Channel:  The Howard Hughes Medical Institute (HHMI)

2,206 Articles

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Global cell-state and gene-program representations reveal conserved and context-specific perturbation responses of cells
Pan, X., Saunders, R., Replogle, J. M., Weissman, J. S., Zhuang, X.
10.64898/2026.05.16.725005 — Posted: 2026-05-18
Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation
Russell, K., Chen, Y., Espinosa, J. R., Gil, D. F., Zhou, H., Maristany, M. J., Lopez, J. I. P., Huertas, J., Orozco, M., Rosen, M. K., Collepardo-Guevara, R.
10.1101/2025.11.17.688899 — Posted: 2026-05-18
Kinetochore clustering is mediated by Mps1 phosphorylation of conserved MELT motifs in Stu1
Mallett, D. R., Jiang, M., Minnuto, G. M., Biggins, S.
10.64898/2026.01.23.701336 — Posted: 2026-05-18
Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism
Tian, W., Chen, S., Yao, L., Kasinath, V., Luger, K.
10.64898/2026.05.17.725740 — Posted: 2026-05-18
A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use
Zhang, R., Wei, Z., How, J. J., Nardin, M., Narayan, S., Kinkhabwala, A., Chen, W., Lim, J.-X., Ruetten, V. M. S., Rupashinge, A., Haesemeyer, M., Mensh, B. D., Fishman, M. C., Engert, F., Babadi, B., Du, J., Prober, D. A., Ahrens, M. B.
10.64898/2026.04.10.717666 — Posted: 2026-05-15
Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles (BEACON) for Mucosal Vaccination Against Genital Herpes
Bhagchandani, S. H., Ehrenzeller, S., Pires, I. S., Chaudhary, N., Booth, C. J., Kwon, D.-i., Koutsioumpa, C., Baker, C. A., Laxton, C., Guedes de Sa, K. S., Matthews, C., Gill, P., Li, S., Olszowka, A., Hudak, A., Fischer, S., Bayarri-Olmos, R., Hooper, W. B., Iwasaki, A.
10.1101/2025.07.31.667899 — Posted: 2026-05-15
BAT protects against hepatic oxidative stress by remodeling the circulating metabolome
Wang, D., Li, M., Lu, T., Matsushita, M., Sakai, J., Saito, M., Yoneshiro, T., Kajimura, S.
10.64898/2026.05.12.722834 — Posted: 2026-05-15
AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD
Wang, S., Zhao, S., Daniels, A., Naaman, E., Gardner, A., Wang, T., Sun, Y., Fu, Z., Smith, L. E. H., Cepko, C. L.
10.64898/2026.05.13.724735 — Posted: 2026-05-15
Structure and Mechanism of a Two-component Lanthipeptide Toxin
Moreira, R., Giurgiu, C., Rahman, I. R., Patterson, M., Huber, S. T., Yang, Y., Jeanne Dit Fouque, K., Fernandez-Lima, F., Liu, G., Guo, R., Kelich, P., Wen, P.-C., Tajkhorshid, E., Johnson, A. G., van der Donk, W. A.
10.64898/2026.05.13.724966 — Posted: 2026-05-14
AAV tools enable functional modulation and readout of central and peripheral nervous systems in spiny mice
Chung, J. H., Donahue, R. R., Griffiths, J. A., Fan, Y., Lin, C., Chen, X., Dutta, S., Mazmanian, S., Seifert, A. W., Gradinaru, V.
10.64898/2026.05.08.723863 — Posted: 2026-05-13

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