Channel:  The Howard Hughes Medical Institute (HHMI)

1,912 Articles

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Separating selection from mutation in antibody language models
Matsen, F. A., Dumm, W., Sung, K., Johnson, M. M., Rich, D., Starr, T., Song, Y. S., Fukuyama, J., Haddox, H. K.
10.1101/2025.10.21.683652 — Posted: 2026-01-25
Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785
Zhang, S., Stix, R., Orabi, E. A., Bernhardt, N., Faraldo-Gomez, J. D.
10.1101/2024.07.25.605170 — Posted: 2026-01-24
Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells
Zaganelli, S., Meehl, J., Abrisch, R. G., Voeltz, G. K.
10.1101/2025.04.18.649598 — Posted: 2026-01-24
Long-term post-ovariectomy mouse model recapitulates hypothalamic transcriptomic changes observed during the menopausal transition in women
Bloom, J. C. B., Torres, E., Pereira, S. A., Arvizu-Sanchez, L., Fontes, A. N., Joffe, H., Page, D. C., Navarro, V. M.
10.1101/2024.10.05.616758 — Posted: 2026-01-24
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Ralph, D. K., Bakis, A. G., Galloway, J., Vora, A. A., Araki, T., Song, Y. S., DeWitt, W. S., Matsen, F. A.
10.1101/2025.08.12.669950 — Posted: 2026-01-22
Evolutionary innovation through fusion of sequences from across the tree of life
Kapoor, R., Schwager, E. E., Phuangphong, S., Rivard, E. L., Kuyyamudi, C., Ghosh, S., Ronai, I., Extavour, C. G.
10.1101/2025.08.30.672725 — Posted: 2026-01-22
Sciphy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data.
Seidel, S., Zwaans, A., Regalado, S., Choi, J., Shendure, J., Stadler, T.
10.1101/2024.10.01.615771 — Posted: 2026-01-22
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Rich, M. S., Pellow, R., Hefel, A., Rog, O., Jorgensen, E. M.
10.1101/2025.11.11.687718 — Posted: 2026-01-21
Inefficient autophagosome formation limits the temporal dynamics of OPTN-mediated mitophagy in neurons
Green, J. R., Gooden, M. K., Ojo, A. E., Kalejaiye, T. D., Evans, C. S.
10.64898/2026.01.16.700014 — Posted: 2026-01-20
Establishing the molecular basis for MDA5 mutation-linked autoimmunity
Xu, L., Chung, K., Guo, R., Pan, A., Pyle, A.
10.64898/2026.01.20.700587 — Posted: 2026-01-20

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