Channel:  The Howard Hughes Medical Institute (HHMI)

1,937 Articles

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A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects
Hart, S. F. M., Alcala, N., Feder, A. F., Harris, K.
10.1101/2025.05.15.654154 — Posted: 2025-12-16
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.
Sakers, K., Ramirez, J. J., Elazar, N., Nagendren, L., Soderblom, E. J., Eroglu, C.
10.64898/2025.12.15.694023 — Posted: 2025-12-16
A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses
Bhattacharya, T., Freeman, T. S., Alleman, E. M., Wang, F., Chechik, L., Emerman, M., Myles, K. M., Malik, H. S.
10.1101/2025.09.27.679005 — Posted: 2025-12-14
Conserved phenotype and function of human brain border-associated macrophages in iPSC-derived models
Barr, H. J., Depp, C., Hingerl, M., Nguyen, T., Reimertz, J. M., Connolly, E., Patel, J., Doman, J. L., Marsh, S. E., Stevens, B.
10.64898/2025.12.11.693582 — Posted: 2025-12-14
Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling
Glaser, A., Padua, R., Ojoawo, A., Sullivan, C., Kern, D.
10.64898/2025.12.12.694068 — Posted: 2025-12-14
Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF
Henikoff, S., Henikoff, J. G.
10.1101/2025.11.10.687711 — Posted: 2025-12-13
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
Raman, P., Khan, H., Young, J. M., Tsukiyama, T., Malik, H. S.
10.64898/2025.12.12.693809 — Posted: 2025-12-13
Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology
Drexler, R., Yalcin, B., Mancusi, R., Rogers, A., Shamardani, K., Woo, P. J., Ravel, A., Wu, S., Yabo, Y., Oliveira de Biagi-Junior, C. A., Lo Cascio, C., Malenka, R. C., Heifets, B. D., Filbin, M. G., Heiland, D. H., Deisseroth, K., Monje, M.
10.64898/2025.12.10.693579 — Posted: 2025-12-12
Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting
Logeman, B. L., Horvath, P. M., Talay, M., Kapoor, V., Kaplan, H. S., Dulac, C.
10.64898/2025.12.11.693766 — Posted: 2025-12-12
Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells
Pearlman, A. H., Mog, B. J., Hwang, M. S., Rincon-Torroella, J., DiNapoli, S. R., Paul, S., Douglass, J., Hsiue, E. H.-C., Glavaris, S. A., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Bettegowda, C., Zhou, S., Vogelstein, B., Konig, M. F.
10.64898/2025.12.09.691975 — Posted: 2025-12-11

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