Channel:  The Howard Hughes Medical Institute (HHMI)

2,121 Articles

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The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation
Li, H., Guan, H., Rapoport, T.
10.1101/2025.11.08.687396 — Posted: 2026-02-28
Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R., Hoffmann, F. T., Xie, D., Wiegand, T., Palmieri, A. I., Sternberg, S. H., Chang, L.
10.1101/2025.06.10.658880 — Posted: 2026-02-28
Aspartate aminotransferase is required for Salmonella expansion in the inflamed gut via TCA anaplerosis
Shealy, N. G., Baltagulov, M., Avalos, H. F., Olivas, J., Jones, K. M., Byndloss, M. X.
10.64898/2026.02.24.707732 — Posted: 2026-02-26
Gaussian Process Inference Reveals Non-separability of Positionand Velocity Tuning in Grid Cells
Warton, L., Ganguli, S., Giocomo, L.
10.64898/2026.02.02.703269 — Posted: 2026-02-26
A druggable redox switch on SHP1 controls macrophage inflammation
Ng, M. Y., Nix, M. N., Du, G., Davidek, I., Burger, N., Shin, S., Toenjes, S., Takeda, H., Cheah Xin Yan, M., Zhang, B., Xiao, H., Wei, S., Seo, H.-S., Dhe-Paganon, S., Wales, T. E., Engen, J., Mills, E., Che, J., Zhang, T., Gray, N., Chouchani, E. T.
10.64898/2026.02.19.706790 — Posted: 2026-02-26
Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF
Henikoff, S., Henikoff, J. G.
10.1101/2025.11.10.687711 — Posted: 2026-02-26
Exploratory analyses of Immunologic Features in a Randomized, Placebo-Controlled Trial of Nirmatrelvir/Ritonavir for Long COVID
Bhattacharjee, B., Sawano, M., Hooper, W. B., Wang, K., Tabachnikova, A., Monteiro, V. S., Lu, P., Baevova, P., Rodrigues, G. C., Fisher, V. L., Caraballo, C., Khera, R., Li, S.-X., Herrin, J., Christian, D., Coppi, A., Warner, F., Holub, J., Henriquez, Y., Johnson, M. A., Goddard, T. B., Rocco, E., Hummel, A. C., Mouslmani, M. A., Carr, K. D., Charnas, L., Jesus, M. D., Nepert, D., Abreu, P., Ziegler, F. W., Spertus, J., Guan, L., Krumholz, H., Iwasaki, A.
10.64898/2026.02.24.26347001 — Posted: 2026-02-26
Benzoxaboroles are structurally unique binders of eukaryotic translation initiation factor 4E
Combs, J. B., Peacock, D. M., Craven, G. B., Jung, S., Chen, Y., Le, S. M., Taunton, J., Shokat, K.
10.64898/2026.02.24.707563 — Posted: 2026-02-25
Discovery of cephalotaxinone enzymes reveals a whole plant model for homoharringtonine biosynthesis
Dho, Y., Smith, K., Sattely, E. S.
10.1101/2025.08.26.672243 — Posted: 2026-02-25
Efficient transgene-free multiplexed genome editing via viral delivery of an engineered TnpB.
Weiss, T., Kamalu, M., Shi, H., Wirnowski, G., Ingelsson, A., Amerasekera, J., Vohra, K., Trinidad, M. I., Li, Z., Freitas, E., Steinmetz, N., Ambrose, C., Chen, K., Doudna, J. A., Jacobsen, S. E.
10.64898/2026.01.23.700382 — Posted: 2026-02-25

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