Channel: Northeastern University

This collection includes bioRxiv and medRxiv papers from authors at Northeastern University.

1346 Articles

Enhanced Radio-sensitization of Glioblastoma using a Dendrimer-Based Metformin Nano-formulation through Direct Tumor Suppression and Indirect Immune Modulation

Mahfooz, S., Wang, F., Chalbatani, G. M., Bronich, T. K., Romanova, S., Jia, Y., Bhat, K., Zhang, C.

10.64898/2026.05.12.724405 — Posted: 2026-05-17

Structure-Led Exploration of the Metagenome Yields Novel RNA-Guided Nucleases with Broad PAM Diversity

de los Santos, E. L., Rieber, L., Wang, M., Catherman, S., Hatfield, S., Bowen, T.

10.64898/2026.03.27.714800 — Posted: 2026-05-15

Sequence-Defined Digital Bottlebrush Polymers for Programmable Oligonucleotide Delivery

Lin, J., Sun, T., Wei, Y., Xue, C., Xu, G., Chen, P., Wang, Y., Yang, S., Cavazos, C., Shen, C., Wang, A., Wang, A., Zhang, K.

10.64898/2026.05.09.723525 — Posted: 2026-05-13

Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo

Amick, J., Bhandarkar, S., Wilcox, D. R., Boloker, S., Gu, C.

10.64898/2026.05.10.724157 — Posted: 2026-05-13

Toward a Random Background for Ligand Optimization

Xu, X., Mailhot, O., Correy, G. J., Huang, X., Braz, J., Shi, D., Srinivasan, K., Zielinski, K., Holota, Y., Kuziv, Y., Tsoutsouvas, C., Levinzon, N., Doruk, Y. U., Rachman, M., Diolaiti, M., Stevens, M., Liu, F., Holland, K., Hubner, H., Wang, J., Wu, Y., Ashworth, A., Makriyannis, A., Zhang, Y., Moroz, Y., Gmeiner, P., Abel, R., Manglik, A., Basbaum, A. I., Roth, B. L., Fraser, J. S., Shoichet, B. K.

10.64898/2026.05.10.724162 — Posted: 2026-05-13

On the state of protein function prediction: a report on the fourth CAFA challenge

Ramola, R., De Paolis Klauza, M. C., Piovesan, D., Peng, Y., Joshi, P., Mehdiabadi, M., Quaglia, F., Pancsa, R., Chemes, L. B., Ahmadi, M., Ahn, H., Altenhoff, A. M., Asgari, E., Aspromonte, M. C., Atalay, V., Babbi, G., Baldazzi, D., Barot, M. M., Ben-Hur, A., Benso, A., Berenberg, D., Bjorne, J., Boecker, F., Boldi, P., Bonello, J., Bordin, N., Borole, P., Ebrahimpour Boroojeny, A., Cao, R., Di Carlo, S., Casadio, R., Casiraghi, E., Chang, J.-M., Chen, C., Chen, T.-M., Cheng, J., Chiu, S., Dalkiran, A., Davidovic, R. S., Dessimoz, C., Diao, R., Djeddi, W. E., Dogan, T., Flannery, S. T., Font

10.64898/2026.05.06.722942 — Posted: 2026-05-11

Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance

Collins, M. A., Friedrich, C., Elcheikhali, M., Stewart, P., Derks, J., Connors Stewart, T., Altig, K., Melloni, A., Petelski, A., Oakley, D., Hyman, B., Slavov, N.

10.1101/2025.05.29.656728 — Posted: 2026-05-10

A complete human pancreatic cancer genome

Wagner, J., Keskus, A. G., Oshima, K. K., Ranallo-Benavidez, T. R., McDaniel, J., Sikic, M., Lin, D., Paulin, L. F., English, A. C., Sedlazeck, F. J., Munding, E. M., Sanborn, J. Z., Carroll, A., Chang, P.-C., Cook, D. E., Shafin, K., de Ligt, J., Hassaine, R., Cameron, D., Catreux, S., Lee, Y., Murray, L., Truong, S., Brueffer, C., Zimin, A. V., Cross, E., McGowan, M., Vernich, M., Liss, A. S., Kocher, J.-P., Stephens, Z., Ahmad, T., Bryant, A., Dwarshuis, N., He, H.-J., He, Z., Olson, N. D., Thibaud-Nissen, F., Antipov, D., Koren, S., Phillippy, A., Musunuri, R. L., Narzisi, G., Jain, M., We

10.64898/2026.05.01.722316 — Posted: 2026-05-10

A multicomponent behavior change intervention to promote walking in adults after traumatic brain injury: A Pilot Randomized Control Trial

Morris, T. P., Tinney, E. M., Toral, S., O'Brien, A., Gobena, E., Hackman, L., Nwakamma, M. C., Perko, M. L., Orchard, E., Odom, H., Chen, C., Hwang, J., Yedidia, N., Stillman, A. M., Kramer, A. F., Espanya-Irla, G.

10.64898/2026.02.26.26347181 — Posted: 2026-05-08

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

Joseph, R. E., Britton, R. G., Lin, D. Y.-w., Roche, J., Purslow, J. A., Fulton, D. B., Fukasem, P., Gleeson, M. P., Dyer, M. J. S., Wales, T. E., Andreotti, A. H.

10.64898/2026.05.07.723540 — Posted: 2026-05-08

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