Channel: Columbia University

This collection includes bioRxiv and medRxiv papers from authors at Columbia University.

5580 Articles

Apathy-anhedonia is associated with pessimistic beliefs yet sharpened goal-directed planning

Liang, S., Russek, E. M., Rutledge, R., Wimmer, G. E.

10.1101/2025.08.14.670362 — Posted: 2026-04-27

Transcriptional regulation of disease-relevant microglial activation programs

McQuade, A., Mishra, R., Hagan, V., Liang, W., Colias, P., Castillo, V. C., Gonzalez, B., Lubin, J., Haage, V., Marshe, V., Fujita, M., Ta, T., Gomes, L., Teter, O., Han, X., Robichaud, N., Chasins, S. E., Rexach, J. E., De Jager, P. L., Nunez, J. K., Kampmann, M.

10.1101/2025.10.12.681832 — Posted: 2026-04-27

Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease

Sun, X., Mews, M., Wheeler, N. R., Benchek, P., Gu, T., Gomez, L., Ray, N., Reitz, C., Naj, A. C., Below, J. E., Tosto, G., Cornejo-Olivas, M., Byrd, G. S., Feliciano-Astacio, B. E., Celis, K., Rajabli, F., Kunkle, B. W., Pericak-Vance, M. A., Haines, J. L., Griswold, A. J., Bush, W. S.

10.1101/2025.11.03.686160 — Posted: 2026-04-27

Transdiagnostic Neurobiological Biotypes of Trauma Timing: Data-driven approach of Childhood and Adulthood-Onset Trauma

Haim-Nachum, S., Zhang, C., Peng, K., Neria, Y., Zilcha-Mano, S., Zhu, X.

10.64898/2026.04.22.720234 — Posted: 2026-04-27

Single-nucleus multiome sequencing identifies candidate regulators of mouse gastric epithelial homeostasis

Monteiro de Barros, M. R., Bosch, K., Soualhi, S., Issa Bhaloo, S., Chu, T., Hemrajani, T., Cho, J., Ozuner, K., Fu, R., Geiger, H., Robine, N., Carter, J. E. B., Maniatis, S., Ryeom, S., Tavare, S., Nowicki-Osuch, K.

10.64898/2026.04.23.720450 — Posted: 2026-04-27

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium

Pak, M., Ryu, Y., Bae, S., Anticevic, A., Costa, A. D., Thorsen, A. L., van der Straten, A. L., Couto, B., Vai, B., Hansen, B., Soriano-Mas, C., Li, C.-s. R., Vriend, C., Lochner, C., Pittenger, C., Moreau, C. A., Rodriguez-Manrique, D., Vecchio, D., Shimizu, E., Stern, E. R., Munoz-Moreno, E., Nurmi, E. L., Piras, F., Colombo, F., Piras, F., Jaspers-Fayer, F., Benedetti, F., Venkatasubramanian, G., Eng, G. K., Simpson, H. B., Ruan, H., Hu, H., van Marle, H. J. F., Tomiyama, H., Martinez-Zalacain, I., Feusner, J., Narayanaswamy, J. C., Yun, J.-Y., Sato, J. R., Ipser, J., Pariente, J. C., Mench

10.64898/2026.04.24.26351711 — Posted: 2026-04-27

LANTERN: Leveraging Local Ancestry Tracts to Enhance Rare-Variant Aggregate Association Testing

Wang, Y., Tuftin, B., Raffield, L. M., Hidalgo, B., Kerns, S. L., DeWan, A. T., Leal, S. M., Auer, P.

10.64898/2026.04.24.26351693 — Posted: 2026-04-27

Human aging reflects increases in entropy across organ networks

Hao, M., Zhang, H., Li, Y., Huang, Y., Wu, J., Zhang, S., Guo, X. A., Li, X., Hu, Z., Li, X., Jiang, S., Tanner, K. T., Rutenberg, A., Chen, J., Bao, Z., Wang, J., Huang, Y., Cohen, A. A., Jin, L., Wang, X.

10.1101/2025.05.06.25327108 — Posted: 2026-04-26

A Remote Comprehensive Neurocognitive Test Battery to Monitor Postoperative Neurocognitive Dysfunction in Older Adults: A Prospective Observational Study

Rockholt, M. M., Wu, R. R., Seidenberg, B., Martinez, H., Momesso, G., Zhu, E., Saba, B. v., Perez, R., Bi, C., Park, W., Hui, J., Bruno, G., Waren, D., O'Brien, C., Denoon, R. B., Commeh, E. B., Aggarwal, V. K., Rozell, J. C., Furgiuele, D., Park, H. G., Schulze, E. T., Macaulay, W., Schwarzkopf, R., Wisniewski, T., Osorio, R. S., Doan, L. v., Wang, J.

10.64898/2026.02.16.26346401 — Posted: 2026-04-26

Adaptive prediction intervals for polygenic risk scores reveal individual variation in genetic predictability

Wang, C., Wang, F., Bogdan, M., Masala, M., Fiorillo, E., Devoto, M., Cucca, F., Belsky, D., Ionita-Laza, I.

10.1101/2025.10.13.682102 — Posted: 2026-04-24

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