Channel:  The Howard Hughes Medical Institute (HHMI)

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Potentially Prebiotic Isocyanide Activation Chemistry Drives RNA Assembly via both Nonenzymatic and Ribozyme-catalyzed Ligation
Zhang, S. J., Jia, X., DasGupta, S., Szostak, J. W.
10.1101/2025.07.11.664453 — Posted: 2025-07-12
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch, J. A., Beltran, P. M. J., Cavers, C., LaGraff, J. T., Melanson, R., Singh, A., Chen, W., Hu, Y., Tattikota, S. G., Liu, Y., Hashmi, Y., Asara, J. M., Branon, T., Ting, A. Y., Carr, S. A., Perrimon, N.
10.1101/2025.07.09.659702 — Posted: 2025-07-11
Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
Chen, S., Basiashvili, T., Hutchings, J., Murillo, M. S., Suarez, A. V., Xiong, E., Louro, J. A., Leschziner, A. E., Villa, E.
10.1101/2024.06.18.599606 — Posted: 2025-07-10
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission
White, K. I., Khan, Y. A., Qiu, K., Balaji, A., Couoh-Cardel, S., Esquivies, L., Pfuetzner, R. A., Diao, J., Brunger, A. T.
10.1101/2024.10.11.617886 — Posted: 2025-07-10
A Congenic C57BL/6 rd1 Mouse Model for Retinal Degeneration Research
Chandler, L. C., Gardner, A., Cepko, C. L.
10.1101/2025.07.09.663548 — Posted: 2025-07-09
Glycogen phase separation drives macromolecular rearrangement and asymmetric division in Escherichia coli
Thappeta, Y., Canas-Duarte, S. J., Wang, H., Kallem, T., Fragasso, A., Xiang, Y., Gray, W., Lee, C., Hardo, G., Cegelski, L., Jacobs-Wagner, C.
10.1101/2024.04.19.590186 — Posted: 2025-07-08
Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
Koochaki, P., Qiu, B., Coker, J. A., Earsley, A., Wang, N. S., Romigh, T., Goins, C. M., Stauffer, S. R., Boudker, O., Chakraborty, A. A.
10.1101/2025.07.03.663021 — Posted: 2025-07-07
Ultrasound imaging of in situ transcriptional activity in opaque tissue
Shivaei, S., Cheung, K. Y. M., Yadav, A., Hurvitz, I. U., Lee, S., Revilla, J., Rabut, C., Criado-Hidalgo, E., Zhang, R. J., Shapiro, M. G.
10.1101/2025.07.06.663365 — Posted: 2025-07-07
Evidence for non-optimal codon choice in highly transcribed sex-biased genes of Drosophila melanogaster
Whittle, C. A., Extavour, C. G.
10.1101/2024.11.24.625100 — Posted: 2025-07-07
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion.
Porubsky, D., Yoo, D., Dishuck, P. C., Koundinya, N., Souche, E., Harvey, W. T., Munson, K. M., Hoekzema, K., Chan, D. D., Leung, T. Y., Santos, M. S., Meynants, S., Swillen, A., Breckpot, J., Tsapalou, V., Hasenfeld, P., Korbel, J. O., Lansdorp, P. M., Vermeesch, J. R., Eichler, E. E.
10.1101/2025.07.04.662981 — Posted: 2025-07-07

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