Channel:  Arc Institute

30 Articles

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Efficient generation of epitope-targeted de novo antibodies with Germinal
Mille-Fragoso, L. S., Wang, J. N., Driscoll, C. L., Dai, H., Widatalla, T. M., Zhang, X., Hie, B. L., Gao, X. J.
10.1101/2025.09.19.677421 — Posted: 2025-09-25
An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates
Wong, M. M.-K., Zhou, S., Carpenter, C., Valbuena, R., Priyadarshini, M., Arya, A., Rizvi, A., Carswell-Crumpton, C., Wileveau, A., Lopez-Lopez, G., Tycko, J., Yao, D., Spees, K., Maynard, J., Bassik, M. C., Goodarzi, H., Sanulli, S.
10.1101/2025.09.21.676939 — Posted: 2025-09-21
Generative design of novel bacteriophages with genome language models
King, S. H., Driscoll, C. L., Li, D. B., Guo, D., Merchant, A. T., Brixi, G., Wilkinson, M. E., Hie, B. L.
10.1101/2025.09.12.675911 — Posted: 2025-09-17
Predicting cellular responses to perturbation across diverse contexts with STATE
Adduri, A. K., Gautam, D., Bevilacqua, B., Imran, A., Shah, R., Naghipourfar, M., Teyssier, N., Ilango, R., Nagaraj, S., Ricci-Tam, C., Carpenter, C., Subramanyam, V., Winters, A., Dong, M., Tirukkovalur, S., Sullivan, J., Plosky, B. S., Eraslan, B., Youngblut, N. D., Leskovec, J., Gilbert, L. A., Konermann, S., Hsu, P. D., Dobin, A., Burke, D. P., Goodarzi, H., Roohani, Y. H.
10.1101/2025.06.26.661135 — Posted: 2025-07-10
Megabase-scale human genome rearrangement with programmable bridge recombinases
Perry, N. T., Bartie, L. J., Katrekar, D., Gonzalez, G. A., Durrant, M. G., Pai, J. J., Fanton, A., Hiraizumi, M., Ricci-Tam, C., Nishimasu, H., Konermann, S., Hsu, P. D.
10.1101/2025.05.14.653916 — Posted: 2025-05-16
Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang, J., Ubas, A. A., de Borja, R., Svensson, V., Thomas, N., Thakar, N., Winters, A., Khan, U., Jones, M. G., Thompson, J. D., Tran, V., Pangallo, J., Papalexi, E., Sapre, A., Nguyen, H., Sanderson, O., Nigos, M., Kaplan, O., Schroeder, S., Hariadi, B., Marrujo, S., Salvino, C. C. A., Gallareta Olivares, G., Koehler, R., Geiss, G., Rosenberg, A., Roco, C., Merico, D., Alidoust, N., Goodarzi, H., Yu, J.
10.1101/2025.02.20.639398 — Posted: 2025-05-10
scBaseCount: An AI agent-curated, uniformly processed, and continually expanding single cell data repository
Youngblut, N. D., Carpenter, C., Prashar, J., Ricci-Tam, C., Ilango, R., Teyssier, N., Konermann, S., Hsu, P., Dobin, A., Burke, D. P., Goodarzi, H., Roohani, Y. H.
10.1101/2025.02.27.640494 — Posted: 2025-05-06
Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis
Chen, S., Markett, D., Karimzadeh, M., Luo, Y., Khoroshkin, M. S., Boyraz, B., Lee, S., Carpenter, C., Nguyen, P., Garcia, K., Joshi, T., Martin, C., Hanisch, B., Molina, H., Tavazoie, S., Ramani, V., Navickas, A., Goodarzi, H.
10.1101/2025.04.26.650725 — Posted: 2025-04-29
Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude
Marti-Mateos, Y., Midha, A. D., Huynh, H., Flanigan, W. R., Blume, S. Y., Jain, I. H.
10.1101/2025.04.24.650365 — Posted: 2025-04-26
BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences
Teyssier, N., Dobin, A.
10.1101/2025.04.08.647863 — Posted: 2025-04-15

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