Channel:  The Howard Hughes Medical Institute (HHMI)

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De novo design of phosphotyrosine peptide binders
Bauer, M. S., Zhang, J. Z., Wu, K., Lee, G. R., Coventry, B., Silvestri, I. M., Klupt, K. A., Shi, J., Brent, R. I., Li, X., Moller, C., Roullier, N., Vafeados, D. K., Kalvet, I., Skotheim, R. K., Zhu, S., Motmaen, A., Herrmann, L. C., Sturmfels, P., Tischer, D., Altae-Tran, H., Juergens, D., Krishna, R., Ahern, W., Yim, J., Bera, A. K., Kang, A., Joyce, E., Lu, A., Stewart, L., DiMaio, F., Mudumbi, K. C., Baker, D.
10.1101/2025.09.29.678898 — Posted: 2026-01-28
MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity
Hsu, T. Y.-T., Wang, X., Isayama, Y., Jung, V., Zhang, J., van Gompel, E., Maadadi, H., Torres, C., Shimazaki-Takahashi, A., Kurihara, N., Kondo, M., Galesic, M., Notarnicola, A., Sultana, S., Maeda, A., Vleugels, R. A., Dellaripa, P. F., Yamashita, T., Ito, Y., Awaji, K., Kotani, H., Matsuda, K. M., Horuluogu, B., Grönwall, C., Joshua, V., Ukai, Y., Hosomi, N., Wagner, D. D., Lundberg, I. E., Kato, K., Hur, S.
10.64898/2026.01.27.702129 — Posted: 2026-01-28
Evolutionary innovation through fusion of sequences from across the tree of life
Kapoor, R., Schwager, E. E., Phuangphong, S., Rivard, E. L., Kuyyamudi, C., Ghosh, S., Ronai, I., Extavour, C. G.
10.1101/2025.08.30.672725 — Posted: 2026-01-27
Live dynamics of induced cell-cell fusion between mitotic and interphasic cells
Afonso, O., Feliciano, D., Lippincott-Schwartz, J.
10.64898/2026.01.27.700572 — Posted: 2026-01-27
Single-molecule dissection of CFTR folding defects and pharmacological rescue
Kim, S. A., Levring, J., Chen, J., Yoon, T.-Y.
10.64898/2026.01.26.701897 — Posted: 2026-01-27
T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells
Obenaus, M., Poupault, C. L., McGinnis, C. S., Prange, C., Jiang, H., Su, L. L., Chen, X., Miao, Z., Muldoon, J. J., Yao, W., Waghray, D., Sun, Q., Eyquem, J., Hernandez-Lopez, R. A., Satpathy, A. T., Sage, J., Garcia, K. C.
10.64898/2025.12.04.692214 — Posted: 2026-01-27
The spliceosome assembles on excised linear introns to protect them from degradation
Li, G. W., Wilkinson, M. E., Bartel, D. P.
10.64898/2026.01.21.700889 — Posted: 2026-01-27
Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy
Khoshkhoo, S., Bae, M., Wang, Y., Tillett, A., Ramirez, R. B., Finander, B., Egan, E. D., Marx, L., Patel, D., Zhou, Z., Chahine, Y., Chhouk, B., Zoullas, S. M., Lai, A., Coras, R., Bielle, F., Navarro, V., Mathon, B., Valiante, T. A., Chameh, H. M., Gao, A., Krings, T., Gooley, S., Hildebrand, M. S., Bulluss, K., Clark, J., Morokoff, A. P., King, J. A., Todaro, M., Kwan, P., O'Brien, T. J., Berkovic, S. F., Scheffer, I. E., Perucca, P., Lapinskas, E., Rolston, J. D., Cosgrove, G. R., Sarkis, R. A., D'Gama, A. M., Alexadrescu, S., Yang, E., Poduri, A., Richardson, R. M., Erson-Omay, E. Z., DeL
10.64898/2026.01.26.701822 — Posted: 2026-01-27
Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila
Fontan, A., Lannes, R., Fingerhut, J., Flynn, J., Yamashita, Y. M.
10.1101/2025.05.22.655455 — Posted: 2026-01-26
A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations
Maples, R. W., Quinn, G., Srinivasan, T., Dende, C., Hooper, L. V., Pfeiffer, J. K.
10.64898/2026.01.24.701519 — Posted: 2026-01-26

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