Channel:  The Howard Hughes Medical Institute (HHMI)

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AAV NRF2 Gene Therapy Preserves Retinal Structure and Function in Rodent Models of Oxidative Damage
Gardner, A., Wang, S., Daniels, A., Li, D., Wu, C., Lin, L., Hong, C., Zhao, S., Kruczek, K., Weist, G., Real, L. B., Haurigot, V., Born, R., Cepko, C.
10.1101/2025.07.09.663952 — Posted: 2025-07-14
A 3D in vitro model of the human hepatobiliary junction
Westerfield, A. D., Grzelak, K. A., Katsuyama, K., Kumar, V., Miller, B. M., Yun, J., Kirkpatrick, J., Mankus, D., Bisher, M. E., Lytton-Jean, A. K., Jiang, Z. G., Lee, D. D., Chen, C. S., Bhatia, S. N.
10.1101/2025.07.11.664464 — Posted: 2025-07-14
Potentially Prebiotic Isocyanide Activation Chemistry Drives RNA Assembly via both Nonenzymatic and Ribozyme-catalyzed Ligation
Zhang, S. J., Jia, X., DasGupta, S., Szostak, J. W.
10.1101/2025.07.11.664453 — Posted: 2025-07-12
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch, J. A., Beltran, P. M. J., Cavers, C., LaGraff, J. T., Melanson, R., Singh, A., Chen, W., Hu, Y., Tattikota, S. G., Liu, Y., Hashmi, Y., Asara, J. M., Branon, T., Ting, A. Y., Carr, S. A., Perrimon, N.
10.1101/2025.07.09.659702 — Posted: 2025-07-11
Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
Chen, S., Basiashvili, T., Hutchings, J., Murillo, M. S., Suarez, A. V., Xiong, E., Louro, J. A., Leschziner, A. E., Villa, E.
10.1101/2024.06.18.599606 — Posted: 2025-07-10
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission
White, K. I., Khan, Y. A., Qiu, K., Balaji, A., Couoh-Cardel, S., Esquivies, L., Pfuetzner, R. A., Diao, J., Brunger, A. T.
10.1101/2024.10.11.617886 — Posted: 2025-07-10
A Congenic C57BL/6 rd1 Mouse Model for Retinal Degeneration Research
Chandler, L. C., Gardner, A., Cepko, C. L.
10.1101/2025.07.09.663548 — Posted: 2025-07-09
Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression
Mao, X., Tokamov, S., Pahmeier, F., Lari, A., Xu, J., Harris, E., Glaunsinger, B.
10.1101/2025.07.08.663778 — Posted: 2025-07-08
Glycogen phase separation drives macromolecular rearrangement and asymmetric division in Escherichia coli
Thappeta, Y., Canas-Duarte, S. J., Wang, H., Kallem, T., Fragasso, A., Xiang, Y., Gray, W., Lee, C., Hardo, G., Cegelski, L., Jacobs-Wagner, C.
10.1101/2024.04.19.590186 — Posted: 2025-07-08
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion.
Porubsky, D., Yoo, D., Dishuck, P. C., Koundinya, N., Souche, E., Harvey, W. T., Munson, K. M., Hoekzema, K., Chan, D. D., Leung, T. Y., Santos, M. S., Meynants, S., Swillen, A., Breckpot, J., Tsapalou, V., Hasenfeld, P., Korbel, J. O., Lansdorp, P. M., Vermeesch, J. R., Eichler, E. E.
10.1101/2025.07.04.662981 — Posted: 2025-07-07

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