Channel:  The Howard Hughes Medical Institute (HHMI)

1,879 Articles

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Modeling protein-small molecule conformational ensembles with PLACER
Anishchenko, I., Kipnis, Y., Kalvet, I., Zhou, G., Krishna, R., Pellock, S. J., Lauko, A., Lee, G. R., An, L., Dauparas, J., DiMaio, F., Baker, D.
10.1101/2024.09.25.614868 — Posted: 2025-09-27
Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning
Liu, Z., Qiu, C., Kubo, C. A., Xu, S., Daza, R. M., Nichols, E., Yang, W., Vo, A., O'Neill, M. B., Lee, C., Shendure, J., Hamazaki, N.
10.1101/2025.09.25.678678 — Posted: 2025-09-26
Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites
Puszynska, A. M., Nguyen, T. P., Cangelosi, A. L., Armani, A., Roberts, J. M., Singh, K. A., Cameron, J. C., Tseyang, T., Liu, G. Y., Lai, S., Sprenger, H.-G., Yang, J., Colgan, W. N., Kedir, J. F., Kajderowicz, K. M., Esantsi, T. K., Lu, Y. R., Waite, M., Kunchok, T., Lewis, C. A., Schulte, F., Bell, G. W., Sabatini, D. M., Weissman, J. S.
10.1101/2025.09.25.678303 — Posted: 2025-09-26
Simulated climate change magnifies genetic vulnerabilities from mutation load and maladaptation
Leventhal, L., Ruffley, M. R., Carnegie Field Consortium, , Exposito-Alonso, M.
10.1101/2025.09.25.677362 — Posted: 2025-09-25
Regulation of Glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons
Zhang, N., Sockanathan, S.
10.1101/2025.09.24.678385 — Posted: 2025-09-25
Observing biological spatio-angular structures and dynamics with statistical image reconstruction and polarized fluorescence microscopy
Liu, J., Chandler, T., Li, Y., Agashe, A., Wei, M., Su, Y., Wu, Y., Baskin, T. I., Jaumouille, V., Chen, J., Xu, P., Ye, H., Zhu, W., Fischer, R. S., Swaminathan, V., Nain, A. S., Mehta, S. B., La Riviere, P. J., Shroff, H., Liu, H., Guo, M.
10.1101/2025.09.23.678164 — Posted: 2025-09-25
EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
Granat, J., Liu, S., Popoca, L., Oksuz, O., Reinberg, D.
10.1101/2025.09.25.678634 — Posted: 2025-09-25
Combining brainwide activity imaging and electron microscopy reveals novel nociceptive circuits
Randel, N., Wang, C., Clayton, M. S., Wang, K., Pang, S., Xu, S. C., Champion, A., Hess, H. F., Cardona, A., Keller, P. J., Zlatic, M.
10.1101/2025.09.25.678485 — Posted: 2025-09-25
Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons
Uyan, O., Sambare, S., Oomen, M. E., Wightman, N., Schooley, A., Klim, J. R., Belaghzal, H., Aydemir, O., Akgol-Oksuz, B., Uslu, Z. S. A., Eggan, K., Brown, R. H., Dekker, J.
10.1101/2025.09.22.677835 — Posted: 2025-09-23
CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1
Wang, S., Li, T., Naish, M., Chuang, R., Lin, E. K., Fonkalsrud, C., Yan, H., Feng, S., Henderson, I. R., Jacobsen, S. E.
10.1101/2025.09.22.677529 — Posted: 2025-09-22

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