Channel:  The Howard Hughes Medical Institute (HHMI)

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Engineered protein circuits for cancer therapy
Lu, A. C., Moeller, L., Moore, S., Xia, S., Ho, K., Zhang, E., Budde, M. W., Larson, H., Ahmed Diaz, A., Gu, B., Linton, J. M., Klock, L., Flynn, M. J., Gao, X. J., Siegwart, D. J., Zhu, H., Elowitz, M. B.
10.1101/2025.04.16.647665 — Posted: 2025-04-17
GESIAP3.0: Sensor-based Image Analysis Program for Transmission Visualization In Vivo
Zhu, R. E., Diao, X., Liu, X., Ru, Q., Wu, Z., Zhang, Z., Looger, L., Zhu, J.
10.1101/2024.10.28.620522 — Posted: 2025-04-17
Distinct satellite DNA composition between core and germline restricted chromosomes in Bradysia (Sciara) coprophila
Kerrebrock, A., Flynn, J. M., Baird, R. B., Hodson, C. N., Ross, L., Yamashita, Y. M. M.
10.1101/2025.04.15.648937 — Posted: 2025-04-16
Super Recombinator (SuRe): An in vivo recombination system for scalable and efficient transgene assembly at a single genomic locus
Luo, J., Huang, C., Taylor, C. A., Li, J., Woo, S. J., Yu, C., Shen, K., Schnitzer, M. J.
10.1101/2025.04.15.646138 — Posted: 2025-04-15
The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis
Vuille, J. A., Tanriover, C., Micalizzi, D. S., Ebright, R. Y., Animesh, S., Morris, R., Hajizadeh, S., Nicholson, Z. J., Russell, H. C., Zaniewski, E. F., Wittner, B. S., Wesley, B. K., Grunewald, J., Szalay, R. N., Antmen, E., Fox, D. B., Yang, M., Joung, J. K., Gulhan, D. C., Elia, A. E. H., Haas, W., Oh, E., Maheswaran, S., Haber, D. A.
10.1101/2025.04.09.647907 — Posted: 2025-04-15
Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation
Raz, A. A., Hassan, H., Yamashita, Y. M.
10.1101/2025.04.10.648217 — Posted: 2025-04-14
De novo design and structure of a peptide-centric TCR mimic binding module
Householder, K. D., Xiang, X., Jude, K. M., Deng, A., Obenaus, M., Wilson, S. C., Chen, X., Wang, N., Garcia, K. C.
10.1101/2024.12.16.628822 — Posted: 2025-04-14
Designed NGF mimetics with reduced nociceptive signatures in neurons
Schlichthaerle, T., Yang, A., Detraux, D., Johnson, D. E., Peach, C. J., Edman, N. I., Sniezek, C., Williams, C. A., Arora, S., Katiyar, N., Chen, I., Etemadi, A., Favor, A., Lee, D., Kubo, C., Coventry, B., Huang, B., Gerben, S., Ennist, N. M., Milles, L., Sankaran, B., Kang, A., Nguyen, H., Bera, A. K., Negahdari, B., Hamazaki, N., Schweppe, D. K., Stewart, L., Young, J. E., Bunnett, N. W., Ruohola-Baker, H., Mathieu, J., Pattwell, S., Garcia, K. C., Baker, D.
10.1101/2025.04.14.648806 — Posted: 2025-04-14
Computational Design of Metallohydrolases
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Hanikel, N., Salike, S., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., Baker, D.
10.1101/2024.11.13.623507 — Posted: 2025-04-11
Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W., Yim, J., Tischer, D., Salike, S., Woodbury, S., Kim, D., Kalvet, I., Kipnis, Y., Coventry, B., Altae-Tran, H., Bauer, M., Barzilay, R., Jaakkola, T., Krishna, R., Baker, D. A.
10.1101/2025.04.09.648075 — Posted: 2025-04-10

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