Channel:  Aligning Science Across Parkinson's (ASAP)

453 Articles

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AutoMorphoTrack: A modular framework for quantitative analysis of organelle morphology, motility, and interactions at single-cell resolution
Bayati, A., Schumacher, J. G., Chen, X.
10.1101/2025.07.19.665650 — Posted: 2025-11-12
Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C.
Li, D., Wang, X., Hu, B., Hao, H., Hamill, S., Li, Y., Chen, G., De Camilli, P., Reinisch, K.
10.1101/2025.11.10.687702 — Posted: 2025-11-11
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
Duan, Y., Lu, Y., Paul, S., Betz, J., Wilhelm, L. P., Cook, A. S. I., Ren, X., Adriaenssens, E., Martens, S., Ganley, I., Hummer, G., Hurley, J. H.
10.1101/2025.11.07.687251 — Posted: 2025-11-09
Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease
Chocarro, J., Marana, S., Espelosin, M., Rico, A. J., Ariznabarreta, G., Lorenzo-Ramos, E., Ilarduya, M. M., Hernandez-Alcoceba, R., Chillon, M., Vila, M., Kordower, J., Schapira, A. H. V., Garcia-Osta, A., Cuadrado-Tejedor, M., Lanciego, J. L.
10.1101/2025.05.09.653000 — Posted: 2025-11-05
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.
Weglage, M., Aehrlund Richter, S., Contestabile, A., Skara, V., Fuzik, J., Santos, I., Lazaridis, I., Meletis, K.
10.1101/2022.03.16.484460 — Posted: 2025-10-30
Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries
Gimenez, P., Shakya, R. T., Santamaria, F., Tonnesen, J.
10.1101/2025.10.29.685288 — Posted: 2025-10-29
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
Adami, A., Garza, R., Dorazehi, F., Douse, C. H., Jakobsson, J.
10.1101/2025.10.24.684366 — Posted: 2025-10-28
The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
Mahoney-Sanchez, L., Clarke-Lucas, H., Penverne, A., Evans, J. R., D'Sa, K., Strohbuecker, S., Lopex Garcia, P., Cosker, K., Soltic, D., O'Callaghan, B. J., Griffiths, A., Pintchovski, S. A., Plun-Favreau, H., Hallqvist, J., Mills, K., Gandhi, S.
10.1101/2025.10.13.682089 — Posted: 2025-10-14
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
Kraus, F., He, Y., Jiang, Y., Li, D., Ambaw, Y. A., Gasparoli, F. M., Paulo, J. A., Walther, T. C., Farese, R., Gygi, S. P., Wilfling, F., Harper, J. W.
10.1101/2025.10.08.681047 — Posted: 2025-10-08
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Ehses, K. L., Lopez-Alonso, J. P., Antico, O., Azem, A., Muqit, M., Ubarretxena-Belandia, I., Fernandez-Busnadiego, R.
10.1101/2025.10.06.680693 — Posted: 2025-10-06

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