Channel:  The Howard Hughes Medical Institute (HHMI)

2,117 Articles

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GAP mimetic activity of pan-Ras TCI daraxonrasib synergizes with K-Ras Switch-II pocket inhibition
Pfaff, P., Shokat, K.
10.64898/2026.03.11.711097 — Posted: 2026-03-13
Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila
Huang, K., Miao, T., Sanford, J., Chen, Y., Moon, S. J., Dantas, E., Han, M., Hu, Y., Wang, K., Goncalves, M., Perrimon, N.
10.1101/2025.04.04.647255 — Posted: 2026-03-12
Large-scale mutational analysis uncovers molecular mechanisms governing dual RNA functions in transposons
Mortman, E. E., Sternberg, S. H.
10.64898/2026.03.11.711047 — Posted: 2026-03-12
Somatic mosaicism in amyotrophic lateral sclerosis and frontotemporal dementia identifies focal mutations associated with widespread degeneration
Zhou, Z., Kim, J., Huang, A. Y., Nolan, M., Park, J., Doan, R., Shin, T., Miller, M. B., Bae, M., Zhao, B., Kim, J., Chhouk, B., Morillo, K., Yeh, R. C., Kenny, C., Neil, J. E., Lee, C.-Z., Ohkubo, T., Ravits, J., Ansorge, O., Ostrow, L. W., Lagier-Tourenne, C., Lee, E. A., Walsh, C. A.
10.1101/2023.11.30.569436 — Posted: 2026-03-12
Enhancer binding kinetics explain transcription factor hub formation
Fallacaro, S., Kapoor, M., Encarnation, L., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M.
10.1101/2025.04.07.647578 — Posted: 2026-03-12
SUMO mediates the coordinate regulation of meiotic chromosome length and crossover rate
Yun, Y., Qiao, H., White, M., Sandhu, S., Qiu, W., Bourne, S., Deshpande, A., Bhatt, S., Sharma, A., Bailey, L., Tran, H., Prasada Rao, H., Hunter, N.
10.64898/2026.03.10.710713 — Posted: 2026-03-11
m6A-dependent microRNA binding to chromatin-associated RNA for transcriptional activation
Zhong, Y., Zheng, L., Li, J., Liu, C., Wei, J., Ye, C., Dou, X., Liu, B., Barbosa, E., Yang, F., Pitroda, S., Chen, M., Weichselbaum, R., He, C.
10.64898/2026.02.02.703428 — Posted: 2026-03-11
Interdependent RNA structural motifs at the 3'-terminus of the West Nile virus genome regulate viral growth
Tsao, L. H., Brackney, D. E., Pyle, A. M.
10.64898/2026.03.11.711107 — Posted: 2026-03-11
Peaceful Queen Succession in the Naked Mole Rat
Abeywardena, S. C., Schraibman, A. M., Delgado Cuevas, V., Ayres, J. S.
10.64898/2026.01.09.698689 — Posted: 2026-03-11
Evolution of Origin Sequence and Recognition for Licensing of Eukaryotic DNA Replication
Bauer, J., Zali, N., Chouhan, O. P., Demerdash, O. E., Loell, K., Kinney, J. B., Joshua-Tor, L. W., Stillman, B.
10.64898/2026.03.10.710760 — Posted: 2026-03-10

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