Channel:  The Howard Hughes Medical Institute (HHMI)

1,285 Articles

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Polyserine peptides are toxic and exacerbate tau pathology in mice
Van Alstyne, M., Nguyen, V. L., Hoeffer, C. A., Parker, R.
10.1101/2024.10.10.616100 — Posted: 2024-10-12
Tuning Insulin Receptor Signaling Using De Novo Designed Agonists
Wang, X., Cardoso, S., Cai, K., Venkatesh, P., Hung, A., Ng, M., Hall, C., Coventry, B., Lee, D., Chowhan, R., Gerben, S., Li, J., An, W., Hon, M., Accili, D., Bai, X., Choi, E., Baker, D.
10.1101/2024.10.07.617068 — Posted: 2024-10-11
A collection of split-Gal4 drivers targeting conserved signaling ligands in Drosophila
Ewen-Campen, B., Joshi, N., Herman, A. S., Thakkar, T., Zirin, J., Perrimon, N.
10.1101/2024.10.10.617664 — Posted: 2024-10-11
Geometry of Braided DNA Dictates Supercoiling Partition
Hong, Y., Park, S. h., Wang, H., Wang, M. D.
10.1101/2024.10.08.617221 — Posted: 2024-10-11
GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes
Sivadasan Bindu, D., Savage, J. T., Brose, N., Bradley, L., Dimond, K., Tan, C. X., Eroglu, C.
10.1101/2023.01.17.524433 — Posted: 2024-10-11
2.6-A resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N3CDP
Westmoreland, D. E., Feliciano, P. R., Kang, G., Cui, C., Kim, A., Stubbe, J., Nocera, D. G., Drennan, C. L.
10.1101/2024.10.09.617422 — Posted: 2024-10-10
Deep mutational scanning identifies variants of Cas1 and Cas2 that increase spacer acquisition in type II-A CRISPR-Cas systems
Hofmann, R., Herman, C., Mo, C., Mathai, J., Marraffini, L. A.
10.1101/2024.10.10.617623 — Posted: 2024-10-10
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction
Geiger, R. A., Khera, D., Tenthorey, J., Kochs, G., Graf, L., Emerman, M., Malik, H. S.
10.1101/2024.10.10.617484 — Posted: 2024-10-10
DNA Polymerase Locks Replication Fork Under Stress
Jia, X., Inman, J. T., Singh, A., Patel, S. S., Wang, M. D.
10.1101/2024.10.09.617451 — Posted: 2024-10-10
Torsional Mechanics of Circular DNA
Singh, G., Hong, Y., Inman, J. T., Sethna, J. P., Wang, M. D.
10.1101/2024.10.08.617281 — Posted: 2024-10-10

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