Channel:  The Howard Hughes Medical Institute (HHMI)

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Humanized Extracellular Vesicles for Efficient RNA Delivery
Ma, X., Zhao, S. R., Cepko, C. L.
10.64898/2025.12.15.694436 — Posted: 2025-12-17
Nanopore-based profiling of PEGylation in nucleic acid therapeutics
Patino Guillen, G., Schmidt, T. T., Baumberg, J. J., Szostak, J. W., Keyser, U. F., Boskovic, F.
10.64898/2025.12.15.694309 — Posted: 2025-12-17
Human acrocentric chromosome short arm de novo mutation and recombination
Lin, J., Mastrorosa, F. K., Noyes, M. D., Yoo, D., Rhie, A., Porubsky, D., Hoekzema, K., Munson, K. M., Koundinya, N., Watkins, W. S., Jorde, L. B., Quinlan, A. R., Neklason, D. W., Phillippy, A. M., Eichler, E. E.
10.64898/2025.12.16.694519 — Posted: 2025-12-17
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
Yamamuro, T., Katoh, D., Silva, G. M., Nishida, H., Oikawa, S., Higuchi, Y., Wang, D., Fujimoto, M., Yoshida, N., Li, M., Shin, J., Zhao, Z., Yook, J.-S., Sun, L., Kajimura, S.
10.64898/2025.12.12.693842 — Posted: 2025-12-16
The Drosophila maternal-effect gene abnormal oocyte (ao) does not repress histone gene expression
Takenaka, R., Albanese, E. H., Simmerman, S. M., Verghese, S., Maddox, M. A. E., de la Cruz, A., Young, J. M., Schmidt, C. A., Rieder, L. E., Malik, H. S.
10.1101/2024.09.17.613536 — Posted: 2025-12-16
A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects
Hart, S. F. M., Alcala, N., Feder, A. F., Harris, K.
10.1101/2025.05.15.654154 — Posted: 2025-12-16
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.
Sakers, K., Ramirez, J. J., Elazar, N., Nagendren, L., Soderblom, E. J., Eroglu, C.
10.64898/2025.12.15.694023 — Posted: 2025-12-16
A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses
Bhattacharya, T., Freeman, T. S., Alleman, E. M., Wang, F., Chechik, L., Emerman, M., Myles, K. M., Malik, H. S.
10.1101/2025.09.27.679005 — Posted: 2025-12-14
Conserved phenotype and function of human brain border-associated macrophages in iPSC-derived models
Barr, H. J., Depp, C., Hingerl, M., Nguyen, T., Reimertz, J. M., Connolly, E., Patel, J., Doman, J. L., Marsh, S. E., Stevens, B.
10.64898/2025.12.11.693582 — Posted: 2025-12-14
Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling
Glaser, A., Padua, R., Ojoawo, A., Sullivan, C., Kern, D.
10.64898/2025.12.12.694068 — Posted: 2025-12-14

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