Channel:  The Howard Hughes Medical Institute (HHMI)

2,004 Articles

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TAK1 integrates the NLRP1 inflammasome into the innate immune response to double-stranded RNA
Corley, M. R., Hyodo, A., Toyoda, H. C., Yonemitsu, M. A., Chantharath, A., Hyde, J. L., Mitchell, P. S.
10.64898/2026.01.23.701331 — Posted: 2026-01-25
Kinetochore clustering is mediated by Mps1 phosphorylation of conserved MELT motifs in Stu1
Mallet, D. R., Jiang, M., Minnuto, G. M., Biggins, S.
10.64898/2026.01.23.701336 — Posted: 2026-01-25
Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells
Zaganelli, S., Meehl, J., Abrisch, R. G., Voeltz, G. K.
10.1101/2025.04.18.649598 — Posted: 2026-01-24
Long-term post-ovariectomy mouse model recapitulates hypothalamic transcriptomic changes observed during the menopausal transition in women
Bloom, J. C. B., Torres, E., Pereira, S. A., Arvizu-Sanchez, L., Fontes, A. N., Joffe, H., Page, D. C., Navarro, V. M.
10.1101/2024.10.05.616758 — Posted: 2026-01-24
Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids
Cheng, L., Chen, J., Bo, Z., Zhang, X., Liu, P., Yang, Y.
10.64898/2026.01.21.700944 — Posted: 2026-01-23
New methods for epigenetic characterization and manipulation of rare fly brain neurons
Ojha, P., Berglund, G., Yu, A. D., Rosbash, M.
10.64898/2026.01.21.700891 — Posted: 2026-01-23
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Ralph, D. K., Bakis, A. G., Galloway, J., Vora, A. A., Araki, T., Song, Y. S., DeWitt, W. S., Matsen, F. A.
10.1101/2025.08.12.669950 — Posted: 2026-01-22
Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
Fattinger, S. A., Chavez, R. A., Witt, K. C., Parisi, B., Rodriguez, J. J., Turcotte, E. A., Brydon, E. C., Fairgrieve, M. R., Dhaliwal, H., Lee, A. Y., Kotov, D. I., Vance, R. E.
10.64898/2026.01.19.700487 — Posted: 2026-01-22
Sciphy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data.
Seidel, S., Zwaans, A., Regalado, S., Choi, J., Shendure, J., Stadler, T.
10.1101/2024.10.01.615771 — Posted: 2026-01-22
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Rich, M. S., Pellow, R., Hefel, A., Rog, O., Jorgensen, E. M.
10.1101/2025.11.11.687718 — Posted: 2026-01-21

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