Channel:  The Howard Hughes Medical Institute (HHMI)

2,491 Articles

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MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity
Hsu, T. Y.-T., Wang, X., Zhang, J., Isayama, Y., Schindler, V., van Gompel, E., Maadadi, H., Torres-Arancivia, C., Shimazaki-Takahashi, A., Kurihara, N., Kondo, M., Galesic, M., Notarnicola, A., Sultana, S., Maeda, A., Vleugels, R. A., Dellaripa, P. F., Yamashita, T., Ito, Y., Awaji, K., Kotani, H., Matsuda, K. M., Horuluogu, B., Grönwall, C., Joshua, V., Ukai, Y., Hosomi, N., Wagner, D. D., Lundberg, I. E., Kato, K., Hur, S.
10.64898/2026.01.27.702129 — Posted: 2026-07-31
IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development
Lee, Y. S., Zhao, J. L., Chryplewicz, A., Land, M., Sharma, R., Chan, J., Smith, P., Kottapalli, S., Fong, L., Chen, Z., Bent, E., Zhao, H., de Stanchina, E., Kang, W., Narine, S., Rosiek, E., Fan, N., Lawrence, K., Sayar, E., Gopalan, A., Chaudhary, O., Xu, T., Masilionis, I., Chaligne, R., Haffner, M., Romero, R., Pe'er, D., Carver, B. S., Sawyers, C. L.
10.64898/2026.07.30.741572 — Posted: 2026-07-31
IL-4 Licenses B Cell Activation Through Cholesterol Synthesis
Steach, H. R., York, A. G., Mattingly, J., Skadow, M. H., Chen, S., Zhao, J., Williams, K. J., Zhou, Q., Hsieh, W.-Y., Brewer, J. R., Qu, R., Shyer, J. A., Harman, C., Sefik, E., Mowell, W. K., Wu, A., Li, M. A., Bailis, W., Cui, C., Kluger, Y., Bensinger, S. J., Craft, J., Flavell, R.
10.1101/2024.05.13.593964 — Posted: 2026-07-31
Activity-driven proprioceptive synaptic refinement in the developing spinal cord by complement signaling mechanisms
Nagaraja, C., Ortiz, S., Murali, A. R., Sarwar, A., Griffith, T. N.
10.1101/2025.08.22.671861 — Posted: 2026-07-30
NFYA regulates spermatogenesis through multifaceted chromatin interactions
Zhang, Y., Wang, B., Jiang, S., Yang, Q.
10.64898/2026.07.29.741030 — Posted: 2026-07-30
Microtubule Engagement by the WD40-Containing Tail of Kinesin-4 KIF21B
Taheri, A., Lafrance, B., Peukes, J., Rai, A., Akhmanova, A., Nogales, E.
10.64898/2026.07.29.741364 — Posted: 2026-07-30
De novo design of cysteine proteases
Choi, H., Bauer, M. S., Coventry, B., Venkatesh, P., Chen, A., Kim, D., Bera, A. K., Kang, A., Nguyen, H., Sadre, S., Decarreau, J., Joyce, E., Shankaran, B., Thompson, T. R., Greenstein, G., Didi, K., Schaaf, L. L., Gershon, J., Shida, A. F., Lee, G. R., Hilvert, D., Pellock, S. J., Baker, D.
10.1101/2025.11.21.689808 — Posted: 2026-07-30
In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis
Yu, Q., Kim, H., Seidel, S., Acosta-Clark, J. F., Martin, B. K., O'Connor, K., Daza, R. M., Gasperini, M., Nathans, J. F., Lam, M., Gamo, E., Vijay Kumar, S., Kuo, L., Lalanne, J.-B., Simeonov, K., Pepper, M., Trapnell, C., Gray, J. M., Choi, J., Qiu, C., Shendure, J.
10.64898/2026.07.29.741625 — Posted: 2026-07-30
Enhancer buffering protects dosage-sensitive housekeeping genes during vulnerable developmental transitions
Ni, C., Ichino, L., Swigut, T., Wysocka, J.
10.64898/2026.07.29.741571 — Posted: 2026-07-30
A minimal kinase-phosphatase system and its lipid substrates self-organize into dynamic patterns
Hsieh, T.-S., Ramm, B., Yu, Q., Yuly, J. L., Pfister, J., Wu, Y., Huang, J., Meir, Y., Wingreen, N. S., Tagliabracci, V. S.
10.64898/2026.07.27.740984 — Posted: 2026-07-29

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