Channel:  The Howard Hughes Medical Institute (HHMI)

2,006 Articles

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Deconvolving SARS-CoV-2 mRNA vaccine impact on immunotherapy-related survival in a pandemic
Jee, J., Zhang, J., Lavery, J., Waters, M., Fong, C., Minn, A., Glickman, M., Panageas, K., Sawyers, C., Schultz, N.
10.1101/2025.11.21.25340753 — Posted: 2025-11-23
Computational design of cysteine proteases
Choi, H., Coventry, B., Bauer, M. S., Venkatesh, P., Chen, A., Kim, D., Bera, A. K., Kang, A., Nguyen, H., Joyce, E., Shankaran, B., Thompson, T. R., Gershon, J., Shida, A. F., Lee, G. R., Hilvert, D., Pellock, S. J., Baker, D.
10.1101/2025.11.21.689808 — Posted: 2025-11-22
A gene expression atlas of a juvenile nervous system
Taylor, S. R., Olson, C., Ripoll-Sanchez, L., Valperga, G., McWhirter, R., Barney, S. T., Atkinson, A., Goel, S., Weinreb, A., Hardin, A., Rolfson, A., Pattee, J., Aguilar, G. R., Merritt, D. M., Eroglu, M., Majeed, M., Grundvig, E., Child, E., Vertes, P. E., Schafer, W., Varol, E., Hammarlund, M., Hobert, O., Miller, D. M.
10.1101/2025.11.21.689793 — Posted: 2025-11-22
Computational design of metalloproteases
Chen, A., Wu, K., Choi, H., Venkatesh, P., Pellock, S. J., Hanikel, N., Coventry, B., Kim, D., Woodbury, S. M., Ji, P., Honda, S., Li, X., Gerben, S., Chang, L., Yan, X., Hyman, A. A., Hilvert, D., Baker, D.
10.1101/2025.11.20.689622 — Posted: 2025-11-21
Targeting peptide-MHC complexes with designed T cell receptors and antibodies
Motmaen, A., Jude, K. M., Wang, N., Minervina, A., Feldman, D., Lichtenstein, M. A., Ebenezer, A., Correnti, C., Thomas, P. G., Garcia, K. C., Baker, D., Bradley, P.
10.1101/2025.11.19.689381 — Posted: 2025-11-20
Nucleotide context models outperform protein language models for predicting antibody affinity maturation
Johnson, M. M., Sung, K., Haddox, H. K., Vora, A. A., Araki, T., Victora, G. D., Song, Y. S., Fukuyama, J., Matsen, F. A.
10.1101/2025.06.16.659977 — Posted: 2025-11-20
Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses
Lezgiyeva, K., Liu, J., Nguyen, K., DeLisle, M. M., Ko, F. C., Fullam, S., Obeidat, A. M., Turecek, J., Alkislar, I., Lehnert, B. P., Martinez-Garcia, R. I., Sivakumar, R., Choi, J., Mazor, O., Garibyan, L., Sharma, N., Emanuel, A. J., Malfait, A.-M., Miller, R. E., Ginty, D. D.
10.1101/2025.11.11.687663 — Posted: 2025-11-20
RNA switch model for localization and translation of the myelin basic protein mRNA
Topkar, V. V., Wu, V., Ho, L. T., Ambiel, N., Valenzuela, A., Yoshimura, K., Zuchero, J. B., Fu, M.-m., Das, R.
10.1101/2025.11.19.689361 — Posted: 2025-11-20
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Butcher, J., Krishna, R., Mitra, R., Brent, R. I., Li, Y., Corley, N., Kim, P. T., Funk, J., Mathis, S. V., Salike, S., Muraishi, A., Eisenach, H., Thompson, T. R., Chen, J., Politanska, Y., Sehgal, E., Coventry, B., Zhang, O., Qiang, B., Didi, K., Kazman, M., DiMaio, F., Baker, D.
10.1101/2025.09.18.676967 — Posted: 2025-11-19
A nucleic acid labeling chemistry reveals surface DNA on exosomes
Boskovic, F., Dutta Gupta, P., Zhang, J., Krishnan, Y., Szostak, J. W.
10.1101/2025.11.18.689134 — Posted: 2025-11-19

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