Channel: The Howard Hughes Medical Institute (HHMI)

1,898 Articles

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ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

Qiao, K., Yang, Q.-L., Li, T., Chen, X., Yazgan, Z., Kim, Y. J., Gilbreath, C., Lim, J. Y. S., Xie, Y., Sun, X., Liu, Y., Jia, Y., Chen, Z. J., Huang, H., Wu, S.

10.1101/2025.11.15.688565 — Posted: 2025-11-16

Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

Coley, A., Batra, K., Delahanty, J., Keyes, L., Pamintuan, R., Ramot, A., Hagemann, J., Lee, C., Liu, V., Adivikolanu, H., Cressy, J., Jia, C., Massa, F., LeDuke, D., Gabir, M., Durubeh, B., linderhof, L., Patel, R., Wichmann, R., Li, H., Fischer, K., Pereira, T., Tye, K.

10.1101/2024.12.18.629202 — Posted: 2025-11-15

Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution

Tulloch, A. J., Delgado, R. N., Catta-Preta, R., Cepko, C. L.

10.1101/2025.05.13.653746 — Posted: 2025-11-14

Modulating MyoD1 dosage activates alternate cell fate beyond myogenic differentiation

Whitney, O. N., Dailey, G. M., McKenna, J. K., Darzacq, X., Tjian, R.

10.1101/2025.11.13.688391 — Posted: 2025-11-14

Evolutionary basis of intermale sexual behavior by multiple pheromone switches in Drosophila

Ouadah, Y., Naragon, T. H., Smihula, H., Behrman, E. L., Khallaf, M. A., Ding, Y., Stern, D. L., Parker, J., Anderson, D. J.

10.1101/2025.10.14.682417 — Posted: 2025-11-14

FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity

Ladewig, E., Nazir, A., Park, T., Fan, V. B., Cao, Z., Hawk, J., Kelly, L., Tjian, R., Leslie, C. S., Sawyers, C.