Channel:  The Howard Hughes Medical Institute (HHMI)

2,696 Articles

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Activity and specificity trade-offs in adenine base editors
Lukarska, M., Oltrogge, L. M., Nisonoff, H., Long, Y., Terrace, C. I., Busia, A., Aquino, C., Kim, S. E., Listgarten, J., Savage, D. F.
10.64898/2026.07.20.739671 — Posted: 2026-07-22
HPRC2: A human pangenome reference with near-complete coverage of common genetic variation
Lucas, J. K., Hebbar, P., Liao, W.-W., Macias-Velasco, J. F., Novak, A. M., Asri, M., Balacco, J. R., Blair, A. P., Ebler, J., Gardner, J. M. V., Geleta, M., Groza, C., Guarracino, A., Heringer, P., Hickey, G., Lu, S., Marin, M. G., Markovic, C., Mastoras, M., Mayoud, C., McNulty, B., Menendez, J. M., Minkina, A., Mohanty, S. K., Monlong, J., Munson, K. M., Oshima, K. K., Porubsky, D., Ranallo-Benavidez, T. R., Seligmann, W. E., Shemirani, R., Violich, I., Yoo, D., Zhuo, X., Albracht, D., Alexandrov, I. A., Allen, J., Alsheikh-Ali, A. A., Andrews, C., Antipov, D., Antonacci-Fulton, L., Arguell
10.64898/2026.07.21.739710 — Posted: 2026-07-22
Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity
Fagniez, I., Tsumura, M., Guerin, A., Abolhassani, H., Sharafian, S., Mesdaghi, M., Nishimura, T., Lashkari, H. P., Rao, S., Richards, S., Han, J. E., Delmonte, O. M., Kergaravat, C., Markle, J. G., Ogishi, M., Han, J., Peel, J., Vellutini, J., Feng, Y., Soudee, C., Migaud, M., Palterer, B., Jackson, K. J. L., Nishimura, S., Sakata, S., Kinoshita, K., Yamamoto, A., Moritake, H., Alzahrani, M., Vallejos, F., Cole, T. L., Smart, J. M., Choo, S., Chavoshzadeh, Z., Armin, S., Toubert, A., Zhang, P., Rosain, J., Notarangelo, L. D., Pan-Hammarstrom, Q., Tangye, S. G., Casanova, J.-L., Ma, C. S., Pue
10.64898/2026.07.18.26358075 — Posted: 2026-07-22
Haplotype and diversity signatures of ultra-soft selective sweeps in HIV-1
Romero, E. V., Clark, D. A., Cohn, L. B., Feder, A. F.
10.64898/2026.07.21.739925 — Posted: 2026-07-22
Isolation and In vitro Characterization of BchE, the Cobalamin-Dependent Anaerobic Magnesium Protoporphyrin IX Monomethylester Cyclase Involved in Bacteriochlorophyll Biosynthesis
York, N., Zhang, X., Booker, S.
10.64898/2026.04.29.721654 — Posted: 2026-07-22
Defining the molecular interaction between influenza hemagglutinin and MHC-II
Dadonaite, B., Dosey, A., Ahn, J. J., Yu, T. C., Sunshine, S. A., Farrell, A. G., King, N. P., Bloom, J. D.
10.64898/2026.07.17.738765 — Posted: 2026-07-22
Principles of in situ protein sequencing: expansion microscopy-adapted Edman degradation and amino acid recognition
Mitchell-Wang, C. M., Tavana, S. Z., Peng, J., Wang, H., Shi, J., Zhang, C., Evgeniou, L., Domecillo, M., Mitchell-Wang, S., Estandian, D. M., Choueiri, A. G., Wong, E., Dohadwala, S., Kenzhebaev, I., Shin, T., Polizzi, N., Kiessling, L. L., Boyden, E. S.
10.64898/2026.01.29.702630 — Posted: 2026-07-21
Thousandfold Expansion Microscopy
Hu, H., Krah, D., Ntolkeras, A., Chanda, S., Heimbrodt, A., Mondal, M., Altendorf, J., Jing, B., Berger, B., Shaib, A. H., Rizzoli, S., Boyden, E. S.
10.64898/2026.05.31.729018 — Posted: 2026-07-21
Pathogenic MYBPC3 missense variants alter protein-protein interactions within the sarcomere
Thompson, A. D., Pankiewicz, C., Plenge, L. S., Lilienthal, U., Kotaru, S., Vignesh, M., Phan, T., McAllister, C., Yob, J., Morley, M. P., Ingles, J., Hespe, S., Helms, A. S., Ginsburg, D., SHaRe-HCM Investigators, , Day, S. M.
10.64898/2026.05.27.727676 — Posted: 2026-07-21
Rapid reconstitution and kinase-controlled regulation of algal pyrenoid condensates in engineered Nicotiana benthamiana
Kazachkova, Y., Punskovsky, J., Rai, A. K., Franklin, E., Jonikas, M. C.
10.64898/2026.07.20.739623 — Posted: 2026-07-21

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