Channel:  The Howard Hughes Medical Institute (HHMI)

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In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles
Seraj, Z., Zottig, X., Huang, C., Loveland, A. B., Diggs, S., Sholi, E., Grigorieff, N., Korostelev, A. A.
10.1101/2025.11.25.690450 — Posted: 2025-11-25
Flavoaffinins, elusive cellulose-binding natural products from an anaerobic bacterium
Kountz, D. J., Yu, R., Lee, J. H., Maloney, K. N., Balskus, E. P.
10.1101/2025.02.08.637243 — Posted: 2025-11-25
A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome
Kim, A.-R., Huang, K., Johnson, J. L., Yaron-Barir, T. M., Wang, K., Cantley, L. C., Hu, Y., Perrimon, N.
10.1101/2025.10.10.681672 — Posted: 2025-11-25
Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila
Fontan, A., Lannes, R., Fingerhut, J., Flynn, J., Yamashita, Y. M.
10.1101/2025.05.22.655455 — Posted: 2025-11-25
Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF
Henikoff, S., Henikoff, J. G.
10.1101/2025.11.10.687711 — Posted: 2025-11-24
Deconvolving SARS-CoV-2 mRNA vaccine impact on immunotherapy-related survival in a pandemic
Jee, J., Zhang, J., Lavery, J., Waters, M., Fong, C., Minn, A., Glickman, M., Panageas, K., Sawyers, C., Schultz, N.
10.1101/2025.11.21.25340753 — Posted: 2025-11-23
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder
Song, B. J., Ge, Y., Nicolella, A., Kwon, M. J., Lodder, B., Bonanno, K., Valle-Tojeiro, A., Hartley, N. D., Mandell, K. P., Adeleye, J., Misri, D., Geng, C., Natarajan, S., Picard, I., Shepard, N., Hall, A., Tian, J., Aryal, S., Farsi, Z., Liu, X.-M., Morshed, N., Nadaf, N. M., Pribiag, H., Simmons, S. K., Mani, D. R., Stevens, B., Kunwar, P. S., Fu, Z., Macosko, E. Z., Levin, J. Z., Sabatini, B. L., Carr, S. A., Dejanovic, B., Keshishian, H., Granger, A. J., Sheng, M.
10.1101/2024.09.24.614783 — Posted: 2025-11-22
A gene expression atlas of a juvenile nervous system
Taylor, S. R., Olson, C., Ripoll-Sanchez, L., Valperga, G., McWhirter, R., Barney, S. T., Atkinson, A., Goel, S., Weinreb, A., Hardin, A., Rolfson, A., Pattee, J., Aguilar, G. R., Merritt, D. M., Eroglu, M., Majeed, M., Grundvig, E., Child, E., Vertes, P. E., Schafer, W., Varol, E., Hammarlund, M., Hobert, O., Miller, D. M.
10.1101/2025.11.21.689793 — Posted: 2025-11-22
Computational design of metalloproteases
Chen, A., Wu, K., Choi, H., Venkatesh, P., Pellock, S. J., Hanikel, N., Coventry, B., Kim, D., Woodbury, S. M., Ji, P., Honda, S., Li, X., Gerben, S., Chang, L., Yan, X., Hyman, A. A., Hilvert, D., Baker, D.
10.1101/2025.11.20.689622 — Posted: 2025-11-21
Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses
Lezgiyeva, K., Liu, J., Nguyen, K., DeLisle, M. M., Ko, F. C., Fullam, S., Obeidat, A. M., Turecek, J., Alkislar, I., Lehnert, B. P., Martinez-Garcia, R. I., Sivakumar, R., Choi, J., Mazor, O., Garibyan, L., Sharma, N., Emanuel, A. J., Malfait, A.-M., Miller, R. E., Ginty, D. D.
10.1101/2025.11.11.687663 — Posted: 2025-11-20

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