Channel:  The Howard Hughes Medical Institute (HHMI)

2,120 Articles

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New methods for epigenetic characterization and manipulation of rare fly brain neurons
Ojha, P., Berglund, G., Yu, A. D., Rosbash, M.
10.64898/2026.01.21.700891 — Posted: 2026-01-23
Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids
Cheng, L., Chen, J., Bo, Z., Zhang, X., Liu, P., Yang, Y.
10.64898/2026.01.21.700944 — Posted: 2026-01-23
Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
Fattinger, S. A., Chavez, R. A., Witt, K. C., Parisi, B., Rodriguez, J. J., Turcotte, E. A., Brydon, E. C., Fairgrieve, M. R., Dhaliwal, H., Lee, A. Y., Kotov, D. I., Vance, R. E.
10.64898/2026.01.19.700487 — Posted: 2026-01-22
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Ralph, D. K., Bakis, A. G., Galloway, J., Vora, A. A., Araki, T., Song, Y. S., DeWitt, W. S., Matsen, F. A.
10.1101/2025.08.12.669950 — Posted: 2026-01-22
Sciphy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data.
Seidel, S., Zwaans, A., Regalado, S., Choi, J., Shendure, J., Stadler, T.
10.1101/2024.10.01.615771 — Posted: 2026-01-22
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Rich, M. S., Pellow, R., Hefel, A., Rog, O., Jorgensen, E. M.
10.1101/2025.11.11.687718 — Posted: 2026-01-21
Decoding the cell intrinsic and extrinsic roles of PRC2 in early embryogenesis
Zhou, C., Wang, M., Chen, Z., Zhang, Y.
10.64898/2026.01.20.700679 — Posted: 2026-01-20
Selective Immune Silencing by Targeted TGF-β Agonists
Sun, Q., Ogishi, M., Jiang, H., Barrett, A. K., Yan, H., Sola, E., Zhang, J., Xiao, P., Lyu, H., Salehi, A., Tang, Q., Lanz, T. V., Davis, M. M., Negrin, R. S., Garcia, K. C.
10.64898/2026.01.19.700410 — Posted: 2026-01-20
Inefficient autophagosome formation limits the temporal dynamics of OPTN-mediated mitophagy in neurons
Green, J. R., Gooden, M. K., Ojo, A. E., Kalejaiye, T. D., Evans, C. S.
10.64898/2026.01.16.700014 — Posted: 2026-01-20
Establishing the molecular basis for MDA5 mutation-linked autoimmunity
Xu, L., Chung, K., Guo, R., Pan, A., Pyle, A.
10.64898/2026.01.20.700587 — Posted: 2026-01-20

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