Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1069 Articles

Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence

Chapuis, A., Mazziotta, F., Martin, L., Eagan, D. N., Bar, M., Kinsella, S., Paulson, K. G., Voillet, V., Lahman, M. C., Hunter, D., Schmitt, T. M., Duerkopp, N., Yeung, C. C., Tang, T.-H., Gottardo, R., Asano, Y., Wilcox, E. C., Lee, B., Zhang, T., Lopedote, P., Penter, L., Wu, C. J., Milano, F., Greenberg, P. D.

10.1101/2024.12.13.24318504 — Posted: 2024-12-16

Large-Scale Deep Learning for Metastasis Detection in Pathology Reports

Krawczuk, P., Fox, Z. R., Petkov, V., Negoita, S., Doherty, J., Stroupe, A., Schwartz, S., Penberthy, L., Hsu, E., Gounley, J., Hanson, H.

10.1101/2024.12.12.24318789 — Posted: 2024-12-14

Single-cell multi-omic analysis of fibrolamellar carcinoma reveals rewired cell-to-cell communication patterns and unique vulnerabilities

Farghli, A. R., Chan, M., Sherman, M. S., Dickerson, L. K., Shui, B., Nukaya, M., Stephanou, A., Ma, R. K., Pepe-Mooney, B. J., Smith, C. J., Long, D., Munn, P. R., McNairn, A., Grenier, J. K., Karski, M., Ronnekleiv-Kelly, S. M., Pillarisetty, V. G., Goessling, W., Gujral, T., Vakili, K., Sethupathy, P.

10.1101/2024.12.11.627911 — Posted: 2024-12-12

Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA

Cucinotta, C., Dell, R., Alavattam, K., Tsukiyama, T.

10.1101/2024.12.12.628092 — Posted: 2024-12-12

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Rawat, P., Shapiro, M. R., Peters, L. D., Widrich, M., Mayer-Blackwell, K., Motwani, K., Pavlovi, M., al Hajj, G., Posgai, A. L., Kanduri, C., Isacchini, G., Chernigovskaya, M., Scheffer, L., Motwani, K., Balzano-Nogueira, L., Pettenger-Willey, C. M., Valkiers, S., Jacobsen, L. M., Haller, M. J., Schatz, D. A., Wasserfall, C. H., Emerson, R. O., Fiore-Gartland, A. J., Atkinson, M. A., Klambauer, G., Sandve, G. K., Greiff, V., Brusko, T. M.

10.1101/2024.12.10.24318751 — Posted: 2024-12-12

Long-Term Carotid Plaque Progression and the Role of Intraplaque Hemorrhage: Analysis from Deep Learning-based Longitudinal Vessel Wall Imaging

Guo, Y., Akcicek, E. Y., Hippe, D. S., HashemizadehKolowri, S., Wang, X., Akcicek, H., Canton, G., Balu, N., Geleri, D. B., Kim, T., Shibata, D., Zhang, K., Ma, X., Ferguson, M. S., Mossa-Basha, M., Hatsukami, T. S., Yuan, C.

10.1101/2024.12.09.24318661 — Posted: 2024-12-10

HIPSTR: highest independent posterior subtree reconstruction in TreeAnnotator X

Baele, G., Carvalho, L. M., Brusselmans, M., Dudas, G., Ji, X., McCrone, J. T., Lemey, P., Suchard, M. A., Rambaut, A.

10.1101/2024.12.08.627395 — Posted: 2024-12-10

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

Estevam, G. O., Linossi, E. M., Rao, J., Macdonald, C. B., Ravikumar, A., Chrispens, K. M., Capra, J. A., Coyote-Maestas, W., Pimentel, H., Collisson, E. A., Jura, N., Fraser, J. S.

10.1101/2024.07.16.603579 — Posted: 2024-12-05

E-box independent chromatin recruitment turns MYOD into a transcriptional repressor

Nicoletti, C., Massenet, J., Pintado-Urbanc, A. P., Connor, L. J., Nicolau, M., Sundar, S., Xu, M., Schmitt, A., Zhang, W., Fang, Z., Chan, T. C. I., Tapscott, S. J., Cheung, T. H., Simon, M. D., Caputo, L., Puri, P. L.

10.1101/2024.12.05.627024 — Posted: 2024-12-05

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection

Perugino, C., Liu, H., Feldman, J., Marbourg, J., Guy, T., Hui, A., Ingram, N., Liebaert, J., Chaudhary, N., Tao, W., Jacob-Dolan, C., Hauser, B. M., Mian, Z., Nathan, A., Zhao, Z., Kaseke, C., Tano-Menka, R., Getz, M., Senjobe, F., Berrios, C., Ofoman, O., Manickas-Hill, Z., Wesemann, D., Lemieux, J., Goldberg, M. B., Nundel, K., Moormann, A. M., Marshak-Rothstein, A., Larocque, R., Ryan, E., Iafrate, A. J., Lingwood, D., Gaiha, G., Charles, R., Balazs, A. B., Pandit, A., Naranbhai, V., Schmidt, A., Pillai, S.

10.1101/2024.11.29.624972 — Posted: 2024-12-04

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