Channel:  The Howard Hughes Medical Institute (HHMI)

2,097 Articles

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Homozygosity for rare or common hypomorphic IL23R variants confers a predisposition to tuberculosis in humans
Olguin Calderon, D., Kilpatrick, L. E., Conil, C., Philippot, Q., Ogishi, M., Vellutini, J., Eun Han, J., Keating, N., Li, H., Rao, G., Bohlen, J., Lay, C. S., Platt, S., Kerner, G., Feredj, E., Peel, J., Momenilandi, M., Seeleuthner, Y., Laine, C., soudee, c., Leloup, C., Debuisson, C., Lanternier, F., Bitoun, S. B., Pavy, S., Mariette, X., Rafik, A., Skhoun, H., EL Ouazzani, H., Abderahmani-Ghorfi, I., EL Baghdadi, J., Baena, A., Tejada-Giraldo, M., Barrera, L. F., Arias, A. A., Fabio, G., Carrabba, M., Emiroglu, M., Bezrodnik, L., EL Zein, L., Hammoud, H., Gregersen, P., Terrier, B., Leon L
10.64898/2026.03.23.713554 — Posted: 2026-03-25
Structural dynamics between Argonaute-2 and CK1α promote target RNA release in microRNA-mediated silencing
Garg, A., Braviner, L., Axhemi, A., Bibel, B., Joshua-Tor, L.
10.64898/2026.03.23.713669 — Posted: 2026-03-25
FoTO1 orchestrates Taxol biosynthesis through catalytic and non-catalytic mechanisms
Wick, C., Somani, A., Liu, J., Karunadasa, S. S., Xu, S.-L., Fordyce, P. M., McClune, C. J., Sattely, E.
10.64898/2026.03.21.713420 — Posted: 2026-03-24
Transcriptomic and functional characterization indicate sexual dimorphism of discrete circadian neuron subtypes
Perez Torres, M., Jiang, R., Ma, D., Herndon, N., Kurmangaliyev, Y. Z., Guo, F., Rosbash, M.
10.64898/2025.12.26.696620 — Posted: 2026-03-23
Inter-individual variation of cellular and gene-expression properties of the human striatum
Burger, S., Yoo, O., Nemesh, J., Muratoglu, E., Vanderburg, C., Yuan, J., Shakir, K., Mello, C. J., Rayan, N. A., Milidantri, J., Kim, K., Drouin, S., Finn, E., Gao, H., Budnik, N., Goldman, M., Fritch, H., Genovese, G., Hogan, M., Catalini, O., Kashin, S., Rockweiler, N., Wysoker, A., Macaisa, L., Reese, L., Flowers, K., Kraft, A. W., Fleming, S. J., Coe, M., Gunaratne, R., Spina, L., Crombie, C., Mohsin, A., Kamitaki, N., Macosko, E. Z., Ichihara, K., McCarroll, S. A.
10.64898/2026.03.20.713160 — Posted: 2026-03-23
Quinone reductase 2 reads H3 serotonylation to support neuronal maturation
Chen, M., Yang, C., Li, X., Kong, L., Weekley, B. H., Wei, X., O'Chan, J. C., Vinson, D. A., Cetin, B., Ramakrishnan, A., Shen, L., Zeng, R., Liu, Z., Zhang, J., Cappuccio, K. M., Sokol, J. R., Baljinnyam, E., Hu, R., Rosenblum, K., Molina, H., Zheng, Q., David, Y., Marro, S. G., Muir, T. W., Li, X. D., Li, H., Maze, I.
10.64898/2026.03.17.712426 — Posted: 2026-03-19
Combining brain-wide activity imaging with electron microscopy reveals a distributed nociceptive network in the brain
Randel, N., Wang, C., Clayton, M. S., Wang, K., Pang, S., Xu, S. C., Champion, A., Hess, H. F., Cardona, A., Keller, P. J., Zlatic, M.
10.1101/2025.09.25.678485 — Posted: 2026-03-19
Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagement
Liao, Z., Arkinson, C., Martin, A.
10.1101/2025.10.27.684972 — Posted: 2026-03-19
Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
Koochaki, P., Qiu, B., Coker, J. A., Earsley, A., Wang, N. S., Romigh, T., Goins, C. M., Salem, C., Mi, D., Days, E., Bauer, J., Stauffer, S. R., Boudker, O., Chakraborty, A. A.
10.1101/2025.07.03.663021 — Posted: 2026-03-19
Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs
Lokshtanov, D., Gao, S. M., Xu, W., Kosman, A., Roncato, F., De La Cruz, N., Khan, N. A., Woods, A., Campbell, I., Woehler, A., Christoforou, C., Ding, L., Hu, A., Copeland, M., Wang, L., Yang, X., Raley, C., Delventhal, K., Herrera, A., Valente, A., Wright, S., Gomez-Cesar, E., Shlomo, R., Golenchenko, S., Oldak, B., Yilmaz, A., Gurhan-Sevinc, G., Comar, M.-Y., Viukov, S., Novershtern, N., Zhang, H., Duong, T., Li, L., Khatib, N., Kakun, R. R., Espinosa-Medina, I., Florian-Rodriguez, M. E., LaManno, G., Tillberg, P. W., Wang, M. C., Maza, I., Srivatsan, S., Solmonson, A., Hanna, J. H., Aguile
10.64898/2026.03.17.710314 — Posted: 2026-03-18

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