Channel:  The Howard Hughes Medical Institute (HHMI)

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IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S., Viragova, S., Koga, S., Liu, M., O'Leary, C., Ricardo-Gonzalez, R. R., Schroeder, A. W., Kochhar, N., Klein, O., Diamond, M., Liang, H.-E., Locksley, R. M.
10.1101/2025.03.25.645270 — Posted: 2025-03-29
Addendum to Ancient DNA data from Mengzi Ren, a Late Pleistocene individual from Southeast Asia, cannot be reliably used in population genetic analysis
Tabin, D. R., Patterson, N. J., Mah, M., Reich, D. E.
10.1101/2025.03.24.645126 — Posted: 2025-03-26
Directed evolution expands CRISPR-Cas12a genome editing capacity
Ma, E., Chen, K., Shi, H., Wasko, K. M., Esain-Garcia, I., Trinidad, M. I., Zhou, K., Ye, J., Doudna, J. A.
10.1101/2025.03.26.645588 — Posted: 2025-03-26
Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P., Schifferli, M., Yang, K., Burcham, T., Cronan, P., Glennon, O., Jacks, O., Laning, E., Marrs, L., Oba, K., Yeung, S., Parker, E., Omah, I., Pekar, J. E., Luebbert, L., Andersen, K. G., Park, D. J., Schaffner, S. F., MacInnis, B. L., Happi, C., Lemieux, J. E., Ozonoff, A., Mitzenmacher, M. D., Fry, B., Sabeti, P. C.
10.1101/2025.03.25.645253 — Posted: 2025-03-26
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Agarwal, G., Antoszewski, M., Xie, X., Pershad, Y., Arora, U. P., Poon, C.-L., Lyu, P., Lee, A. J., Guo, C.-J., Ye, T., Norford, L. B., Neehus, A.-L., della Volpe, L., Wahlster, L., Ranasinghe, D., Ho, T.-C., Barlowe, T. S., Chow, A., Schurer, A., Taggart, J., Durham, B. H., Abdel-Wahab, O., McGraw, K. L., Allan, J. M., Soldatov, R., Bick, A. G., Kharas, M. G., Sankaran, V. G.
10.1101/2025.03.24.645017 — Posted: 2025-03-26
Long-term editing of brain circuits in mice using an engineered electrical synapse
Ransey, E., Thomas, G., Wisdom, E., Almoril-Porras, A., Bowman, R., Adamson, E., Walder-Christensen, K. K., White, J. A., Hughes, D. N., Schwennesen, H., Ferguson, C., Tye, K., Mague, S. D., Niu, L.-G., Wang, Z.-W., Colon-Ramos, D., Hultman, R., Bursac, N., Dzirasa, K.
10.1101/2025.03.25.645291 — Posted: 2025-03-26
Short-term alterations in dietary amino acids override host genetic susceptibility and reveal mechanisms of Salmonella Typhimurium small intestine colonization
Shealy, N., Baltagulov, M., de Brito, C., McGovern, A., Castro, P., Schrimpe-Rutledge, A. C., Malekshahi, C., Condreanu, S. G., Sherrod, S. D., Jana, S., Jones, K., Machado Ribeiro, T. R., McLean, J., Beiting, D. P., Byndloss, M. X.
10.1101/2025.03.25.645332 — Posted: 2025-03-25
Long-term hunter-gatherer continuity in the Rhine-Meuse region was disrupted by local formation of expansive Bell Beaker groups
Olalde, I., Altena, E., Bourgeois, Q., Fokkens, H., Amkreutz, L., Deguilloux, M.-F., Fichera, A., Flas, D., Gandini, F., Kegler, J. F., Kootker, L. M., Leijnse, K., Kooijmans, L. L., Lauwerier, R., Miller, R., Molthof, H., Noiret, P., Raemaekers, D. C. M., Rivollat, M., Smits, L., Stewart, J. R., ten Anscher, T., Toussaint, M., Callan, K., Cheronet, O., Frost, T., Iliev, L., Mah, M., Micco, A., Oppenheimer, J., Patterson, I., Qiu, L., Soos, G., Workman, J. N., Edwards, C. J., Lazaridis, I., Mallick, S., Patterson, N., Rohland, N., Richards, M. B., Pinhasi, R., Haak, W., Pala, M., Reich, D.
10.1101/2025.03.24.644985 — Posted: 2025-03-25
Membrane-associated polymerases deliver most of the actin subunits to a lamellipodial network
Skruber, K., Sept, D., Mullins, D.
10.1101/2025.03.24.645090 — Posted: 2025-03-25
Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex
Johansen, N. J., Kempynck, N., Zemke, N. R., Somasundaram, S., Winter, S. D., Hooper, M., Dwivedi, D., Lohia, R., Wehbe, F., Li, B., Abaffyova, D., Armand, E. J., Man, J. D., Eksi, E. C., Hecker, N., Hulselmans, G., Konstantakos, V., Mauduit, D., Mich, J. K., Partel, G., Daigle, T. L., Levi, B. P., Zhang, K., Tanaka, Y., Gillis, J., Ting, J. T., Ben-Simon, Y., Miller, J., Ecker, J. R., Ren, B., Aerts, S., Lein, E. S., Tasic, B., Bakken, T. E.
10.1101/2024.08.21.609075 — Posted: 2025-03-25

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