Channel:  The Howard Hughes Medical Institute (HHMI)

2,121 Articles

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Selective Immune Silencing by Targeted TGF-β Agonists
Sun, Q., Ogishi, M., Jiang, H., Barrett, A. K., Yan, H., Sola, E., Zhang, J., Xiao, P., Lyu, H., Salehi, A., Tang, Q., Lanz, T. V., Davis, M. M., Negrin, R. S., Garcia, K. C.
10.64898/2026.01.19.700410 — Posted: 2026-01-20
Inefficient autophagosome formation limits the temporal dynamics of OPTN-mediated mitophagy in neurons
Green, J. R., Gooden, M. K., Ojo, A. E., Kalejaiye, T. D., Evans, C. S.
10.64898/2026.01.16.700014 — Posted: 2026-01-20
Establishing the molecular basis for MDA5 mutation-linked autoimmunity
Xu, L., Chung, K., Guo, R., Pan, A., Pyle, A.
10.64898/2026.01.20.700587 — Posted: 2026-01-20
Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression
Mao, X., Tokamov, S., Pahmeier, F., Lari, A., Xu, J., Harris, E., Glaunsinger, B.
10.1101/2025.07.08.663778 — Posted: 2026-01-19
Modular mRNA LNP design integrates RNA, lipid, and antigen engineering for protective vaccination
Farzani, T., Espinoza, N., M. Manafi, M., R. Welch, S., D. Coleman-McCray, J., Aida-Ficken, V., R. Spengler, J., Bergeron, E., F. Spiropoulou, C., Borges, C., Bielecki, K., Li, L., Shah, D., Paye, M., Rojas, E., N. Spector, S., Samani, P., E. Hensley, L., Ozonoff, A., Sabeti, P.
10.64898/2026.01.17.699915 — Posted: 2026-01-18
B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing
Hartweger, H., Ruprecht, C., Yao, K.-H., Laffont, P., Lima dos Reis, G., Zhou, P., Hägglöf, T., Binet, L., Loewe, M., Hong, J. P., Xiao, T., Sefik, E., Hernandez, B., Gazumyan, A., Jankovic, M., Seaman, M. S., Costa, G., Nelson, S. A., Clark, J., Kanatani, S., Wilson, P. C., Krammer, F., Levashina, E. A., Julien, J.-P., Wardemann, H., Sinnis, P., Stamatatos, L., Flavell, R. A., Nussenzweig, M. C.
10.64898/2026.01.16.699998 — Posted: 2026-01-18
Discovery of a Human Metabolite that Mimics the Bacterial Quorum-Sensing Autoinducer AI-2
Shine, E., Valastyan, J. S., Ying, V. Y., Huang, J. Z., Seyedsayamdost, M. R., Bassler, B. L.
10.64898/2026.01.16.699917 — Posted: 2026-01-17
Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms
Petsakou, A., Filine, E., Li, M., Chen, Y., Zheng, A., Perrimon, N.
10.1101/2025.01.02.631110 — Posted: 2026-01-16
Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer
Galsky, M. D., Izadmehr, S., Yu, M., Curtis, S. D., Douville, C., Popoli, M., Ptak, J., Dobbyn, L., Silliman, N., Chan, K. G., Dorff, T. B., Cetnar, J. P., O'Neil, B., D'Souza, A., Mamtani, R., Kyriakopoulos, C. E., Brody, R., Sadimin, E., Mehrazin, R., Chowell, D., Sfakianos, J., Daneshmand, S., Pal, S. K., Bettegowda, C., Kinzler, K. W., Papadopoulos, N., Vogelstein, B., Wang, Y.
10.64898/2026.01.14.26344033 — Posted: 2026-01-16
Hypomethylation on cfDNA within transposable elements can predict ovarian malignancy in women with adnexal masses
Weigert, M., Cui, X., Zhang, P., Kowitwanich, K., West-Szymanski, D., Rauch, S., Zhang, W., He, C., Lengyel, E.
10.64898/2026.01.14.26344128 — Posted: 2026-01-16

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