Channel:  Francis Crick Institute

1,177 Articles

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Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases
Lee, R., Hooper, S., Pallett, L., Diniz, M., Mckinnon-Snell, T., Ramsden, Z., Rabas, N., Boeing, S., Kennedy, O., Buttercase, C., Aidoo-Micah, G., Price, G., Macfarlane, S. C., Bailey, S., Davies, J., Mathur, A., Pistocchi, G., Carminati, A., Gupta, A., Serra, P., Davidson, B. R., Pollok, J.-M., Papayannopoulos, V., Malanchi, I., Lorigan, P., Maini, M. K., Sahai, E.
10.1101/2025.09.30.679035 — Posted: 2025-10-01
Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context
Park, S. Y., Sheridan, A., An, B., Jarvis, E., Lyudchik, J., Patton, W., Axup, J. Y., Chan, S. W., Damstra, H. G. J., Leible, D., Leung, K. S., Magno, C. A., Meeran, A., Michalska, J. M., Rieger, F., Wang, C., Wu, M., Church, G. M., Funke, J., Huffman, T., Leeper, K. G. C., Truckenbrodt, S., Winnubst, J., Kornfeld, J. M. R., Boyden, E. S., Rodriques, S. G., Payne, A. C.
10.1101/2025.09.26.678648 — Posted: 2025-09-28
Protein degradation shapes developmental tempo in mouse and human neural progenitors
Nakanoh, S., Stamataki, D., Garcia-Perez, L., Azzi, C., Carr, H. L., Pokhilko, A., Doshi, L., Boezio, G. L. M., Melchionda, M., Howell, S., Yu, L., Skehel, M., Oxley, D., Andrews, S., Briscoe, J., Rayon, T.
10.1101/2024.08.01.604391 — Posted: 2025-09-27
CLONAL SELECTION SUPPORTED BY SINGLE CELL DNA SEQUENCING REVEALS HORMONAL ADAPTATION AND RESISTANCE IN LOCALLY ADVANCED BREAST CANCER DURING NEOADJUVANT AROMATASE INHIBITION
O'Mahony, D. G., Lesluyes, T., Brorson, I. S., Vernhoff, P., Sokolova, K., Aure, M. R., Alnaes, G. G., Hooen, R. M., Sundaram, A. Y., Theesfeld, C., Geisler, S. B., Sauer, T., Bahrami, N., Parulkar, R., Tahiri, A., Luders, T., Troyanskaya, O., Vaske, C., Van Loo, P., Geisler, J., Kristensen, V. N.
10.1101/2025.09.24.678208 — Posted: 2025-09-26
Substrate heterogeneity promotes cancer cell dissemination through interface roughening
Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M., Hannezo, E.
10.1101/2025.05.20.655037 — Posted: 2025-09-25
Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development
Korbonits, M., Wang, X., Barry, S., Lim, C. T., Suleyman, O., De Tito, S., Uddin, N. B., Vignola, M. L., Hall, C., Perna, L., Chapple, P., Henson, S., Morales, V., Bianchi, K., Edvardsson, V. O., Ragnarsson, K. A., Kristinsdottir, V. E., Debeer, A., Sleyp, Y., Zinchenko, R. A., Anderson, G., Duchen, M., Singh, K., Chung, C.-Y., Yuan, Y., Patel, S., Aksoy, E., Borovikov, A., Bjornsson, H. T., Van Esch, H., Czibik, G., Tooze, S., Brennan, C. H., Haworth, O.
10.1101/2025.09.18.677011 — Posted: 2025-09-24
Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
Patel, K., Mohanty, B., Norman, A., Franck, C., Pachl, P., Yang, L., Jing, X., Reid, X. J., Walshe, J. L., Solomon, P., Tran, D. H., Ford, D., Low, J. K. K., Wilkinson-White, L., Passioura, T., Payne, R. J., Suga, H., Walport, L. J., Mackay, J. P.
10.1101/2025.09.24.678353 — Posted: 2025-09-24
Distinct ATRX functions cooperate with 9-1-1 and CST complexesto safeguard replication and telomere integrity
Segura-Bayona, S., Maric, M., Takaki, T., Manova, Z., Li, S., Stanage, T. H., Idilli, A. I., Hewitt, G., Ruis, P., Millar, R., Patel, H., Howell, S., Kotsantis, P., Howell, M., Boulton, S. J.
10.1101/2025.09.22.677761 — Posted: 2025-09-22
Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation
Olthof, A. M., Gonzalez, M. N., Poulsen, N. B., Moreno, N. N., Bautu, T., Cugusi, S., Svejstrup, J.
10.1101/2025.09.18.677100 — Posted: 2025-09-18
Characterisation of LAMP1- and LAMP2A-positive organelles in neurons
Abouward, R., Abdelhafid, A. M., Wilkins, O. G., Lee, S.-Y., Ibrahim, F., Skehel, M., Ting, A., Birsa, N., Ule, J., Schiavo, G.
10.1101/2025.09.17.676809 — Posted: 2025-09-17

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