Channel:  The Howard Hughes Medical Institute (HHMI)

1,945 Articles

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Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids
Cheng, L., Chen, J., Bo, Z., Zhang, X., Liu, P., Yang, Y.
10.64898/2026.01.21.700944 — Posted: 2026-01-23
Efficient transgene-free multiplexed genome editing via viral delivery of an engineered TnpB.
Weiss, T., Kamalu, M., Shi, H., Wirnowski, G., Ingelsson, A., Amerasekera, J., Vohra, K., Trinidad, M. I., Li, Z., Freitas, E., Steinmetz, N., Ambrose, C., Chen, K., Doudna, J. A., Jacobsen, S. E.
10.64898/2026.01.23.700382 — Posted: 2026-01-23
New methods for epigenetic characterization and manipulation of rare fly brain neurons
Ojha, P., Berglund, G., Yu, A. D., Rosbash, M.
10.64898/2026.01.21.700891 — Posted: 2026-01-23
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Ralph, D. K., Bakis, A. G., Galloway, J., Vora, A. A., Araki, T., Song, Y. S., DeWitt, W. S., Matsen, F. A.
10.1101/2025.08.12.669950 — Posted: 2026-01-22
Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
Fattinger, S. A., Chavez, R. A., Witt, K. C., Parisi, B., Rodriguez, J. J., Turcotte, E. A., Brydon, E. C., Fairgrieve, M. R., Dhaliwal, H., Lee, A. Y., Kotov, D. I., Vance, R. E.
10.64898/2026.01.19.700487 — Posted: 2026-01-22
Sciphy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data.
Seidel, S., Zwaans, A., Regalado, S., Choi, J., Shendure, J., Stadler, T.
10.1101/2024.10.01.615771 — Posted: 2026-01-22
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Rich, M. S., Pellow, R., Hefel, A., Rog, O., Jorgensen, E. M.
10.1101/2025.11.11.687718 — Posted: 2026-01-21
UnionLoops: a workflow for calling chromatin loops across related Hi-C datasets with improved specificity, precision, and sensitivity
Liu, J., Gibcus, J. H., Dekker, J.
10.64898/2026.01.19.700311 — Posted: 2026-01-20
PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.
Khushu, M., Kissel, R. C., Kauffman, J., Taccheri, C., Singh, N., Summers, R. L., Plant, L. D., Wirth, D., Catteruccia, F., Bopp, S.
10.64898/2026.01.20.700404 — Posted: 2026-01-20
Structural and Spectroscopic Basis for Catalysis by a Class C Radical S-adenosylmethionine Methylase Involved in Nosiheptide/Nocathiacin Biosynthesis
Wang, B., Knox, H. L., York, N. J., Radle, M. I., Silakov, A., Booker, S. J.
10.64898/2026.01.19.700444 — Posted: 2026-01-20

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