Channel:  The Howard Hughes Medical Institute (HHMI)

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Distributed control circuits across a brain-and-cord connectome
Bates, A. S., Phelps, J. S., Kim, M., Yang, H. H., Matsliah, A., Ajabi, Z., Perlman, E., Delgado, K. M., Osman, M. A. M., Salmon, C. K., Gager, J., Silverman, B., Renauld, S., Salman, F., Patel, J., Collie, M. F., Fan, J., Pacheco, D. A., Zhao, Y., Zhang, W., Serratosa Capdevilla, L., Roberts, R. J., Munnelly, E. J., Griggs, N., Langley, H., Moya-Llamas, B., Zhang, Z., Maloney, R. T., Yu, S.-c., Sterling, A. R., Sorek, M., Kruk, K., Serafetinidis, N., Dhawan, S., Klemm, F., Brooks, P., Lesser, E., Jones, J. M., Pierce-Lundgren, S. E., Lee, S.-Y., Luo, Y., Cook, A. P., McKim, T. H., Giakoumas
10.1101/2025.07.31.667571 — Posted: 2026-02-14
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia
Ding, W., Klein, A., Baez-Becerra, C. T., Rink, J. A., Bartlett, A., Zeng, Q., Wang, R., Castanon, R. G., Nery, J. R., Osgood, E., Owens, W., Petrella, A., Chen, C., Acerbo, A. S., Barcoma, A. S., Liu, J., Russo, K. G., Knutson, K. W., Young, C. K., Willier, J. K., Barragan, C., Arzavala, J., Cho, S., Altshul, J., Chan, D., Soma, E., Luo, J., Jain, M., Velazquez, S., Schenker-Ahmed, N., Sundaram, G. V., Manning, A. C., Sanchez, Y., Bikkina, A., Fu, S., OConnor, C., Liem, M., Marrin, M. V., Rose, C., Alt, S. N., Berry, J., Kern, C., Boone, E., Tian, W., Wu, Y., Hariharan, M., Fu, Y., Xie, Y., L
10.64898/2026.02.12.705594 — Posted: 2026-02-14
A Preoptic Neurocircuit That Modulates Metabolic Flexibility
Roessler, J. M., Alkire, M., Nigrin, N., Wang, H., Reid, C. M., Cortopassi, M. D., Waite, M., Linnehan, B., Griffith, E. C., Madigan, M., Kunchok, T., Banks, A. S., Schulte, F., Kim, B., Kim, B.-Y., Kim, J. K., Hrvatin, S.
10.64898/2026.01.15.699760 — Posted: 2026-02-14
Machine learning-guided spatial omics for tissue-scale discovery of cell-type-specific architectures
Lian, Y., Adjavon, D., Kawase, T., Kim, J., Fleishman, G., Preibisch, S., Funke, J., Liu, Z. J.
10.64898/2026.02.12.705598 — Posted: 2026-02-13
4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity
Skinner, O. S., Miranda, M., Dong, F., Struhl, T., Walker, M. A., Schleifer, G., Henke, M. T., Clardy, J., Hirano, M., De Vivo, D. C., Schon, E. A., Engelstad, K., Siegmund, S. E., Laprise, C., Des Rosiers, C., Sharma, R., Mootha, V. K.
10.64898/2026.02.10.705117 — Posted: 2026-02-12
Evidence for non-optimal codon choice in highly transcribed sex-biased genes of Drosophila melanogaster
Whittle, C. A., Extavour, C. G.
10.1101/2024.11.24.625100 — Posted: 2026-02-12
Chromatin boundary permeability is controlled by CTCF conformational ensembles
Rudnizky, S., Murray, P. J., Sorensen, E. W., Koenig, T. J. R., Pangeni, S., Merino-Urteaga, R., Chhabra, H., Caccianini, L., Davidson, I. F., Osorio-Valeriano, M., Hook, P. W., Meneses, P., Hao, J., Zarb, J. S., Hatzakis, N. S., Timp, W., Farnung, L., Vos, S. M., Peters, J.-M., Aksimentiev, A., Ha, T.
10.1101/2025.11.25.690553 — Posted: 2026-02-12
The dynamic evolution of panarthropod germ cell specification mechanisms
Kao, J. A., Rivard, E. L., Kapoor, R. R., Extavour, C. G.
10.1101/2025.08.05.668520 — Posted: 2026-02-12
Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges
Wu, P., Wang, Y., Cohen, J. C., Hobbs, H. H.
10.1101/2025.10.27.684800 — Posted: 2026-02-11
A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation
Wang, Y., Xie, J., Pasca, S., Popoli, M., Ptak, J., Dobbyn, L., Silliman, N., Paul, S., Jones, R. J., Levis, M. J., Curtis, S. D., Douville, C., Shams, C., Guo, M. Z., Mo, S., Gocke, C. D., Malek, S. N., Bollard, C. M., Bettegowda, C., Kinzler, K. W., Vogelstein, B., Papadopoulos, N., Gondek, L. P.
10.64898/2026.02.10.26345949 — Posted: 2026-02-11

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