Channel:  Arc Institute

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

23 Articles

Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang, J., Ubas, A. A., de Borja, R., Svensson, V., Thomas, N., Thakar, N., Winters, A., Khan, U., Jones, M. G., Tran, V., Pangallo, J., Papalexi, E., Sapre, A., Nguyen, H., Sanderson, O., Nigos, M., Kaplan, O., Schroeder, S., Hariadi, B., Marrujo, S., Salvino, C. C. A., Gallareta Olivares, G., Koehler, R., Geiss, G., Rosenberg, A., Roco, C., Merico, D., Alidoust, N., Goodarzi, H., Yu, J.
10.1101/2025.02.20.639398 — Posted: 2025-04-23
scBaseCamp: An AI agent-curated, uniformly processed, and continually expanding single cell data repository
Youngblut, N. D., Carpenter, C., Prashar, J., Ricci-Tam, C., Ilango, R., Teyssier, N., Konermann, S., Hsu, P., Dobin, A., Burke, D. P., Goodarzi, H., Roohani, Y. H.
10.1101/2025.02.27.640494 — Posted: 2025-03-04
Genome modeling and design across all domains of life with Evo 2
Brixi, G., Durrant, M. G., Ku, J., Poli, M., Brockman, G., Chang, D., Gonzalez, G. A., King, S. H., Li, D. B., Merchant, A. T., Naghipourfar, M., Nguyen, E., Ricci-Tam, C., Romero, D. W., Sun, G., Taghibakshi, A., Vorontsov, A., Yang, B., Deng, M., Gorton, L., Nguyen, N., Wang, N. K., Adams, E., Baccus, S. A., Dillmann, S., Ermon, S., Guo, D., Ilango, R., Janik, K., Lu, A. X., Mehta, R., Mofrad, M. R. K., Ng, M. Y., Pannu, J., Re, C., Schmok, J. C., St. John, J., Sullivan, J., Zhu, K., Zynda, G., Balsam, D., Collison, P., Costa, A. B., Hernandez-Boussard, T., Ho, E., Liu, M.-Y., McGrath, T., P
10.1101/2025.02.18.638918 — Posted: 2025-02-21
Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease
Tjaden, N. E. B., Liou, M. J., Sax, S., Lassoued, N., Lou, M., Schneider, S., Beigel, K., Eisenberg, J. D., Loeffler, E., Anderson, S. E., Yan, G., Litichevskiy, L., Dohnalova, L., Zhu, Y., Jin, D. M. J. C., Raab, J., Furth, E. E., Thompson, Z., Rubenstein, R. C., Pilon, N., Thaiss, C. A., Heuckeroth, R.
10.1101/2025.02.10.637436 — Posted: 2025-02-11
scGPT-spatial: Continual Pretraining of Single-Cell Foundation Model for Spatial Transcriptomics
Wang, C. X., Cui, H., Zhang, A. H., Xie, R., Goodarzi, H., Wang, B.
10.1101/2025.02.05.636714 — Posted: 2025-02-08
Learning single-cell spatial context through integrated spatial multiomics with CORAL
He, S., Bieniosek, M., Song, D., Zhou, J., Chidester, B., Wu, Z., Boen, J., Sharma, P., Trevino, A. E., Zou, J.
10.1101/2025.02.01.636038 — Posted: 2025-02-06
Decoy-seq unlocks scalable genetic screening for regulatory small noncoding RNAs
Choi, B., Sobti, S., Soto, L. M., Charbonneau, T., Sababi, A., Navickas, A., Najafabadi, H. S., Goodarzi, H.
10.1101/2025.01.25.634869 — Posted: 2025-01-27
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers
Yang, M. G., Richter, H. J., Wang, S., McNally, C. P., Harris, N., Dhillon, S., Maresca, M., de Wit, E., Willenbring, H., Maher, J., Goodarzi, H., Ramani, V.
10.1101/2025.01.17.633622 — Posted: 2025-01-22
Targeting Osteosarcoma heterogeneity to improve therapeutic response
Melano, B., Dinh, T., Zirak, B., Karimzadeh, M., Woo, B. J., Choi, B., Goodarzi, H., Sweet-Cordero, A.
10.1101/2025.01.02.631118 — Posted: 2025-01-03
A generative framework for enhanced cell-type specificity in rationally designed mRNAs
Khoroshkin, M. S., Zinkevich, A., Aristova, E., Yousefi, H., Lee, S. B., Mittmann, T., Manegold, K., Penzar, D., Raleigh, D. R., Kulakovskiy, I. V., Goodarzi, H.
10.1101/2024.12.31.630783 — Posted: 2024-12-31

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