Channel:  The Howard Hughes Medical Institute (HHMI)

2,491 Articles

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De novo design of autocatalytically forming intra- and intermolecular isopeptide bonds to construct rigid covalent protein assemblies
Milles, L. F., Huddy, E. B., Carr, A., Hsia, Y., Li, X., Kang, A., Sankaran, B., Bera, A. K., Baker, D.
10.64898/2026.08.13.744004 — Posted: 2026-08-18
Temporal single-cell profiling of the parabrachial Calca neurons reveals molecular dynamics driving nociplastic pain
Park, S., Clarke, H. H., Cao, F., Rose, A. D., Yang, E., Felix, R. R., Read, J., Chen, J. Y., Pauli, J. L., Palmiter, R. D.
10.64898/2026.08.07.743567 — Posted: 2026-08-17
Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis
Olguin Calderon, D., Kilpatrick, L. E., Conil, C., Philippot, Q., Ogishi, M., Vellutini, J., Eun Han, J., Keating, N., Li, H., Rao, G., Bohlen, J., Lay, C. S., Platt, S., Kerner, G., Feredj, E., Peel, J., Momenilandi, M., Seeleuthner, Y., Laine, C., soudee, c., Leloup, C., Debuisson, C., Lanternier, F., Bitoun, S. B., Pavy, S., Mariette, X., Rafik, A., Skhoun, H., EL Ouazzani, H., Abderahmani-Ghorfi, I., EL Baghdadi, J., Baena, A., Tejada-Giraldo, M., Barrera, L. F., Arias, A. A., Fabio, G., Carrabba, M., Emiroglu, M., Bezrodnik, L., EL Zein, L., Hammoud, H., Gregersen, P., Terrier, B., Leon L
10.64898/2026.03.23.713554 — Posted: 2026-08-13
The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall
Hart, E. M., de Bruin, D. A., Marando, V. M., Alemany, M. A., Snow, E. D., Schultz, B. J., Kuru, E., Walker, S., Vettiger, A., Bernhardt, T. G.
10.1101/2025.10.14.682376 — Posted: 2026-08-12
Photometallobiocatalytic Asymmetric Radical-Mediated Cross-Coupling of Organotrifluoroborate Salts and Pyridotriazoles
Wang, H., Mai, B. K., Zhang, X., Li, C., Liu, P., Yang, Y.
10.64898/2026.08.11.744224 — Posted: 2026-08-12
Coordination of turn-related activity in the superior colliculus with locomotor dynamics and hippocampal representations of possible futures
Wilhite, C., Frank, L. M., Scanziani, M.
10.64898/2026.06.12.731955 — Posted: 2026-08-12
Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity
Mehta, N., Larson, D. T., Wozney, M., Mishra, S., Subramani, S., Kaur, S., Jain, A., Chapman, E. R.
10.1101/2025.10.27.684894 — Posted: 2026-08-11
Reprogramming Cas9 PAM Recognition for Allele-Specific Editing
Tartaglia, J. A., Nguyen, V., Desmarais, J., Weissman, R., Thornton, B., Trinidad, M., Briseno, K., Hudson, T., Catamura, C., Lareau, L., Urnov, F., Doudna, J. A., Savage, D.
10.64898/2026.08.10.744034 — Posted: 2026-08-11
A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage
Ontoso, D., Mehta, M., Shabro, A., Dittmar, J., Reid, R. J. D., Rothstein, R., Nitiss, J. L., Keeney, S.
10.64898/2026.05.09.723998 — Posted: 2026-08-11
RADIX: a deep learning framework that maps root barriers across species and reveals genetic and environmental contributions
Gu, Y., Sanow, S., Taylor, T., Morimoto, K. W., Nemer, A., Hadley, D. J., Zafar, S. A., DeMello, L., Chen, Y., Knab, H., Busch Castro, A., Kumaravelu, V., Bailey-Serres, J., Carney, R., Brady, S.
10.64898/2026.08.07.743584 — Posted: 2026-08-10

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