Channel:  The Howard Hughes Medical Institute (HHMI)

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Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling
Exposit, M., Abedi, M., Krishnakumar, A., Jain, S., Yu, T.-Y., Hercus, T. R., Mathew, D., Gray-Gaillard, S., Chen, Z., Grubbe, W. S., Favor, A., Kan, W. L., Schlichthaerle, T., Chen, W., Parker, M. W., Mendoza, J. L., Lopez, A. F., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681819 — Posted: 2025-10-13
Multiplex design and discovery of proximity handles for programmable proteome editing
Suiter, C. C., Ahn, G., Chiu, M., Fu, Y., Sadre, S., Simon, J. J., Lee, D. S., Fowler, D. M., Maly, D. J., Baker, D., Shendure, J.
10.1101/2025.10.13.681693 — Posted: 2025-10-13
Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak
Gopal, N., Abay, T., Payne, C., Gomez, M., Fofanah, I. U., Rogers, M. M., Kallon, T. P., Kamara, M. S., Suk, H.-J., Sandi, J. D., Brock-Fisher, T., Stachler, E., Allan-Blitz, L.-T., Roach, D. J., Paye, M. F., Wilkason, C., Grant, D. S., Ozonoff, A., Sabeti, P. C.
10.1101/2025.10.08.25337506 — Posted: 2025-10-13
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
He, C., Dai, Q., Baldwin, T., Lyu, R., Daniels, B., Ye, C., Cao, C., Zhu, C., Fan, D., Lin, L., Liu, Y., Wang, Y.
10.1101/2025.10.09.681456 — Posted: 2025-10-11
A family of lethal exotoxins defined by cell entry via the Attractin receptor
Viswanatha, R., Lee, D., Robins, W. P., Mameli, E., Hu, Y., Kim, A.-R., Hashmi, Y., Nishida, H., Prakash, G., Butnaru, M., Churchman, L. S., Mohr, S., Mekalanos, J., Perrimon, N.
10.1101/2025.10.08.681221 — Posted: 2025-10-11
Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions
He, S., Lemma, L. M., Martinez-Calvo, A., He, G., Hennacy, J. H., Wang, L., Ergun, S. L., Rai, A. K., Wang, C., Bunday, L., Kayser-Browne, A., Wang, Q., Brangwynne, C. P., Wingreen, N. S., Jonikas, M. C.
10.1101/2025.10.09.681382 — Posted: 2025-10-10
Cell type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem-cell like cells
Urban, J., Ringwalt, D., Urban, J., Xue, W., Gleason, R., Zhao, K., Chen, X.
10.1101/2025.04.19.649648 — Posted: 2025-10-10
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
Dong, K. X., Ji, H., Luginbuhl, D. J., Luo, L., McLaughlin, C.
10.1101/2025.10.09.681358 — Posted: 2025-10-10
Ingestion-activated CGRP neurons control learning but not satiety
Jarvie, B. C., Ravi, A., Nanavati, R., Qui, L., Ly, T., Oh, J. Y., Barnhill, O. K., Knight, Z. A.
10.1101/2025.10.08.681275 — Posted: 2025-10-09
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Wang, Y., Rattner, A., Li, Z., Smallwood, P. M., Nathans, J.
10.1101/2025.04.11.648449 — Posted: 2025-10-09

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