J.; Engstler, M.; Kollmannsberger, P.; Fenz, S.
10.1101/2022.08.03.502583 — biophysics — Posted on 2022-08-05
3189 Convection and extracellular matrix binding control interstitial transport of extracellular vesicles
Sariano, P. A.; Mizenko, R.; Shirure, V. S.; Brandt, A.; Nesiri, C.; Shergill, B.; Rocke, D. M.; Carney, R. P.; George, S. C.
10.1101/2022.08.03.502657 — bioengineering — Posted on 2022-08-05
3190 Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells
Gumuskaya, G.; Srivastava, P.; Cooper, B. G.; Lesser, H.; Semegran, B.; Garnier, S.; Levin, M.
10.1101/2022.08.04.502707 — bioengineering — Posted on 2022-08-05
3191 Neuronal Maturation-dependent Nano-Neuro Interaction and Modulation
Gupta, P.; Rathi, P.; Gupta, R.; Baldi, H.; Coquerel, Q.; Debnath, A.; Gholami Derami, H.; Raman, B.; Singamaneni, S.
10.1101/2022.08.03.502650 — bioengineering — Posted on 2022-08-05
3192 Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration
Wisdom, K. M.; Suijker, J.; van den Broek, L.; Sridharan, B.; Grandhi, T. S. P.; Cheng, A.; Lamb, M.; Titus, S. A.; Gehman, A.; Poore, D.; Shah, N.; Cheng, S.-H.; Kim, E.; Griffin, S.; Ekert, J.
10.1101/2022.08.03.502507 — bioengineering — Posted on 2022-08-05
3194 Detection of YAP1 and AR-V7 mRNA for Prostate Cancer prognosis using an ISFET Lab-On-Chip platform
Broomfield, J. J.; Kalofonou, M.; Pataillot-Meakin, T.; Powell, S. M.; Moser, N.; Bevan, C. L.; Georgiou, P.
10.1101/2022.08.04.502773 — bioengineering — Posted on 2022-08-05
3196 Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon
Tenjo Castano, F.; Sofos, N.; Lopez-Mendez, B.; fuglsang, a.; Stutzke, L.; Stella, S.; Montoya, G.
10.1101/2022.08.05.502904 — biochemistry — Posted on 2022-08-05
3197 FANCD2 and RAD51 recombinase directly inhibit DNA2 nucleases at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
Liu, W.; Polaczek, P.; Roubal, I.; Meng, Y.; Choe, W.-c.; Caron, M. C.; Sedgeman, C. A.; Xi, Y.; Liu, C.; Wu, Q.; Zheng, L.; Masson, J. Y.; Shen, B.; Campbell, J. L.
10.1101/2021.07.08.450798 — biochemistry — Posted on 2022-08-05
3201 A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics.
Daly, K. G.; Arbuckle, B. S.; Rossi, C.; Mattiangeli, V.; Lawlor, P. A.; Mashkour, M.; Sauer, E.; Lesur, J.; Atici, L.; Erek, C. M.; Bradley, D. G.
10.1101/2022.04.08.487619 — genomics — Posted on 2022-08-05
3202 Deep molecular, cellular and temporal phenotyping of developmental perturbations at whole organism scale
Saunders, L. M.; Srivatsan, S. R.; Duran, M.; Dorrity, M. W.; Ewing, B.; Linbo, T.; Shendure, J.; Raible, D.; Moens, C. B.; Kimelman, D.; Trapnell, C.
10.1101/2022.08.04.502764 — genomics — Posted on 2022-08-05
3205 SNP discovery by exome capture and resequencing in a pea genetic resource collection
AUBERT, G.; Kreplak, J.; Leveugle, M.; Duborjal, H.; Klein, A.; Boucherot, K.; Vieille, E.; Chabert-Martinello, M.; Cruaud, C.; Bourion, V.; Lejeune-Henaut, I.; Pilet-Nayel, M.-L.; Francillonne, N.; Tayeh, N.; Pichon, J.-P.; Riviere, N.; Burstin, J.
10.1101/2022.08.03.502586 — genomics — Posted on 2022-08-05
3206 Polygenic Transcriptome Risk Scores Can Translate Genetic Results Between Species
Santhanam, N.; Sanchez-Roige, S.; Liang, Y.; Chitre, A.; Munro, D.; Chen, D.; Cheng, R.; Nyasimi, F.; Perry, M.; Gao, J.; George, A. M.; Gileta, A.; Holl, K.; Hughson, A.; King, C. P.; Lamparelli, A. C.; Martin, C. D.; Martinez, A. G.; Mi, S.; St. Pierre, C. L.; Tripi, J.; Wang, T.; Chen, H.; Flagel, S.; Ishiwari, K.; Meyer, P.; Saba, L.; Woods, L. S.; Polesskaya, O.; Palmer, A. A.; Im, H. K.
10.1101/2022.06.03.494719 — genomics — Posted on 2022-08-05
3207 Characterization of a Novel Hyper-Variable Variable Number Tandem Repeat in the Dopamine Transporter Gene (SLC6A3)
Apsley, A. T.; Domico, E. R.; Verbiest, M. A.; Brogan, C. A.; Buck, E. R.; Burich, A. J.; Cardone, K. M.; Stone, W. J.; Anisimova, M.; Vandenbergh, D. J.
10.1101/2022.08.03.502653 — genomics — Posted on 2022-08-05
3210 Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance
Copier, J. S.; Bootsma, M.; Ng, C. A.; Wilde, A. A. M.; Bertels, R. A.; Bikker, H.; Christiaans, I.; van der Crabben, S. N.; Hol, J. A.; Koopmann, T. T.; Knijnenburg, J.; Lommerse, A. A. J.; van der Smagt, J. J.; Bezzina, C. R.; Vandenberg, J. I.; Verkerk, A. O.; Barge-Schaapveld, D. Q. C. M.; Lodder, E. M.
10.1101/2022.08.05.502917 — genetics — Posted on 2022-08-05
3216 Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation
Azzoni, R.; Filbey, K. J.; Daw, R. H.; Krauss, M. Z.; Hepworth, M. R.; Konkel, J. E.; Hessel, E. M.; Kannan, Y.; Grainger, J. R.
10.1101/2022.08.04.502285 — immunology — Posted on 2022-08-05
3218 Sex and APOE Genotype Influence Respiratory Function Under Hypoxic and Hypoxic-Hypercapnic Conditions
Taylor, C. E.; Mendenhall, L. E.; Sunshine, M. D.; Wilson, J. N.; Calulot, C. M.; Johnson, L. A.; Alilain, W. J.
10.1101/2022.08.03.502692 — neuroscience — Posted on 2022-08-05
3220 Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression
Osimiri, L. C.; Bonny, A. R.; Takagishi, S. R.; Luecke, S.; Riehs, N.; Hoffmann, A.; El-Samad, H.
10.1101/2022.08.03.502739 — systems biology — Posted on 2022-08-05
3221 Subcellular spatially resolved gene neighborhood networks in single cells
Fang, Z.; Form, A. J.; Hu, T. K.; Zhang, N.; Mantalaris, A.; Coskun, A. F.
10.1101/2022.08.03.502409 — systems biology — Posted on 2022-08-05
3225 Short communication: automatic real-time monitoring of fungal spores: the case of Alternaria spp.
Erb, S.; Berne, A.; Burgdorfer, N. C. C.; Clot, B. A.; Graber, M.-J.; Lieberherr, G.; Sallin, C.; Tummon, F.; Crouzy, B.
10.1101/2022.08.03.500168 — pathology — Posted on 2022-08-05
3226 Bacterial phylogenetic markers in lake sediments as evidence for historical hemp retting
Rull, V.; Sacristan-Soriano, O.; Sanchez-Melsio, A.; Borrego, C.; Vegas-Vilarrubia, T.
10.1101/2022.08.03.502709 — paleontology — Posted on 2022-08-05
3229 Genetic drivers of chromosomal integron stability
Richard, E.; Darracq, B.; Littner, E.; Vit, C.; Whiteway, C.; Bos, J.; Fournes, F.; Garriss, G.; Conte, V.; Lapaillerie, D.; Parissi, V.; Rousset, F.; Skovgaard, O.; Bikard, D.; Rocha, E.; Mazel, D.; Loot, C.
10.1101/2022.08.03.502626 — genetics — Posted on 2022-08-05
3230 Human activities impact microbial communities of Amazon Mangroves
da Costa, G. M.; Costa, S. d. S.; Barauna, R. A.; Castilho, B. P.; Pinheiro, I. C.; da Silva, A. L. d. C.; Silva, A. P. S.; dos Santos, A. K. C. R.; das Gracas, D. A.
10.1101/2022.08.03.501699 — genetics — Posted on 2022-08-05
3234 Recent Reconfiguration Of An Ancient Developmental Gene Regulatory Network In Heliocidaris Sea Urchins
Davidson, P. L.; Guo, H.; Swart, J. S.; Massri, A. J.; Edgar, A.; Wang, L.; Berrio, A.; Devens, H. R.; Koop, D.; Cisternas, P.; Zhang, H.; Zhang, Y.; Byrne, M.; Fan, G.; Wray, G. A.
10.1101/2022.03.03.482868 — evolutionary biology — Posted on 2022-08-05
3238 MOSQUITO MICROBIOMES OF RWANDA: CHARACTERIZING MOSQUITO HOST AND MICROBIAL COMMUNITIES IN THE LAND OF A THOUSAND HILLS
Tokash-Peters, A. G.; Niyonzima, J. D.; Kayirwangwa, M.; Muhayimana, S.; Tokash, I. W.; Jabon, J. D.; Lopez, S. G.; Woodhams, D. C.
10.1101/2022.08.03.502589 — ecology — Posted on 2022-08-05
3241 Multi-organ functions of yolk sac during human early development
Botting, R. A.; Goh, I.; Rose, A.; Webb, S.; Engelbert, J.; Gitton, Y.; Stephenson, E.; Quiroga Londono, M.; Mather, M.; Mende, N.; Imaz-Rosshandler, I.; Horsfall, D.; Basurto-Lozada, D.; Chipampe, N.-J.; Rook, V.; Mazin, P.; Vijayabaskar, M.; Hannah, R.; Gambardella, L.; Green, K.; Ballereau, S.; Inoue, M.; Tuck, L.; Lorenzi, V.; Kwakwa, K.; Alsinet, C.; Olabi, B.; Miah, M.; Admane, C.; Popescu, D.-M.; Acres, M.; Dixon, D.; Coulthard, R.; Lisgo, S.; Henderson, D. J.; Dann, E.; Su, C.; Kinston, S. J.; Park, J.-e.; Polanski, K.; Van Dongen, S.; Meyer, K. B.; de Bruijn, M.; Palis, J.; Behjati, S
10.1101/2022.08.03.502475 — developmental biology — Posted on 2022-08-05
3243 Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons
Gainetdinov, I.; Cecchini, K.; Vega-Badillo, J.; Bagci, A.; Colpan, C.; Arif, A.; Wu, P.-H.; Zamore, P. D.
10.1101/2022.08.04.502788 — molecular biology — Posted on 2022-08-05
3244 Human endogenous retrovirus-R envelope is a host restriction factor against severe acute respiratory syndrome-coronavirus-2
Gupta, N.; Ansari, S.; Verma, R.; Singh, O. N.; Yadav, M. K.; Binayke, A.; Jakhar, K.; Mani, S.; Awasti, A.; Shalimar, ; Nayak, B.; Ranjith-Kumar, C.; Surjit, M.
10.1101/2022.08.05.502940 — microbiology — Posted on 2022-08-05
3245 Harnessing diversity and antagonism within the pig skin microbiota to identify novel mediators of colonization resistance to methicillin-resistant Staphylococcus aureus
Flowers, L.; Wei, M.; Knight, S. A. B.; Zheng, Q.; Uberoi, A.; Campbell, A.; Pan, T.-C. J.; Walsh, J.; Schroeder, E.; Chu, E. W.; Bradley, C. W.; Duran-Struuck, R.; Grice, E. A.
10.1101/2022.08.05.502505 — microbiology — Posted on 2022-08-05
3247 Mixed Heavy Metals Stress Induces Global Iron Starvation as Revealed by System Level Multi-Omic Analyses
Goff, J. L.; Chen, Y.; Thorgersen, M. P.; Hoang, L. T.; Poole, F. L.; Szink, E. G.; Siuzdak, G.; Petzold, C. J.; Adams, M. W. W.
10.1101/2022.08.05.502853 — microbiology — Posted on 2022-08-05
3248 Comparative genomics of Streptococcus oralis identifies large scale homologous recombination and a genetic variant associated with infection
Joyce, L. R.; Youngblom, M. A.; Cormaty, H.; Gartstein, E.; Barber, K. E.; Akins, R. L.; Pepperell, C. S.; Palmer, K. L.
10.1101/2022.08.05.502949 — microbiology — Posted on 2022-08-05
3249 Long-lived central memory γδ T cells confer protection against murine cytomegalovirus reinfection
Yared, N.; Papadopoulou, M.; Netzer, S.; Burguet, L.; Mora-Charrot, L.; Rousseau, B.; Zouine, A.; Gauthereau, X.; Vermijlen, D.; Dechanet-Merville, J.; CAPONE, M.
10.1101/2022.08.05.502906 — immunology — Posted on 2022-08-05
3250 Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature.
Natalini, A.; Simonetti, S.; Favaretto, G.; Lucantonio, L.; Peruzzi, G.; Munoz-Ruiz, M.; Kelly, G.; Contino, A. M.; Sbrocchi, R.; Battella, S.; Capone, S.; Folgori, A.; Nicosia, A.; Santoni, A.; Hayday, A. C.; Di Rosa, F.
10.1101/2022.08.04.502772 — immunology — Posted on 2022-08-05
3251 Subfunctionalization and constrained size of the immunoglobulin loci in Ambystoma mexicanum
Martinez-Barnetche, J.; Godoy-Lozano, E. E.; Saint Remy-Hernandez, S.; Pacheco-Olvera, D. L.; Tellez-Sosa, J.; Valdovinos-Torres, H.; Pastelin-Palacios, R.; Mena-Gonzalez, H.; Zambrano-Gonzalez, L.; Lopez-Macias, C.
10.1101/2022.08.03.502689 — immunology — Posted on 2022-08-05
3252 Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte-Derived Macrophage Fate Specification following Myocardial Infarction
Kadyrov, F. F.; Koenig, A. L.; Amrute, J. M.; Li, W.; Lai, L.; Weinheimer, C. J.; Nigro, J. M.; Kovacs, A.; Bredemeyer, A. L.; Kreisel, D.; Lavine, K. J.
10.1101/2022.08.04.502542 — immunology — Posted on 2022-08-05
3253 An unbiased characterization of the HLA-E and CD94/NKG2x peptide repertoire reveals peptide ligands that skew NK cell activation
Huisman, B. D.; Guan, N.; Ruckert, T.; Garner, L.; Singh, N. K.; McMichael, A. J.; Gillespie, G. M.; Romagnani, C.; Birnbaum, M. E.
10.1101/2022.08.03.502719 — immunology — Posted on 2022-08-05
3256 An adhesive signaling axis regulates the establishment of the cortical glial scaffold.
Wong, W.; Estep, J. A.; Ubina, T.; Jahncke, J. N.; Wright, K. M.; Riccomagno, M. M.
10.1101/2022.08.02.502565 — neuroscience — Posted on 2022-08-05
3257 A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays
Buccino, A. P.; Damart, T.; Bartram, J.; Mandge, D.; Xue, X.; Zbili, M.; Gänswein, T.; Jaquier, A.; Emmenegger, V.; Markram, H.; Hierlemann, A.; Van Geit, W.
10.1101/2022.08.03.502468 — neuroscience — Posted on 2022-08-05
3260 Novel algorithms for improved detection and analysis of fluorescent signal fluctuations
Stopper, G.; Caudal, L. C.; Rieder, P.; Gobbo, D.; Felix, L.; Everaerts, K.; Bai, X.; Stopper, L.; Rose, C. R.; Scheller, A.; Kirchhoff, F.
10.1101/2022.08.03.502593 — neuroscience — Posted on 2022-08-05
3261 Decoding Subject's Own Name in the Primary Auditory Cortex
Wu, H.; Wang, D.; Liu, Y.; Xie, M.; Zhou, L.; Wang, Y.; Cao, J.; Huang, Y.; Qiu, M.; Qin, P.
10.1101/2022.07.30.502169 — neuroscience — Posted on 2022-08-05
3273 Analysis of companion cell and phloem metabolism using a transcriptome-guided model of Arabidopsis metabolism
Hunt, H.; Brueggen, N.; Galle, A.; Vanderauwera, S.; Frohberg, C.; Fernie, A. R.; Sonnewald, U.; Sweetlove, L. J.
10.1101/2022.08.04.502830 — plant biology — Posted on 2022-08-05
3279 Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Agam, G.; Gebhardt, C.; Popara, M.; Maechtel, R.; Folz, J.; Ambrose, B.; Chamachi, N.; Chung, S. Y.; Craggs, T. D.; de Boer, M.; Grohmann, D.; Ha, T.; Hartmann, A.; Hendrix, J.; Hirschfeld, V.; Huebner, C. G.; Hugel, T.; Kammerer, D.; Kang, H. S.; Kapanidis, A.; Krainer, G.; Kramm, K.; Lemke, E.; Lerner, E.; Margeat, E.; Martens, K.; Michaelis, J.; Mitra, J.; Munoz, G. G. M.; Quast, R.; Robb, N.; Sattler, M.; Schlierf, M.; Schneider, J.; Schroeder, T.; Sefer, A.; Tan, P. S.; Thurn, J.; Tinnefeld, P.; van Noort, J.; Weiss, S.; Wendler, N.; Barth, A.; Seidel, C. A. M.; Lamb, D. C.; Cordes, T.
10.1101/2022.08.03.502619 — biophysics — Posted on 2022-08-05
3280 Mouse Skeletal Muscle Decrease in the MICOS Complex and Altered Mitochondrial Networks with age
Vue, Z.; Lopez, E. G.; Neikirk, K.; Vang, L.; Beasley, H.; Shao, J.; Marshall, A. G.; Crabtree, A.; Evans, C.; Taylor, B.; Christensen, T. A.; Lam, J.; Rodriguez, B.; Phillips, M. A.; Davis, J.; Reddy, A. K.; Quintana, A. M.; Murray, S. A.; Exil, V.; Mobley, B. C.; Gomez, J. A.; Dai, D.-F.; Hinton, A.
10.1101/2022.03.22.485341 — biophysics — Posted on 2022-08-05
3282 Expansion microscopy at one nanometer resolution
Shaib, A. H.; Chouaib, A. A.; Imani, V.; Chowdhury, R.; Georgiev, S. V.; Mougios, N.; Monga, M.; Reshetniak, S.; Mihaylov, D.; Chen, H.; Fatehbasharzad, P.; Crzan, D.; Saal, K. A.; Trenkwalder, C.; Mollenhauer, B.; Outeiro, T. F.; Preobraschenski, J.; Becherer, U.; Moser, T.; Boyden, E. S.; Aricescu, A. R. A.; Sauer, M.; Opazo, F.; Rizzoli, S.
10.1101/2022.08.03.502284 — biophysics — Posted on 2022-08-05
3283 Coarse-graining made easy with the MArtini Database Server
Hilpert, C.; Beranger, L.; Souza, P. C. T.; Vainikka, P. A.; Nieto, V.; Marrink, S. J.; Monticelli, L.; Launay, G.
10.1101/2022.08.03.502585 — biophysics — Posted on 2022-08-05
3284 CaMKII activity spreads by inter-holoenzyme phosphorylation
Lucic, I.; Heluin, L.; Jiang, P.-L.; Castro Scalise, A. G.; Wang, C.; Franz, A.; Wahl, M.; Liu, F.; Plested, A. J. R.
10.1101/2022.08.03.502606 — biophysics — Posted on 2022-08-05
3285 ALOHA: AI-guided tool for the quantification of venom-induced haemorrhage in mice
Jenkins, T. P.; Laprade, W. M.; Sanchez, A.; Tulika, T.; OBrien, C.; Sorensen, C. V.; Stewart, T. K.; Fryer, T.; Laustsen, A. H.; Gutierrez, J. M.
10.1101/2022.08.04.502754 — bioinformatics — Posted on 2022-08-05
3286 LambdaPP: Fast and accessible protein-specific phenotype predictions
Olenyi, T.; Marquet, C.; Heinzinger, M.; Kroeger, B.; Nikolova, T.; Saendig, P.; Bernhofer, M.; Schuetze, K.; Littmann, M.; Mirdita, M.; Steinegger, M.; Dallago, C.; Rost, B.
10.1101/2022.08.04.502750 — bioinformatics — Posted on 2022-08-05
3288 Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics
Gueto Tettay, C. A.; Tang, D.; Happonen, L.; Heusel, M.; Khakzad, H.; Malmström, J.; Malmström, L.
10.1101/2022.08.03.502594 — bioinformatics — Posted on 2022-08-05
3289 High-frequency quantitative ultrasound to assess the acoustic properties of engineeredtissues in vitro
Sebastian, J. A.; Strohm, E. M.; Cherin, E.; Mirani, B.; Demore, C.; Kolios, M. C.; Simmons, C. A.
10.1101/2022.08.03.502702 — bioengineering — Posted on 2022-08-05
3292 The hologenome of Osedax frankpressi reveals the genetic interplay for the symbiotic digestion of vertebrate bone
Moggioli, G.; Panossian, B.; Sun, Y.; Thiel, D.; Martin-Zamora, F. M.; Tran, M.; Clifford, A. M.; Goffredi, S. K.; Rimskaya-Korsakova, N.; Jekelly, G.; Tresguerres, M.; Qian, P.-Y.; Qiu, J.-W.; Rouse, G. W.; Henry, L. M.; Martin-Duran, J. M.
10.1101/2022.08.04.502725 — genomics — Posted on 2022-08-05
3294 Proteostasis governs differential temperature sensitivity across embryonic cell types
Dorrity, M. W.; Saunders, L. M.; Duran, M.; Srivatsan, S. R.; Ewing, B.; Queitsch, C.; Shendure, J.; Raible, D.; Kimelman, D.; Trapnell, C.
10.1101/2022.08.04.502669 — genomics — Posted on 2022-08-05
3295 Ecology, not host phylogeny, shapes the oral microbiome in closely related species of gorillas
Moraitou, M.; Forsythe, A.; Fellows Yates, J. A.; Brealey, J. C.; Warinner, C.; Guschanski, K.
10.1101/2022.06.06.494923 — evolutionary biology — Posted on 2022-08-05
3297 Re-inventing pathogen passage for social microbes
Dimitriu, T.; Souissi, W.; Morwool, P.; Darby, A.; Crickmore, N.; Raymond, B.
10.1101/2022.08.04.502769 — evolutionary biology — Posted on 2022-08-05
3298 Resource asynchrony and landscape homogenization as drivers of virulence evolution
Kürschner, T.; Scherer, C.; Radchuk, V.; Blaum, N.; Kramer-Schadt, S.
10.1101/2022.08.03.502590 — ecology — Posted on 2022-08-05
3302 Heterodimerization-dependent secretion of BMPs in Drosophila
Bauer, M.; Aguilar, G.; Wharton, K. A.; Matsuda, S.; Affolter, M.
10.1101/2022.08.04.502599 — developmental biology — Posted on 2022-08-05
3303 Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5
Tamura, T.; Yamasoba, D.; Oda, Y.; Ito, J.; Kamasaki, T.; Nao, N.; Hashimoto, R.; Fujioka, Y.; Suzuki, R.; Wang, L.; Ito, H.; Kimura, I.; Yokota, I.; Kishimoto, M.; Tsuda, M.; Sawa, H.; Yoshimatsu, K.; Ohba, Y.; Yamamoto, Y.; Nagamoto, T.; Kanamune, J.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Matsuno, K.; Takayama, K.; Tanaka, S.; Sato, K.; Fukuhara, T.
10.1101/2022.08.05.502758 — microbiology — Posted on 2022-08-05
3304 SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes
Qu, B.; Miskey, C.; Goemer, A.; Potmus, D.; Nocke, M.; Kleinert, R. D. V.; Itotia, T. K.; Valder, L.; Brueckmann, J.; Hoeck, S.; Hastert, F. D.; von Rhein, C.; Schuermann, C.; Ebenig, A.; Widera, M.; Ciesek, S.; Pfaender, S.; Ivics, Z.; Schnierle, B. S.; Tarr, A. W.; Goffinet, C.; Muehlebach, M. D.; Todt, D.; Brown, R. J. P.
10.1101/2022.08.05.502936 — microbiology — Posted on 2022-08-05
3305 mRNA vaccines and hybrid immunity use different B cell germlines to neutralize Omicron BA.4 and BA.5
Andreano, E.; Paciello, I.; Pierleoni, G.; Maccari, G.; Antonelli, G.; Abbiento, V.; Pileri, P.; Benincasa, L.; Giglioli, G.; Piccini, G.; De Santi, C.; Sala, C.; Medini, D.; Montomoli, E.; Maes, P.; Rappuoli, R.
10.1101/2022.08.04.502828 — immunology — Posted on 2022-08-05
3306 The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation
Fettig, N. M.; Robonson, H. G.; Allanach, J. R.; Davis, K. M.; Simister, R. L.; Wang, E. J.; Sharon, A. J.; Jiayu, Y.; Popple, S. J.; Gibson, D. L.; Crowe, S. A.; Horwitz, M. S.; Osborne, L. C.
10.1101/2022.08.04.502686 — immunology — Posted on 2022-08-05
3307 Persistent Hypersomnia Following Repetitive Mild Experimental Traumatic Brain Injury: Roles of Chronic Stress and Sex Differences
Portillo, E.; Zi, X.; Kim, Y.; Tucker, L. B.; Fu, A.; Miller, L. A.; Valenzuela, K. S.; Sullivan, G. M.; Gauff, A. K.; Yu, F.; Radomski, K. L.; McCabe, J. T.; Armstrong, R. C.
10.1101/2022.08.03.502603 — neuroscience — Posted on 2022-08-05
3308 Effect of contact pressure on porcine postmortem brain tissue impedance
Possner, L.; Wilhelmy, F.; Pliquett, U.; Knoesche, T.; Weise, K.; Lindner, D.
10.1101/2022.08.04.502741 — neuroscience — Posted on 2022-08-05
3309 AVP neurons act as the primary circadian pacesetter cells in vivo
Tsuno, Y.; Peng, Y.; Horike, S.-i.; Yamagata, K.; Sugiyama, M.; Nakamura, T. J.; Daikoku, T.; Maejima, T.; Mieda, M.
10.1101/2022.08.04.502742 — neuroscience — Posted on 2022-08-05
3311 Activation of Cerebellar Lobule VI PCTH+boxhMed Pathway Selectively blocks METH-induced Conditioned Place Preference in mice
Ge, F.; Wang, Z.; Wang, G.; Chen, L.; Yang, P.; Wen, J.; Pan, W.; Yu, W.; Cai, Q.; Fan, Y.; Chang, J.; Guan, X.
10.1101/2022.08.04.502761 — neuroscience — Posted on 2022-08-05
3315 Nanoblades allow high-level genome editing in organoids
Tiroille, V.; Krug, A.; Bokobza, E.; Bulcaen, M.; Ensinck, M.; Geurts, M.; Hendriks, D.; Vermeulen, F.; Larbret, F.; gutierrez-Guerrero, A.; Louise, M.; Gijsbers, R.; Mangeot, P. E.; Clevers, H.; Carlon, M.; Bost, F.; Verhoeyen, E.
10.1101/2022.08.04.502859 — bioengineering — Posted on 2022-08-05
3317 Disrupting cellular memory to overcome drug resistance
Harmange, G.; Reyes Hueros, R. A.; Schaff, D. L.; Emert, B. L.; Saint-Antoine, M. M.; Nellore, S.; Fane, M. E.; Alicea, G. M.; Weeraratna, A. T.; Singh, A.; Shaffer, S. M.
10.1101/2022.06.16.496161 — systems biology — Posted on 2022-08-05
3321 Estimating abundance of a recovering transboundary brown bear population with capture-recapture models
Vanpe, C.; Piedallu, B.; Quenette, P.-Y.; Sentilles, J.; Queney, G.; Palazon, S.; Jordana, I. A.; Jato, R.; Irurtia, M. M. E.; de la Torre, J. S.; Gimenez, O.
10.1101/2021.12.08.471719 — ecology — Posted on 2022-08-05
3322 Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Mouse Blastocyst-derived Stem Cells
Thomas, C.; Haimson, R. B.; Zacharia, A.; Orih, P.; Shehadeh, A.; Saidemberg, D.; Kogan, N. M.; Alfandary, S.; Serruya, R.; Dagan, A.; Petit, I.; Moussaieff, A.
10.1101/2022.07.28.501839 — developmental biology — Posted on 2022-08-05
3324 Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae
Bueno, E.; Typas, A.; Savitski, M.; Mateus, A.; Pinedo, V.; Shinde, D.; Thomas, V.; Cava, F.
10.1101/2022.08.04.502822 — microbiology — Posted on 2022-08-05
3326 Trait Stacking Simultaneously Enhances Provitamin A Carotenoid and Mineral Bioaccessibility in Biofortified Sorghum bicolor
Dzakovich, M. P.; Debelo, H.; Albertsen, M. C.; Che, P.; Jones, T. J.; Simon, M. K.; Zhao, Z.-Y.; Glassman, K.; Ferruzzi, M. G.
10.1101/2022.08.03.501587 — plant biology — Posted on 2022-08-05
3327 Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron
Lemercier, C. E.; Garenne, A.; Poulletier de Gannes, F.; El Khoueiry, C.; Arnaud-Cormos, D.; Leveque, P.; Lagroye, I.; Percherancier, Y.; Lewis, N.
10.1101/2022.04.05.487108 — neuroscience — Posted on 2022-08-05
3328 Hepatocellular carcinoma hosts immature neurons and cholinergic tumors that correlate with adverse molecular features and outcomes
Hernandez, C. A.; Verzeroli, C.; Chicherova, I.; Farca-Luna, A.-J.; Tonon, L.; Bellaud, P.; Turlin, B.; Fautrel, A.; Macek-Jilkova, Z.; Decaens, T.; Rebouissou, S.; Viari, A.; Zoulim, F.; Parent, R.
10.1101/2022.06.14.495889 — cancer biology — Posted on 2022-08-05
3329 Modelling biochemical gradients in vitro to control cell compartmentalization in a microengineered 3D model of the intestinal epithelium
Altay, G.; Abad-Lazaro, A.; Gualda, E. J.; Folch, J.; Insa, C.; Tosi, S.; Hernando-Momblona, X.; Batlle, E.; Loza, P.; Fernandez-Majada, V.; Martinez, E.
10.1101/2021.12.13.472418 — bioengineering — Posted on 2022-08-05
3332 Warming During Embryogenesis Induces a Lasting Transcriptomic Signature in Fishes
Ripley, D. M.; Garner, T.; Hook, S. A.; Verissimo, A.; Grunow, B.; Moritz, T.; Clayton, P.; Shiels, H. A.; Stevens, A.
10.1101/2021.12.07.470713 — developmental biology — Posted on 2022-08-05
3333 Comparative study between radiofrequency-induced and muscimol-induced inhibition of cul-tured networks of cortical neuron
Lemercier, C. E.; Garenne, A.; Poulletier de Gannes, F.; El Khoueiry, C.; Arnaud-Cormos, D.; Leveque, P.; Lagroye, I.; Percherancier, Y.; Lewis, N.
10.1101/2022.04.05.487108 — neuroscience — Posted on 2022-08-05
3337 Intermediate Filaments Associate with Aggresome-like Structures and Influence Rate of Cellular Expulsion of Neuronal Disease Aggregates
Arnold, M. L.; Cooper, J. F.; Androwski, R.; Ardeshna, S.; Melentijevic, I.; Smart, A. J.; Guasp, R. J.; Nguyen, K. C.; Bai, G.; Hall, D. H.; Grant, B. D.; Driscoll, M.
10.1101/2022.08.03.501714 — cell biology — Posted on 2022-08-05
3340 Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein1 (LRP1) as crucial cellular receptor
Schmidt, G.; Schoellkopf, J.; Mueller, T.; Hippchen, L.; Mueller, T.; Grossmann, S.; Reuten, R.; Backofen, R.; Klugbauer, N.; Orth, J.
10.1101/2022.08.04.502755 — pharmacology and toxicology — Posted on 2022-08-05
3342 Rhometa: Population recombination rate estimation from metagenomic read datasets
Krishnan, S.; DeMaere, M. Z.; Beck, D.; Ostrowski, M.; Seymour, J. R.; Darling, A. E.
10.1101/2022.08.04.502887 — bioinformatics — Posted on 2022-08-05
3353 Distinct hyperactive RAS/MAPK alleles converge on common GABAergic interneuron core programs
Knowles, S. J.; Stafford, A. M.; Zaman, T.; Angara, K.; Williams, M. R.; Newbern, J. M.; Vogt, D.
10.1101/2022.08.04.502867 — neuroscience — Posted on 2022-08-05
3354 The sum and the parts: dynamics of multiple and individual metastases during adaptive therapy
Gallaher, J. A.; Strobl, M.; West, J.; Zhang, J.; Gatenby, R. A.; Robertson-Tessi, M.; Anderson, A. R. A.
10.1101/2022.08.04.502852 — systems biology — Posted on 2022-08-05
3355 From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles
Naudin, E. A.; Albanese, K. I.; Smith, A. J.; Mylemans, B.; Baker, E. G.; Weiner, O. D.; Andrews, D. M.; Tigue, N.; Savery, N. J.; Woolfson, D. N.
10.1101/2022.08.04.502660 — synthetic biology — Posted on 2022-08-05
3356 Precision engineering of biological function with large-scale measurements and machine learning
Tack, D. S.; Tonner, P. D.; Pressman, A.; Olson, N. D.; Levy, S. F.; Romantseva, E. F.; Alperovich, N.; Vasilyeva, O.; Ross, D.
10.1101/2022.08.04.502789 — synthetic biology — Posted on 2022-08-05
3358 Structural basis for lipid and copper regulation of the ABC transporter MsbA
Lyu, J.; Liu, C.; Zhang, T.; Schrecke, S.; Elam, N.; Hocberg, G.; Russell, D.; Zhao, M.; Laganowsky, A.
10.1101/2022.08.04.502837 — biochemistry — Posted on 2022-08-04
3359 Regioselective control of biocatalytic C-H activation and halogenation
Kissman, E. N.; Neugebauer, M. E.; Sumida, K. H.; Swenson, C. V.; Sambold, N. A.; Marchand, J. A.; Millar, D. C.; Chang, M. C. Y.
10.1101/2022.08.04.502814 — biochemistry — Posted on 2022-08-05
3361 Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Wang, J. Y.; Khmelinskaia, A.; Sheffler, W.; Miranda, M. C.; Antanasijevic, A.; Borst, A. J.; Torres, S. V.; Shu, C.; Hsia, Y.; Nattermann, U.; Ellis, D.; Walkey, C.; Ahlrichs, M.; Chan, S.; Kang, A.; Nguyen, H.; Sydeman, C.; Sankaran, B.; Wu, M.; Bera, A. K.; Carter, L.; Fiala, B.; Murphy, M.; Baker, D.; Ward, A.; King, N. P.
10.1101/2022.08.04.502842 — biochemistry — Posted on 2022-08-05
3363 Influenza A virus liquid condensates can undergo pharmacological hardening
Etibor, T. A.; Sridharan, S.; Vale-Costa, S.; Bras, D.; Becher, I.; Vello, V.; Ferreira, F.; Alenquer, M.; Savitski, M. M.; Amorim, M. J.
10.1101/2022.08.03.502602 — cell biology — Posted on 2022-08-05
3364 CRHR1-mediated Akt activation involves endocytosis and soluble adenylyl cyclase activity
dos Santos Claro, P. A.; Armando, N. G.; Attorresi, A.; Lindl, K. E.; Silbermins, M.; Inda, C.; Silberstein, S.
10.1101/2022.08.04.502800 — cell biology — Posted on 2022-08-05
3365 Cellular Uptake of His-Rich Peptide Coacervates Occurs by a Macropinocytosis-Like Mechanism
Shebanova, A.; Perrin, Q.; Gudlur, S.; Sun, Y.; Lim, Z. W.; Sun, R.; Lim, S.; Ludwig, A.; Miserez, A.
10.1101/2022.08.04.502757 — cell biology — Posted on 2022-08-05
3366 Talin regulates steady-state tensional homeostasis to drive vascular morphodynamics and cancer
Nikolopoulou, P.; Arapatzi, C.; Rouni, G.; MItrossilis, D.; Gaitanis, A.; Anagnostopoulos, C. D.; Grammenoudi, S.; Kostourou, V.
10.1101/2022.08.03.502607 — cell biology — Posted on 2022-08-05
3368 CAMSAP-driven microtubule release from γ-TuRC and its regulation by nucleation-promoting factors
Rai, D.; Hua, S.; Monster, J. L.; Stucchi, R.; Stecker, K.; Zhang, Y.; Katrukha, E. A.; Altelaar, M. A.; Wieczorek, M.; Jiang, K.; Akhmanova, A.
10.1101/2022.08.03.502613 — cell biology — Posted on 2022-08-05
3369 Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches
Madhivanan, K.; Subramanian, S.; Cao, L.; Mukherjee, D.; Sen, A.; Hsieh, W.-C.; Hanna, C. B.; Wang, B.; Chen, H.; Staiger, C. J.; Aguilar, R. C.
10.1101/2022.08.04.502746 — cell biology — Posted on 2022-08-05
3371 Mitochondrial uncouplers impair human sperm motility without altering ATP content
Skinner, W. M.; Petersen, N. T.; Unger, B.; Tang, S.; Tabarsi, E.; Lamm, J.; Jalalian, L.; Smith, J.; Bertholet, A. M.; Xu, K.; Kirichok, Y.; Lishko, P.
10.1101/2022.08.04.502752 — cell biology — Posted on 2022-08-05
3373 Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae
Bueno, E.; Cava, F.; Typas, A.; Savitski, M.; Mateus, A.; Pinedo, V.; Shinde, D.; Thomas, V.
10.1101/2022.08.04.502822 — microbiology — Posted on 2022-08-04
3374 Phages against non-capsulated Klebsiella pneumoniae: broader host range, slower resistance
Lourenco, M.; Osbelt, L.; Passet, V.; Gravey, F.; Strowig, T.; Rodrigues, C.; Brisse, S.
10.1101/2022.08.04.502604 — microbiology — Posted on 2022-08-04
3381 Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins
Hirose, Y.; Poudel, S.; Sastry, A. V.; Szubin, R.; Zielinski, D. C.; Lim, H. G.; Menon, N. D.; Bergsten, H.; Uchiyama, S.; Hanada, T.; Kawabata, S.; Palsson, B. O.; Nizet, V.
10.1101/2022.08.04.502797 — microbiology — Posted on 2022-08-04
3382 Vibrio cholerae alkalizes its environment via citrate metabolism to inhibit enteric growth
Kostiuk, B.; Becker, M. E.; Churaman, C. N.; Black, J. J.; Payne, S. M.; Pukatzki, S.; Koestler, B. J.
10.1101/2022.08.04.502819 — microbiology — Posted on 2022-08-04
3394 A specific anti-IFITM2 antibody bars the way to SARS-CoV-2 entry into host cells.
Basile, A.; Zannella, C.; De Marco, M.; Franci, G.; Galdiero, M.; Sanna, G.; Manzin, A.; Chetta, M.; Turco, M. C.; Rosati, A.; Marzullo, L.
10.1101/2022.08.04.502768 — microbiology — Posted on 2022-08-04
3395 Double-dose mRNA vaccination to SARS-CoV-2 progressively increases recognition of variants-of-concern by Spike RBD-specific memory B cells
Hartley, G. E.; Edwards, E. S. J.; Varese, N.; Boo, I.; Aui, P. M.; Bornheimer, S. J.; Hogarth, P. M.; Drummer, H. E.; O'Hehir, R. E.; van Zelm, M. C.
10.1101/2022.08.03.502703 — immunology — Posted on 2022-08-04
3397 Running modulates primate and rodent visual cortex via common mechanism but quantitatively distinct implementation
Liska, J. P.; Rowley, D. P.; Nguyen, T. T. K.; Muthmann, J.-O.; Butts, D. A.; Yates, J. L.; Huk, A. C.
10.1101/2022.06.13.495712 — neuroscience — Posted on 2022-08-04
3398 Hippocampal Place-like Signal in Latent Space
Schafer, M.; Kamilar-Britt, P.; Sahani, V.; Bachi, K.; Schiller, D.
10.1101/2022.07.15.499827 — neuroscience — Posted on 2022-08-04
3399 A long interval between priming and boosting SARS-CoV-2 mRNA vaccine doses enhances B cell responses with limited impact on T cell immunity
Nicolas, A.; Sannier, G.; Dube, M.; Nayrac, M.; Painter, M. M.; Goel, R. R.; Laporte, M.; Medjahed, H. R.; Williams, J.; Brassard, N.; Niessl, J.; Gokool, L.; Morrisseau, C.; Arlotto, P.; Tremblay, C.; Martel-Laferriere, V.; Finzi, A.; Greenplate, A.; Wherry, E. J.; Kaufmann, D. E.
10.1101/2022.08.03.502672 — immunology — Posted on 2022-08-04
3400 Neutralization sensitivity of the SARS-CoV-2 Omicron BA.2.75 sublineage
Gruell, H.; Vanshylla, K.; Tober-Lau, P.; Hillus, D.; Sander, L. E.; Kurth, F.; Klein, F.
10.1101/2022.08.04.502609 — immunology — Posted on 2022-08-04
3401 Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents
Cao, Y. R.; Jian, F.; Zhang, Z.; Yisimayi, A.; Hao, X.; Bao, L.; Yuan, F.; Yu, Y.; Du, S.; Wang, J.; Xiao, T.; Song, W.; Zhang, Y.; Liu, P.; An, R.; Wang, P.; Wang, Y.; Yang, S.; Niu, X.; Zhang, Y.; Gu, Q.; Shao, F.; Hu, Y.; Yin, W.; Zheng, A.; Wang, Y.; Qin, C.; Jin, R.; Xiao, J.; Xie, X. S.
10.1101/2022.08.03.499114 — immunology — Posted on 2022-08-04
3404 Coordinated cadherin functions sculpt respiratory motor circuit connectivity
Vagnozzi, A. N.; Moore, M. T.; Lin, M.; Brozost, E. M.; KC, R.; Agarwal, A.; Schwarz, L. A.; Duan, X.; Zampieri, N.; Landmesser, L. T.; Philippidou, P.
10.1101/2022.08.02.502511 — neuroscience — Posted on 2022-08-04
3405 Disrupting cellular memory to overcome drug resistance
Harmange, G.; Reyes Hueros, R. A.; Schaff, D. L.; Emert, B. L.; Saint-Antoine, M. M.; Nellore, S.; Fane, M. E.; Alicea, G. M.; Weeraratna, A. T.; Singh, A.; Shaffer, S. M.
10.1101/2022.06.16.496161 — systems biology — Posted on 2022-08-04
3409 Analysis of pre-symptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration
Garcia-Vaquero, M.; Heim, M.; Flix, B.; Pereira, M.; Palin, L.; Marques, T. M.; Pinto, F. R.; DE LAS RIVAS, J.; Voigt, A.; Besse, F.; Gama-Carvalho, M.
10.1101/2022.06.20.496821 — neuroscience — Posted on 2022-08-04
3415 A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA
de Regt, A. K.; Anand, K.; Ciupka, K.; Gatterdam, K.; Putschli, B.; Fusshoeller, D.; Hilbig, D.; Kirchhoff, A.; Hunkler, C.; Wolter, S.; Gruenewald, A.; Schuberth-Wagner, C.; Ludwig, J.; Paeschke, K.; Bartok, E.; Zillinger, T.; Hagelueken, G.; Hartmann, G.; Geyer, M.; Schlee, M.
10.1101/2022.08.02.502180 — immunology — Posted on 2022-08-04
3417 Sleep/wake changes in perturbational complexity in rats and mice
Cavelli, M. L.; Mao, R.; Findlay, G.; Driessen, K.; Bugnon, T.; Tononi, G.; Cirelli, C.
10.1101/2022.08.02.502525 — neuroscience — Posted on 2022-08-04
3418 Ablation of Tmem65 Causes Lethal Mitochondrial Encephalomyopathy in Mouse
Zhang, Y.; Willingham, T. B.; Reyes, L.; Liu, C.; Springer, D.; Noguchi, A. C.; Aponte, A. M.; Munasinghe, J.; Covian, R.; Glancy, B.
10.1101/2022.08.02.502535 — physiology — Posted on 2022-08-04
3421 IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2.
Laliotis, G. I.; Kenney, A.; Chavdoula, E.; Orlacchio, A.; Kaba, A. K.; La Ferlita, A.; Anastas, V.; Tsatsanis, C.; Beane, J. D.; Sehgal, L.; Coppola, V.; Yount, J. S.; Tsichlis, P. N.
10.1101/2020.12.26.424461 — cancer biology — Posted on 2022-08-04
3423 AbBERT: Learning Antibody Humanness via Masked Language Modeling
Vashchenko, D.; Nguyen, S.; Goncalves, A.; Leno da Silva, F.; Petersen, B.; Desautels, T.; Faissol, D.
10.1101/2022.08.02.502236 — bioinformatics — Posted on 2022-08-04
3424 Untethered Muscle Tracking Using Magnetomicrometry
Taylor, C. R.; Yeon, S. H.; Clark, W. H.; Clarrissimeaux, E. G.; O'Donnell, M. K.; Roberts, T. J.; Herr, H. M.
10.1101/2022.08.02.502527 — bioengineering — Posted on 2022-08-04
3426 Genetic architecture of natural variation of cardiac performance in flies: from flies to Humans
Saha, S.; Spinelli, L.; Castro-Mondragon, J. A.; Kervadec, A.; Lynott, M.; Kremmer, L.; Roder, L.; Krifa, S.; Torres, M.; Brun, C.; Vogler, G.; Bodmer, R.; COLAS, A.; Ocorr, K.; Perrin, L.
10.1101/2021.06.08.447524 — genetics — Posted on 2022-08-04
3428 Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis
Zhang, B.; Tarkhov, A. E.; Ratzan, W.; Ying, K.; Moqri, M.; Poganik, J. R.; Barre, B. P.; Trapp, A.; Zoller, J. A.; Haghani, A.; Horvath, S.; Peshkin, L.; Gladyshev, V. N.
10.1101/2022.08.02.502559 — genetics — Posted on 2022-08-04
3431 Global convergence of dominance and neglect in flying insect diversity
Srivathsan, A.; Ang, Y.; Heraty, J.; Hwang, W. S.; Wan, J. F. A.; Kutty, S. N.; Puniamoorthy, J.; Yeo, D.; Roslin, T.; Meier, R.
10.1101/2022.08.02.502512 — ecology — Posted on 2022-08-04
3433 Direct Speech Reconstruction from Sensorimotor Brain Activity with Optimized Deep Learning Models
Berezutskaya, J.; Freudenburg, Z. V.; Vansteensel, M. J.; Aarnoutse, E. J.; Ramsey, N. F.; van Gerven, M. A. J.
10.1101/2022.08.02.502503 — neuroscience — Posted on 2022-08-04
3434 Selective Androgen Receptor Modulator Microparticle Formulation Reverses Muscle Hyperalgesia in Mouse Model of Widespread Muscle Pain
Lesnak, J. B.; Nakhla, D. S.; Plumb, A. N.; McMillan, A.; Saha, S.; Gupta, N.; Xu, Y.; Phruttiwanichakun, P.; Rasmussen, L.; Meyerholz, D. K.; Salem, A. K.; Sluka, K. A.
10.1101/2022.08.02.502353 — neuroscience — Posted on 2022-08-04
3436 A novel beta-adrenergic like octopamine receptor modulates the audition of malaria mosquitoes and serves as insecticide target
Georgiades, M.; Alampounti, C. A.; Somers, J.; Su, M.; Ellis, D.; Bagi, J.; Ntabaliba, W.; Moore, S. J.; Albert, J. T.; Andres, M.
10.1101/2022.08.02.502538 — neuroscience — Posted on 2022-08-04
3438 Acquirement of the autonomic nervous system modulation evaluated by heart rate variability in medaka (Oryzias latipes)
Watanabe-Asaka, T.; Niihori, M.; Igarashi, K.; Oda, S.; Iwasaki, K.-i.; Katada, Y.; Yamashita, T.; Sonobe, H.; Terada, M.; Baba, S. A.; Mitani, H.; Mukai, C.
10.1101/2022.08.02.502546 — physiology — Posted on 2022-08-04
3439 Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program.
Laliotis, G. I.; Chavdoula, E.; Anastas, V.; Singh, S.; Kenney, A. I.; Achaya, S.; Yount, J. S.; Sehgal, L.; Tsichlis, P. N.
10.1101/2021.08.12.454141 — cancer biology — Posted on 2022-08-04
3440 IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.
Laliotis, G. I.; Chavdoula, E.; Paraskevopoulou, M. D.; Kaba, A. D.; La Ferlita, A.; Singh, S.; Anastas, V.; Alaimo, S.; Orlacchio, A.; Nair, K. A.; Taraslia, V.; Vlachos, I.; Capece, M.; Hatzigeorgiou, A.; Palmieri, D. I.; Tsatsanis, C.; Sehgal, L.; Carbone, D. P.; Coppola, V.; Tsichlis, P. N.
10.1101/2020.07.14.195297 — cancer biology — Posted on 2022-08-04
3442 Oncogenic EFNA4 amplification promotes lung adenocarcinoma lymph node metastasis
Zhao, X.; Chen, Y.; Sun, X.; He, Z.; Wu, T.; Wu, C.; Chen, J.; Wang, J.; Diao, K.; Liu, X.-S.
10.1101/2022.08.01.502413 — cancer biology — Posted on 2022-08-04
3443 A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response
Xu, L.; Saunders, K. N.; Knutsdottir, H.; Chen, K.; Maues, J.; Hodgdon, C.; Roussos-Torres, E. T.; Reddy, S.; Xu, L.; Chan, I. S.
10.1101/2022.08.01.501918 — cancer biology — Posted on 2022-08-04
3444 Activation of hTREK-1 by polyunsaturated fatty acids does not only involve membrane tension
Bechard, E.; Arel, E.; Bride, J.; Louradour, J.; Bussy, X.; Elloumi, A.; Vigor, C.; Oger, C.; Galano, J.-M.; Durand, T.; Le Guennec, J.-Y.; Demion, M.
10.1101/2022.08.01.502268 — biophysics — Posted on 2022-08-04
3445 α-Arrestins maintain phospholipid balance and Atg18 distribution to permit efficient autophagy
Bowman, R. W.; Davis, S.; Jordahl, E. M.; Chera, K.; Ozbaki-Yagan, N.; Franks, J.; Hawbaker, S.; Chiang, A.; Acar, O.; Beer-Stoltz, D.; ODonnell, A. F.
10.1101/2022.08.03.502596 — cell biology — Posted on 2022-08-04
3446 Competitive HIV budding suggests that a self-packaging gRNA:Gag-Pol complex directs HIV assembly and enforces infectivity.
Durden, H.; Saha, I.; Preece, B.; MacArthur, B.; Petersen, A.; Peppel, W.; Gallegos, R.; Saffarian, S.
10.1101/2022.08.03.502595 — microbiology — Posted on 2022-08-04
3447 Helicobacter chronic stage inflammation undergoes fluctuations that are altered in tlpA mutants
Johnson, K. S.; Yang, C.; Carter, J. E.; Worthington, A.; Robinson, E. K.; Lopez Magana, R.; Salgado, F.; Arnold, I.; Ottemann, K. M.
10.1101/2022.08.01.502425 — microbiology — Posted on 2022-08-04
3448 RNA-protein interactome at the Hepatitis E virus internal ribosome entry site
Kumar, S.; Verma, R.; Saha, S.; Agrahari, A.; Shukla, S.; Anurag, ; Maiti, T. K.; Asthana, S.; Ranjith-Kumar, C. T.; Surjit, M.
10.1101/2022.04.11.487827 — microbiology — Posted on 2022-08-04
3449 A multispecific antibody confers pan-reactive SARS-CoV-2 neutralization and prevents immune escape
Misasi, J.; Wei, R. R.; Wang, L.; Pegu, A.; Wei, C.-J.; Oloniniyi, O.; Zhou, T.; Zhao, B.; Choe, M.; Boruszczak, M.; Chen, M.; Leung, K.; Li, J.; Yang, E. S.; Yang, Z.-Y.; Zhang, Y.; Carlton, K.; Harris, D. R.; Ivleva, V. B.; Lei, P.; Liu, C.; Longobardi, L.; Olia, A. S.; Shi, W.; Wolff, J. J.; Gall, J.; Koup, R. A.; Kwong, P. D.; Mascola, J. R.; Nabel, G. J.; Sullivan, N. J.
10.1101/2022.07.29.502029 — immunology — Posted on 2022-08-04
3450 Coordinated cadherin functions sculpt respiratory motor circuit connectivity
Vagnozzi, A. N.; Moore, M. T.; Lin, M.; Brozost, E. M.; KC, R.; Agarwal, A.; Lindsay, S.; Duan, X.; Zampieri, N.; Landmesser, L. T.; Philippidou, P.
10.1101/2022.08.02.502511 — neuroscience — Posted on 2022-08-04
3451 A Role for the Fornix in Temporal Sequence Memory
Read, M.-L.; Umla-Runge, K.; Lawrence, A. D.; Costigan, A. G.; Hsieh, L.-T.; Chamberland, M.; Ranganath, C.; Graham, K. S.
10.1101/2022.08.01.498998 — neuroscience — Posted on 2022-08-04
3452 Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity
Rem, P. D.; Sereikaite, V.; Fernandez-Fernandez, D.; Reinartz, S.; Ulrich, D.; Fritzius, T.; Trovo, L.; Roux, S.; Chen, Z.; Rondard, P.; Pin, J.-P.; Schwenk, J.; Fakler, B.; Gassmann, M.; Barkat, T. R.; Stromgaard, K.; Bettler, B.
10.1101/2022.08.02.502499 — neuroscience — Posted on 2022-08-04
3453 Comparative study between radiofrequency- and muscimol-induced inhibition of cultured networks of cortical neuron
Lemercier, C. E.; Garenne, A.; Poulletier de Gannes, F.; El Khoueiry, C.; Arnaud-Cormos, D.; Leveque, P.; Lagroye, I.; Percherancier, Y.; Lewis, N.
10.1101/2022.05.05.490795 — neuroscience — Posted on 2022-08-04
3455 Sequence Dependent UV Damage of Complete Pools of Oligonucleotides
Kufner, C. L.; Krebs, S.; Fischaleck, M.; Philippou-Massier, J.; Blum, H.; Bucher, D. B.; Braun, D.; Zinth, W.; Mast, C. B.
10.1101/2022.08.01.502267 — biophysics — Posted on 2022-08-04
3458 Genome-wide single cell annotation of the human protein-coding genes
Karlsson, M. J.; Bueno Alvez, M.; Shi, M.; Mear, L.; Schutten, R.; Hikmet, F.; Digre, A.; Katona, B.; Vuu, J.; Bosic, M.; Sjöstedt, E.; Edfors, F.; Oksvold, P.; von Feilitzen, K.; Zwahlen, M.; Forsberg, M.; Johansson, F.; Mulder, J.; Hökfelt, T.; Luo, Y.; Butler, L.; Zhong, W.; Mardinoglu, A.; Sivertsson, A.; Ponten, F.; Zhang, C.; Lindskog, C.; Fagerberg, L.; Uhlen, M.
10.1101/2022.08.03.502627 — systems biology — Posted on 2022-08-04
3459 The redlegged earth mite draft genome provides new insights into pesticide resistance evolution and demography in its invasive Australian range
Thia, J. A.; Korhonen, P. K.; Young, N. D.; Gasser, R. B.; Umina, P. A.; Yang, Q.; Edwards, O.; Walsh, T.; Hoffmann, A. A.
10.1101/2022.08.03.502713 — genomics — Posted on 2022-08-04
3460 Single cell, whole embryo phenotyping of pleiotropic disorders of mammalian development
Huang, X.; Henck, J.; Qiu, C.; Sreenivasan, V. K. A.; Balachandran, S.; Behncke, R.; Chan, W.-L.; Despang, A.; Dickel, D. E.; Haag, N.; Hagerling, R.; Hansmeier, N.; Hennig, F.; Marshall, C.; Rajderkar, S.; Ringel, A.; Robson, M.; Saunders, L.; Srivatsan, S. R.; Ulferts, S.; Wittler, L.; Zhu, Y.; Kalscheuer, V. M.; Ibrahim, D.; Kurth, I.; Kornak, U.; Beier, D. R.; Visel, A.; Pennacchio, L. A.; Trapnell, C.; Cao, J.; Shendure, J.; Spielmann, M.
10.1101/2022.08.03.500325 — genomics — Posted on 2022-08-04
3463 Canonical Wnt signaling regulates soft palate development through mediating ciliary homeostasis
Janeckova, E.; Feng, J.; Guo, T.; Han, X.; Pareek, S.; Ghobadi, A.; Ho, T.-V.; Araujo-Villalba, A.; Alvarez, J.; Chai, Y.
10.1101/2022.08.03.502715 — developmental biology — Posted on 2022-08-04
3464 A Mycobacterium tuberculosis effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit.
Martin, M.; deVisch, A.; Barthe, P.; Turapov, O.; Aydogan, T.; Heriaud, L.; Gracy, J.; Mukamolova, G.; Letourneur, F.; Cohen-Gonsaud, M.
10.1101/2021.01.31.428746 — microbiology — Posted on 2022-08-04
3465 Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neurons
Knowles, S. J.; Holter, M. C.; Li, G.; Bjorklund, G. R.; Rees, K. P.; Martinez-Fuentes, J. S.; Nishimura, K. J.; Afshari, A. E.; Fry, N.; Stafford, A. M.; Vogt, D.; Mangone, M.; Anderson, T.; Newbern, J. M.
10.1101/2022.08.02.502073 — neuroscience — Posted on 2022-08-04
3469 Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors
Minhas, V.; Domenech, A.; Synefiaridou, D.; Straume, D.; Brendel, M.; Cebrero, G.; Liu, X.; Costa, C.; Baldry, M.; Sirard, J.-C.; Perez, C.; Gisch, N.; Hammerschmidt, S.; Havarstein, L. S.; Veening, J.-W.
10.1101/2022.08.03.502730 — microbiology — Posted on 2022-08-04
3470 The Hypoxia-regulated Ectonucleotidase CD73 is a Host Determinant of HIV Latency
Sperber, H. S.; Raymond, K. A.; Bouzidi, M. S.; Ma, T.; Valdebenito, S.; Eugenin, E.; Roan, N. R.; Schwarzer, R.; Pillai, S. K.
10.1101/2022.08.03.502655 — microbiology — Posted on 2022-08-04
3471 Concomitant immunity to M. tuberculosis infection
Joslyn, L. R.; Flynn, J. L.; Kirschner, D. E.; Linderman, J. J.
10.1101/2022.08.02.502562 — immunology — Posted on 2022-08-04
3473 Quantitative assaying of SpCas9-NG with fluorescent reporters
Baccouche, A.; Montagne, K.; Yachie, N.; Fujii, T.; Genot, A. J.
10.1101/2022.08.04.502727 — synthetic biology — Posted on 2022-08-04
3474 Rapid generation of precision preclinical cancer models using regulatable in vivo base editing
Katti, A.; Foronda, M.; Zimmermann, J.; Zafra, M. P.; Goswami, S.; Gardner, E. E.; Diaz, B. J.; Simon, J. M.; Wuest, A.; Luan, W.; Fernandez, M. T. C.; Kadina, A. P.; Walker, J. A.; Holden, K.; Sanchez-Rivera, F. J.; Lowe, S. W.; Dow, L. E.
10.1101/2022.08.03.502708 — cancer biology — Posted on 2022-08-04
3476 Rationally designed Gla-domainless FXa as TFPI bait in hemophilia
Thomas, A.; Dagher, M.-C.; Ersayin, A.; Seyve, L.; Castellan, M.; Moreau, C.; Choisnard, L.; Thielens, N.; Marlu, R.; Polack, B.
10.1101/2022.08.03.502629 — bioengineering — Posted on 2022-08-04
3483 Energy dissipation in early detection of cellular responses to metabolic challenges
Bento, R. N.; Rendas, M. A.; Semedo, V. A. R.; Marques, C. F.; Justino, G. C.; Bernardes, C. E. S.; Piedade, M. E. M. d.; Antunes, F.
10.1101/2022.08.03.502646 — microbiology — Posted on 2022-08-04
3485 Novel Viroid-like RNAs Naturally Infect a Filamentous Fungus
Dong, K.; Xu, C.; Lv, R.; Kotta-Loizou, I.; Jiang, J.; Kong, L.; Li, S.; Hong, N.; Wang, G.; Robert, C. H. A.; xu, w.
10.1101/2022.08.03.502636 — microbiology — Posted on 2022-08-04
3486 The Parasite Intraerythrocytic Cycle and Human Circadian Cycle are Coupled During Malaria Infection
Motta, F. C.; Mcgoff, K.; Moseley, R. C.; Cho, C.-Y.; Kelliher, C. M.; Smith, L. M.; Ortiz, M. S.; Leman, A. R.; Campione, S. A.; Devos, N.; Chaorattanakawee, S.; Uthaimongkol, N.; Kuntawunginn, W.; Thongpiam, C.; Thamnurak, C.; Arsanok, M.; Wojnarski, M.; Vanachayangkul, P.; Boonyalai, N.; Smith, P. L.; Spring, M.; Jongsakul, K.; Chuang, I.; Harer, J.; Haase, S. B.
10.1101/2022.08.02.499203 — systems biology — Posted on 2022-08-04
3488 A novel RHH family transcription factor aCcr1 and its viral homologs dictate cell cycle progression in archaea
Yang, Y.; Liu, J.; Fu, X.; Zhou, F.; Zhang, S.; Zhang, X.; Huang, Q.; Krupovic, M.; She, Q.; Ni, J.; Shen, Y.
10.1101/2022.07.07.499082 — microbiology — Posted on 2022-08-03
3489 Neural support for contributions of utility and narrative processing of evidence in juror decision making
Castrellon, J. J.; Hakimi, S.; Parelman, J. M.; Yin, L.; Law, J. R.; Skene, J. A. G.; Ball, D. A.; Malekpour, A.; Beskind, D. H.; Vidmar, N.; Pearson, J. M.; Carter, R. M.; Skene, J. H. P.
10.1101/2020.11.11.378935 — neuroscience — Posted on 2022-08-03
3490 SpatialSort: A Bayesian Model for Clustering and CellPopulation Annotation of Spatial Proteomics Data
Lee, E.; Chern, K.; Nissen, M.; Wang, X.; IMAXT Consortium, ; Huang, C.; Gandhi, A. K.; Bouchard-Cote, A.; Weng, A. P.; Roth, A.
10.1101/2022.07.27.499974 — bioinformatics — Posted on 2022-08-03
3492 A proton pump enhancing photosynthesis links phagocytosis to marine algae symbiogenesis
Yee, D. P.; Samo, T. J.; Abbriano, R. M.; Shimasaki, B.; Vernet, M.; Mayali, X.; Weber, P. K.; Mitchell, B. G.; Hildebrand, M.; Tresguerres, M.
10.1101/2022.05.26.493626 — evolutionary biology — Posted on 2022-08-03
3494 Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.
Sarkar, A.; Jin, Y.; DeFelice, B. C.; Logan, C. Y.; Yang, Y.; Anbarchian, T.; Wu, P.; Morri, M.; Neff, N.; Nguyen, H.; Rulifson, E.; Fish, M.; Martinez Jaimes, A. M.; Nusse, R.
10.1101/2021.10.16.464650 — cell biology — Posted on 2022-08-03
3496 On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis
Key, F. M.; Khadka, V. D.; Romo-Gonzalez, C.; Blake, K. J.; Deng, L.; Lynn, T. C.; Lee, J. C. M.; Chiu, I.; Garcia, M. T.; Lieberman, T. D.
10.1101/2021.03.24.436824 — microbiology — Posted on 2022-08-03
3501 Insights into the diversity and function of DNA methyltransferases in microeukaryotes using the model diatom Phaeodactylum tricornutum
HOGUIN, A.; Yang, F.; Groisillier, A.; Bowler, C.; Genovesio, A.; Ait Mohamed, O.; Vieira, F. R.; TIRICHINE, L.
10.1101/2021.06.11.447926 — genomics — Posted on 2022-08-03
3502 Monkeypox DNA correlates with virus infectivity in clinical samples
Paran, N.; Yahalom-Ronen, Y.; Shifman, O.; Lazar, S.; Ben-Ami, R.; Yakubovsky, M.; Levy, I.; Wieder Feinsod, A.; Amit, S.; Katzir, M.; Carmi Oren, N.; Levcovich, A.; Hershman-Sarafov, M.; Paz, A.; Thomas, R.; Tamir, H.; Cherry-Mimran, L.; Erez, N.; Melamed, S.; Barlev-Gross, M.; Karmi, S.; Politi, B.; Achdout, H.; Weiss, S.; Levy, H.; Schuster, O.; Beth-Din, A.; Israely, T.
10.1101/2022.08.02.502454 — microbiology — Posted on 2022-08-03
3503 A Network Approach to Mapping Mouse Brain-wide Mitochondrial Respiratory Chain Capacity in Relation to Behavior
Rosenberg, A. M.; Saggar, M.; Rogu, P.; Limoges, A.; Junker, A.; Sandi, C.; Mosharov, E. V.; Dumitriu, D.; Anacker, C.; Picard, M.
10.1101/2021.06.02.446767 — neuroscience — Posted on 2022-08-03
3504 BayesDeBulk: A Flexible Bayesian Algorithm for the Deconvolution of Bulk Tumor Data
Petralia, F.; Krek, A.; Calinawan, A. P.; Feng, S.; Gosline, S. J.; Pugliese, P.; Ceccarelli, M.; Wang, P.
10.1101/2021.06.25.449763 — bioinformatics — Posted on 2022-08-03
3505 Precise targeting for 3D cryo-correlative light and electron microscopy volume imaging of tissues using a FinderTOP
de Beer, M.; Daviran, D.; Roverts, R.; Rutten, L.; Sanchez, e. M.; Metz, J.; Sommerdijk, n.; Akiva, A.
10.1101/2022.07.31.502212 — cell biology — Posted on 2022-08-03
3507 Members of Venezuelan Equine Encephalitis Complex entry into host cells by clathrin-mediated endocytosis in a pH-dependent manner
Ghietto, L. M.; Gil, P. I.; Olmos Quinteros, P.; Gomez, E.; Piris, F. M.; Kunda, P.; Contigiani, M.; Paglini, M. G.
10.1101/2022.03.11.483939 — microbiology — Posted on 2022-08-03
3510 Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation
Kim, T.-E.; Tsuboyama, K.; Houliston, S.; Martell, C. M.; Phoumyvong, C. M.; Lemak, A.; Haddox, H. K.; Arrowsmith, C. H.; Rocklin, G. J.
10.1101/2021.12.17.472837 — synthetic biology — Posted on 2022-08-03
3514 GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element
Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A.; Stoetzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.
10.1101/2022.08.02.502458 — genetics — Posted on 2022-08-03
3519 How subjective idea valuation energizes and guides creative idea generation
Lopez-Persem, A.; Moreno Rodriguez, S.; Ovando-Tellez, M.; Bieth, T.; Guiet, S.; Brochard, J.; Volle, E.
10.1101/2022.08.02.502491 — neuroscience — Posted on 2022-08-03
3520 Primary Somatosensory Cortex Bidirectionally Modulates Sensory Gain and Nociceptive Behavior in a Layer-Specific Manner
Ziegler, K.; Burghardt, J.; Folkard, R.; Gonzalez, A.; Antharvedi-Goda, S.; Martin-Cortecero, J.; Isaias-Camacho, E.; Kaushalya, S.; Tan, L. L.; Kuner, T.; Kuner, R.; Mease, R.; Groh, A.
10.1101/2022.08.02.502350 — neuroscience — Posted on 2022-08-03
3521 A minimum Bayes Factor based threshold for activation likelihood estimation
Costa, T.; Liloia, D.; Cauda, F.; Fox, P.; Dalla Mutta, F.; Duca, S.; Manuello, J.
10.1101/2022.08.02.502470 — neuroscience — Posted on 2022-08-03
3522 A high-speed, modular display system for diverse neuroscience applications
Isaacson, M.; Ferguson, L.; Loesche, F.; Ganguly, I.; Chen, J.; Chiu, A.; Liu, J.; Dickson, W.; Reiser, M.
10.1101/2022.08.02.502550 — neuroscience — Posted on 2022-08-03
3526 Global Protein-Turnover Quantification in Escherichia coli Reveals Cytoplasmic Recycling under Nitrogen-Limitation
Gupta, M.; Johnson, A.; Cruz, E.; Costa, E.; Guest, R. L.; Li, S. H.-J.; Hart, E. M.; Nguyen, T.; Stadlmeier, M.; Bratton, B. P.; Silhavy, T. J.; Wingreen, N. S.; Gitai, Z.; Wuhr, M.
10.1101/2022.08.01.502339 — systems biology — Posted on 2022-08-03
3529 Abscisic acid plays a key role in the regulation of date palm fruit ripening
Elbar, S.; Maytal, Y.; David, I.; Carmeli-Weissberg, M.; Shaya, F.; Barnea-Danino, Y.; Bustan, A.; Harpaz-Saad, S.
10.1101/2022.08.02.502463 — plant biology — Posted on 2022-08-03
3531 Alveolar macrophage lipid burden correlates with clinical improvement in patients with Pulmonary Alveolar Proteinosis
Lee, E.; Williams, K. J.; McCarthy, C. C.; Bridges, J. P.; Redente, E. F.; de Aguiar Vallim, T. Q.; Wang, T. F.; Tarling, E.
10.1101/2022.08.01.502377 — physiology — Posted on 2022-08-03
3532 Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.
Papadopoulou, D.; Roumelioti, F.; Tzaferis, C.; Chouvardas, P.; Pedersen, A.-K.; Charalampous, F.; Christodoulou-Vafeiadou, E.; Ntari, L.; Karagianni, N.; Denis, M.; Olsen, J. V.; Matralis, A. N.; Kollias, G.
10.1101/2022.08.02.500956 — pharmacology and toxicology — Posted on 2022-08-03
3534 Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids
Alsaadi, A.; Artibani, M.; Hu, Z.; Wietek, N.; Morotti, M.; Gonzalez, L. S.; Alazzam, M.; Jiang, J.; Abdul, B.; Soleymani, H.; Blazer, L. L.; Adams, J. J.; Sidhu, S.; Brugge, J. S.; Ahmed, A. A.
10.1101/2022.08.02.502319 — cancer biology — Posted on 2022-08-03
3537 DeepST: A versatile graph contrastive learning framework for spatially informed clustering, integration, and deconvolution of spatial transcriptomics
Long, Y.; Ang, K. S.; Li, M.; Chong, K. L. K.; Sethi, R.; Zhong, C.; Xu, H.; Ong, Z.; Sachaphibulkij, K.; Chen, A.; Li, Z.; Fu, H.; Wu, M.; Lim, H. K. L.; Liu, L.; Chen, J.
10.1101/2022.08.02.502407 — bioinformatics — Posted on 2022-08-03
3539 Prediction, scanning and designing of TNF-α inducing epitopes for human and mouse
Dhall, A.; Patiyal, S.; Choudhury, S.; Jain, S.; Narang, K.; Raghava, G. P. S.
10.1101/2022.08.02.502430 — bioinformatics — Posted on 2022-08-03
3541 Continuously perfusable, customisable and matrix-free vasculature on a chip platform.
Chesnais, F.; Joel, J.; Hue, J.; Shakib, S.; Di-Silvio, L.; Grigoriadis, A.; Coward, T.; Veschini, L.
10.1101/2022.08.02.499348 — bioengineering — Posted on 2022-08-03
3544 Next generation digital PCR: high dynamic range single molecule DNA counting via ultra-partitioning
Shum, E. Y.; Lai, J. H.; Li, S.; Lee, H. G.; Soliman, J.; Raol, V. K.; Lee, C. K.; Fodor, S. P.; Fan, H. C.
10.1101/2022.08.01.502071 — genomics — Posted on 2022-08-03
3545 Whole genome assembly and annotation of the lucerne weevil Sitona discoideus
Katuwal, M.; Bhattarai, U. R.; Phillips, C.; Gemmell, N. J.; Dowle, E.
10.1101/2022.08.01.502324 — genomics — Posted on 2022-08-03
3546 A globally distributed major virus-resistance association in Arabidopsis thaliana
Butkovic, A.; Ellis, T. J.; Gonzalez, R.; Jaegle, B.; Nordborg, M.; Elena, S. F.
10.1101/2022.08.02.502433 — genetics — Posted on 2022-08-03
3547 Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria
Opi, H.; Ndila, C. M.; Uyoga, S.; Macharia, A. W.; Fennell, C.; Nyutu, G.; Ojal, J.; Shebe, M.; Awuondo, K. O.; Mturi, N.; Peshu, N.; Tsofa, B.; Band, G.; Maitland, K.; Kwiatkowski, D.; Rockett, K.; Williams, T. N.; Rowe, J. A.
10.1101/2022.08.02.501704 — genetics — Posted on 2022-08-03
3560 Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons
Chamberland, S.; Nebet, E. R.; Valero, M.; Hanani, M.; Egger, R.; Larsen, S. B.; Eyring, K. W.; Buzsaki, G.; Tsien, R. W.
10.1101/2022.08.02.502477 — neuroscience — Posted on 2022-08-03
3562 Antagonistic interactions between odorants alter human odor perception.
Fukutani, Y.; Abe, M.; Saito, H.; Eguchi, R.; Tazawa, T.; de March, C. A.; Yohda, M.; Matsunami, H.
10.1101/2022.08.02.502184 — neuroscience — Posted on 2022-08-03
3563 A greenhouse-based high-throughput phenotyping platform for identification and genetic dissection of resistance to Aphanomyces root rot in field pea
Bari, M. A. A.; Fonseka, D.; Stenger, J.; Zitnick-Anderson, K.; Atanda, S. A.; Worral, H.; Piche, L.; Kim, J.; Morales, M.; Johnson, J.; Saludares, R. A.; Flores, P.; Pasche, J.; Bandillo, N.
10.1101/2022.08.01.502415 — pathology — Posted on 2022-08-03
3569 Characterization of the Y Chromosome in Newfoundland and Labrador: Evidence of a Founder Effect
Zurel, H.; Bherer, C.; Batten, R.; MacMillan, M. E.; Demiriz, S.; Mirhendi, S.; Gilbert, E. H.; Cavalleri, G. L.; Leach, R. A.; Scott, R. E. M.; Mugford, G.; Randhawa, R.; Symington, A. L.; Stephens, J. C.; Phillips, M. S.
10.1101/2022.08.01.502327 — genomics — Posted on 2022-08-03
3570 Genomic selection in organisms with biphasic lifecycles: a Saccharina latissima (sugar kelp) case study
Huang, M.; Robbins, K. R.; Li, Y.; Umanzor, S.; Marty-Rivera, M.; Bailey, D.; Aydlett, M.; Schmutz, J.; Grimwood, J.; Yarish, C.; Lindell, S.; Jannink, J.-L.
10.1101/2022.08.01.502376 — genetics — Posted on 2022-08-03
3572 Effects of fire regime on birds community in an Amazonian savanna
Coelho, L. A.; Ritter, C. d.; Lima, A.; Cintra, R.; Magnusson, W.; Sanaiotti, T.
10.1101/2022.08.01.502386 — ecology — Posted on 2022-08-03
3574 A Drosophila glial cell atlas reveals that transcriptionally defined cell types can be morphologically diverse
Lago-Baldaia, I.; Cooper, M.; Seroka, A. P.; Trivedi, C.; Powell, G. T.; Wilson, S. W.; Ackerman, S. D.; Fernandes, V. M.
10.1101/2022.08.01.502305 — neuroscience — Posted on 2022-08-03
3576 Adolescent binge drinking leads to long lasting changes in cortical microcircuits
Sicher, A. R.; Starnes, W. D.; Griffith, K. R.; Dao, N. C.; Smith, G. C.; Brockway, D. F.; Crowley, N. A.
10.1101/2022.08.02.502367 — neuroscience — Posted on 2022-08-03
3578 Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol
Tang, V. T.; McCormick, J.; Xu, B.; Wang, Y.; Fang, H.; Wang, X.; Siemieniak, D.; Khoriaty, R.; Emmer, B. T.; Chen, X.-W.; Ginsburg, D.
10.1101/2022.08.01.502222 — physiology — Posted on 2022-08-03
3579 Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis
Madel, M.-B.; Halper, J.; Ibanez, L.; Lozano, C.; Rouleau, M.; Boutin, A.; Pontier-Bres, R.; Ciucci, T.; Topi, M.; Hue, C.; Amiaud, J.; Iborra, S.; Sancho, D.; Heymann, D.; Garchon, H.-J.; Czerucka, D.; Apparially, F.; Duroux-Richard, I.; Wakkach, A.; Blin-Wakkach, C.
10.1101/2022.08.01.502322 — physiology — Posted on 2022-08-03
3582 CIARA: a cluster-independent algorithm for the identification of markers of rare cell types from single-cell RNA seq data
Lubatti, G.; Stock, M.; Iturbe, A.; Segura, M. L. R. T.; Tyser, R.; Theis, F. J.; Srinivas, S.; Torres-Padilla, M.-E.; Scialdone, A.
10.1101/2022.08.01.501965 — bioinformatics — Posted on 2022-08-03
3587 Clinical Viability of Magnetic Bead Implants in Muscle
Taylor, C. R.; Clark, W. H.; Clarrissimeaux, E. G.; Yeon, S. H.; Carty, M. J.; Lipsitz, S. R.; Bronson, R. T.; Roberts, T. J.; Herr, H. M.
10.1101/2022.08.01.502296 — bioengineering — Posted on 2022-08-03
3589 Imputed genomes and haplotype-based analyses of the Picts of early medieval Scotland reveal fine-scale relatedness between Iron Age, early medieval and the modern people of the UK.
Morez, A.; Britton, K.; Noble, G.; Günther, T.; Götherström, A.; Rodriguez-Varela, R.; Kashuba, N.; Martiniano, R.; Talamo, S.; Evans, N. J.; Irish, J. D.; Donald, C.; Girdland Flink, L.
10.1101/2022.08.01.502257 — genomics — Posted on 2022-08-03
3590 Divergent risky decision-making and impulsivity behaviors in two Lewis substrains of rats with low genetic difference
Gabriel, D. B. K.; Liley, A. E.; Franks, H. T.; Tutaj, M.; Dwinell, M. R.; de Jong, T.; Williams, R. W.; Mulligan, M. K.; Chen, H.; Simon, N. W.
10.1101/2022.08.01.501451 — genomics — Posted on 2022-08-03
3595 Neuromodulation by Monoamines is a Bilaterian Innovation
Goulty, M.; Botton-Amiot, G.; Rosato, E.; Sprecher, S.; Feuda, R.
10.1101/2022.08.01.501419 — evolutionary biology — Posted on 2022-08-03
3597 Warming undermines emergence success in a threatened alpine stonefly: a multi-trait perspective on vulnerability to climate change
Shah, A. A.; Hotaling, S.; Lapsansky, A.; Malison, R. L.; Birrell, J. H.; Keeley, T.; Giersch, J. J.; Tronstad, L. M.; Woods, H. A.
10.1101/2022.08.01.502337 — ecology — Posted on 2022-08-03
3600 MYC overrides HIF to regulate proliferating primary cell metabolism in hypoxia
Copeland, C. A.; Olenchock, B. A.; Ziehr, D.; McGarrity, S.; Leahy, K.; Young, J. D.; Loscalzo, J.; Oldham, W. M.
10.1101/2020.09.21.306464 — cell biology — Posted on 2022-08-03
3605 Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
Chao, T.-H. H.; Lee, B.; Hsu, L.-M.; Cerri, D. H.; Zhang, W.; Wang, T.-W. W.; Ryali, S.; Menon, V.; Shih, Y.-Y. I.
10.1101/2022.08.01.501899 — neuroscience — Posted on 2022-08-03
3608 Persistence of FoxJ1+ Pax6+ Sox2+ ependymal cells throughout life in the human spinal cord
Ripoll, C.; Poulen, G.; Chevreau, R.; Lonjon, N.; Vachiery-Lahaye, F.; Bauchet, L.; Hugnot, J.-P.
10.1101/2022.08.01.502176 — neuroscience — Posted on 2022-08-03
3612 Transcriptome Response of Cannabis (Cannabis sativa L.) to the Pathogenic fungus Golovinomyces ambrosiae
Adhikary, D.; El-Mezawy, A.; Khatri-Chhetri, U.; Wu, L.; Smith, S. W.; Zhang, J.; Slaski, J. J.; Kav, N. N. V.; Deyholos, M. K.
10.1101/2022.08.01.501243 — plant biology — Posted on 2022-08-03
3613 Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women
Ding, Y. C.; Song, H.; Adamson, A.; Schmolze, D.; Hu, D.; Huntsman, S.; Steele, L.; Patrick, C.; Hernandez, N.; Adams, C. D.; Fejerman, L.; Gardner, K. L.; Napoles, A. M.; Perez-Stable, E. J.; Weitzel, J. N.; Bengtsson, H.; Huang, F. W.; Neuhausen, S. L.; Ziv, E.
10.1101/2022.08.01.502349 — cancer biology — Posted on 2022-08-03
3614 3D-Beacons: Decreasing the gap between protein sequences and structures through a federated network of protein structure data resources
Varadi, M.; Nair, S. S.; Sillitoe, I.; Tauriello, G.; Anyango, S.; Bienert, S.; Borges, C.; Deshpande, M.; Green, T.; Hatos, A.; Hegedus, T.; Hekkelman, M. L.; Joosten, R.; Jumper, J.; Laydon, A.; Molodenskiy, D.; Piovesan, D.; Salladini, E.; Salzberg, S. L.; Sommer, M. J.; Steinegger, M.; Suhajda, E.; Svergun, D.; Tenorio-Ku, L.; Tosatto, S.; Tunyasuvunakool, K.; Waterhouse, A. M.; Zidek, A.; Hassabis, D.; Schwede, T.; Orengo, C.; Velankar, S.
10.1101/2022.08.01.501973 — bioinformatics — Posted on 2022-08-03
3618 Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits H. pylori infection
Khan, U.; Karmakar, B. C.; Basak, P.; Paul, S.; Gope, A.; Sarkar, D.; Mukhopadhyay, A. K.; Dutta, S.; Bhattacharya, S.
10.1101/2022.08.02.502584 — microbiology — Posted on 2022-08-03
3619 Tumor necrosis factor is a necroptosis-associated alarmin
Pinci, F.; Gaidt, M.; Jung, C.; Nagl, D.; Kuut, G.; Hornung, V.
10.1101/2022.08.01.502280 — immunology — Posted on 2022-08-03
3620 YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth
Zhuo, S.; Li, X.; Cho, Y. S.; Liu, Y.; Yang, Y.; Zhu, J.; Jiang, J.
10.1101/2022.08.01.502314 — cancer biology — Posted on 2022-08-03
3621 A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
Gonzalez-Gualda, E.; Macias, D.; Morsli, S.; Martin, E.; Ou, H.-L.; Denholm, M.; Olan, I.; Hoffmann, R.; Dane, M.; Veroutis, D.; Medrano, G.; Mulero, F.; Martins, C.; Barbacid, M.; Gorgoulis, V.; Korkola, J.; Rassl, D. M.; Doherty, G. J.; Rintoul, R. C.; Narita, M.; Munoz-Espin, D.
10.1101/2022.08.01.502019 — cancer biology — Posted on 2022-08-03
3622 A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response
Xu, L.; Saunders, K. N.; Knutsdottir, H.; Chen, K.; Maues, J.; Hodgdon, C.; Roussos-Torres, E. T.; Reddy, S.; Xu, L.; Chan, I. S.
10.1101/2022.08.01.501918 — cancer biology — Posted on 2022-08-03
3623 Mars, a molecule archive suite for reproducible analysis and reporting of single molecule properties from bioimages
Huisjes, N. M.; Retzer, T. M.; Scherr, M. J.; Agarwal, R.; Rajappa, L.; Safaric, B.; Minnen, A.; Duderstadt, K. E.
10.1101/2021.11.26.470105 — biophysics — Posted on 2022-08-03
3624 Structure of a volume-regulated heteromeric LRRC8A/C channel
Rutz, S.; Deneka, D.; Dittmann, A.; Sawicka, M.; Dutzler, R.
10.1101/2022.08.03.502623 — biochemistry — Posted on 2022-08-03
3629 Biofilm matrix proteome of clinical strain of P. aeruginosa
Egorova, D. A.; Solovyev, A. I.; Polyakov, N. B.; Danilova, K. V.; Scherbakova, A. A.; Kravtsov, I. N.; Dmitrieva, M. A.; Rykova, V. S.; Tutykhina, I. L.; Romanova, Y. M.; Gintsburg, A. L.
10.1101/2021.12.21.473640 — microbiology — Posted on 2022-08-03
3630 Short-term monocular deprivation boosts neural responsiveness to audio-visual events for the undeprived eye
Federici, A.; Bernardi, G.; Senna, I.; Fantoni, M.; Ernst, M. O.; Ricciardi, E.; Bottari, D.
10.1101/2022.05.17.492319 — neuroscience — Posted on 2022-08-03
3631 Activating mutations in FGFR3 are associated with clonal expansion events and high de novo rates in the male germline
Moura, S.; Hartl, I.; Brumovska, V.; Striedner, Y.; Bishara, M.; Mair, T.; Ebner, T.; Schuetz, G.; Sevcsik, E.; Tiemann-Boege, I.
10.1101/2022.07.31.502216 — genetics — Posted on 2022-08-03
3633 Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Pearson, G. L.; Walker, E. M.; Lawlor, N.; Lietzke, A.; Sidarala, V.; Zhu, J.; Stromer, T.; Reck, E. C.; Renberg, A.; Mohamed, K.; Parekh, V. S.; Zhang, I. X.; Thompson, B.; Zhang, D.; Duplaga, S. A.; Haataja, L.; Parker, S. C. J.; Arvan, P.; Yin, L.; Kaufman, B. A.; Satin, L. S.; Sussel, L.; Stitzel, M. L.; Soleimanpour, S. A.
10.1101/2022.08.02.502357 — cell biology — Posted on 2022-08-03
3634 Deep neural network automated segmentation of cellular structures in volume electron microscopy
Gallusser, B.; Maltese, G.; Di Caprio, G.; Vadakkan, T. J.; Sanyal, A.; Somerville, E.; Sahasrabudhe, M.; O'Connor, J.; Weigert, M.; Kirchhausen, T.
10.1101/2022.08.02.502534 — cell biology — Posted on 2022-08-03
3636 Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles
Thierer, J. H.; Foresti, O.; Yadav, P. K.; Wilson, M. H.; Moll, T.; Shen, M.-C.; Busch-Nentwich, E.; Morash, M.; Mohlke, K.; Rawls, J. F.; Malhotra, V.; Hussain, M. M.; Farber, S. A.
10.1101/2022.08.02.502564 — cell biology — Posted on 2022-08-03
3639 Next-generation large-scale binary protein interaction network for Drosophila
Tang, H.-W.; Spirohn, K.; Hu, Y.; Hao, T.; Kovacs, I. A.; Gao, Y.; Binari, R.; Yang-Zhou, D.; Wan, K. H.; Bader, J. S.; Balcha, D.; Bian, W.; Booth, B. W.; Cote, A. G.; De Rouck, S.; Desbuleux, A.; Kim, D.-K.; Knapp, J. J.; Lee, W. X.; Lemmens, I.; Li, C.; Li, M.; Li, R.; Lim, H.; Luck, K.; Markey, D.; Pollis, C.; Rangarajan, S.; Rodiger, J.; Schlabach, S.; Shen, Y.; TeeKing, B.; Roth, F. P.; Tavernier, J.; Calderwood, M.; Hill, D. E.; Celniker, S. E.; Vidal, M.; Perrimon, N.; Mohr, S.
10.1101/2022.08.02.502359 — cell biology — Posted on 2022-08-03
3643 HD-PTP/PTPN23 hypomorphic mice display lipodystrophy
Davies, B. A.; Payne, J. A.; Martin, C. P.; Schultz, D.; Childs, B. G.; Zhang, C.; Jeganathan, K.; Sturmlechner, I.; White, T. A.; Bruin, A. d.; Chen, H.; Davies, M. A.; Jachim, S.; LeBrasseur, N. K.; Piper, R. C.; Li, H.; Baker, D. J.; van Deursen, J.; Katzmann, D. J.
10.1101/2022.08.02.502401 — cell biology — Posted on 2022-08-03
3644 Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signalling
Marechal, E.; Poliard, A.; Henry, K.; Moreno, M.; Legrix, M.; Macagno, N.; Mondielli, G.; Fauquier, T.; Barlier, A.; Etchevers, H. C.
10.1101/2022.04.05.487130 — developmental biology — Posted on 2022-08-03
3645 Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system
Galvao Ferrarini, M.; Dell'Aglio, E.; Vallier, A.; Balmand, S.; Vincent-Monegat, C.; Hughes, S.; Gillet, B.; Parisot, N.; Zaidman-Remy, A.; Vieira, C.; Heddi, A.; Rebollo, R.
10.1101/2022.03.18.484386 — immunology — Posted on 2022-08-03
3651 Coupling of protein condensates to ordered lipid domains determines functional membrane organization
Wang, H.-Y.; Chan, S. H.; Dey, S.; Castello-Serrano, I.; Ditlev, J.; Rosen, M. K.; Levental, K. R.; Levental, I.
10.1101/2022.08.02.502487 — cell biology — Posted on 2022-08-03
3652 A universal influenza mRNA vaccine candidate boosts T-cell responses and reduces zoonotic influenza virus disease in ferrets
van de Ven, K.; Lanfermeijer, J.; van Dijken, H.; Muramatsu, H.; de Melo, C. V. B.; Lenz, S.; Peters, F.; Beattie, M. B.; Lin, P. J.; Ferreira, J. A.; van den Brand, J.; van Baarle, D.; Pardi, N.; de Jonge, J.
10.1101/2022.08.02.502529 — immunology — Posted on 2022-08-03
3653 Global Motor Inhibition Precedes Stuttering Events
Orpella, J.; Flick, G.; Assaneo, F.; Pylkkanen, L.; Poeppel, D.; Jackson, E.
10.1101/2022.08.02.501857 — neuroscience — Posted on 2022-08-03
3655 SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
Kotler, O.; Khrapunsky, Y.; Shvartsman, A.; Dai, H.; Plant, L. D.; Goldstein, S. A. N.; Fleidervish, I.
10.1101/2022.08.02.502500 — neuroscience — Posted on 2022-08-03
3657 Mechanisms by Which Small Molecule Inhibitors Arrest Sec14 Phosphatidylinositol Transfer Protein Activity
Chen, X. R.; Poudel, L.; Hong, Z.; Johnen, P.; Katti, S. S.; Tripathi, A.; Nile, A. H.; Green, S. M.; Schaaf, G.; Bono, F.; bankaitis, v.; Igumenova, T. I.
10.1101/2022.08.01.502361 — biophysics — Posted on 2022-08-02
3660 Lipid Oxidation Controls Peptide Self-Assembly near Membranes
John, T.; Piantavigna, S.; Dealey, T. J. A.; Abel, B.; Risselada, H. J.; Martin, L. L.
10.1101/2022.08.02.502408 — biophysics — Posted on 2022-08-03
3661 Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities
Casalino, L.; Seitz, C.; Lederhofer, J.; Tsybovsky, Y.; Wilson, I. A.; Kanekiyo, M.; Amaro, R. E.
10.1101/2022.08.02.502576 — biophysics — Posted on 2022-08-03
3664 Human ATG3 contains a non-canonical LIR motif crucial for its enzymatic activity in autophagy
Farnung, J.; Muhar, M.; Liang, J. R.; Tolmachova, K. A.; Benoit, R. M.; Corn, J. E.; Bode, J. W.
10.1101/2022.08.02.502437 — biochemistry — Posted on 2022-08-02
3670 The small cell lung cancer neuroendocrine transdifferentiation explorer
Cai, L.; Sondhi, V.; Zhu, M.; Akbay, E.; DeBerardinis, R. J.; Xie, Y.; Minna, J.; Xiao, G.; Gazdar, A.
10.1101/2022.08.01.502252 — cancer biology — Posted on 2022-08-02
3671 How talin allosterically activates vinculin
Franz, F.; Tapia-Rojo, R.; Winograd-Katz, S. E.; Boujemaa-Paterski, R.; Li, W.; Unger, T.; Albeck, S.; Aponte-Santamaria, C.; Garcia-Manyes, S.; Medalia, O.; Geiger, B.; Grater, F.
10.1101/2022.08.01.502287 — biophysics — Posted on 2022-08-02
3672 Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
Lan, C.; Kim, J.; Ulferts, S.; Aprile-Garcia, F.; Anandamurugan, A.; Grosse, R.; Sawarkar, R.; Reinhardt, A.; Hugel, T.
10.1101/2022.08.01.502196 — biophysics — Posted on 2022-08-02
3674 MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol
Kraemer, L.; Dalheimer, N.; Raeschle, M.; Storchova, Z.; Pielage, J.; Boos, F.; Herrmann, J. M.
10.1101/2022.08.02.502474 — biochemistry — Posted on 2022-08-02
3675 Strategy for selective acquisition of transgenic marmosets using the piggyBac transposon system
Takahashi, T.; Maeda, T.; Goto, M.; Yamamoto, M.; Kumita, W.; Ito, R.; Eto, T.; Inoue, T.; Okano, H.; Sasaki, E.
10.1101/2022.08.02.502441 — molecular biology — Posted on 2022-08-02
3678 Bacterial droplet-based single-cell RNA-seq reveals heterogeneity in bacterial populations and in response to antibiotic perturbation
Ma, P.; Amemiya, H. M.; He, L. L.; Gandhi, S. J.; Nicol, R.; Bhattacharyya, R. P.; Smillie, C. S.; Hung, D. T.
10.1101/2022.08.01.502326 — microbiology — Posted on 2022-08-02
3680 Longitudinal metatranscriptomic sequencing of Southern California wastewater representing 16 million people from August 2020-21 reveals widespread transcription of antibiotic resistance genes.
Rothman, J. A.; Saghir, A.; Chung, S.-A.; Boyajian, N.; Dinh, T.; Kim, J.; Oval, J.; Sharavanan, V.; York, C.; Zimmer-Faust, A. G.; Langlois, K.; Steele, J. A.; Griffith, J. F.; Whiteson, K. L.
10.1101/2022.08.02.502560 — microbiology — Posted on 2022-08-02
3685 Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum
Singh, A. K.; Phillips, M.; Alkrimi, S.; Tonelli, M.; Boyson, S. P.; Malone, K. L.; Nix, J. C.; Glass, K. C.
10.1101/2022.08.02.501158 — biophysics — Posted on 2022-08-02
3686 Design Principles for Inflammasome Inhibition by Pyrin-Only-Proteins
Mazanek, Z.; Wu, S.; Belotte, G.; Zhou, J. J.; Stallings, C. M.; Garg, A.; Lueck, J.; Sohn, J.
10.1101/2022.08.02.502519 — biochemistry — Posted on 2022-08-02
3688 LC-MS/MS-PRM Quantification of IgG glycoforms using stable isotope labeled IgG1 Fc glycopeptide standard
Sanda, M.; Yang, Q.; Zong, G.; Chen, H.; Zheng, Z.; Dhani, H.; Khan, K.; Kroemer, A.; Wang, L.-X.; Goldman, R.
10.1101/2022.08.02.501850 — biochemistry — Posted on 2022-08-02
3692 Comparative genomic analyses of Lactococcus garvieae isolated from bovine mastitis in China
Lin, Y.; Han, J.; Barkema, H. W.; Wang, Y.; Gao, J.; Kastelic, J. P.; Han, B.; Qin, S.; Deng, Z.
10.1101/2022.08.01.502421 — microbiology — Posted on 2022-08-02
3693 Ecophysiology and genomics of the brackish water adapted SAR11 subclade IIIa
Lanclos, V. C.; Rasmussen, A. N.; Kojima, C. Y.; Cheng, C.; Henson, M. W.; Faircloth, B. C.; Francis, C. A.; Thrash, C.
10.1101/2022.08.02.502558 — microbiology — Posted on 2022-08-02
3696 High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny
Lieberman, N. A. P.; Armstrong, T. D.; Chung, B.; Pfalmer, D.; Hennelly, C. M.; Haynes, A.; Romeis, E.; Wang, Q.-Q.; Zhang, R.-L.; Kou, C.-X.; Ciccarese, G.; Dal Conte, I.; Cusini, M.; Drago, F.; Nakayama, S.-i.; Lee, K.; Ohnishi, M.; Konda, K. A.; Vargas, S. K.; Eguiluz, M.; Caceres, C. F.; Klausner, J. D.; Mitja, O.; Rompalo, A.; Mulcahy, F.; Hook, E. W.; Hoffman, I. F.; Matoga, M. M.; Zheng, H.; Yang, B.; Lopez-Medina, E.; Ramirez, L. G.; Radolf, J. D.; Hawley, K. L.; Salazar, J. C.; Lukehart, S. A.; Sena, A. C.; Parr, J. B.; Giacani, L.; Greninger, A. L.
10.1101/2022.08.02.502389 — microbiology — Posted on 2022-08-02
3698 Addictions may be driven by competition-induced microbiome dysbiosis
Lewin-Epstein, O.; Jaques, Y.; Feldman, M. W.; Kaufer, D.; Hadany, L.
10.1101/2022.08.02.502262 — microbiology — Posted on 2022-08-02
3699 Triterpenoid production with a minimally engineered Saccharomyces cerevisiae chassis
Guo, H.; Jacobsen, S. A. B.; Walter, K.; Lewandowski, A.; Czarnotta, E.; Knuf, C.; Polakowski, T.; Maury, J.; Lang, C.; Foerster, J.; Blank, L. M.; Ebert, B. E.
10.1101/2022.07.11.499565 — bioengineering — Posted on 2022-08-02
3701 Prey Size Spectra and Predator to Prey Size Ratios of Southern Ocean Salps
Fender, C. K.; Decima, M.; Gutierrez-Rodriguez, A.; Selph, K. E.; Yingling, N.; Stukel, M. R.
10.1101/2022.02.16.480784 — ecology — Posted on 2022-08-02
3703 Thalamus sends information about arousal but not valence to the amygdala
Leppla, C. A.; Keyes, L.; Glober, G.; Matthews, G. A.; Batra, K.; Jay, M.; Feng, Y.; Chen, H. S.; Mills, F.; Delahanty, J.; Olson, J. M.; Nieh, E. H.; Namburi, P.; Wildes, C.; Wichmann, R.; Beyelar, A.; Kimchi, E. Y.; Tye, K. M.
10.1101/2022.07.18.500471 — neuroscience — Posted on 2022-08-02
3706 Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications
Ewart, L.; Apostolou, A.; Briggs, S. A.; Carman, C. V.; Chaff, J. T.; Heng, A. R.; Jadalannagari, S.; Janardhanan, J.; Jang, K.-J.; Joshipura, S. R.; Kadam, M.; Kanellias, M.; Kujala, V. J.; Kulkarni, G.; Le, C. Y.; Lucchesi, C.; Manatakis, D.; Maniar, K. K.; Quinn, M. E.; Ravan, J. S.; Rizos, A. C.; Sauld, J. F. K.; Sliz, J.; Tien-Street, W.; Trinidad, D. R.; Velez, J.; Wendell, M.; Irrechukwu, O.; Mahalingaiah, P. K.; Ingber, D. E.; Scannell, J. W.; Levner, D.
10.1101/2021.12.14.472674 — pharmacology and toxicology — Posted on 2022-08-02
3707 Poison frog dietary preference depends on prey type and alkaloid load
Moskowitz, N. A.; D'Agui, R.; Alvarez-Buylla, A.; Fiocca, K.; O'Connell, L. A.
10.1101/2022.01.20.476996 — animal behavior and cognition — Posted on 2022-08-02
3708 Genomic epidemiology and multilevel genome typing of Australian Salmonella enterica serovar Enteritidis
Luo, L.; Payne, M.; Wang, Q.; Kaur, S.; Rathnayake, I. U.; Graham, R.; Gall, M.; Draper, J.; Martinez, E.; Octavia, S.; Tanaka, M. M.; Jennison, A. V.; Sintchenko, V.; Lan, R.
10.1101/2022.05.18.492204 — genomics — Posted on 2022-08-02
3710 Validity Assessment of Michigan's Proposed qPCR Threshold Value for Rapid Water-Quality Monitoring of E. coli Contamination
McNair, J. N.; Lane, M. J.; Hart, J. J.; Porter, A.; Briggs, S.; Southwell, B.; Sivy, T.; Szlag, D. C.; Scull, B. T.; Pike, S.; Dreelin, E.; Vernier, C.; Carter, B.; Sharp, J.; Nowlin, P.; Rediske, R. R.
10.1101/2022.07.16.500300 — ecology — Posted on 2022-08-02
3715 UVC-based air disinfection system for rapid inactivation of SARS-CoV-2 present in the air
Garg, H.; Ringe, R. P.; Das, S.; Parkash, S.; Thakur, B.; Delipan, R.; Kumar, A.; Kulkarni, K. S.; Bansal, K.; Patil, P. B.; Alam, T.; Balam, N. B.; Meena, C. S.; Thakur, K. G.; Kumar, A.; Kumar, A.
10.1101/2022.08.02.502427 — microbiology — Posted on 2022-08-02
3716 Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5
Muik, A.; Lui, B. G.; Bacher, M.; Wallisch, A.-K.; Toker, A.; Finlayson, A.; Krueger, K.; Ozhelvaci, O.; Grikscheit, K.; Hoehl, S.; Ciesek, S.; Tuereci, O.; Sahin, U.
10.1101/2022.08.02.502461 — immunology — Posted on 2022-08-02
3717 NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids
Simoneau, C. R.; Chen, P.-Y.; Xing, G. X.; Khalid, M. M.; Meyers, N. L.; Hayashi, J. M.; Taha, T. Y.; Leon, K. E.; Ashuach, T.; Fontaine, K. A.; Rodriguez, L.; Joehnk, B.; Walcott, K.; Vasudevan, S.; Fang, X.; Maishan, M.; Schultz, S.; Roose, J.; Matthay, M. A.; Sil, A.; Arjomandi, M.; Yosef, N.; Ott, M.
10.1101/2022.08.02.502100 — microbiology — Posted on 2022-08-02
3718 Serological surveillance for wild rodent infection with SARS-CoV-2 in Europe
Bourret, V.; Dutra, L.; Alburkat, H.; Maki, S.; Lintunen, E.; Wasniewski, M.; Kant, R.; Grzybek, M.; Venkat, V.; Asad, H.; Pradel, J.; Bouilloud, M.; Leirs, H.; Colombo, V. C.; Sluydts, V.; Stuart, P.; McManus, A.; Eccard, J. A.; Firozpoor, J.; Imholt, C.; Nowicka, J.; Goll, A.; Ranc, N.; Castel, G.; Charbonnel, N.; Sironen, T.
10.1101/2022.08.02.502439 — microbiology — Posted on 2022-08-02
3719 SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
van Doremalen, N.; Singh, M.; Saturday, T.; Yinda, K. C.; Perez-Perez, L.; Bohler, W. F.; Weishampel, Z.; Lewis, M.; Schulz, J.; Williamson, B.; Meade-White, K.; Gallogly, S.; Okumura, A.; Feldmann, F.; Lovaglio, J.; Hanley, P.; Shaia, C.; Feldmann, H.; de Wit, E.; Munster, V.; Rosenke, K.
10.1101/2022.08.01.502390 — microbiology — Posted on 2022-08-02
3720 Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments
Akazawa, D.; Ohashi, H.; Hishiki, T.; Morita, T.; Iwanami, S.; Kim, K. S.; Jeong, Y. D.; Park, E.-S.; Kataoka, M.; Shionoya, K.; Mifune, J.; Tsuchimoto, K.; Ojima, S.; Azam, A. H.; Nakajima, S.; Park, H.; Yoshikawa, T.; Shimojima, M.; Kiga, K.; Iwami, S.; Maeda, K.; Suzuki, T.; Ebihara, H.; Takahashi, Y.; Watashi, K.
10.1101/2022.08.02.502485 — microbiology — Posted on 2022-08-02
3721 Transcranial electrical stimulation modulates emotional experience and metabolites in the prefrontal cortex in a donation task
Mugnol-Ugarte, L.; Bortolini, T.; Mikkelsen, M.; Monteiro, M. C.; Andorinho, A. C.; Bramatti, I.; Melo, B.; Hoefle, S.; Meireles, F.; Yao, B.; Moll, J.; Pobric, G.
10.1101/2022.07.31.502214 — neuroscience — Posted on 2022-08-02
3722 The small cell lung cancer neuroendocrine transdifferentiation explorer
Cai, L.; Sondhi, V.; Zhu, M.; Akbay, E.; DeBerardinis, R. J.; Xie, Y.; Mina, J.; Xiao, g.
10.1101/2022.08.01.502252 — cancer biology — Posted on 2022-08-02
3724 The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response
Patrick, D.; Meinzinger, J.; Schulz, S. R.; Corte-Real, J.; Hauke, M.; Roth, E.; Schuh, W.; Mielenz, D.; Wittmann, J.; Jäck, H.-M.; Pracht, K.
10.1101/2022.07.31.501995 — immunology — Posted on 2022-08-02
3728 Learning Optimal White Matter Tract Representations from Tractography using a Deep Generative Model for Population Analyses
Feng, Y.; Chandio, B. Q.; Chattopadhyay, T.; Thomopoulos, S. I.; Owens-Walton, C.; Jahanshad, N.; Garyfallidis, E.; Thompson, P. M.
10.1101/2022.07.31.502227 — neuroscience — Posted on 2022-08-02
3731 Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels
Kern, D. M.; Bleier, J.; Mukherjee, S.; Hill, J. M.; Kossiakoff, A. A.; Isacoff, E. Y.; Brohawn, S. G.
10.1101/2022.07.31.502239 — biophysics — Posted on 2022-08-02
3734 Biomaterials, oxygen delivery, necrosis
Rastinfard, A.; Dalisson, B.; Gilardino, M.; Watters, K.; Merle, G.; Lasagabaster, A.; Ouhaddi, Y.; Barralet, J.
10.1101/2022.07.31.502155 — bioengineering — Posted on 2022-08-02
3737 Coronaviruses using different strategies to antagonize antiviral responses and pyroptosis
Fu, X.; Yang, Y.; Xu, W.; Li, D.; Li, X.; Chen, N.; Lv, Q.; Shi, Y.; Li, X.; Xu, J.; Shi, F.
10.1101/2022.07.29.502014 — immunology — Posted on 2022-08-02
3738 Decoding Subject's Own Name in the Primary Auditory Cortex
Wu, H.; Wang, D.; Liu, Y.; Xie, M.; Zhou, L.; Wang, Y.; Cao, J.; Huang, Y.; Qiu, M.; Qin, P.
10.1101/2022.07.30.502169 — neuroscience — Posted on 2022-08-02
3739 Neural patterns differentiate traumatic from sad autobiographical memories in PTSD
Perl, O.; Duek, O.; Kulkarni, K. R.; Kelmendi, B.; Amen, S.; Gordon, C.; Krystal, J. H.; Levy, I.; Harpaz-Rotem, I.; Schiller, D.
10.1101/2022.07.30.502151 — neuroscience — Posted on 2022-08-02
3747 The ENCODE Imputation Challenge: A critical assessment of methods for cross-cell type imputation of epigenomic profiles
Schreiber, J. M.; Boix, C. A.; Lee, J. w.; Li, H.; Guan, Y.; Chang, C.-C.; Chang, J.-C.; Hawkins-Hooker, A.; Schoelkopf, B.; Schweikert, G.; Rojas Carulla, M.; Canakoglu, A.; Guzzo, F.; Nanni, L.; Masseroli, M.; Carman, M. J.; Pinoli, P.; Hong, C.; Yip, K. Y.; Spence, J. P.; Batra, S. S.; Song, Y. S.; Mahony, S.; Zhang, Z.; Tan, W.; Shen, Y.; Sun, Y.; Shi, M.; Adrian, J.; Sandstrom, R. S.; Farrell, N.; Halow, J. M.; Lee, K.; Jiang, L.; Yang, X.; Epstein, C. B.; Strattan, J. S.; Snyder, M. P.; Kellis, M.; Noble, W. S.; Kundaje, A. B.
10.1101/2022.07.30.502157 — bioinformatics — Posted on 2022-08-02
3748 Identification of bacteriophage genome sequences with representation learning
Bai, Z.; Zhang, Y.-z.; Miyano, S.; Yamaguchi, R.; Fujimoto, K.; Uematsu, S.; Imoto, S.
10.1101/2021.09.25.461359 — bioinformatics — Posted on 2022-08-02
3753 An economic and robust TMT labeling approach for high throughput proteomic and metaproteomic analysis
Creskey, M.; Li, l.; Ning, Z.; Brown, E.; Mayne, J.; Walker, K.; Ampaw, A.; Ben, R.; Zhang, X.; Figeys, D.
10.1101/2022.07.30.502163 — systems biology — Posted on 2022-08-02
3757 Surgical techniques and tips for a reliable murine model of primary and metastatic pancreatic cancer
Hue, J. J.; Zarei, M.; Graor, H. J.; Hajihassani, O.; Katayama, E. S.; Loftus, A. W.; Vaziri-Gohar, A.; Winter, J. M.
10.1101/2022.07.30.502136 — cancer biology — Posted on 2022-08-02
3758 Obesity promotes breast epithelium DNA damage in BRCA mutation carriers
Bhardwaj, P.; Iyengar, N. M.; Zahid, H.; Carter, K. M.; Byun, D. J.; Choi, M.-H.; Sun, Q.; Savenkov, O.; Louka, C.; Liu, C.; Piloco, P.; Acosta, M.; Bareja, R.; Elemento, O.; Foronda, M.; Dow, L. E.; Oshchepkova, S.; Giri, D. D.; Pollak, M.; Zhou, X. K.; Hopkins, B. D.; Laughney, A. M.; Frey, M. K.; Hedrick Ellenson, L.; Morrow, M.; Spector, J. A.; Cantley, L. C.; Brown, K. A.
10.1101/2022.07.29.502090 — cancer biology — Posted on 2022-08-02
3760 Sensitivity analysis of genome-scale metabolic flux prediction
Niu, P.; Qian, X.; Soto, M. J.; Blaby, I.; Alexander, F.; Dougherty, E.; Yoon, B.-J.; Huang, S.
10.1101/2022.07.30.502133 — bioinformatics — Posted on 2022-08-02
3761 Absorbable Conductive Electrotherapeutic Scaffolds (ACES) for Enhanced Peripheral Nerve Regeneration and Stimulation
Srinivasan, S.; Gfrerer, L.; Karandikar, P.; Alshareef, A.; Liu, S.; Higginbotham, H.; Ishida, K.; Hayward, A.; Kalva, S.; Langer, R.; Traverso, G.
10.1101/2022.07.30.500547 — bioengineering — Posted on 2022-08-02
3762 Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis
Jia, M.; Rosas, L.; Kapetanaki, M. G.; Tabib, T.; Sembrat, J.; Cruz, T.; Bondonese, A. R.; Mora, A. L.; Lafyatis, R. A.; Rojas, M.; Benos, P. V.
10.1101/2022.07.29.501956 — genomics — Posted on 2022-08-02
3764 SEX-BIASED INFECTIONS SCALE TO POPULATION IMPACTS FOR AN EMERGING WILDLIFE DISEASE
Kailing, M. J.; Hoyt, J. R.; White, J. P.; Kaarakka, H. M.; Redell, J. A.; Leon, A. E.; Rocke, T. E.; DePue, J. E.; Scullon, W. H.; Parise, K. L.; Foster, J. T.; Kilpatrick, A. M.; Langwig, K. E.
10.1101/2022.07.29.502066 — ecology — Posted on 2022-08-02
3769 Standing balance in aging is robust against head rotation during visual tracking.
Georgiadis, P.; Chatzinikolaou, K.; Voudouris, D.; van Dieen, J.; Hatzitaki, V.
10.1101/2022.07.30.502138 — neuroscience — Posted on 2022-08-02
3770 High-precision neural stimulation by a highly efficient candle soot fiber optoacoustic emitter
Chen, G.; Shi, L.; Lan, L.; Wang, R.; Li, Y.; Du, Z.; Hyman, M.; Cheng, J.-X.; Yang, C.
10.1101/2022.07.30.502146 — neuroscience — Posted on 2022-08-02
3776 Age-related differences in ocular features of a naturalistic free-ranging population of rhesus macaques
Fernandes, A. G.; Alexopoulos, P.; Burgos, A.; Martinez, M. I.; Cayo Biobank Research Unit, ; Ghassibi, M.; Leskov, I.; Brent, L. J. N.; Snyder-Mackler, N.; Danias, J.; Wollstein, G.; Higham, J.; Melin, A. D.
10.1101/2022.07.29.501993 — systems biology — Posted on 2022-08-02
3777 Catalyst: Fast Biochemical Modeling with Julia
Loman, T.; Ma, Y.; Ilin, V.; Gowda, S.; Korsbo, N.; Yewale, N.; Rackauckas, C. V.; Isaacson, S. A.
10.1101/2022.07.30.502135 — systems biology — Posted on 2022-08-02
3778 Ageing impairs the neuro-vascular interface in the heart
Wagner, J.; Tombor, L.; Malacarne, P.; Kettenhausen, L.-M.; Panthel, J.; Cipca, M.; Stilz, K.; Fischer, A.; Muhly-Reinholz, M.; Abplanalp, W.; John, D.; Buchmann, G.; Angerdohr, S.; Amir, E.; Scherschel, K.; Kloeckner, N.; Kelm, M.; Schuettler, D.; Clauss, S.; Guenther, S.; Boettger, T.; Braun, T.; Baer, C.; Nardini, E.; Osmanagic-Myers, S.; Meyer, C.; Zeiher, A.; Brandes, R.; Luxan, G.; Dimmeler, S.
10.1101/2022.07.29.501999 — physiology — Posted on 2022-08-02
3789 Microglia Depletion Selectively Eliminates a Singular Form of Hippocampal Long Term Potentiation
Chavez, J.; Le, A. A.; Quintanilla, J.; Tagne, A. M.; Piomelli, D.; Lynch, G. M.; Gall, C. M.
10.1101/2022.07.29.501926 — neuroscience — Posted on 2022-08-02
3790 Sensing the Full Dynamics of the Human Hand with a Neural Interface and Deep Learning
Simpetru, R.; Arkudas, A.; Braun, D.; Osswald, M.; Oliveira, D. S.; Eskofier, B.; Kinfe, T. M.; Del Vecchio, A.
10.1101/2022.07.29.502064 — neuroscience — Posted on 2022-08-02
3791 The molecular foundation of proprioceptor muscle-type identity
Dietrich, S.; Company, C.; Song, K.; Lowenstein, E. D.; Riedel, L.; Birchmeier, C.; Gargiulo, G.; Zampieri, N.
10.1101/2022.07.29.501977 — neuroscience — Posted on 2022-08-02
3793 Acanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection
Nuri, R.; Feldmesser, E.; Fridmann-Sirkis, Y.; Keren-Shaul, H.; Nevo, R.; Minsky, A.; Reich, Z.
10.1101/2022.07.20.500700 — microbiology — Posted on 2022-08-02
3794 The kinase occupancy of T-cell coreceptors reconsidered
Morch, A. M.; Schneider, F.; Jenkins, E.; Santos, A. M.; Fraser, S. E.; Davis, S.; Dustin, M. L.
10.1101/2022.08.01.502332 — immunology — Posted on 2022-08-02
3802 The late ISC pathway interactome reveals mitosomal-cytoplasmic crosstalk in Giardia intestinalis
Motyckova, A.; Voleman, L.; Najdrova, V.; Markova, L.; Benda, M.; Dohnalek, V.; Janowicz, N.; Malych, R.; Sutak, R.; Ettema, T.; Svard, S.; Stairs, C.; Dolezal, P.
10.1101/2022.08.01.502261 — cell biology — Posted on 2022-08-02
3804 Precise targeting for 3D cryo-correlative light and electron microscopy volume imaging of tissues using a FinderTOP
de Beer, M.; Daviran, D.; Roverts, R.; Rutten, L.; Sanchez, e. M.; Metz, J.; Sommerdijk, n.; Akiva, A.
10.1101/2022.07.31.502212 — cell biology — Posted on 2022-08-02
3805 The kinase occupancy of T-cell coreceptors reconsidered
Morch, A. M.; Schneider, F.; Jenkins, E.; Santos, A. M.; Fraser, S. E.; Davis, S.; Dustin, M. L.
10.1101/2022.08.01.502332 — immunology — Posted on 2022-08-02
3807 Idiosyncratic relation between human brain activity and behavior
Nakuci, J.; Yeon, J.; Xue, K.; Kim, J.-H.; Kim, S.-P.; Rahnev, D.
10.1101/2022.08.01.502338 — neuroscience — Posted on 2022-08-02
3810 Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor
Xu, H. E.; Zhang, Y.; Zhang, S.; Duan, J.; Xu, P.; Zhang, H.; Luan, X.; Yang, J.; Ji, Y.; He, X.; Jiang, H.; Cheng, X.; Jiang, Y.; Mao, C.; Shen, D.
10.1101/2022.08.01.502312 — cell biology — Posted on 2022-08-01
3811 Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human
Lin, Y.; Banno, K.; Gil, C.-H.; Myslinski, J.; Hato, T.; Shelley, W. C.; Gao, H.; Xuei, X.; Liu, Y.; Basile, D. P.; Yoshimoto, M.; Prasain, N.; Tarnawsky, S. P.; Adams, R. H.; Naruse, K.; Yoshida, J.; Murphy, M. P.; Horie, K.; Yoder, M. C.
10.1101/2022.07.31.502241 — cell biology — Posted on 2022-08-01
3812 Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.
Khani, S.; Topel, H.; Josephrajan, A.; Larsen, B. D. M.; Tavanez, A. R. A. d. A.; Gaudry, M. J.; Leyendecker, P.; Stanic, N.; Gaziano, I.; Hansmeier, N. R.; Schmidt, E.; Klemm, P.; Vagliano, L.-M.; Engelhard, C. A.; Nielsen, S.; Jespersen, N. Z.; Rehimi, R.; Gohlke, S.; Frommolt, P.; Gnad, T.; Rada-Iglesias, A.; Pradas-Juni, M.; Schulz, T. J.; Wunderlich, F. T.; Pfeifer, A.; Jastroch, M.; Wachten, D.; Kornfeld, J.-W.
10.1101/2022.08.01.502156 — cell biology — Posted on 2022-08-01
3816 Large vesicle extrusion from C. elegans neurons requires phagocytic interaction via the ARF-6 and CED-1/DRAPER pathways
Wang, Y.; Arnold, M. L.; Smart, A. J.; Wang, G.; Morera, A.; Nguyen, K. C.; Schweinsberg, P. J.; Bai, G.; Cooper, J.; Hall, D. H.; Driscoll, M.; Grant, B.
10.1101/2022.07.31.502194 — neuroscience — Posted on 2022-08-01
3820 Diversity, distribution, and expression of opsin genes in freshwater lakes
He, S.; Linz, A. M.; Stevens, S. L. R.; Tran, P. Q.; Moya-Flores, F.; Oyserman, B. O.; Dwulit-Smith, J. R.; Forest, K. T.; McMahon, K. D.
10.1101/2022.08.01.502354 — microbiology — Posted on 2022-08-01
3821 Correcting the Hebbian Mistake: Toward a Fully Error-Driven Hippocampus
Zheng, Y.; Liu, X. L.; Nishiyama, S.; Ranganath, C.; O'Reilly, R. C.
10.1101/2021.10.29.466546 — neuroscience — Posted on 2022-08-01
3824 NEMO- and RelA-dependent NF-kB Signaling Promotes Small Cell Lung Cancer
Koerner, L.; Yang, T.-P.; Schmiel, M.; Peifer, M.; Buettner, R.; Pasparakis, M.
10.1101/2022.07.29.501988 — cancer biology — Posted on 2022-08-01
3827 A metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis
Moretton, A.; Kourtis, S.; Calabro, C.; Ganez-Zapater, A.; Fontaine, F.; Müller, A. C.; Loizou, J. I.; Sdelci, S.
10.1101/2022.08.01.500855 — molecular biology — Posted on 2022-08-01
3831 Representations of complex contexts: A role for hippocampus
Dimsdale-Zucker, H. R.; Montchal, M. E.; Reagh, Z. M.; Wang, S.-F.; Libby, L. A.; Ranganath, C. R.
10.1101/766311 — neuroscience — Posted on 2022-08-01
3832 Precision fMRI reveals that the language-selective network supports both phrase-structure building and lexical access during language production
Hu, J.; Small, H.; Kean, H.; Takahashi, A.; Zekelman, L.; Kleinman, D.; Ryan, E.; Nieto-Castanon, A.; Ferreira, V.; Fedorenko, E.
10.1101/2021.09.10.459596 — neuroscience — Posted on 2022-08-01
3836 Super-resolution mass spectrometry enables rapid, accurate, and highly-multiplexed proteomics at the MS2-level
Kozhinov, A. N.; Johnson, A.; Nagornov, K. O.; Stadlmeier, M.; Martin, L.; Wuhr, M.; Tsybin, Y. O.
10.1101/2022.07.29.501912 — systems biology — Posted on 2022-08-01
3838 FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice
Calubag, M. F.; Ademi, I.; Yeh, C.-Y.; Babygirija, R.; Bhoopat, A. M.; Sonsalla, M. M.; Pak, H. H.; Lamming, D.
10.1101/2022.07.29.501882 — physiology — Posted on 2022-08-01
3839 Inflammatory response induced in pulmonary embolic lung: Evaluation usinga reproducible murine pulmonary embolism model.
Okabe, H.; Kato, H.; Yoshida, M.; Kotake, M.; Tnabe, R.; Matano, Y.; Yoshida, M.; Nomura, S.; Yamashita, A.; Nagai, N.
10.1101/2022.07.29.501960 — pathology — Posted on 2022-08-01
3841 Machine Learning Informs RNA-Binding Chemical Space
Yazdani, K.; Jordan, D.; Yang, M.; Fullenkamp, C. R.; Allen, T. E. H.; Khan, R. T.; Schneekloth, J. S.
10.1101/2022.08.01.502065 — biochemistry — Posted on 2022-08-01
3842 Mutational screens highlight glycosylation as a modulator of CSF3R activity
Hollander, M. J.; Malaker, S. A.; Perez, I.; Maxson, J. E.; Cochran, J. R.; Bertozzi, C. R.
10.1101/2022.08.01.502088 — biochemistry — Posted on 2022-08-01
3844 Plasma FIB milling for the determination of structures in situ
Berger, C.; Dumoux, M.; Glen, T.; Yee, N. B. y.; Mitchels, J. M.; Patakova, Z.; Naismith, J. H.; Grange, M.
10.1101/2022.08.01.502333 — biochemistry — Posted on 2022-08-01
3845 A chromosome-level genome resource for studying virulence mechanisms and evolution of the coffee rust pathogen Hemileia vastatrix
Tobias, P. A.; Edwards, R. J.; Surana, P.; Mangelson, H.; Inacio, V.; do Ceu Silva, M.; Varzea, V.; Park, R. F.; Batista, D.
10.1101/2022.07.29.502101 — genomics — Posted on 2022-08-01
3846 A curated human cellular microRNAome based on 196 primary cell types
Patil, A. H.; Baran, A.; Brehm, Z.; McCall, M. N.; Halushka, M. K.
10.1101/2022.05.16.492160 — genomics — Posted on 2022-08-01
3847 CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity
Lv, W.; Shao, Y.; Hoshino, A.; Arany, Z.; Musunuru, K.; McDermott-Roe, C.
10.1101/2022.08.01.502373 — cell biology — Posted on 2022-08-01
3848 PRMT5-mediated regulatory arginine methylation of RIPK3
Chauhan, C.; Del Val, A. M.; Niedenthal, R.; Olsen, J. V.; Kotlyarov, A.; Bekker-Jensen, S.; Gaestel, M.; Menon, M. B.
10.1101/2022.08.01.502351 — cell biology — Posted on 2022-08-01
3853 Emergence of CC17 vancomycin variable Enterococcus faecium in India
Sugumar, M.; Peela, S. C. M.; Viswanath, L. S.; Walia, K.; Sistla, S.
10.1101/2022.07.29.501338 — microbiology — Posted on 2022-08-01
3854 Distribution and origins of Mycobacterium tuberculosis L4 in Southeast Asia
Ashton, P. M.; Cha, J.; Anscombe, C.; Thuong, N. T. T.; Thwaites, G. E.; Walker, T. M.
10.1101/2022.08.01.502309 — microbiology — Posted on 2022-08-01
3856 Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis
Sawyer, A. J.; Patrick, E.; Edwards, J.; Wilmott, J. S.; Fielder, T.; Yang, Q.; Barber, D. L.; Ernst, J. D.; Britton, W. J.; Palendira, U.; Chen, X.; Feng, C. G.
10.1101/2022.07.31.502240 — immunology — Posted on 2022-08-01
3858 Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype
Maus, M.; Lopez-Polo, V.; Lafarga, M.; Aguilera, M.; De Lama, E.; Meyer, K.; Manonelles, A.; Sola, A.; Lopez Martinez, C.; Lopez-Alonso, I.; Hernandez-Gonzales, F.; Chaib, S.; Rovira, M.; Sanchez, M.; Faner, R.; Agusti, A.; Prats, N.; Albaiceta, G.; Cruzado, J. M.; Serrano, M.
10.1101/2022.07.29.501953 — physiology — Posted on 2022-08-01
3859 Polarized localization of phosphatidylserine in endothelium regulates Kir2.1
Ruddiman, C. A.; Peckham, R.; Luse, M. A.; Chen, Y. L. A.; Kuppusamy, M.; Corliss, B.; Hall, P. J.; Lin, C.-J.; Peirce, S. M.; Sonkusare, S. K.; Mecham, R. P.; Wagenseil, J. E.; Isakson, B. E.
10.1101/2022.08.01.502310 — physiology — Posted on 2022-08-01
3861 Laminar VASO fMRI in focal hand dystonia patients
Huber, L.; Kassavetis, P.; Gulban, O. F.; Hallett, M.; Horovitz, S. G.
10.1101/2022.07.28.501870 — neuroscience — Posted on 2022-08-01
3868 Cortical dynamics of speech feedback control in non-fluent Primary Progressive Aphasia
Kothare, H.; Ranasinghe, K.; Hinkley, L. B.; Mizuiri, D.; Licata, A.; Lauricella, M.; Honma, S.; Borghesani, V.; Dale, C.; Shwe, W.; Welch, A.; Miller, Z.; Gorno-Tempini, M. L.; Houde, J. F.; Nagarajan, S. S.
10.1101/2022.07.28.501928 — neuroscience — Posted on 2022-08-01
3869 Free energy perturbation calculations of mutation effects on SARS-CoV-2 RBD::ACE2 binding affinity
Sergeeva, A. P.; Katsamba, P. S.; Sampson, J. M.; Bahna, F.; Mannepalli, S.; Morano, N. C.; Shapiro, L.; Friesner, R. A.; Honig, B.
10.1101/2022.08.01.502301 — biophysics — Posted on 2022-08-01
3871 TSNAdb v2.0: the updated version of tumor-specific neoantigen database
Wu, J.; Chen, W.; Zhou, Y.; Chi, Y.; Hua, X.; Wu, J.; Gu, X.; Chen, S.; Zhou, Z.
10.1101/2022.07.28.501872 — bioinformatics — Posted on 2022-08-01
3874 The spectral underpinnings of pathogen spread on animal networks
Fountain-Jones, N. M.; Silk, M.; Appaw, R.; Hamede, R.; Rushmore, J.; VanderWaal, K.; Craft, M. E. M.; Carver, S.; Charleston, M.
10.1101/2022.07.28.501936 — ecology — Posted on 2022-08-01
3875 SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells
Pothast, C. R.; Dijkland, R. C.; Thaler, M.; Hagedoorn, R. S.; Kester, M. G.; Wouters, A. K.; Hiemstra, P. S.; van Hemert, M. J.; Gras, S.; Falkenburg, J. F.; Heemskerk, M. H.
10.1101/2022.07.31.502203 — immunology — Posted on 2022-08-01
3876 Graph lesion-deficit mapping of fluid intelligence
Cipolotti, L.; Ruffle, J. K.; Mole, J.; Xu, T.; Hyare, H.; Shallice, T.; Chan, E.; Nachev, P.
10.1101/2022.07.28.501722 — neuroscience — Posted on 2022-08-01
3877 The 3D Structural Architecture of the Human Hand Area is Non-Topographic
Doehler, J.; Northall, A.; Liu, P.; Fracasso, A.; Chrysidou, A.; Speck, O.; Lohmann, G.; Wolbers, T.; Kuehn, E.
10.1101/2022.07.28.501903 — neuroscience — Posted on 2022-08-01
3886 InterClone: Store, Search and Cluster Adaptive Immune Receptor Repertoires
Wilamowski, J.; Xu, Z.; Ismanto, H. S.; Li, S.; Teraguchi, S.; Covarrubias, M. A. L.; Lu, X.; Yamasaki, S.; Standley, D. M.
10.1101/2022.07.31.501809 — bioinformatics — Posted on 2022-08-01
3887 PEMT: A patent enrichment tool for drug discovery
Gadiya, Y.; Zaliani, A.; Gribbon, P.; Hofmann-Apitius, M.
10.1101/2022.07.28.501730 — bioinformatics — Posted on 2022-08-01
3890 Multiple origins of nematode-Wolbachia symbiosis in supergroup F and convergent loss of bacterioferritin in filarial Wolbachia
Sinha, A.; Li, Z.; Poole, C. B.; Ettwiller, L.; Lima, N. F.; Ferreira, M. U.; Fombad, F. F.; Wanji, S.; Carlow, C.
10.1101/2021.03.23.436630 — genomics — Posted on 2022-08-01
3892 Using agent-based models to predict pollen deposition in a dioecious crop
Broussard, M. A.; Jochym, M.; Tomer, N.; Jesson, L.; Shaw, A. K.; Crowder, D. W.; Bosque-Perez, N. A.; Li, J.; Peace, A.; Fonseka, D.; Howlett, B.; Pattemore, D. E.
10.1101/2022.07.28.501917 — ecology — Posted on 2022-08-01
3893 Recombinant Human ACE2-Fc : A promising therapy for SARS-CoV2 infection
P.K, S.; Shandil, R. K.; Suresh, P.; Biswas, K.; Rudramurthy, G. R.; Nanjegowda, N. C.; Kumaraswamy, B.; Battula, N. P.; Chowdhury, S. D.; Sinha, S.; Dutta, S.; Dhar, S. K.; Narayanan, S.; Das, M.
10.1101/2022.07.30.501940 — molecular biology — Posted on 2022-08-01
3895 SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses
Kohyama, M.; Suzuki, T.; Nakai, W.; Ono, C.; Matsuoka, S.; Iwatani, K.; Liu, Y.; Sakai, Y.; Nakagawa, A.; Tomii, K.; Ohmura, K.; Okada, M.; Matsuura, Y.; Oshima, S.; Maeda, Y.; Okamoto, T.; Arase, H.
10.1101/2022.08.01.502275 — microbiology — Posted on 2022-08-01
3896 Coronaviruses using different strategies to antagonize antiviral responses and pyroptosis
Fu, X.; Yang, Y.; Xu, W.; Li, D.; Li, X.; Chen, N.; Lv, Q.; Shi, Y.; Li, X.; Shi, F.
10.1101/2022.07.29.502014 — immunology — Posted on 2022-08-01
3897 Pallidin function in drosophila surface glia regulates sleep and is dependent on amino acid availability
Li, H.; Aboudhiaf, S.; Parrot, S.; Scote-Blachon, C.; Benetollo, C.; Lin, J.-S.; Seugnet, L.
10.1101/2022.05.03.490434 — neuroscience — Posted on 2022-08-01
3898 Multi-modal analysis and integration of single-cell morphological data
Govek, K. W.; Crawford, J.; Saturnino, A. B.; Zoga, K.; Hart, M. P.; Camara, P. G.
10.1101/2022.05.19.492525 — bioinformatics — Posted on 2022-08-01
3900 Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells
Roostaei, T.; Sabrin, A.; Kivisakk, P.; McCabe, C.; Nejad, P.; Felsky, D.; Touil, H.; Vlachos, I.; Hui, D.; Fransson, J.; Patsopoulos, N. A.; Kuchroo, V. K.; Zujovic, V.; Weiner, H. L.; Klein, H.-U.; De Jager, P. L.
10.1101/2022.06.29.498195 — genomics — Posted on 2022-08-01
3901 Memory B cells and memory T cells induced by SARS-CoV-2 booster vaccination or infection show different dynamics and efficacy to the Omicron variant.
Mise-Omata, S.; Ikeda, M.; Takeshita, M.; Uwamino, Y.; Wakui, M.; Arai, T.; Yoshifuji, A.; Murano, K.; Siomi, H.; Nakagawara, K.; Ohyagi, M.; Ando, M.; Hasegawa, N.; Saya, H.; Murata, M.; Fukunaga, K.; Namkoong, H.; Lu, X.; Yamasaki, S.; Yoshimura, A.
10.1101/2022.07.31.500554 — immunology — Posted on 2022-08-01
3903 Repeat Detector: versatile sizing of expanded tandem repeats and identification of interrupted alleles from targeted DNA sequencing
Taylor, A. S.; Barros, D.; Gobet, N.; Schuepbach, T.; McAllister, B.; Aeschbach, L.; Randall, E. L.; Trofimenko, E.; Heuchan, E. R.; Barszcz, P.; Ciosi, M.; Morgan, J.; Hafford-Tear, N. J.; Davidson, A. E.; Massey, T. H.; Monckton, D. G.; Jones, L.; REGISTRY Investigators of the European Huntington's disease network, ; Xenarios, I.; Dion, V.
10.1101/2022.03.08.483398 — neuroscience — Posted on 2022-08-01
3906 Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75
Wang, Q.; Iketani, S.; Li, Z.; Guo, Y.; Yeh, A. Y.; Liu, M.; Yu, J.; Sheng, Z.; Huang, Y.; Liu, L.; Ho, D. D.
10.1101/2022.07.31.502235 — microbiology — Posted on 2022-08-01
3909 Genomic evidence of natural selection for ash dieback resistance
Metheringham, C. L.; Plumb, W.; Stocks, J.; Kelly, L.; Nemesio Gorriz, M.; Moat, J.; Buggs, R.; Nichols, R. A.
10.1101/2022.08.01.502033 — evolutionary biology — Posted on 2022-08-01
3911 Sensbio: An online server for biosensor design
Tellechea-Luzardo, J.; Moreno Lopez, R.; Carbonell, P.
10.1101/2022.07.28.501596 — bioinformatics — Posted on 2022-08-01
3915 Causal identification of single-cell experimental perturbation effects with CINEMA-OT
Dong, M.; Wang, B.; Wei, J.; Frey, A.; Ouerghi, F.; Foxman, E. F.; Ishizuka, J. J.; Dhodapkar, R. M.; van Dijk, D.
10.1101/2022.07.31.502173 — bioinformatics — Posted on 2022-08-01
3918 Comprehensive visualization of cell-cell interactions in single-cell and spatial transcriptomics with NICHES
Raredon, M. S. B.; Yang, J.; Kothapalli, N.; Lewis, W.; Kaminski, N.; Niklason, L. E.; Kluger, Y.
10.1101/2022.01.23.477401 — bioinformatics — Posted on 2022-08-01
3919 Structural Mechanisms of Actin Isoforms
Arora, A. S.; Huang, H.-L.; Singh, R.; Narui, Y.; Hatano, T.; Heissler, S.; Balasubramanian, M. K.; Chinthalapudi, K.; Suchenko, A.
10.1101/2022.08.01.502282 — biochemistry — Posted on 2022-08-01
3920 A Gene Expression Atlas of Lohmann White Chickens
Zhang, J.; Wang, X.; Lv, C.; Wan, Y.; Zhang, X.; Li, J.; Wang, Y.
10.1101/2022.07.30.500160 — genomics — Posted on 2022-08-01
3922 Why is Babesia not killed by artemisinin like Plasmodium?
Si, W.; Fang, C.; Liu, C.; Yin, M.; Xu, W.; Li, Y.; Yan, X.; Shen, Y.; Cao, J.; Sun, J.
10.1101/2022.08.01.502256 — evolutionary biology — Posted on 2022-08-01
3923 Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin
Sacristan, C.; Samejima, K.; Andrade Ruiz, L.; Lambers, M. L. A.; Buckle, A.; Brackley, C. A.; Robertson, D.; Hori, T.; Webb, S.; Fukagawa, T.; Gilbert, N.; Marenduzzo, D.; Earnshaw, W. C.; Kops, G. J. P. L.
10.1101/2022.08.01.502248 — cell biology — Posted on 2022-08-01
3924 Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities
Bird, S.; Ford, S.; Thompson, C. M. A.; Little, R.; Hall, J. P. J.; Jackson, R.; Malone, J. G.; Harrison, E. G.; Brockhurst, M.
10.1101/2022.08.01.502293 — microbiology — Posted on 2022-08-01
3925 Streptococcus suis infection on European farms is associated with an altered tonsil microbiome and resistome
Fredriksen, S.; Neila-Ibanez, C.; Hennig-Pauka, I.; Guan, X.; Dunkelberger, J.; Fernandes de Oliveira, I.; Ferrando, M. L.; Correa-Fiz, F.; Aragon, V.; Boekhorst, J.; van Baarlen, P.; Wells, J. M.
10.1101/2022.08.01.500980 — microbiology — Posted on 2022-08-01
3926 A Cellular Taxonomy of the Adult Human Spinal Cord
Yadav, A.; Matson, K. J. E.; Li, L.; Hua, I.; Petrescu, J.; Kang, K.; Alkaslasi, M. R.; Lee, D. I.; Hasan, S.; Galuta, A.; Dedek, A.; Ameri, S.; Parnell, J.; Alshardan, M. M.; Ququmji, F. A.; Alhamad, S. M.; Wang, A. P.; Poulen, G.; Lonjon, N.; Vachiery-Lahaye, F.; Gaur, P.; Nalls, M. A.; Qi, Y. A.; Ward, M. E.; Hildebrand, M. E.; Mery, P.-F.; Bourinet, E.; Bauchet, L.; Tsai, E. C.; Phatnani, H.; Le Pichon, C.; Menon, V.; Levine, A.
10.1101/2022.03.25.485808 — neuroscience — Posted on 2022-08-01
3927 Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated to Plasmopara viticola development
Maia, M.; McCann, A.; Malherbe, C.; Far, J.; Cunha, J.; Eiras-Dias, J.; Cordeiro, C.; Eppe, G.; Quinton, L.; Figueiredo, A.; De Pauw, E.; Sousa Silva, M.
10.1101/2022.08.01.502001 — plant biology — Posted on 2022-08-01
3928 ObiWan-Microbi: OMERO-based integrated workflow for annotating microbes in the cloud
Seiffarth, J.; Scherr, T.; Wollenhaupt, B.; Neumann, O.; Scharr, H.; Kohlheyer, D.; Mikut, R.; Noeh, K.
10.1101/2022.08.01.502297 — bioinformatics — Posted on 2022-08-01
3930 Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
Juette, M. F.; Carelli, J. D.; Rundlet, E. J.; Brown, A.; Shao, S.; Ferguson, A.; Wasserman, M. R.; Holm, M.; Taunton, J.; Blanchard, S. C.
10.1101/2022.08.01.502281 — biochemistry — Posted on 2022-08-01
3931 Parasite genotype is a major predictor of mortality from visceral leishmaniasis
Grace, C. A.; Sousa Carvalho, K. S.; Sousa Lima, M. I.; Costa Silva, V.; Reis-Cunha, J. L.; Brune, M. J.; Forrester, S.; Pedrozo e Silva de Azevedo, C. d. M.; Costa, D. L.; Speed, D.; Mottram, J.; Jeffares, D. C.; Costa, C. H. N.
10.1101/2022.07.28.501951 — evolutionary biology — Posted on 2022-08-01
3932 DLC3/Cv-c function in testis development in humans and Drosophila: implication for variants of sex development
Sotillos, S.; von der Decken, I.; Domenech Mercade, I.; Srinivasan, S.; Vanni, S.; Nef, S.; Biason-Lauber, A.; Rodriguez Gutierrez, D.; C-G Hombria, J.
10.1101/2022.07.28.501838 — developmental biology — Posted on 2022-08-01
3933 Dually targeted proteins regulate proximity between peroxisomes and partner organelles
Stehlik, T.; Bittner, E.; Lam, J.; Dimitrov, L.; Schöck, I.; Harberding, J.; Heymons, N.; Schuldiner, M.; Zalckvar, E.; Bölker, M.; Schekman, R.; Freitag, J.
10.1101/2022.07.29.501968 — cell biology — Posted on 2022-08-01
3935 Multiscale light-sheet organoid imaging framework
de Medeiros, G.; Ortiz, R.; Strnad, P.; Boni, A.; Moos, F.; Repina, N.; Chalet-Meylan, L.; Maurer, F.; Liberali, P.
10.1101/2021.05.12.443427 — cell biology — Posted on 2022-08-01
3936 Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in Aspergillus fumigatus
van Rhijn, N.; Hemmings, S.; Storer, I. S. R.; Valero, C.; Alshammri, H.; Goldman, G.; Gsaller, F.; Amich, J.; Bromley, M. J.
10.1101/2021.11.18.469075 — microbiology — Posted on 2022-08-01
3937 Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.
Green, J. P.; El-Sharkawy, L. Y.; Roth, S.; Zhu, J.; Cao, J.; Leach, A.; Liesz, A.; Freeman, S.; Brough, D.
10.1101/2022.07.28.501942 — immunology — Posted on 2022-08-01
3946 Hierarchical Interleaved Bloom Filter: Enabling ultrafast, approximate sequence queries
Mehringer, S.; Seiler, E.; Droop, F.; Darvish, M.; Rahn, R.; Vingron, M.; Reinert, K.
10.1101/2022.08.01.502266 — bioinformatics — Posted on 2022-08-01
3949 SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion
Canson, D. M.; Kondrashova, O. M.; de la Hoya, M.; Parsons, M. T.; Glubb, D. M.; Spurdle, A. B.
10.1101/2022.07.30.502132 — bioinformatics — Posted on 2022-08-01
3951 Two shifts in evolutionary lability underlie independent gains and losses of root-nodule symbiosis in a single clade of plants
Kates, H.; O'Meara, B. C.; LaFrance, R.; Stull, G. W.; James, E. K.; Liu, S.; Tan, Q.; Yi, T.; Ane, J.-M.; Conde, D.; Kirst, M.; Soltis, D. E.; Guralnick, R. P.; Soltis, P. S.; Folk, R. A.
10.1101/2022.07.31.502231 — evolutionary biology — Posted on 2022-08-01
3952 Dynamics and consequences of the HTLV-1 proviral plus-strand burst
Ramanayake, S.; Moulding, D.; Tanaka, Y.; Singh, A.; Bangham, C. R. M.
10.1101/2022.08.01.502260 — microbiology — Posted on 2022-08-01
3957 miR167-ARF8, an auxin-responsive module involved in the formation of root-knot nematode-induced galls in tomato
Noureddine, Y.; da Rocha, M.; An, J.; Medina, C.; Mejias, J.; Mulet, K.; Quentin, M.; Abad, P.; Zouine, M.; Favery, B.; Jaubert, S.
10.1101/2022.07.29.501986 — plant biology — Posted on 2022-08-01
3958 Overexpression profiling reveals cellular requirements in context of genetic backgrounds and environments
Saeki, N.; Yamamoto, C.; Eguchi, Y.; Sekito, T.; Shigenobu, S.; Yashiroda, Y.; Boone, C.; Moriya, H.
10.1101/2022.07.29.502095 — systems biology — Posted on 2022-08-01