Channel:  The Howard Hughes Medical Institute (HHMI)

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B Cell Receptor Signaling Sets Boundaries for Selection of Broadly Neutralizing Antibody Functional Mutations
Singh, A., Anasti, K., Itallie, E. V., Newman, A., Kane, A. P., Barr, M., Parks, R., Venkatayogi, S., Tian, M., Saunders, K., Henderson, R., Cain, D. W., Alt, F. W., Haynes, B. F., Verkoczy, L., Wiehe, K., Alam, S. M.
10.64898/2026.08.13.744461 — Posted: 2026-08-19
Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates
Barber, J. S., Tonouchi, K., Yeh, C.-H., Berry, M., Kirshner, H. F., Wiehe, K., Eaton, A., Montefiori, D. C., Tian, M., Alt, F. W., Saunders, K. O., Shaw, G. M., Haynes, B. F., Kelsoe, G.
10.64898/2026.08.11.744292 — Posted: 2026-08-19
Architectures and biochemical activities of Mtl1-Red1 MTREC helicase complexes
Repeta, L. D., Lima, C. D.
10.64898/2026.08.18.745603 — Posted: 2026-08-19
The south Congo Basin was critical to Bantu settlement of south central Africa
Choin, J., de Luna, K., Fleisher, J., Sawchuk, E., Goldstein, S., Kaliba, P., Katongo, M., Morris, A. G., Mudenda, G., Welling, M., Sirak, K., Callan, K., Iliev, L., Lawson, A. M., Michel, M., Oppenheimer, J., Qiu, L., Workman, J. N., Kearns, A., Mah, M., Soos, G., Mallick, S., Rohland, N., Thompson, J., Prendergast, M. E., Reich, D.
10.64898/2026.08.14.741591 — Posted: 2026-08-19
Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization
Joseph, J., Wang, L., Vasquez, S., Su, C.-M., Wrapp, D., Rosen, O., Abiona, O. M., Dzuvor, C. K. O., Kirchdoerfer, R. N., Moak, S. P., Sheahan, T. P., Hammond, C., Shi, W., Kong, W.-P., Zhang, Y., Eso, M. R., Brown, A. J., Dangi, T., Penaloza-MacMaster, P., Ward, A. B., Baric, R., McLellan, J. S., Pierson, T. C., Mascola, J., Graham, B. S., Yassine, H. M., Saeed, M., Barnes, C. O., Corbett-Helaire, K. S.
10.1101/2025.10.29.685445 — Posted: 2026-08-19
VTA dopamine neuron activity produces spatially organized stimulus and action value representations through conditioned reinforcement
Pan-Vazquez, A., Zimmerman, C. A., McMannon, B., Fabre, J. M. J., Louka, M., Jia, T., Sagiv, Y., West, S. J., Faulkner, M., International Brain Laboratory, , Dayan, P., Witten, I. B.
10.1101/2025.11.04.685995 — Posted: 2026-08-19
Genetic innovation in coronaviruses driven by a viral nuclease
Bianco, C., Stabell, A. C., Lodha, M., Aldis, M., Tartell, M. A., Hatziioanou, T., Bieniasz, P. D.
10.64898/2026.08.15.744938 — Posted: 2026-08-19
Cryo-EM of a nucleotide-polymerizing ribozyme enables its predictive improvement
Szokoli, D., Hingey, J., Wu, V., Haack, D. B., Spellmon, N., Rudolfs, B., Mancino, A., Yu, Z., Toor, N., Das, R.
10.64898/2026.08.14.744467 — Posted: 2026-08-19
Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies
Crivelli, V., Guerra, C., Abernathy, M. E., Sgrignani, J., Zoppi, G., Greeson, M. L., Sanga, A., Locatelli, P., Cantergiani, J., Cena, B., Cervantes Rincon, T., Lee, Y. E., Eso, M., Jarrossay, D., Biggiogero, M., Calvaruso, V., Franzetti Pellanda, A., Garzoni, C., Tamagnini, E., Lestani, S., Varani, L., Sommer, S., Fernandez, D., Barba Spaeth, G., Niejadlik, E. G., Bournazos, S., Robbiani, D. F., Barnes, C. O., Cavalli, A.
10.64898/2026.08.17.745160 — Posted: 2026-08-18
De novo design of autocatalytically forming intra- and intermolecular isopeptide bonds to construct rigid covalent protein assemblies
Milles, L. F., Huddy, E. B., Carr, A., Hsia, Y., Li, X., Kang, A., Sankaran, B., Bera, A. K., Baker, D.
10.64898/2026.08.13.744004 — Posted: 2026-08-18

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