Channel:  The Howard Hughes Medical Institute (HHMI)

2,124 Articles

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A membrane-bound nuclease directly cleaves phage DNA during genome injection
Saxton, D. S., Deweirdt, P. C., Doering, C. R., Roney, I. J., Laub, M. T.
10.1101/2025.11.03.685801 — Posted: 2025-11-03
Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics
Basta, D. W., Zingl, F. G., Yang, Y., Nguyen, K. T., Liu, Y.-Y., Waldor, M. K.
10.1101/2025.10.31.685825 — Posted: 2025-11-01
De novo design of metal-oxide templating proteins
Saragovi, A., Pyles, H., Huddy, T. F., Li, X., Borst, A. J., Hanikel, N., Courbet, A., Kwon, P., Davila-Hernandez, F. A., Kibler, R. D., Vafeados, D. K., Allen, A., Carr, K. D., Bera, A., Kang, A., Brackenbrough, E., Schmid, S., Bae, Y., Stewart, L., Zhang, S., De Yoreo, J., Baker, D.
10.1101/2024.06.24.600095 — Posted: 2025-11-01
Specialized parallel pathways for adaptive control of visual object pursuit
Collie, M. F., Jin, C., Rockwell, V., Kellogg, E., Vanerbeck, Q. X., Hartman, A. K., Holtz, S. L., Wilson, R. I.
10.1101/2025.04.23.650240 — Posted: 2025-11-01
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation
Pisa, R., Rapoport, T. A.
10.1101/2025.10.31.685944 — Posted: 2025-11-01
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes
Zhou, P., Hartweger, H., MacLean, A. J., Ramos, V., Yao, K.-h., Hernandez, B., Wang, Z., Gazumyan, A., Nussenzweig, M. C.
10.1101/2025.10.30.685663 — Posted: 2025-11-01
Sleep-dependent clearance of brain lipids by peripheral blood cells
Cho, B., Youngstrom, D. E., Killiany, S., Guevara, C., Randolph, C. E., Beveridge, C. H., Saklani, P., Chopra, G., Sehgal, A.
10.1101/2025.10.30.685668 — Posted: 2025-10-31
larch: mapping the parsimony-optimal landscape of trees for directed exploration
Barker, M., Milanov, O., Dumm, W., Rich, D., Turakhia, Y., Matsen, F. A.
10.1101/2025.10.29.685337 — Posted: 2025-10-31
HaloTrace: A spatiotemporally precise fluorescent readout of blood-brain barrier permeability in mice
Zucker, H. L., Konshina, E., Mitchell, P., Gu, C.
10.1101/2025.10.30.685531 — Posted: 2025-10-31
Trimodal brain-wide ultrasound imaging of brain-tumor interaction
Rabut, C., Shivaei, S., Heiles, B., Shapiro, M. G.
10.1101/2025.10.29.685462 — Posted: 2025-10-31

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