Channel:  Francis Crick Institute

1,182 Articles

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Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction
Pulschen, A. A., Booth, J., Satanowski, A., Soudy, C., Caro-Astorga, J., Ather, O., Patel, N., Alidoust, A., Aoudjane, S., Nematollahi, L., DeBenedictis, E.
10.1101/2025.10.08.681035 — Posted: 2025-10-08
DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells
Mantica, G., Vedi, A., Tuval, A., Huerga Encabo, H., Hayler, D., Krzywon, A., Mitchell, E., Dunn, W. G., Biezuner, T., Bastos, H. P., Sham, K., Santoro, A., Lee, J., Williams, N., Danin, A., Chapal, N., Moskovitz, Y., Arruda, A., Fiorillo, E., Orru, V., Marongiu, M., McKinney, E., Cucca, F., Collin, M., Minden, M., Campbell, P., Vassiliou, G. S., Fabre, M. A., Nangalia, J., Bonnet, D., Shlush, L., Laurenti, E.
10.1101/2025.10.08.679225 — Posted: 2025-10-08
Inactivation of Airborne Pathogen Surrogates by Triethylene Glycol
Desai, G., Goldman, E., Jordan, W., Balarashti, J., Caravanos, J., Edgar, R. S., Grignard, E., Ramachandran, G., Mainelis, G.
10.1101/2025.08.08.669335 — Posted: 2025-10-08
Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy.
Wilkins, A. C., Makris, S., Green, M., Hooper, S., Mikolajczak, A., Giangreco, G., Allanki, S., Nye, E., Connick, E., Mitter, R., Cooper, S., Durie, E., Pedersen, M., Burley, A., O'Fee, K., O'Leary, B., Shewring, D., Ramsden, Z., Melcher, A., Harrington, K., Somaiah, N., Acton, S. E., Sahai, E.
10.1101/2025.10.07.680949 — Posted: 2025-10-07
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates
Davi, V., Parutto, P., Crapart, C., Zhang, Y., Konno, T., Chambers, J., Franklin, J. P., Maddison, D., Awadelkareem, M. A., Devine, M. J., Koslover, E., Avezov, E.
10.1101/2025.10.06.677012 — Posted: 2025-10-07
Inferring gene-regulatory networks using epigenomic priors
Bartlett, T. E., Li, M., Song, C., Gao, Y., Huang, Q.
10.1101/2024.04.23.590858 — Posted: 2025-10-07
Apicortin defines the Plasmodium apical conoid body during transmission but is dispensable for the parasite life cycle
Zeeshan, M., Mishra, A., Pashley, S. L., Markus, R., Brady, D., Holder, A. A., Moores, C., Tewari, R.
10.1101/2025.10.01.678762 — Posted: 2025-10-03
The adaptive molecular landscape of reprogrammed telomeric sequences
D'Angiolo, M., Barre, B. P., Khaiwal, S., Muenzner, J., Hallin, J., De Chiara, M., Tellini, N., Warringer, J., Ralser, M., Gilson, E., Liti, G.
10.1101/2025.06.24.661269 — Posted: 2025-10-03
Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases
Lee, R., Hooper, S., Pallett, L., Diniz, M., Mckinnon-Snell, T., Ramsden, Z., Rabas, N., Boeing, S., Kennedy, O., Buttercase, C., Aidoo-Micah, G., Price, G., Macfarlane, S. C., Bailey, S., Davies, J., Mathur, A., Pistocchi, G., Carminati, A., Gupta, A., Serra, P., Davidson, B. R., Pollok, J.-M., Papayannopoulos, V., Malanchi, I., Lorigan, P., Maini, M. K., Sahai, E.
10.1101/2025.09.30.679035 — Posted: 2025-10-01
Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context
Park, S. Y., Sheridan, A., An, B., Jarvis, E., Lyudchik, J., Patton, W., Axup, J. Y., Chan, S. W., Damstra, H. G. J., Leible, D., Leung, K. S., Magno, C. A., Meeran, A., Michalska, J. M., Rieger, F., Wang, C., Wu, M., Church, G. M., Funke, J., Huffman, T., Leeper, K. G. C., Truckenbrodt, S., Winnubst, J., Kornfeld, J. M. R., Boyden, E. S., Rodriques, S. G., Payne, A. C.
10.1101/2025.09.26.678648 — Posted: 2025-09-28

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