Channel:  Aligning Science Across Parkinson's (ASAP)

476 Articles

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Machine learning-based image analysis of Parkinson's disease iPS-derived neurons predicts genotype and reveals mitochondria-lysosome abnormalities
Li, Y., Powell, M., Chedid, J., Sutharsan, R., Garrido, A. L., Abu-Bonsrah, D., Pavan, C., Fraser, T., Ovchinnikov, D., Zhong, M., Davis, R., Strbenac, D., Johnston, J. A., Thompson, L. H., Kirik, D., Parish, C. L., Halliday, G. M., Sue, C. M., Dzamko, N., Wali, G.
10.64898/2026.01.28.702423 — Posted: 2026-01-29
Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
Peat, C., Prasad, A., Finkelstein, D. I., Sue, C., Johnston, J., Parish, C., Thompson, L., Kirik, D., Halliday, G.
10.1101/2025.01.09.632283 — Posted: 2026-01-25
Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations
Lee, Y. J., Syed, K., Busquets, O., Li, H., Dunnack, J., Bateup, H., Soldner, F., Hockemeyer, D., Rio, D.
10.1101/2024.02.28.582420 — Posted: 2026-01-22
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
Adami, A., Garza, R., Dorazehi, F., Douse, C. H., Jakobsson, J.
10.1101/2025.10.24.684366 — Posted: 2026-01-22
An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement
Bouabid, S., Vu, M.-A. T., Noggle, C., Vietti-Michelina, S., Brimblecombe, K., Platt, N., Zhang, L., Joshi, A., Cragg, S., Howe, M. W.
10.64898/2026.01.20.700614 — Posted: 2026-01-21
Multi-omics reveal critical differentiation target for Parkinsons' Disease-vulnerable midbrain dopaminergic neurons
Garcia Swinburn, R., Lyu, G., Kreutzmann, J. C., Xiong, A., Kojima, R., Abaurre, C., Tremolanti, C., Gellhaar, S., Uhlen, P., Svenningsson, P., Castelo Branco, G., Dagliyan, O., Salto, C., Arenas, E.
10.1101/2025.06.18.660098 — Posted: 2026-01-20
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
Li, D., Zhang, W., Medina, M., Stuke, J. F. M., Schwarz, A., Brill, J., Brenner, J., Kraus, F., Ohlerich, S., Lizarrondo, J., Pflaum, J., Grass, J. H., Soltow, L.-M., Hammerschmid, D., Weber, N., Welsch, S., Langer, J., Windbergs, M., Harper, W. J., Schuman, E., Hummer, G., Grotjahn, D. A., Wilfling, F.
10.64898/2026.01.17.700056 — Posted: 2026-01-19
In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.
Shonai, D., Kent, J., Okafor, A., Gao, Y., Parameswaran, P., Bustamante, E., Ramani, B., Diao, Y., Kampmann, M., Soderblom, E. J., Soderling, S. H.
10.64898/2026.01.16.699530 — Posted: 2026-01-17
The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance
Lange, L. M., Fang, Z.-H., Makarious, M. B., Kuznetsov, N., Atterling Brolin, K., Ballard, S., Bardien, S., Doquenia, M. L., Heutink, P., Houlden, H., Iwaki, H., Jasaityte, S., Jones, L., Junker, J., Kaiyrzhanov, R., Koretsky, M., Kumar, K. R., the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), , Leonard, H., Levine, K., Lim, S.-Y., Mencacci, N. E., Mohamed, W. M. Y., Nalls, M. A., Noyce, A., Ojha, R., Okubadejo, N. U., Rehman, S. u., Screven, L., Shashkin, C., Sopromadze, S., Stafford, E. J., Tan, A. H., Tan, M., Tavadyan, Z., Trinh, J., Tserensodnom, B
10.1101/2025.07.08.25330815 — Posted: 2026-01-14
Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons
Filimontseva, A., Fu, Y., Halliday, G.
10.64898/2026.01.12.699117 — Posted: 2026-01-12

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