Channel:  The Howard Hughes Medical Institute (HHMI)

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Mre11-Rad50 enhances spacer acquisition in a haloarchaeal Type I-B CRISPR-Cas system
Cassell, A. K., Carion, H., Marraffini, L. A.
10.64898/2026.05.08.723854 — Posted: 2026-05-09
Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding
Zeng, J., Cheng, Z., Chen, H., Thompson, J., Crosby, K. T., Hang, H., Ngo, W., Xia, C., Rosas-Rivera, D., Kang, M. H., Mao, Y., Lee, G., Diffley, J. F. X., Song, Y., Qiu, L., Krah, N. M., Murthy, N., Jackson, R. N., Liu, Y., Ashworth, A., Doudna, J. A.
10.64898/2026.05.08.723607 — Posted: 2026-05-09
A massively parallel reporter assay of MECP2 cis-regulatory elements reveals genetic candidates for male-biased autism
Meyer-Schuman, R., Cherry, F., Sui, Y., Papastathopoulos-Katsaros, A., Zhong, Y., Li, Y., Wang, T., Hennick, K., Karunakaran, D., Berk-Rauch, H., Liu, Z., Chakravarti, A., Nowakowski, T. J., Eichler, E., Zoghbi, H. Y.
10.64898/2026.05.08.723809 — Posted: 2026-05-09
Conserved principles of central carbon partitioning in Hippo-Yorkie-driven Drosophila gut tumors
Park, Y., Qadiri, M., Asara, J. M., Hu, Y., Perrimon, N.
10.64898/2026.05.05.722979 — Posted: 2026-05-08
A widespread internal brain state for fentanyl withdrawal
Abdelaal, K., Walder-Christensen, K., Blount, C., Williford, K., Adams-Grimaldi, m., Mague, S., Carlson, D., Dzirasa, K.
10.64898/2026.05.04.722791 — Posted: 2026-05-08
Localized heme sensing through a ternary molecular glue
Heider, M., Hipp, C., Yang, Z., Xiao, H., Beschauner, T., Wehri, E., Walter, W., Sherriff, R., Chandrasekhar, S., Haferlach, T., Schaletzky, J., Rape, M.
10.64898/2026.05.07.723605 — Posted: 2026-05-08
A Fungal Natural Product that Inhibits Plant Cellulose Biosynthesis by disrupting Cellulose Synthase Complexes
Wu, Z., Liu, L., Han, W., Cai, X., Xiao, P., Sun, Z., Yan, C., Reid, S., Chen, Y., Ma, Z., Tang, Y., Jacobsen, S. E.
10.64898/2026.04.12.718067 — Posted: 2026-05-08
Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening
Zaidi, S., Buttner, M., Feng, W., Baxter, C., Kates, D. H., Paiva Prudente, T., Zakharova, D., Mehta, S., Nandakumar, S., Wong, C. K., Lee, H., Hamard, P.-J., Kang, W., Choi, J., Chaligne, R., Cohen, R., Chen, Y., Firestone, A. J., Chen, Z., Sawyers, C.
10.64898/2026.05.07.723570 — Posted: 2026-05-08
MYC pathway reprogramming through a TIP60 coactivator switch in neuroendocrine lineage transition in prostate cancer
Sun, Z., Zhao, J., Khan, Z., Ismail, W., Han, T., Nandakumar, S., Young, S., Lange, M., Cheng, P., Koche, R., Schultz, N., Gaspar-Maia, A., Sawyers, C.
10.64898/2026.05.05.723058 — Posted: 2026-05-08
Genome-wide CRISPR knockout cell screening platform for the disease vector tick species Ixodes scapularis
Butnaru, M., McKenna, W., Goswami, S., Wu-Chuang, A., Mameli, E., Wilcox, A., Quennesson, L., Kim, A.-R., Veal, A., Chen, W., Verzone, H., Lane, E. A., Laukaitis-Yousey, H. J., Araneo, C., Singh, N., Pedra, J., Hu, Y., Viswanatha, R., Perrimon, N., Mohr, S. E.
10.64898/2026.05.05.721418 — Posted: 2026-05-07

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