Channel:  Aligning Science Across Parkinson's (ASAP)

503 Articles

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Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease
Sah, S., Sauerbeck, A. D., Gupta, J., Perez-Acuna, D., Reiber, J. E., Russell, D., Goralski, T., Henderson, M., Volpicelli-Daley, L. A., Higley, M. J., Kummer, T. T., Biederer, T.
10.1101/2024.06.20.599774 — Posted: 2026-05-08
Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum
Miller-Hansen, A. J., Zhu, M., Kovaleski, R. F., Demir, B., Lerner, T. N.
10.64898/2026.05.08.723861 — Posted: 2026-05-08
An isogenic single-cell atlas of familial Parkinson's disease mutations reveals convergent changes in dopamine neurons
Syed, K. M., Dunnack, J., Paatz, S., Ajjarapu, K., Sahagun, A., Rio, D., Soldner, F., Bateup, H., Hockemeyer, D.
10.64898/2026.05.04.722458 — Posted: 2026-05-06
Health phenome of Parkinson's patients reveals prominent mood-sleep cluster
Olsen, A. L., Locascio, J. J., Tuncali, I., Laroussi, N., Abatzis, E., Kamenskaya, P., Kuras, Y., Yi, T., Videnovic, A., Hayes, M. T., Ho, G. P. H., Paulson, J., Khurana, V., Herrington, T. M., Hyman, B. T., Selkoe, D. J., Growdon, J. H., Gomperts, S. N., Riise, T., Schwarzschild, M. A., Hung, A. Y., Wills, A.-M., Scherzer, C. R.
10.1101/2022.02.01.22270276 — Posted: 2026-05-04
Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Microphysiological System
Mesentier-Louro, L. A., Goldman, C., Gaese, S., Buonfiglioli, A., Kyriakis, D., Harlock, A., Ndayisaba, A., Sartori, E. R., Uchitelev, A., Fullard, J. F., Hennigan, E., Lee, D., Schuldt, B. R., Rooklin, R. B., Barra, J., Bravo-Cordero, J. J., Roussos, P., Khurana, V., Blanchard, J. W.
10.1101/2025.02.09.637107 — Posted: 2026-05-04
Utilizing Intraindividual Cognitive Variability to Predict Stage 2 Neuronal Synuclein Disease Progression
Combs, H. L., Kurth, R., Nair, A., York, M. K., Weintraub, D., Lafontant, D.-E., Caspell-Garcia, C., and the Parkinson's Progression Markers Initiative
10.1101/2025.10.21.25338482 — Posted: 2026-05-01
A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention
Marciano, S., Velazquez, L. G., Rodriguez Lopez, C., De Silva, N., Sommer, G., Tower, W., Torrres, E. R. S., Kaplitt, M. G., Milner, T. A., Marongiu, R.
10.64898/2026.03.20.712963 — Posted: 2026-04-30
Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease
Lin, Z., Parker, J., Nithianandam, V., Mathivanan, S., Wang, T., Liao, Z., Simmons, S. K., Tuncali, I., Adiconis, X., Haywood, N., Weykopf, B., Teng, X., Sharma, M., Yuan, J., Baecher-Allan, C., Dong, X., Beach, T. G., Serrano, G. E., Levin, J. Z., Zhang, S., Feany, M. B., Scherzer, C. R.
10.64898/2026.04.24.720642 — Posted: 2026-04-29
LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death
Goldman, A., Nguyen, M., Lanoix, J., Li, C., Fahmy, A., Zhong Xu, Y., Schurr, E., Thibault, P., Desjardins, M., McBride, H.
10.1101/2025.08.25.672135 — Posted: 2026-04-17
Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
Simmons, D. V., Moreno-Ramos, O. A., Raj, D. D. A., Kaganovsky, K., Pamukcu, A., Vrieler, N., Tkatch, T., Xie, Z., Zampese, E., De Sousa, A. I. S., Ding, J., Awatramani, R. V., Wilson, C., Surmeier, D. J.
10.1101/2024.03.27.586699 — Posted: 2026-04-17

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