Channel:  The Howard Hughes Medical Institute (HHMI)

1,286 Articles

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Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors
Ni, X., Richardson, R. B., de Godoy, A. S., Ferla, M. P., Kikawa, C., Scheen, J., Hannon, W. W., Capkin, E., Lahav, N., Balcomb, B. H., Marples, P. G., Fairhead, M., Wang, S., Williams, E., Tomlinson, C. W. E., Aschenbrenner, J. C., Lithgo, R., Winokan, M., Girould, C., Chandran, A. V., Walsh, M. A., Thompson, W., Bloom, J. D., Barr, H., Kirkegaard, K., Koekemoer, L., Fearon, D., Evans, M. J., von Delft, F.
10.1101/2024.04.29.591502 — Posted: 2025-02-13
A lateralized pathway for associating nutrients with flavors
Grove, J. C. R., Li, Q., Backes, H., Kuzmanovic, B., Choi, J., Ubadiah, V., Qiu, L., Zhang, J., Liu, Z., Small, D. M., Tittgemeyer, M., Knight, Z. A.
10.1101/2025.02.09.637334 — Posted: 2025-02-10
Evaluation of sequencing reads at scale using rdeval
Formenti, G., Koo, B., Sollitto, M., Balacco, J., Brajuka, N., Burhans, R., Duarte, E., Giani, A. M., McCaffrey, K., Medico, J. A., Myers, E. W., Smeds, P., Nekrutenko, A., Jarvis, E. D.
10.1101/2025.02.01.636073 — Posted: 2025-02-08
Cutaneous lupus features specialized stromal niches and altered retroelement expression
Gehlhausen, J. R., Kong, Y., Baker, E., Ramachandran, S., Koumpouras, F., Ko, C., Vesely, M., Little, A., Damsky, W., King, B., Iwasaki, A.
10.1101/2025.02.01.636053 — Posted: 2025-02-06
De novo design of Ras isoform selective binders
Zhang, J. Z., Li, X., Liu, C., Jiang, H., Wu, K., Baker, D.
10.1101/2024.08.29.610300 — Posted: 2025-02-05
Population Representation of the Confidence in a Decision in the Parietal Cortex
Zylberberg, A., Shadlen, M. N.
10.1101/2024.08.15.608159 — Posted: 2025-02-02
The first complete 3D reconstruction and morphofunctional mapping of an insect eye
Makarova, A. A., Chua, N. J., Diakova, A. V., Desyatirkina, I. A., Gunn, P., Pang, S., Xu, C. S., Hess, H. F., Chklovskii, D. B., Polilov, A. A.
10.1101/2024.09.30.615804 — Posted: 2025-01-29
The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity
Witt, K. C., Dziulko, A., An, J., Pekovic, F., Cheng, A. X., Liu, G. Y., Lee, O. V., Turner, D. J., Lari, A. C., Gaidt, M. M., Chavez, R., Fattinger, S. A., Abraham, P., Dhaliwal, H., Lee, A. Y., Kotov, D. I., Coscoy, L., Glaunsinger, B., Valkov, E., Chuong, E. B., Vance, R. E.
10.1101/2024.08.28.610186 — Posted: 2025-01-29
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation
Wolff, T., Eddison, M., Chen, N., Nern, A., Sundaramurthi, P., Sitaraman, D., Rubin, G. M.
10.1101/2024.10.21.619448 — Posted: 2025-01-24
Multi-scale structure of chromatin condensates rationalizes phase separation and material properties
Zhou, H., Huertas, J., Maristany, M. J., Russell, K., Hwang, J. H., Yao, R., Hutchings, J., Shiozaki, M., Zhao, X., Doolittle, L. K., Gibson, B. A., Riggi, M., Rene Espinosa, J., Yu, Z., Villa, E., Collepardo-Guevara, R., Rosen, M. K.
10.1101/2025.01.17.633609 — Posted: 2025-01-22

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