Channel:  The Howard Hughes Medical Institute (HHMI)

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Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer's Disease
Wang, W., Berube, P., Yang, B., Castanon, R., Bartlett, A., Komandur, K., Nery, J. R., Barragan, C., Kenworthy, M., Valadon, C., Altshul, J., Petrella, A., Chan, D., Chen, C., Acerbo, A. S., Luo, J., Jain, M., Soma, E., Chen, H., Liem, M., Marrin, M., O'Connor, C., Zemke, N., Oakley, D. H., Ren, B., Hyman, B. T., Ecker, J. R.
10.1101/2025.09.29.678849 — Posted: 2025-09-30
Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants
Dadonaite, B., Harari, S., Larsen, B. B., Kampman, L., Harteloo, A., Elias-Warren, A., Chu, H. Y., Bloom, J. D.
10.1101/2025.08.18.671001 — Posted: 2025-09-30
Cell-cycle-dependent repression of histone gene transcription by histone H4
Ahmad, K., Wooten, M., Takushi, B. N., Vidaurre, V., Chen, X., Henikoff, S.
10.1101/2024.12.23.630206 — Posted: 2025-09-29
Computational design of pH-sensitive binders
Ahn, G., Coventry, B., Sadre, S., Haefner, E., Hu, J., Van, M., Huang, B., Sappington, I. W., Broerman, A. J., Lichtenstein, M., Glögl, M., Goreshnik, I., Vafeados, D., Baker, D.
10.1101/2025.09.29.678932 — Posted: 2025-09-29
Determination of Aedes mosquito mating success by a rapidly-evolving female-controlled lock-and-key mechanism
Houri-Zeevi, L., Walker, M. M., Razzauti, J., Sharma, A., Pasolli, H. A., Vosshall, L. B.
10.1101/2025.04.11.648401 — Posted: 2025-09-28
Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
Pakharukova, N., Thomas, B. N., Bansia, H., Li, L., Bassford, D. K., Abzalimov, R. R., Kim, J., Kahsai, A. W., Pani, B., Xiao, K., Ochakovski, R., Liu, S., Zhang, X., Ahn, S., des Georges, A., Lefkowitz, R. J.
10.1101/2024.07.31.605623 — Posted: 2025-09-27
Modeling protein-small molecule conformational ensembles with PLACER
Anishchenko, I., Kipnis, Y., Kalvet, I., Zhou, G., Krishna, R., Pellock, S. J., Lauko, A., Lee, G. R., An, L., Dauparas, J., DiMaio, F., Baker, D.
10.1101/2024.09.25.614868 — Posted: 2025-09-27
Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning
Liu, Z., Qiu, C., Kubo, C. A., Xu, S., Daza, R. M., Nichols, E., Yang, W., Vo, A., O'Neill, M. B., Lee, C., Shendure, J., Hamazaki, N.
10.1101/2025.09.25.678678 — Posted: 2025-09-26
Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites
Puszynska, A. M., Nguyen, T. P., Cangelosi, A. L., Armani, A., Roberts, J. M., Singh, K. A., Cameron, J. C., Tseyang, T., Liu, G. Y., Lai, S., Sprenger, H.-G., Yang, J., Colgan, W. N., Kedir, J. F., Kajderowicz, K. M., Esantsi, T. K., Lu, Y. R., Waite, M., Kunchok, T., Lewis, C. A., Schulte, F., Bell, G. W., Sabatini, D. M., Weissman, J. S.
10.1101/2025.09.25.678303 — Posted: 2025-09-26
Observing biological spatio-angular structures and dynamics with statistical image reconstruction and polarized fluorescence microscopy
Liu, J., Chandler, T., Li, Y., Agashe, A., Wei, M., Su, Y., Wu, Y., Baskin, T. I., Jaumouille, V., Chen, J., Xu, P., Ye, H., Zhu, W., Fischer, R. S., Swaminathan, V., Nain, A. S., Mehta, S. B., La Riviere, P. J., Shroff, H., Liu, H., Guo, M.
10.1101/2025.09.23.678164 — Posted: 2025-09-25

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