Channel:  The Howard Hughes Medical Institute (HHMI)

2,006 Articles

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Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells
Pearlman, A. H., Mog, B. J., Hwang, M. S., Rincon-Torroella, J., DiNapoli, S. R., Paul, S., Douglass, J., Hsiue, E. H.-C., Glavaris, S. A., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Bettegowda, C., Zhou, S., Vogelstein, B., Konig, M. F.
10.64898/2025.12.09.691975 — Posted: 2025-12-11
Reconstructing a physiological state space via chronic jugular microdialysis in freely moving mice
Nardin, M., Wang, N., Elziny, S., Boyer, C., Pjanovic, V., Schuster, L., Boklund, P., Lindo, S., Morris, K., Ilanges, A., Voigts, J., Dennis, E. J.
10.64898/2025.12.08.692974 — Posted: 2025-12-11
Drosophila maintain a consistent navigational goal angle for days to weeks
Weisman, J. L., Mohren, T. L., Ryu, J. D., Wyse, M. Z., Dias-Ferreira, E., Maimon, G.
10.64898/2025.12.09.693277 — Posted: 2025-12-11
A shared DNA-repeat toxicity threshold, reached somatically at cell-type-specific rates, unites cortical and striatal neurodegeneration in Huntingtons disease
Kashin, S., Lee, W.-S., McDonald, T. M., Morris, K., Handsaker, R. E., Mello, C., Spina, L., Reed, N. M., de Rivera, H., Jana, S. H., Hogan, M., Berretta, S., McCarroll, S. A.
10.64898/2025.12.09.688862 — Posted: 2025-12-11
The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
Barr, H. J., Caldwell, S. K., Reimertz, J. M., Depp, C., Walker, A. J., Marsh, S. E., Gupte, A. S., Hingerl, M., Patel, J., Park, S.-O., Ferraro, S., Lipton, J., Stevens, B.
10.64898/2025.12.08.693074 — Posted: 2025-12-11
Design of Orthogonal Far-Red, Orange and Green Fluorophore-binding Proteins for Multiplex Imaging
Tran, L., Klein, S., Sharma, S., Juergens, D., Decarreau, J., Liu, B., Wang, Y., Bera, A. K., Kang, A., Woods, J., Joyce, E., Vafeados, D. K., Roullier, N., Chen, W., Lee, G. R., Lavis, L. D., Mahamid, J., An, L., Baker, D.
10.1101/2025.08.03.668343 — Posted: 2025-12-10
Structural basis of stepwise G protein activation by a viral chemokine receptor
Jude, K. M., Suomivuori, C.-M., Waghray, D., Maeda, S., Fujiyoshi, Y., Inoue, A., Garcia, K. C., Tsutsumi, N.
10.64898/2025.12.10.692789 — Posted: 2025-12-10
Multimodal cell lineage reconstruction in the hindbrain reveals a link between progenitor origin and activity patterning
Blanc, M., Meister, L., Lemon, W. C., Fiuza, U.-M., Keller, P. J., Espinosa-Medina, I., Pujades, C.
10.1101/2025.11.14.688499 — Posted: 2025-12-09
Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels
Moon, S. J., Hu, Y., Dzieciatkowska, M., Kim, A.-R., Asara, J. M., D'Alessandro, A., Perrimon, N.
10.1101/2024.04.24.591006 — Posted: 2025-12-09
High-efficiency, transgene-free plant genome editing by viral delivery of an engineered TnpB
Nagalakshmi, U., Rodriguez, J. E., Nguyen, T., Weissman, R. F., Thornton, B. W., Savage, D. F., Dinesh-Kumar, S. P.
10.64898/2025.12.05.692691 — Posted: 2025-12-09

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