Channel: HHMI

1037 Articles

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

Ni, X., Richardson, R. B., de Godoy, A. S., Ferla, M. P., Kikawa, C., Scheen, J., Hannon, W. W., Capkin, E., Lahav, N., Balcomb, B. H., Marples, P. G., Fairhead, M., Wang, S., Williams, E., Tomlinson, C. W. E., Aschenbrenner, J. C., Lithgo, R., Winokan, M., Girould, C., Chandran, A. V., Walsh, M. A., Thompson, W., Bloom, J. D., Barr, H., Kirkegaard, K., Koekemoer, L., Fearon, D., Evans, M. J., von Delft, F.

10.1101/2024.04.29.591502 — Posted: 2025-02-13

De novo design of Ras isoform selective binders

Zhang, J. Z., Li, X., Liu, C., Jiang, H., Wu, K., Baker, D.

10.1101/2024.08.29.610300 — Posted: 2025-02-05

Population Representation of the Confidence in a Decision in the Parietal Cortex

Zylberberg, A., Shadlen, M. N.

10.1101/2024.08.15.608159 — Posted: 2025-02-02

The first complete 3D reconstruction and morphofunctional mapping of an insect eye

Makarova, A. A., Chua, N. J., Diakova, A. V., Desyatirkina, I. A., Gunn, P., Pang, S., Xu, C. S., Hess, H. F., Chklovskii, D. B., Polilov, A. A.

10.1101/2024.09.30.615804 — Posted: 2025-01-29

The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

Witt, K. C., Dziulko, A., An, J., Pekovic, F., Cheng, A. X., Liu, G. Y., Lee, O. V., Turner, D. J., Lari, A. C., Gaidt, M. M., Chavez, R., Fattinger, S. A., Abraham, P., Dhaliwal, H., Lee, A. Y., Kotov, D. I., Coscoy, L., Glaunsinger, B., Valkov, E., Chuong, E. B., Vance, R. E.

10.1101/2024.08.28.610186 — Posted: 2025-01-29

Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

Wolff, T., Eddison, M., Chen, N., Nern, A., Sundaramurthi, P., Sitaraman, D., Rubin, G. M.

10.1101/2024.10.21.619448 — Posted: 2025-01-24

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

Chen, J., Richardson, P. R., Kirby, C., Eddy, S. R., Hoekstra, H.

10.1101/2024.08.22.608850 — Posted: 2025-01-21

Cell-scale gene-expression measurements in Vibrio cholerae biofilms reveal spatiotemporal patterns underlying development

Johnson, G. E., Fei, C., Wingreen, N. S., Bassler, B. L.

10.1101/2024.07.17.603784 — Posted: 2025-01-16

Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation

Singer, R. A., Rajchin, V., Park, K., Heintz, N., Darnell, R. B.