Channel:  Breakthrough Discoveries for Thriving with Bipolar Disorder

8 Articles

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Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations
Liao, C., Ye, R., Sealock, J. M., Boltz, T., Ivankovic, F., Finucane, H., Howrigan, D., Liu, Y. C., Satterstrom, F. K., Hassan, A., Alemayehu, M., Gichuru, S., Mwende, R., Newton, C., Koen, N., Zingela, Z., Diaz-Zuluaga, A. M., Ramirez-Diaz, A. M., Reus, V. I., Teshiba, T., Palotie, A., Hamalainen, E., Pietilainen, O., Lind, P. A., Siskind, D. J., Hickie, I. B., Morales-Cedillo, P., Jimenez-Pavon, J., Sanabrais-Jimenez, M. A., Sotelo-Ramirez, C. E., Hahn, E., Nguyen, V. P., Karlson, E., Chang, C.-E., Chen, H.-C., Alda, M., Landen, M., Smoller, J. W., Craddock, N., Vawter, M. P., Curtis, D., Mc
10.64898/2026.09.30.26364416 — Posted: 2026-10-05
A founder population reveals genetic variation with major effect on serious mental illness
Gerdes, G., Tozzo, V., Service, S. K., Frydman-Gani, C., Diaz-Zuluaga, A. M., Valencia-Echeverry, J., Arias, A., Bicks, L. K., Ramirez-Diaz, A. M., Sealock, J. M., Liao, C., Howrigan, D. P., Liu, C., Lopera-Maya, E. A., Pimplaskar, A., De la Hoz, J. F., Arango-Gomez, M. A., Arango-Restrepo, C., Arbelaez-Herrera, M. C., Camacho-Gualteros, K., Cardona-Arango, M., Castano-Ramirez, M., Castaneda-Hoyos, J. A., Cerrato, F., Chapman, S. B., Franco-Gomez, R. E., Londono-Martinez, J. D., Mazo-Morales, J. S., Mejia-Piedrahita, J. C., Mir, E., Moore, T. M., Perez-Jaramillo, L. E., Perez-Vallejo, M., Posa
10.64898/2026.09.25.26363706 — Posted: 2026-09-27
Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia
Sealock, J. M., Dowd, C., Liao, C., Ye, R., Howrigan, D., Satterstrom, F. K., Auwerx, C., Kim, S., Huai, C., He, L., Alemayehu, M., Gichuru, S., Mwende, R. M., Newton, C. R. J. C., Koen, N., Zingela, Z., Kyebuzibwa, J., Stevenson, A., Hassan, A., Wang, K., Arai, M., Horiuchi, Y., Itokawa, M., Serrano, N. A., Bearden, C. E., Belangero, S. I., Castor Albuquerque, S. G., Crossley, N., de Souza Rodrigues, A. L., Diaz-Zuluaga, A. M., Diniz, M. M., Freitas, T. H., Gadelha, A., Gomez-Makhinson, J., Holanda, N., Kopelowicz, A., Lorencetti, P. G., Quarantini, L. C., Ramirez-Diaz, A. M., Reus, V. I., Sa
10.64898/2026.09.18.752670 — Posted: 2026-09-21
Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability
Ju, Y. H., Zhao, J. Y., Sianati, S., Egebjerg, C., Gonzalez, O. C., Criswell, A., Lee, C. Y., Du, K., Luff, C. E., Stralka, J., Knapp, V., de Lecea, L., Kozorovitskiy, Y., Kauer, J. A., Fenno, L. E.
10.64898/2026.06.03.730017 — Posted: 2026-06-25
Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder
Kim, J., Choe, M., Kaya, K., Hu, Y., Ng, K., Qiu, C., Zhong, M., Yang, W., Kiral, F., Scandura, M., Cha, H.-J., Gruen, J., Lek, M., Jonas, E., Blumberg, H., Park, I.-H.
10.64898/2026.04.10.717745 — Posted: 2026-04-12
Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment
Fernandez Garcia, M., Retallick-Townsley, K., Pruitt, A., Davidson, E., Balafkan, N., Warrell, J., Huang, T.-C., Kibowen, A., Chu, Z., Dai, Y., Fitzpatrick, S. E., Meng, R., Sen, A., Cohen, S., Livoti, O., Khan, S., Becker, C., Luiz Teles Silva, A., Liu, J., Dossou, G., Cheung, J., Liu, S., Ghorbani, S., Deans, P. J. M., DeCiucis, M., Emani, P., Gao, H., Shen, H., Gerstein, M., Wang, Z., Huckins, L., Hoffman, E., Brennand, K.
10.1101/2024.08.23.609190 — Posted: 2025-07-16
Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder
Meyer, K., Woodworth, M., Goncalves, M. C. B., Yue, M., AlJandal, H., Morton, S., Lewandowski, M., Liu, N., Zigon, E., Fortuna, P., Garcia-Corral, M., Budnik, B., Church, G. M., Tam, J. M.
10.1101/2025.04.01.646642 — Posted: 2025-04-01
A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner
Boltz, T. A., Chu, B. B., Liao, C., Sealock, J. M., Ye, R., Majara, L., Fu, J. M., Service, S., Zhan, L., Medland, S. E., Chapman, S. B., Rubinacci, S., DeFelice, M., Grimsby, J. L., Abebe, T., Alemayehu, M., Ashaba, F. K., Atkinson, E. G., Bigdeli, T., Bradway, A. B., Brand, H., Chibnik, L. B., Fekadu, A., Gatzen, M., Gelaye, B., Gichuru, S., Gildea, M. L., Hill, T. C., Huang, H., Hubbard, K. M., Injera, W. E., James, R., Joloba, M., Kachulis, C., Kalmbach, P. R., Kamulegeya, R., Kigen, G., Kim, S., Koen, N., Kwobah, E. K., Kyebuzibwa, J., Lee, S., Lennon, N. J., Lind, P. A., Lopera-Maya, E.
10.1101/2024.09.06.611689 — Posted: 2024-09-09

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