Channel:  The Howard Hughes Medical Institute (HHMI)

2,202 Articles

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Targeting peptide-MHC complexes with designed T cell receptors and antibodies
Motmaen, A., Jude, K. M., Wang, N., Minervina, A., Feldman, D., Lichtenstein, M. A., Ebenezer, A., Correnti, C., Thomas, P. G., Garcia, K. C., Baker, D., Bradley, P.
10.1101/2025.11.19.689381 — Posted: 2025-11-20
Nucleotide context models outperform protein language models for predicting antibody affinity maturation
Johnson, M. M., Sung, K., Haddox, H. K., Vora, A. A., Araki, T., Victora, G. D., Song, Y. S., Fukuyama, J., Matsen, F. A.
10.1101/2025.06.16.659977 — Posted: 2025-11-20
Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses
Lezgiyeva, K., Liu, J., Nguyen, K., DeLisle, M. M., Ko, F. C., Fullam, S., Obeidat, A. M., Turecek, J., Alkislar, I., Lehnert, B. P., Martinez-Garcia, R. I., Sivakumar, R., Choi, J., Mazor, O., Garibyan, L., Sharma, N., Emanuel, A. J., Malfait, A.-M., Miller, R. E., Ginty, D. D.
10.1101/2025.11.11.687663 — Posted: 2025-11-20
Rapid neocortical network modifications via dendritic plateau potential induced plasticity
Xiao, K., Li, Y., Sullivan, B. J., Li, G., Magee, J. C.
10.1101/2025.11.19.689338 — Posted: 2025-11-19
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Butcher, J., Krishna, R., Mitra, R., Brent, R. I., Li, Y., Corley, N., Kim, P. T., Funk, J., Mathis, S. V., Salike, S., Muraishi, A., Eisenach, H., Thompson, T. R., Chen, J., Politanska, Y., Sehgal, E., Coventry, B., Zhang, O., Qiang, B., Didi, K., Kazman, M., DiMaio, F., Baker, D.
10.1101/2025.09.18.676967 — Posted: 2025-11-19
A nucleic acid labeling chemistry reveals surface DNA on exosomes
Boskovic, F., Dutta Gupta, P., Zhang, J., Krishnan, Y., Szostak, J. W.
10.1101/2025.11.18.689134 — Posted: 2025-11-19
Unconventional linkers facilitate potent stabilized coronavirus stem antibody responses following nanoparticle vaccination
Dzuvor, C. K. O., Moak, S. P., McManus, L. R., Dzordzorme, A. E., Evanson, L. R., Kim, T., Thomas, A., Adeyemi, O., Foley, V., Limaye, A., McNamara, R. P., Corbett-Helaire, K. S.
10.1101/2025.11.19.689216 — Posted: 2025-11-19
Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis
Azur, R. A. G., Feliciano, D., Espinosa-Medina, I., Adhikari, R., Lilao-Garzon, J., Jansen, E., Yang, C.-P., Lee, T.
10.1101/2025.11.18.688993 — Posted: 2025-11-18
Structural Basis for Iterative Methylation by a Cobalamin-dependent Radical S-Adenosylmethionine Enzyme in Cystobactamids Biosynthesis
Cui, J., Wang, B., Maurya, R., Booker, S. J.
10.1101/2025.11.17.688841 — Posted: 2025-11-17
Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation
Russell, K., Chen, Y., Espinosa, J. R., Gil, D. F., Zhou, H., Maristany, M. J., Lopez, J. I. P., Huertas, J., Orozco, M., Rosen, M. K., Collepardo-Guevara, R.
10.1101/2025.11.17.688899 — Posted: 2025-11-17

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