Channel:  The Howard Hughes Medical Institute (HHMI)

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Exapted CRISPR-Cas12f homologs drive RNA-guided transcription
Hoffmann, F. T., Wiegand, T., Palmieri, A. I., Glass-Klaiber, J., Xiao, R., Tang, S., Le, H., Meers, C., Lampe, G. D., Chang, L., Sternberg, S. H.
10.1101/2025.06.10.658865 — Posted: 2025-06-10
Pan-angiosperm analysis of the CLE signaling peptide family unveils paths, patterns, and predictions of paralog diversification
Gentile, I., Santo Domingo, M., Zebell, S. G., Fitzgerald, B., Lippman, Z.
10.1101/2025.06.04.657892 — Posted: 2025-06-09
Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice
Burdge, J., Jhumka, A., Khan, A., Ogundare, S., Baer, N., Fulton, S., Kaplan, A., Bistis, B., Foster, W., Thackray, J., Toussaint, A., Li, M., Morizawa, Y. M., Nazarian, J., Yadessa, L., George, A., Delinois, A., Mayiseni, W., Loran, N., Yang, G., Margolis, D. J., Abraira, V. E. G., Abdus-Saboor, I.
10.1101/2024.05.06.592101 — Posted: 2025-06-08
Constant light impairs memory processing transgenerationally in D. melanogaster
Moore, R. S., Sehgal, A.
10.1101/2025.06.04.657854 — Posted: 2025-06-08
Engineering gene expression dynamics via self-amplifying RNA with drug-responsive non-structural proteins
Yousefpour, P., Gregory, J. R., Si, K., Lonzaric, J., Li, Y., Wang, J., Qureshi, K., Ledbetter, A., Melo, M. B., Lemnios, A. A., Dye, J., Remba, T. K., Yeung, R., Rodriguez, L., Guereca, M., Wu, S., Zhang, Y., Dong, Y., Weiss, R., Irvine, D. J.
10.1101/2025.06.08.658495 — Posted: 2025-06-08
Replaying germinal center evolution on a quantified affinity landscape
DeWitt, W. S. S., Vora, A. A., Araki, T., Galloway, J. G., Alkutkar, T., Bortolatto, J., Castro, T. B., Dumm, W., Jennings-Schaffer, C., Jia, T., Mesin, L., Ozorowski, G., Pae, J., Ralph, D. K., Bloom, J. D., Nourmohammad, A., Song, Y. S., Ward, A., Starr, T. N., Matsen, F. A., Victora, G. D.
10.1101/2025.06.02.656870 — Posted: 2025-06-05
Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
Pratap, P. P., Cottrell, C. A., Quinn, J., Carnathan, D. G., Bader, D. L. V., Tran, A. S., Enemuo, C. A., Ngo, J. T., Richey, S. T., Gao, H., Shen, X., Greene, K. M., Hurtado, J., Michaels, K. K., Ben-Akiva, E., Lemnios, A., Melo, M. B., Allen, J. D., Ozorowski, G., Crispin, M., Briney, B., Montefiori, D., Silvestri, G., Irvine, D. J., Crotty, S., Ward, A. B.
10.1101/2024.11.27.625755 — Posted: 2025-06-05
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Muratspahic, E., Feldman, D., Kim, D. E., Qu, X., Bratovianu, A.-M., Rivera-Sanchez, P., Dimitri, F., Cao, J., Cary, B. P., Belousoff, M. J., Keov, P., Chen, Q., Ren, Y., Fine, J., Sappington, I., Schlichthaerle, T., Zhang, J. Z., Pillai, A., Mihaljevic, L., Bauer, M., Torres, S. V., Motmaen, A., Lee, G. R., Tran, L., Wang, X., Goreshnik, I., Vafeados, D. K., Svendsen, J. E., Hosseinzadeh, P., Lindegaard, N., Brandt, M., Waltenspühl, Y., Deibler, K., Oostdyk, L., Cao, W., Anantharaman, L., Stewart, L., Halloran, L., Spangler, J. B., Sexton, P. M., Roth, B. L., Krumm, B. E., Wootten, D., Tate
10.1101/2025.03.23.644666 — Posted: 2025-06-05
A covalent recognition strategy enables conspecific mate identification
Jang, S. S., Mandala, S., Jiang, H., Zhang, X., Cole, P. A., del Marmol, J. I.
10.1101/2025.05.30.657074 — Posted: 2025-06-03
Polyserine-tau interactions modulate tau fibrilization
Pratt, J., McCann, K., Kuo, J., Parker, R.
10.1101/2025.06.03.657713 — Posted: 2025-06-03

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