Channel:  The Michael J. Fox Foundation

187 Articles

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
Wang, S., Baumert, R., Sejourne, G., Sivadasan Bindu, D., Dimond, K., Sakers, K., Vazquez, L., Moore, J. L., Tan, C. X., Takano, T., Rodriguez, M. P., Brose, N., Bradley, L., Lessing, R., Soderling, S. H., La Spada, A. R., Eroglu, C.
10.1101/2023.04.09.536178 — Posted: 2025-04-29
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., Kelly, J. W., Finley, D., Wernig, M., Wyss-Coray, T., Frydman, J.
10.1101/2023.03.27.534444 — Posted: 2025-01-13
Classification of Parkinson's Disease and Delineating Progression Markers from the Sebum Volatilome
Walton-Doyle, C., Heim, B., Sinclair, E., Lim, S. H., Hollywood, K., Milne, J., Holzknecht, E., Stefani, A., Hogl, B., Seppi, K., Silverdale, M., Poewe, W., Barran, P., Trivedi, D. K.
10.1101/2023.03.01.530578 — Posted: 2024-11-19
Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling
Singh, P., Agarwal, S., Volpi, I., Wilhelm, L. P., Becchi, G., Keenlyside, A., Macartney, T., Toth, R., Rousseau, A., Masson, G., Ganley, I. G., Muqit, M. M. K.
10.1101/2023.03.20.533516 — Posted: 2024-08-27
Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging and disease
Kilfeather, P., Khoo, J. H., Wagner, K., Liang, H., Caiazza, M.-C., An, Y., Zhang, X., Chen, X., Connor-Robson, N., Shang, Z., Wade-Martins, R.
10.1101/2023.04.20.537553 — Posted: 2023-12-04
Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson's GBA-N370S mutation
Do, Q. B., Ng, B., Marquez-Gomez, R., Beccano-Kelly, D., Ibarra-Aizpurua, N., Caiazza, M.-C., Lang, C., Baleriola, J., Bengoa-Vergniory, N., Wade-Martins, R.
10.1101/2023.03.01.530566 — Posted: 2023-06-07
Modulatory Effect of Levodopa on the Basal Ganglia-Cerebellum Connectivity in Parkinson's Disease
Abulikemu, S., Tai, Y. F., Haar, S.
10.1101/2023.01.16.524229 — Posted: 2023-05-04
The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neurons
Mamais, A., Sanyal, A., Fajfer, A., Zykoski, C. G., Guldin, M., Riley-DiPaolo, A., Subrahmanian, N., Gibbs, W. S., Lin, S., LaVoie, M. J.
10.1101/2023.04.30.538317 — Posted: 2023-04-30
Longitudinal brain structure changes in Parkinson's disease: a replication study
Sokolowski, A., Bhagwat, N., Chatelain, Y., Dugre, M., Hanganu, A., Monchi, O., McPherson, B., Wang, M., Poline, J.-B., Sharp, M., Glatard, T.
10.1101/2023.04.28.538743 — Posted: 2023-04-29
Prospective role of PAK6 and 14-3-3 gamma as biomarkers for Parkinson's disease
Giusto, E., Maistrello, L., Iannotta, L., Giusti, V., Iovino, L., Bandopadhyay, R., Antonini, A., Bubacco, L., Barresi, R., Plotegher, N., Greggio, E., Civiero, L.
10.1101/2023.04.28.538525 — Posted: 2023-04-28

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