Channel:  HHMI

1037 Articles

Accurate de novo design of high-affinity protein binding macrocycles using deep learning
Rettie, S., Juergens, D., Adebomi, V., Bueso, Y. F., Zhao, Q., Leveille, A., Liu, A., Bera, A., Wilms, J., Üffing, A., Kang, A., Brackenbrough, E., Lamb, M., Gerben, S., Murray, A., Levine, P., Schneider, M., Vasireddy, V., Ovchinnikov, S., Weiergräber, O., Willbold, D., Kritzer, J., Mougous, J., Baker, D., DiMaio, F., Bhardwaj, G.
10.1101/2024.11.18.622547 — Posted: 2024-11-18
Brainwide hemodynamics predict neural rhythms across sleep and wakefulness in humans
Jacob, L. P. L., Bailes, S. M., Williams, S. D., Stringer, C., Lewis, L. D.
10.1101/2024.01.29.577429 — Posted: 2024-11-17
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Wang, Y., Zhang, W., Zhang, C., Van, H. T., Seino, T., Zhang, Y.
10.1101/2024.11.09.622774 — Posted: 2024-11-17
Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen
Serrano, A., Puerner, C., Plumb, E., Chevalier, L., Elferich, J., Sinn, L. R., Grigorieff, N., Ralser, M., Delarue, M., Bassilana, M., Arkowitz, R. A.
10.1101/2024.11.16.623909 — Posted: 2024-11-17
Generalized cell phenotyping for spatial proteomics with language-informed vision models
Wang, X., Dilip, R., Bussi, Y., Brown, C., Pradhan, E., Jain, Y., Yu, K., Li, S., Abt, M., Borner, K., Keren, L., Yue, Y., Barnowski, R., Van Valen, D. A.
10.1101/2024.11.02.621624 — Posted: 2024-11-17
A novel rhodopsin-based voltage indicator for simultaneous two-photon optical recording with GCaMP in vivo
Villette, V., Yang, S., Valenti, R., Macklin, J. J., Bradley, J., Mathieu, B., Lombardini, A., Podgorski, K., Dieudonne, S., Schreiter, E. R., Abdelfattah, A. S.
10.1101/2024.11.15.623698 — Posted: 2024-11-17
Design of facilitated dissociation enables control over cytokine signaling duration
Broerman, A. J., Pollmann, C., Lichtenstein, M. A., Jackson, M. D., Tessmer, M. H., Ryu, W. H., Abedi, M. H., Sahtoe, D. D., Allen, A., Kang, A., De La Cruz, J., Brackenbrough, E., Sankaran, B., Bera, A. K., Zuckerman, D. M., Stoll, S., Praetorius, F., Piehler, J., Baker, D.
10.1101/2024.11.15.623900 — Posted: 2024-11-16
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
McClune, C. J., Liu, J. C.-T., Wick, C., De La Pena, R., Lange, B. M., Fordyce, P. M., Sattely, E. S.
10.1101/2024.11.06.622305 — Posted: 2024-11-16
Biochemical principles of miRNA targeting in flies
Vega-Badillo, J., Zamore, P., Jouravleva, K.
10.1101/2024.11.16.623948 — Posted: 2024-11-16
Real-time volumetric imaging of cells and molecules in deep tissues with Takoyaki ultrasound
Lee, S., Wu, D., Malounda, D., Rabut, C., Shapiro, M. G.
10.1101/2024.11.14.623368 — Posted: 2024-11-15

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