Channel:  The Howard Hughes Medical Institute (HHMI)

1,286 Articles

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Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing
Shi, H., Al-Sayyad, N., Wasko, K., Trinidad, M. I., Doherty, E. E., Vohra, K., Boger, R. S., Colognori, D., Cofsky, J. C., Skopintsev, P., Bryant, Z., Doudna, J. A.
10.1101/2024.10.01.616117 — Posted: 2024-10-02
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
Bizzotto, S., Stronge, E. A., Talukdar, M., Hu, Q., Zhou, Z., Huang, A. Y., Chhouk, B. H., D'Gama, A. M., Yang, E., Green, T. E., Reutens, D. C., Mullen, S. A., Hildebrand, M. S., Buono, R. J., Poduri, A. H., Khoshkhoo, S., Walsh, C. A.
10.1101/2024.10.01.615793 — Posted: 2024-10-02
Remote activation of place codes by gaze in a highly visual animal
Payne, H. L., Aronov, D.
10.1101/2024.09.30.615982 — Posted: 2024-10-02
An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer
Magesh, R. Y., Kaur, A. N., Keller, F. N., Frederick, A., Tseyang, T., Haley, J. A., Rivera Nieves, A. M., Liang, A. C., Guertin, D., Spinelli, J., Elledge, S. J., Watson, E. V.
10.1101/2024.09.30.615609 — Posted: 2024-10-01
Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording
McDiarmid, T. A., Taylor, M. L., Chen, W., Chardon, F. M., Choi, J., Liao, H., Li, X., Kim, H., Lalanne, J.-B., Li, T., Nathans, J. F., Martin, B. K., Knuth, J., Coradini, A. L. V., Gray, J. M., Pinglay, S., Shendure, J.
10.1101/2024.09.30.615957 — Posted: 2024-10-01
Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells
Grzywa, T., Mehta, N., Cossette, B., Romanov, A., Paruzzo, L., Ramasubramanian, R., Cozzone, A., Morgan, D., Sukaj, I., Bergaggio, E., Tannir, R., Kadauke, S., Myers, R., Yousefpour, P., Ghilardi, G., Schuster, S., Neeser, A., Frey, N., Goncalves, B., Zhang, L., Abraham, W., Suh, H., Ruella, M., Grupp, S., Chiarle, R., Wittrup, K. D., Ma, L., Irvine, D. J.
10.1101/2024.04.16.589780 — Posted: 2024-10-01
Latent-TGF-β has a domain swapped architecture
Jin, M., Seed, R., Shing, T., Cheng, Y., Nishimura, S.
10.1101/2024.09.27.615443 — Posted: 2024-09-30
Mapping and engineering RNA-controlled architecture of the multiphase nucleolus
Quinodoz, S. A., Jiang, L., Abu-Alfa, A. A., Comi, T. J., Zhao, H., Yu, Q., Wiesner, L. W., Botello, J. F., Donlic, A., Soehalim, E., Zorbas, C., Wacheul, L., Kosmrlj, A., Lafontaine, D. L., Klinge, S., Brangwynne, C. P.
10.1101/2024.09.28.615444 — Posted: 2024-09-29
Functional protein mining with conformal guarantees
Boger, R. S., Chithrananda, S., Angelopoulos, A. N., Yoon, P. H., Jordan, M. I., Doudna, J. A.
10.1101/2024.06.27.601042 — Posted: 2024-09-28
DNA polymerase Zeta is a robust reverse transcriptase
Mayle, R., Holloman, W. K., O'Donnell, M. E.
10.1101/2024.09.27.615452 — Posted: 2024-09-28

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