Channel:  The Howard Hughes Medical Institute (HHMI)

1,892 Articles

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Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation
Russell, K., Chen, Y., Espinosa, J. R., Gil, D. F., Zhou, H., Maristany, M. J., Lopez, J. I. P., Huertas, J., Orozco, M., Rosen, M. K., Collepardo-Guevara, R.
10.1101/2025.11.17.688899 — Posted: 2025-11-17
Structure and mechanism of microtubule stabilization and motor regulation by MAP9
Cetin, B., Taheri, A., Golcuk, M., Monroy, B. Y., Fernandes, J., Ori-McKenney, K. M., Gur, M., Nogales, E., Yildiz, A.
10.1101/2025.11.17.688911 — Posted: 2025-11-17
Structural Basis for Iterative Methylation by a Cobalamin-dependent Radical S-Adenosylmethionine Enzyme in Cystobactamids Biosynthesis
Cui, J., Wang, B., Maurya, R., Booker, S. J.
10.1101/2025.11.17.688841 — Posted: 2025-11-17
ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment
Qiao, K., Yang, Q.-L., Li, T., Chen, X., Yazgan, Z., Kim, Y. J., Gilbreath, C., Lim, J. Y. S., Xie, Y., Sun, X., Liu, Y., Jia, Y., Chen, Z. J., Huang, H., Wu, S.
10.1101/2025.11.15.688565 — Posted: 2025-11-16
Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression
Coley, A., Batra, K., Delahanty, J., Keyes, L., Pamintuan, R., Ramot, A., Hagemann, J., Lee, C., Liu, V., Adivikolanu, H., Cressy, J., Jia, C., Massa, F., LeDuke, D., Gabir, M., Durubeh, B., linderhof, L., Patel, R., Wichmann, R., Li, H., Fischer, K., Pereira, T., Tye, K.
10.1101/2024.12.18.629202 — Posted: 2025-11-15
Evolutionary basis of intermale sexual behavior by multiple pheromone switches in Drosophila
Ouadah, Y., Naragon, T. H., Smihula, H., Behrman, E. L., Khallaf, M. A., Ding, Y., Stern, D. L., Parker, J., Anderson, D. J.
10.1101/2025.10.14.682417 — Posted: 2025-11-14
FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Ladewig, E., Nazir, A., Park, T., Fan, V. B., Cao, Z., Hawk, J., Kelly, L., Tjian, R., Leslie, C. S., Sawyers, C.
10.1101/2025.11.13.688263 — Posted: 2025-11-14
Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution
Tulloch, A. J., Delgado, R. N., Catta-Preta, R., Cepko, C. L.
10.1101/2025.05.13.653746 — Posted: 2025-11-14
Modulating MyoD1 dosage activates alternate cell fate beyond myogenic differentiation
Whitney, O. N., Dailey, G. M., McKenna, J. K., Darzacq, X., Tjian, R.
10.1101/2025.11.13.688391 — Posted: 2025-11-14
Extracting task-relevant preserved dynamics from contrastive aligned neural recordings
Jiang, Y., Sheng, K., Gao, Y., Buchanan, E. K., Shikano, Y., Kim, T. H., Zhao, Y., Woo, S. J., Dinc, F., Linderman, S. W., Schnitzer, M. J.
10.1101/2025.11.11.686428 — Posted: 2025-11-13

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