Channel:  The Howard Hughes Medical Institute (HHMI)

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Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes
Jung, S., Zheng, Q., Shokat, K.
10.1101/2025.09.16.676163 — Posted: 2025-10-13
Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling
Exposit, M., Abedi, M., Krishnakumar, A., Jain, S., Yu, T.-Y., Hercus, T. R., Mathew, D., Gray-Gaillard, S., Chen, Z., Grubbe, W. S., Favor, A., Kan, W. L., Schlichthaerle, T., Chen, W., Parker, M. W., Mendoza, J. L., Lopez, A. F., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681819 — Posted: 2025-10-13
Multiplex design and discovery of proximity handles for programmable proteome editing
Suiter, C. C., Ahn, G., Chiu, M., Fu, Y., Sadre, S., Simon, J. J., Lee, D. S., Fowler, D. M., Maly, D. J., Baker, D., Shendure, J.
10.1101/2025.10.13.681693 — Posted: 2025-10-13
Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak
Gopal, N., Abay, T., Payne, C., Gomez, M., Fofanah, I. U., Rogers, M. M., Kallon, T. P., Kamara, M. S., Suk, H.-J., Sandi, J. D., Brock-Fisher, T., Stachler, E., Allan-Blitz, L.-T., Roach, D. J., Paye, M. F., Wilkason, C., Grant, D. S., Ozonoff, A., Sabeti, P. C.
10.1101/2025.10.08.25337506 — Posted: 2025-10-13
High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists
Abedi, M., Exposit, M., Coventry, B., Mathew, D., Jain, S., Krishnakumar, A., Goreshnik, I., Gray-Gaillard, S., Lunn-Halbert, M., Yu, T.-Y., Glögl, M., Mitchell, U., Keshri, R., Chun, J. H., Ruohola-Baker, H., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681920 — Posted: 2025-10-13
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Rehfeld, F., Lundstrom, C., Zhang, H., Mendell, J. T.
10.1101/2025.10.13.682107 — Posted: 2025-10-13
Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity
Keshri, R., Exposit, M., Abedi, M., R Hicks, D., Foreman, Z., Phal, A., Lim, Y. C., Barrett, P., Sniezek, C., Lin, J., Schlichthaerle, T., J Robinson, A., Detraux, D., Ching, T. C., Wu, K., Coventry, B., Chang, L., S.T. Smith, A., L Mack, D., K Schweppe, D., Martin, B. E., Hristova, K., Mathieu, J., Baker, D., Ruohola-Baker, H.
10.1101/2025.10.12.681903 — Posted: 2025-10-13
A family of lethal exotoxins defined by cell entry via the Attractin receptor
Viswanatha, R., Lee, D., Robins, W. P., Mameli, E., Hu, Y., Kim, A.-R., Hashmi, Y., Nishida, H., Prakash, G., Butnaru, M., Churchman, L. S., Mohr, S., Mekalanos, J., Perrimon, N.
10.1101/2025.10.08.681221 — Posted: 2025-10-11
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
He, C., Dai, Q., Baldwin, T., Lyu, R., Daniels, B., Ye, C., Cao, C., Zhu, C., Fan, D., Lin, L., Liu, Y., Wang, Y.
10.1101/2025.10.09.681456 — Posted: 2025-10-11
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
Dong, K. X., Ji, H., Luginbuhl, D. J., Luo, L., McLaughlin, C.
10.1101/2025.10.09.681358 — Posted: 2025-10-10

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