Channel:  The Howard Hughes Medical Institute (HHMI)

2,121 Articles

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Structural basis of stepwise G protein activation by a viral chemokine receptor
Jude, K. M., Suomivuori, C.-M., Waghray, D., Maeda, S., Fujiyoshi, Y., Inoue, A., Garcia, K. C., Tsutsumi, N.
10.64898/2025.12.10.692789 — Posted: 2025-12-10
High-efficiency, transgene-free plant genome editing by viral delivery of an engineered TnpB
Nagalakshmi, U., Rodriguez, J. E., Nguyen, T., Weissman, R. F., Thornton, B. W., Savage, D. F., Dinesh-Kumar, S. P.
10.64898/2025.12.05.692691 — Posted: 2025-12-09
Multimodal cell lineage reconstruction in the hindbrain reveals a link between progenitor origin and activity patterning
Blanc, M., Meister, L., Lemon, W. C., Fiuza, U.-M., Keller, P. J., Espinosa-Medina, I., Pujades, C.
10.1101/2025.11.14.688499 — Posted: 2025-12-09
Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels
Moon, S. J., Hu, Y., Dzieciatkowska, M., Kim, A.-R., Asara, J. M., D'Alessandro, A., Perrimon, N.
10.1101/2024.04.24.591006 — Posted: 2025-12-09
Acute in vivo proximity labeling for membrane targeted proteomics in neuronal circuits
Anguiano, M., Zhang, R., Robles, M., Salemi, M. R., Phinney, B. S., Fenton, E. M., Leung, C. S., Lewis, E., Lin, S., Whistler, J. L., Nord, A. S., Kim, C. K.
10.64898/2025.12.04.691871 — Posted: 2025-12-09
Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates
Blevins, A. M., Peng, W., Kinch, L., Monshad, Z., Paredes, A. G., Volz, C., Rutter, J., Casey, A., Hicks, K., Orth, K.
10.64898/2025.12.08.693056 — Posted: 2025-12-08
Structure and evolution-guided design of minimal RNA-guided nucleases
Skopintsev, P., Esain-Garcia, I., DeTurk, E. C., Yoon, P. H., Zhou, Z., Weiss, T., Kamalu, M., Chamraj, A., Loi, K. J., Langeberg, C. J., Boger, R., Nisonoff, H., Karp, H. M., Chen, L., Shi, H., Vohra, K., Banfield, J. F., Cate, J. H. D., Jacobsen, S. E., Doudna, J. A.
10.64898/2025.12.08.692503 — Posted: 2025-12-08
The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome
Shen, B. A., Asfahl, K. L., Lim, B., Bertolli, S. K., Minot, S. S., Radey, M. C., Penewit, K., Ngo, B., Salipante, S. J., Johnston, C. D., Peterson, S. B., Goodman, A. L., Mougous, J. D.
10.1101/2025.11.29.690828 — Posted: 2025-12-08
Brain-immune interactions generate pathogen-specific sickness states
Sullivan, Z. A., Wong, B. J., Kapoor, V., Vincze, P. K., Kaplan, H. S., Giraudet, P., Watson, B. R., Misherghi, A., Lourido, S., Moffitt, J. R., Dulac, C.
10.64898/2025.12.06.692770 — Posted: 2025-12-08
Mouse germline cysts contain a fusome that mediates oocyte development
Pathak, M., Spradling, A. C.
10.1101/2025.07.25.666884 — Posted: 2025-12-07

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