Channel:  The Howard Hughes Medical Institute (HHMI)

1,871 Articles

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Multimodal cell lineage reconstruction in the hindbrain reveals a link between progenitor origin and activity patterning
Blanc, M., Meister, L., Lemon, W. C., Fiuza, U.-M., Keller, P. J., Espinosa-Medina, I., Pujades, C.
10.1101/2025.11.14.688499 — Posted: 2025-12-09
Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels
Moon, S. J., Hu, Y., Dzieciatkowska, M., Kim, A.-R., Asara, J. M., D'Alessandro, A., Perrimon, N.
10.1101/2024.04.24.591006 — Posted: 2025-12-09
Structure and evolution-guided design of minimal RNA-guided nucleases
Skopintsev, P., Esain-Garcia, I., DeTurk, E. C., Yoon, P. H., Zhou, Z., Weiss, T., Kamalu, M., Chamraj, A., Loi, K. J., Langeberg, C. J., Boger, R., Nisonoff, H., Karp, H. M., Chen, L., Shi, H., Vohra, K., Banfield, J. F., Cate, J. H. D., Jacobsen, S. E., Doudna, J. A.
10.64898/2025.12.08.692503 — Posted: 2025-12-08
The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome
Shen, B. A., Asfahl, K. L., Lim, B., Bertolli, S. K., Minot, S. S., Radey, M. C., Penewit, K., Ngo, B., Salipante, S. J., Johnston, C. D., Peterson, S. B., Goodman, A. L., Mougous, J. D.
10.1101/2025.11.29.690828 — Posted: 2025-12-08
Brain-immune interactions generate pathogen-specific sickness states
Sullivan, Z. A., Wong, B. J., Kapoor, V., Vincze, P. K., Kaplan, H. S., Giraudet, P., Watson, B. R., Misherghi, A., Lourido, S., Moffitt, J. R., Dulac, C.
10.64898/2025.12.06.692770 — Posted: 2025-12-08
Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates
Blevins, A. M., Peng, W., Kinch, L., Monshad, Z., Paredes, A. G., Volz, C., Rutter, J., Casey, A., Hicks, K., Orth, K.
10.64898/2025.12.08.693056 — Posted: 2025-12-08
Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes
Zhou, J., Zhao, Y., Yildiz, A., Nogales, E.
10.64898/2025.12.06.692780 — Posted: 2025-12-07
Mouse germline cysts contain a fusome that mediates oocyte development
Pathak, M., Spradling, A. C.
10.1101/2025.07.25.666884 — Posted: 2025-12-07
Bispecific T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells
Obenaus, M., Poupault, C. L., McGinnis, C. S., Prange, C., Jiang, H., Su, L. L., Chen, X., Miao, Z., Muldoon, J. J., Yao, W., Waghray, D., Sun, Q., Eyquem, J., Hernandez-Lopez, R. A., Satpathy, A. T., Sage, J., Garcia, K. C.
10.64898/2025.12.04.692214 — Posted: 2025-12-06
Biological causes and impacts of rugged tree landscapes in phylodynamic inference
Gao, J., Brusselmans, M., Carvalho, L. M., Suchard, M. A., Baele, G., Matsen, F. A.
10.1101/2025.06.10.657742 — Posted: 2025-12-05

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