Channel: The Howard Hughes Medical Institute (HHMI)

2,454 Articles

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Engineered caspases directly rewire mutant Ras to cell death

Moeller, L., Lu, A. C., Ho, K., Zhang, E., Elowitz, M. B.

10.64898/2026.08.06.743376 — Posted: 2026-08-07

Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis

Ramanathan, V., Guo, C.-J., Nagano, M., Goel, V. Y., Hong, C. K., Swett, A. D., Caulier, A., King, E., Tothova, Z., Sankaran, V. G., Hansen, A. S.

10.64898/2026.08.02.741886 — Posted: 2026-08-06

Pangenome discovery and characterization of human protein-coding duplicated genes

Ren, L., Yoo, D., Vlajic, K., Dishuck, P. C., Guitart, X., Kwon, Y., Lin, J., Munson, K. M., Hoekzema, K., Stergachis, A., Vollger, M. R., Schweppe, D. K., Eichler, E. E.

10.64898/2026.08.05.743125 — Posted: 2026-08-06

Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain

Olalde, I., Armit, I., Büster, L., Lillie, M., Urkixo F. de Zuazo, E., Ringbauer, H., Akbari, A., Castells Navarro, L., Esteve-Gomez, D., Goodchild, H., Hamilton, D., Puig i Riera, N., Sanchez-Sanz, A., Buckberry, J., Budd, C., Caffell, A., Halkon, P., Holst, M., Jerand, P., Panagiotakopulu, E., Stephens, M., Stubbings, M., Ware, P., Bleasdale, M., Booth, T., Callan, K., Caughran, E., Fischer, C.-E., Frost, T., Iliev, L., Kearns, A., Legge, M., Mah, M., Masters, M. K., Manjila, N., Nawaz, M., Oppenheimer, J., Ponce, P., Primeau, C., Silva, M., Skoglund, P., Swali, P., Qiu, L., Gregory, S., Wo

10.64898/2026.08.03.742615 — Posted: 2026-08-06

Tobacco smoke-induced DNA adducts sensitize genomes to APOBEC mutagenesis and carcinogenesis through nucleotide excision repair

Durfee, C., Stefanovska, B., Wu, R., Cordoba-Caballero, J., Ibrahim, M. A., Carpenter, M. A., Liu, L., Nandi, S. P., Argyris, P. P., Bielo, L. B., Li, E. C. L., Temiz, N. A., Zhou, Y., Bergstrom, E. N., Mullally, C., Wang, Y., Liu, X., Barreto Duran, E., Troness, B., Proehl, J., Gupta, H., York, A., Vogel, R. I., Wells, J. M., Steele, C. D., Stuewe, I., Muldoon, D., Woo, J., Donoghue, M. T. A., Lindsey-Boltz, L. A., Sancar, A., Bandlamudi, C., Chandarlapaty, S., Yang, W., Malkova, A., Diaz-Gay, M., Alexandrov, L. B., Harris, R.

10.1101/2025.01.18.633716 — Posted: 2026-08-06

Large-scale mutational analysis uncovers molecular mechanisms governing dual RNA functions in transposons

Mortman, E. E., Sternberg, S. H.

10.64898/2026.03.11.711047 — Posted: 2026-08-06

The Phantom of the PCR: detection and consequences of spurious UMIs in mainstream RNA sequencing

Sugino, K., Lee, T.

10.64898/2026.08.01.742199 — Posted: 2026-08-06

Endogenous APOBEC3B Promotes CHK1 Inhibitor Sensitivity

Stefanovska, B., Troness, B., Mullally, C., de la Pena Avalos, B., Ibrahim, M., Chen, Y., Fanunza, E., Carpenter, M., Harris, R.

10.64898/2026.08.04.742831 — Posted: 2026-08-05

In situ pulse dispersion estimation via third-harmonic generation interferometric autocorrelation for multiphoton microscopy

Shaughnessy, L., Vannell, L., Fernando-Peiris, S., Rodriguez, C.