Channel: Columbia University

This collection includes bioRxiv and medRxiv papers from authors at Columbia University.

4878 Articles

Sex bias determines MERS-CoV infection outcomes in a mouse model of differential pathogenicity

Habbick, M. R., Bushmaker, T., Singh, R., Sharma, P., Munster, V. J., van Doremalen, N., Rasmussen, A. L.

10.1101/2025.06.19.660369 — Posted: 2025-06-19

From Mechanistic Interpretability to Mechanistic Biology: Training, Evaluating, and Interpreting Sparse Autoencoders on Protein Language Models

Adams, E., Bai, L., Lee, M., Yu, Y., AlQuraishi, M.

10.1101/2025.02.06.636901 — Posted: 2025-06-18

Clinicogenomic landscape and function of PIK3CA, AKT1, and PTEN mutations in breast cancer

Tao, J. J., Sisoudiya, S., Tukachinsky, H., Schrock, A., Sivakumar, S., Sokol, E. S., Vasan, N.

10.1101/2025.06.18.25329632 — Posted: 2025-06-18

APALORD: An R-based tool for differential alternative polyadenylation analysis of long-read RNA-seq data

Zhang, Z., Glatt-Deeley, H., Zou, L., Song, D., Miura, P.

10.1101/2025.06.11.658931 — Posted: 2025-06-17

Seahorse Metabolic Analysis for Human and Mouse Cardiac Organotypic Slices

Trampel, K. A., Li, B., Melisova, A., Madrid, M. K., George, S. A., Efimov, I. R.

10.1101/2025.06.11.659150 — Posted: 2025-06-17

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization

Ghosh, A. R., Habib, R., Mishra, N., Roark, R. S., Akauliya, M., Albowaidey, A. A., Allen, J. D., Amereh, K., Avillion, G., Bottermann, M., Liang, B., Chaudhary, N., Callaghan, S., Dye, J., Li, X., Ellis-Pugh, J. R., Chowdhury, R. R., James, N. E., Liu, X., Maiorino, L., Villavicencio, P. M., Nedellec, R., Oberoi, P., Sowers, K. J., Park, Y., Prum, T., Rodriguez, L., Ssozi, M., Torres, J., Walsh, A. A., Warner, J. E., Weldon, S. R., Xu, L., Wiehe, K., Crispin, M., Ward, A. B., Nair, U., Hahn, B. H., Burton, D. R., Shapiro, L., Kwong, P. D., Irvine, D. J., Andrabi, R., Shaw, G. M., Batista, F.

10.1101/2025.06.12.659380 — Posted: 2025-06-17

Pulsed-laser lensing for phase modulation in electron microscopy

Du, D. X., Bartnik, A. C., Duncan, C. J. R., Choudhry, U., Tabachnik, T., Sallah, C., Ogawa, Y., Najafi, E., Yang, D.-S., Maxson, J. M., Fitzpatrick, A. W. P.

10.1101/2025.06.12.659428 — Posted: 2025-06-17

Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis

Steele, N., Morey, R., Hussain, A., Russell, C., Suarez-Jimenez, B., Pozzi, E., Jameei, H., Schmaal, L., Veer, I., Waller, L., Jahanshad, N., Thomopoulos, S., Salminen, L., Olff, M., Frijling, J., Veltman, D., Koch, S., Nawijn, L., van Zuiden, M., Wang, L., Zhu, Y., Li, G., Stein, D., Ipser, J., Neria, Y., Zhu, X., Ravid, O., Zilcha-Mano, S., Lazarov, A., Huggins, A., Stevens, J., Ressler, K., Jovanovic, T., van Rooij, S., Fani, N., Mueller, S., Hudson, A., Daniels, J., Sierk, A., Manthey, A., Walter, H., van der Wee, N., van der Werff, S., Vermeiren, R., Schmahl, C., Herzog, J., Rektor, I., i

10.1101/2025.06.16.657725 — Posted: 2025-06-17

The contribution of native protein complexes to targeted protein degradation

Glennie, L., Curnutt, N., Cartwright, T., Dunbar, K. J., Chatelier, B. L., Wood, N., Macartney, T. J., Woo, C. M., Sapkota, G. P.

10.1101/2025.06.17.660125 — Posted: 2025-06-17

A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

Safari, M. S., Makori, T. O., Gicheru, E. T., Mburu, M. W., Nyawa, O. K., Shee, F. M., Nyagwange, J., Kagucia, E. W., Ndungu, F. M., Chege, T., Tuju, J. O., Sande, C. J.

10.1101/2025.05.26.25328345 — Posted: 2025-06-17

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