Channel:  The Howard Hughes Medical Institute (HHMI)

1,788 Articles

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Genetic diversity and regulatory features of human-specific NOTCH2NL duplications
Real, T. D., Hebbar, P., Yoo, D., Antonacci, F., Pacar, I., Diekhans, M., Mikol, G. J., Popoola, O. G., Mallory, B., Vollger, M. R., Dishuck, P. C., Guitart, X., Rozanski, A. N., Munson, K. M., Hoekzema, K., Ranchalis, J. E., Neph, S. J., Sedeno-Cortes, A. E., Paten, B., Salama, S., Stergachis, A., Eichler, E. E.
10.1101/2025.03.14.643395 — Posted: 2025-03-17
Type IV pili-associated secretion of a biofilm matrix protein from Clostridium perfringens that forms intermolecular isopeptide bonds
Kivimaki, S. E., Dempsey, S., Tani, J. M., Camper, C., Hicklin, I. K., Blaby-Haas, C. E., Brown, A. M., Melville, S.
10.1101/2024.11.04.621531 — Posted: 2025-03-17
Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli
Papagiannakis, A., Yu, Q., Govers, S. K., Lin, W.-H., Wingreen, N. S., Jacobs-Wagner, C.
10.1101/2024.10.08.617237 — Posted: 2025-03-15
A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni
Stephens, D. R., Fung, H. Y. J., Han, Y., Liang, J., Chen, Z., Ready, J., Collins, J.
10.1101/2025.03.14.643303 — Posted: 2025-03-15
HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions
Rokicki, K., Schauder, D., Olbris, D. J., Goina, C., Clements, J., Edson, P., Kawase, T., Svirskas, R., Arshadi, C., Feng, D., Chandrashekar, J., Ferreira, T. A., MouseLight Project Team
10.1101/2025.03.13.642887 — Posted: 2025-03-14
Design of solubly expressed miniaturized SMART MHCs
White, W. L., Bai, H., Kim, C. J., Jude, K. M., Sun, R., Guerrero, L., Han, X., Chen, X. T., Chaudhuri, A., Bonzanini, J. E., Sun, Y., Onwuka, A. E., Wang, N., Wang, C., Li, X., Goreshnik, I., Allen, A., Levine, P. M., Kueh, H. Y., Jewett, M. C., Sgourakis, N., Achour, A., Garcia, K. C., Baker, D.
10.1101/2025.03.14.643101 — Posted: 2025-03-14
Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
Xue, J., Zeng, W., John, S., Attiq, N., Ottolia, M., Jiang, Y.
10.1101/2024.12.05.627058 — Posted: 2025-03-13
Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes
Wang, S.-T., Anahtar, M., Kim, D. M., Samad, T. S., Zhang, C. M., Patel, S., Ko, H., Ngambenjawong, C., Wang, C. S., Kirkpatrick, J. D., Kumar, V., Fleming, H. E., Bhatia, S. N.
10.1101/2024.12.30.630769 — Posted: 2025-03-13
Canonical Wnt Signaling Suppresses Brain Endothelial Cell Transcytosis to Maintain Blood-Brain Barrier Integrity
du Maine, X., Gu, C.
10.1101/2025.03.10.642437 — Posted: 2025-03-13
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Lee, Y., Biasini, A., Tipping, C., Hong, S. H., Zamore, P.
10.1101/2025.03.05.641556 — Posted: 2025-03-11

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