Channel:  Somatic Cell Genome Editing Program

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

12 Articles

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function
McCutcheon, S., Swartz, A., Brown, M., Barrera, A., McRoberts Amador, C., Siklenka, K., Humayun, L., Isaacs, J., Reddy, T. E., Nair, S., Antonia, S., Gersbach, C. A.
10.1101/2023.05.01.538906 — Posted: 2023-05-01
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo
Zhang, H., Kelly, K., Lee, J., Echeverria, D., Cooper, D., Panwala, R., Chen, Z., Gaston, N., Newby, G. A., Xie, J., Liu, D. R., Gao, G., Wolfe, S. A., Khvorova, A., Watts, J. K., Sontheimer, E. J.
10.1101/2023.03.20.533459 — Posted: 2023-03-23
The FusX TALE Base Editor (FusXTBE) for rapid mitochondrial DNA programming of human cells in vitro and zebrafish disease models in vivo
Sabharwal, A., Kar, B., Castillo, S. R., Holmberg, S. R., Kendall, B. L., Cotter, R. P., WareJoncas, Z., Clark, K. J., Ekker, S. C.
10.1101/2021.05.18.444740 — Posted: 2021-05-20
Diverse ATPase proteins in mobilomes constitute a large potential sink for prokaryotic host ATP
Shim, H., Shivram, H., Lei, S., Doudna, J. A., Banfield, J.
10.1101/2021.04.01.438130 — Posted: 2021-04-01
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Liu, P., Liang, S., Zheng, C., Mintzer, E., Zhao, Y. G., Ponnienselvan, K., Mir, A., Sontheimer, E. J., Gao, G., Flotte, T. R., Wolfe, S., Xue, W.
10.1101/2020.12.15.422970 — Posted: 2021-03-17
Genome-wide annotation of gene regulatory elements linked to cell fitness
Klann, T., Barrera, A., Ettyreddy, A., Rickels, R., Bryois, J., Jiang, S., Adkar, S., Iglesias, N., Sullivan, P., Reddy, T. E., Crawford, G. E., Gersbach, C.
10.1101/2021.03.08.434470 — Posted: 2021-03-09
Transgenic mice for in vivo epigenome editing with CRISPR-based systems
Gemberling, M., Siklenka, K., Rodriguez, E., Eisinger, K., Barrera, A., Liu, F., Kantor, A., Li, L., Cigliola, V., Hazlett, M., Williams, C., Bartelt, L., Bodle, J., Daniels, H., Rouse, C., Hilton, I., Madigan, V., Asokan, A., Ciofani, M., Poss, K., Reddy, T. E., West, A., Gersbach, C.
10.1101/2021.03.08.434430 — Posted: 2021-03-08
5' Modifications Improve Potency and Efficacy of DNA Donors for Precision Genome Editing
Ghanta, K. S., Chen, Z., Mir, A., Dokshin, G. A., Krishnamurthy, P. M., Yoon, Y., Gallant, J., Xu, P., Zhang, X.-O., Ozturk, A., Shin, M., Idrizi, F., Liu, P., Gneid, H., Lawson, N. D., Rivera-Perez, J. A., Sontheimer, E. J., Watts, J. K., Mello, C. C.
10.1101/354480 — Posted: 2021-03-04
Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors
Ibraheim, R., Tai, P. W. L., Mir, A., Javeed, N., Wang, J., Rodriguez, T. C., Nelson, S., Khokhar, E., Mintzer, E., Maitland, S., Cao, Y., Tsagkaraki, E., Wolfe, S. A., Wang, D., Pai, A. A., Xue, W., Gao, G., Sontheimer, E. J.
10.1101/2020.10.09.333997 — Posted: 2020-10-09
Methods Matter -- Standard Production Platforms For Recombinant AAV Produce Chemically And Functionally Distinct Vectors
Rumachik, N. G., Malaker, S. A., Poweleit, N., Maynard, L. H., Adams, C. M., Leib, R. D., Cirolia, G., Thomas, D., Stamnes, S., Holt, K., Sinn, P., May, A. P., Paulk, N. K.
10.1101/640169 — Posted: 2020-05-25

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