Channel:  The Howard Hughes Medical Institute (HHMI)

1,285 Articles

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miRNA circuit modules for precise, tunable control of gene expression
Du, R., Flynn, M. J., Mahe, K., Honsa, M., Gu, B., Li, D., McGeary, S. E., Gradinaru, V., Jungmann, R., Elowitz, M. B.
10.1101/2024.03.12.583048 — Posted: 2025-07-16
Programmable translational inhibition by a molecular glue-oligonucleotide conjugate
Wang, S., Kovalski, J. R., Zapatero-Belinchon, F. J., Bennett, M., Kuzuoglu-Öztürk, D., Li, Q., Stevenson, E., Liu, J., Krogan, N. J., Ott, M., Swaney, D. L., Ruggero, D., Lou, K., Shokat, K.
10.1101/2025.07.15.664547 — Posted: 2025-07-16
Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells
Lyu, P., Agarwal, G., Guo, C.-J., Ye, T., Weng, C., Antoszewski, M., Joubran, S., Caulier, A., Poeschla, M., Sankaran, V. G.
10.1101/2025.07.16.664824 — Posted: 2025-07-16
Complete chromosome 21 centromere sequencing of families with Down syndrome reveals centromere size asymmetry
Mastrorosa, F. K., Daponte, A., Wertz, J., Rozanski, A. N., Harvey, W. T., Porubsky, D., Knuth, J., Garcia, G., Ayllon, M., Munson, K. M., Hoekzema, K., He, W., Sherman, S. L., Allen, E. G., Rosser, T. C., Catacchio, C. R., Ventura, M., Logsdon, G. A., Eichler, E. E.
10.1101/2024.02.25.581464 — Posted: 2025-07-16
A 3D in vitro model of the human hepatobiliary junction
Westerfield, A. D., Grzelak, K. A., Katsuyama, K., Kumar, V., Miller, B. M., Yun, J., Kirkpatrick, J., Mankus, D., Bisher, M. E., Lytton-Jean, A. K., Jiang, Z. G., Lee, D. D., Chen, C. S., Bhatia, S. N.
10.1101/2025.07.11.664464 — Posted: 2025-07-14
AAV NRF2 Gene Therapy Preserves Retinal Structure and Function in Rodent Models of Oxidative Damage
Gardner, A., Wang, S., Daniels, A., Li, D., Wu, C., Lin, L., Hong, C., Zhao, S., Kruczek, K., Weist, G., Real, L. B., Haurigot, V., Born, R., Cepko, C.
10.1101/2025.07.09.663952 — Posted: 2025-07-14
Potentially Prebiotic Isocyanide Activation Chemistry Drives RNA Assembly via both Nonenzymatic and Ribozyme-catalyzed Ligation
Zhang, S. J., Jia, X., DasGupta, S., Szostak, J. W.
10.1101/2025.07.11.664453 — Posted: 2025-07-12
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch, J. A., Beltran, P. M. J., Cavers, C., LaGraff, J. T., Melanson, R., Singh, A., Chen, W., Hu, Y., Tattikota, S. G., Liu, Y., Hashmi, Y., Asara, J. M., Branon, T., Ting, A. Y., Carr, S. A., Perrimon, N.
10.1101/2025.07.09.659702 — Posted: 2025-07-11
Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
Chen, S., Basiashvili, T., Hutchings, J., Murillo, M. S., Suarez, A. V., Xiong, E., Louro, J. A., Leschziner, A. E., Villa, E.
10.1101/2024.06.18.599606 — Posted: 2025-07-10
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission
White, K. I., Khan, Y. A., Qiu, K., Balaji, A., Couoh-Cardel, S., Esquivies, L., Pfuetzner, R. A., Diao, J., Brunger, A. T.
10.1101/2024.10.11.617886 — Posted: 2025-07-10

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