Channel:  The Howard Hughes Medical Institute (HHMI)

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Isolation and In vitro Characterization of BchE, the Cobalamin-Dependent Anaerobic Magnesium Protoporphyrin IX Monomethylester Cyclase Involved in Bacteriochlorophyll Biosynthesis
York, N., Zhang, X., Booker, S.
10.64898/2026.04.29.721654 — Posted: 2026-07-22
Defining the molecular interaction between influenza hemagglutinin and MHC-II
Dadonaite, B., Dosey, A., Ahn, J. J., Yu, T. C., Sunshine, S. A., Farrell, A. G., King, N. P., Bloom, J. D.
10.64898/2026.07.17.738765 — Posted: 2026-07-22
Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center
Guan, Y., Mikhova, M., Yang, Z., Xu, K., Xie, S., Lin, X., Ye, A. Y., Williams, T., Wang, J., Schatz, D. G., Alt, F. W., Chen, X.
10.64898/2026.07.20.739632 — Posted: 2026-07-22
Self-reinforcing ROS-aneuploidy feedback loop shapes preimplantation development
Lee, S. H., Alamban, A., Simbulan, R. K., Marsh, P., Rosen, M., Aydogan, M. G., Rinaudo, P. F.
10.64898/2026.07.21.739791 — Posted: 2026-07-22
Munc18 reprograms the intrinsic neuronal SNARE complex assembly pathway
Vishvakarma, V., Chapman, E. R.
10.64898/2026.07.21.739636 — Posted: 2026-07-22
Activity and specificity trade-offs in adenine base editors
Lukarska, M., Oltrogge, L. M., Nisonoff, H., Long, Y., Terrace, C. I., Busia, A., Aquino, C., Kim, S. E., Listgarten, J., Savage, D. F.
10.64898/2026.07.20.739671 — Posted: 2026-07-22
Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity
Fagniez, I., Tsumura, M., Guerin, A., Abolhassani, H., Sharafian, S., Mesdaghi, M., Nishimura, T., Lashkari, H. P., Rao, S., Richards, S., Han, J. E., Delmonte, O. M., Kergaravat, C., Markle, J. G., Ogishi, M., Han, J., Peel, J., Vellutini, J., Feng, Y., Soudee, C., Migaud, M., Palterer, B., Jackson, K. J. L., Nishimura, S., Sakata, S., Kinoshita, K., Yamamoto, A., Moritake, H., Alzahrani, M., Vallejos, F., Cole, T. L., Smart, J. M., Choo, S., Chavoshzadeh, Z., Armin, S., Toubert, A., Zhang, P., Rosain, J., Notarangelo, L. D., Pan-Hammarstrom, Q., Tangye, S. G., Casanova, J.-L., Ma, C. S., Pue
10.64898/2026.07.18.26358075 — Posted: 2026-07-22
HPRC2: A human pangenome reference with near-complete coverage of common genetic variation
Lucas, J. K., Hebbar, P., Liao, W.-W., Macias-Velasco, J. F., Novak, A. M., Asri, M., Balacco, J. R., Blair, A. P., Ebler, J., Gardner, J. M. V., Geleta, M., Groza, C., Guarracino, A., Heringer, P., Hickey, G., Lu, S., Marin, M. G., Markovic, C., Mastoras, M., Mayoud, C., McNulty, B., Menendez, J. M., Minkina, A., Mohanty, S. K., Monlong, J., Munson, K. M., Oshima, K. K., Porubsky, D., Ranallo-Benavidez, T. R., Seligmann, W. E., Shemirani, R., Violich, I., Yoo, D., Zhuo, X., Albracht, D., Alexandrov, I. A., Allen, J., Alsheikh-Ali, A. A., Andrews, C., Antipov, D., Antonacci-Fulton, L., Arguell
10.64898/2026.07.21.739710 — Posted: 2026-07-22
Human GPR174 deficiency drives polyclonal lymphoproliferative disease via defects in T cell function
Huang, Y.-H., Arana, K., Rachimi, S., Tam, H., Spegarova, J. S., Engelhardt, K. R., Griffin, H., Mee, M., Miano, M., Raggi, F., Grossi, A., Rusmini, M., Ceccherini, I., DellOrso, G., Ferro, J., Giarratana, M. C., Pillai, V., Banka, S., Garcez, T., Briggs, T. A., Mellouli, F., Hardenberg, S. v., Beier, R., Auber, B., Baumann, U., Tawamie, H., Behrens, E., Oldridge, D. A., Cabrera, E. C., Xu, Y., Ouyang, S., Hambleton, S., Romberg, N., Cyster, J. G.
10.64898/2026.07.14.26357774 — Posted: 2026-07-21
Enhancer binding kinetics explain transcription factor hub formation
Fallacaro, S., Kapoor, M., Encarnation, L., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M.
10.1101/2025.04.07.647578 — Posted: 2026-07-21

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