Channel:  Aligning Science Across Parkinson's (ASAP)

524 Articles

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Genetic screening identifies glial adenosine as a therapeutic target in alpha-synucleinopathy
Sodders, M. J., Avila-Pacheco, J., Okorie, E. C., Tahmasebidehkordi, H., Marathi, A., Kumari, N., Lakhani, M., Schiro, A., Shen, M., Sriram, N., Sarkar, S., Olsen, A. L.
10.1101/2024.05.15.594309 — Posted: 2026-08-19
ATG2A interacts with RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis
Fuller, D. M., Wu, Y., Schueder, F., Rasool, B., Nag, S., Korfhage, J. L., Garcia-Milian, R., Melnyk, K. D., Bewersdorf, J., De Camilli, P., Melia, T.
10.1101/2025.03.24.645038 — Posted: 2026-08-18
Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation
Alexandersen, C. G., Brynildsen, J. K., Prigent, A., Tamborrino, M., Mantziou, A., Kurgat, K., Henderson, M. X., Bassett, D. S.
10.64898/2026.03.27.714785 — Posted: 2026-08-17
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
Duan, Y., Lu, Y., Paul, S., Betz, J., Wilhelm, L. P., Cook, A. S. I., Ren, X., Adriaenssens, E., Martens, S., Ganley, I., Hummer, G., Hurley, J. H.
10.1101/2025.11.07.687251 — Posted: 2026-08-12
Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagy
Chen, M., Bishnu, A., Duan, Y., Riley, J. F., Ni, Q., Joiner, A., Allen, I. J., Holzbaur, E., Ganley, I., Hurley, J. H.
10.64898/2026.08.07.743589 — Posted: 2026-08-10
A guanosine nucleotide metabolism-bioenergetics intersection drives Parkinson's disease
Kokotos, A. C., Unda, S. R., Reyes-Perez, P. R., Isayan, M., Perinan, M. T., Kaplitt, M. G., Ryan, T. A.
10.64898/2026.07.29.741503 — Posted: 2026-08-10
Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
Penuelas, N., Xicoy, H., Lorente-Picon, M., Nicolau-Vera, A., Parent, A., Gonzalez-Sepulveda, M., Laguna, A., Vila, M.
10.64898/2026.08.03.742448 — Posted: 2026-08-07
A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
Holzer, E., Sawa-Makarska, J., Bernklau, D., Romanov, J., Schuschnig, M., Martens, S.
10.1101/2025.08.16.670665 — Posted: 2026-08-04
Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model
Mesentier-Louro, L. A., Goldman, C., Gaese, S., Buonfiglioli, A., Kyriakis, D., Harlock, A., Ndayisaba, A., Sartori, E. R., Uchitelev, A., Fullard, J. F., Hennigan, E., Lee, D., Schuldt, B. R., Rooklin, R. B., Barra, J., Bravo-Cordero, J. J., Roussos, P., Khurana, V., Blanchard, J. W.
10.1101/2025.02.09.637107 — Posted: 2026-08-04
Health phenome of Parkinson's patients reveals prominent mood-sleep cluster
Olsen, A. L., Locascio, J. J., Tuncali, I., Laroussi, N., Abatzis, E., Kamenskaya, P., Kuras, Y., Yi, T., Videnovic, A., Hayes, M. T., Ho, G. P. H., Paulson, J., Khurana, V., Herrington, T. M., Hyman, B. T., Selkoe, D. J., Growdon, J. H., Gomperts, S. N., Riise, T., Schwarzschild, M. A., Hung, A. Y., Wills, A.-M., Scherzer, C. R.
10.1101/2022.02.01.22270276 — Posted: 2026-08-03

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